Plus de 40 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Regulation of obesity and fatty acid-induced inflammation by AMP-activated protein kinase in obese/type 2 diabetic and inactive human skeletal muscle (AMPKANTIINFLAMMATION)
Date du début: 8 juil. 2011, Date de fin: 7 janv. 2013,
It is increasingly recognised that obesity is characterised by chronic activation of inflammatory pathways in skeletal muscle and that this is a causative factor of obesity associated insulin resistance; also contributing to the pathogenesis of complications of diabetes. My work has shown that activation of AMP-activated protein kinase (AMPK) can regulate inflammatory signalling by antagonising fa ...
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1
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TERMINÉ
"Intramembrane Proteases, their Inactive cognates, and Disease" (IPAD)
Date du début: 1 janv. 2014, Date de fin: 31 déc. 2017,
...egulated by diverse physiological and pathological stimuli, but little is known about the mechanism of regulation.Recently I have shown that iRhoms, endoplasmic reticulum (ER)-localized catalytically inactive homologs of rhomboid proteases, are essential TACE regulators. iRhoms act as trafficking factors: they bind to TACE in the ER and control its trafficking into the Golgi apparatus, wherein TAC ...
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1
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TERMINÉ
Improving the selectivity of kinase inhibitors: Characterizing binding mechanisms of inhibitors targeting inactive states and allosteric sites (KIBinding)
Date du début: 1 mars 2013, Date de fin: 28 févr. 2015,
...ng site, which is highly conserved among the different kinases. In order to increase inhibitor selectivity toward a desired target kinase, the focus has turned to developing inhibitors which bind to inactive conformations or allosteric sites.The techniques frequently used to study inhibitor binding such as X-ray crystallography and docking are limited because they only sample a single structure. ...
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2
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TERMINÉ
The project will - based on desk-research of the partners and a survey based broad user needs analysis - adapt and develop an innovative training package and on-line platform for entrepreneurship skills targeting unemployed and inactive young and women to be tested and evaluated by the target groups (TGs).
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6
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TERMINÉ
Do what you like! And like what you do! Envolving the inactive young person
Date du début: 2 déc. 2010,
The 7-days training "Do what you like! And like what you do! Involving the inactive young person" will give opportunities for 22 youth workers from Europe and EECA countries to share their experience, to gain new knowledge and to explore the concept of an active European Citizenship, to explore different kind of youth work and youth art techniques that can be used as non-formal learning tools to s ...
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11
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TERMINÉ
Increasing employability of women with physical disabilities and inactive women via intergrated e-training & e-mentoring
Date du début: 1 sept. 2014, Date de fin: 31 août 2016,
... to the EU statistics, we still see significant differences between male and female unemployment. In addition to gender differences unemployment, a new term has been introduced: that of people being "inactive", i.e. neither employed nor unemployed and sitting at home. Moreover; employment has always been a problem for disabled people. Disabled people face a lot of unusual obstacles and barriers in ...
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8
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TERMINÉ
Activating the Inactive Young Volunteer
Date du début: 15 mars 2012,
Activating the Inactive young Volunteer will be a 7 day training course for international youth workers which support them in developing the skills to recruit, train and manage young people as volunteers within their own organizations; and to support those volunteers in developing their creative and entrepreneurial skills. The training will focus on volunteers from all social and cultural backgrou ...
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12
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TERMINÉ
...ion in continuous manner. Acccording to the latest statistics the rate of employment of women in this sector is 46%, highlighting the importance of the sector in female employment. There are a lot of inactive women who are neither in work nor seeking employment because of family responsibilities. Although they have natural "talent" combined with experience, they are still among the most disadvanta ...
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5
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TERMINÉ
ObLoMoV: Obesity and Low Motility Victims – “physical short shocks” and “theatre short stories” to convert inactive victims into HEPA social actors
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2019,
...re lifestyle as it involves other epidemic diseases such as overweight and obesity. The Oblomov Project (acronym of Overweight/Obesity and Low Motility Victims) takes inspiration from this lazy and inactive literary character to propose a new pedagogic method aimed at tackling the inactivity problem among at least 1.000 European young students of 11/13 years old, as an effective strategy to preve ...
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7
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TERMINÉ
Be Active and activate the inactive young volunteer
Date du début: 12 janv. 2015, Date de fin: 11 juil. 2015,
see above
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14
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TERMINÉ
To Be Employed or Not
Date du début: 6 sept. 2015, Date de fin: 5 mai 2016,
...percent of the young are unemployed, this rate is expected to increase to the rate of 12.8 when 2 million people are included in this figure.
According to an estimation, in 2011 economic loss the ‘inactive youth’ cause who don’t have any jobs or aren’t studying anywhere is 153 billion American dollars in other words, more than 1 % of GDP. Thus, failure in the youth employment not only slows down ...
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5
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TERMINÉ
I CARE
Date du début: 5 août 2015, Date de fin: 4 oct. 2016,
...ral problems to their life, such as sedentary lifestyle, unhealthy nutritional habits, lack of exercise and other related unhealthy behaviors, which itself leads young people to become socially inactive and socially excluded.
This is why the project organizers decided to focus on this topic. Project will gather 28 participants and 5 group leaders in Kaunas, Lithuania to share, and extend their cur ...
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4
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TERMINÉ
New Eyes & Toys
Date du début: 1 déc. 2014, Date de fin: 30 avr. 2016,
...tance between young people and decision makers in Klis, Gavoi and Baixo Tâmega through the creation of a youth council that would help to solve problems of local youth;
*Reducing the number of inactive young citizens (NEETs) in Klis, Gavoi and Baixo Tâmega.
Main outputs will be:
*Completing a guide for youth workers, where trainers, facilitators and people working with young people will find new t ...
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3
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TERMINÉ
Designing quality and training tools for competence profile of supported employment specialists
Date du début: 1 sept. 2015, Date de fin: 31 août 2018,
... or charitable support, enabling full workplace inclusion and career enhancement. Llong term impact of the project will increase the employment rates of people with disabilities who are currently inactive in the labour market and have low or no work experience or vocational training. This will lead to greater independence and financial security, allowing them to become fully active members of soci ...
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6
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TERMINÉ
Adults Acquiring Digital Skills
Date du début: 1 sept. 2015, Date de fin: 30 nov. 2017,
...re digital working life. Trainers in adult learning organisations can play a key role in helping to meet the needs of the 64% of disadvantaged people i.e. aged 55+, low educated, unemployed or inactive who have insufficient level of digital skills. They give training in basics skills not only for inclusion in society but also to improve the employability of adults.
Digi4Adults addresses the lac ...
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5
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TERMINÉ
Molecular modelling of the cannabinoid CB1 receptor homodimer and its interaction with ligands: the role of membrane cholesterol and the CRIP1a protein (CannabiDim)
Date du début: 1 août 2012, Date de fin: 31 juil. 2014,
...s: (i) homodimerization of the CB1R is agonist-mediated; (ii) the interface transmits cross-talk between protomers; (iii) cholesterol promotes CB1R homodimerization; (iv) cholesterol stabilizes the inactive state of the CB1R homodimer; (v) the CRIP1a stabilizes the inactive state of the CB1R monomer; (vi) the CRIP1a hampers CB1R homodimerization. The project involves the following detailed objecti ...
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1
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TERMINÉ
Skills Innovation Training
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2018,
...nhancing basic skills, in particular digital skills for specific adult groups -– adults with low level or no qualifications, those in low skilled occupations, unemployed, migrants and economically inactive, older people and least skilled. Skill IT will:a) address the issues of low levels of digital literacy and competency amongst adults who are disadvantaged and at risk of exclusionb) address st ...
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7
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TERMINÉ
digiUP. Interactive groups for digital inclusion through intergenerational dialogue
Date du début: 31 déc. 2015, Date de fin: 30 déc. 2017,
...-creation, safety and problem-solving. It is addressed to the disadvantage group identified in the Digital Agenda Report as the most vulnerable (aged 55-74, low educated, unemployed, retired and inactive people) focusing on migrant and Roma who are those suffering more educative and employment exclusion at this moment in Europe. The project will be based in a participative and intergenerational a ...
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5
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TERMINÉ
Promoting Physical Activity and Health in Ageing
Date du début: 1 janv. 2015, Date de fin: 30 sept. 2016,
...cal Activity recommendations 35 - 37 which are specific in the area of active ageing to show how supervised, structured exercise programming for older adults can help to convert currently inactive people to become regular exercisers at a level that is beneficial to their health.
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9
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TERMINÉ
Peptidomimetics with photocontrolled biological activity (PELICO)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,
...upon irradiation with light of different wavelength. The participating parties possess general know-how for design of the peptidomimetics which can exist in two photo-forms, biologically active and inactive ones, reversibly interconvertible by light of different wavelength. This opens a possibility to convert inactive peptidomimetics to active compounds by irradiation with physiologically benign l ...
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4
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TERMINÉ
Novel somatic mutations in ABCA1 in chronic myelomonocytic leukaemia (NOVAMOLE)
Date du début: 1 juin 2014, Date de fin: 31 mai 2018,
..., which exhibit anti-myeloproliferative activity in preclinical mouse models.Hypothesis: Somatic mutations in ABCA1 and ABCG1 may be observed in myeloproliferative disorders and could be functionally inactive disabling both cholesterol efflux and anti-tumor activity.Preliminary data: Five new somatic mutations in ABCA1 were identified out of 26 tumor samples from patients with chronic myelomonocyt ...
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1
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TERMINÉ
Optical strategies to investigate NMDA receptor functional diversity and its therapeutic potential (OptoNMDA)
Date du début: 1 avr. 2016, Date de fin: 31 mars 2018,
...ontaining the GluN2B subunit (GluN2B-NMDARs) in ex vivo and in vivo preparations. This approach consists in developing photo-convertible polyamine derivatives that can reversibly isomerize between an inactive and active configuration with light to act on the GluN2B-NMDAR polyamine allosteric modulating site in a precise spatio-temporal manner (opto-allostery). I will study the physiological and po ...
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1
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TERMINÉ
Disability Awareness: A New Paths to develop Skills and Abilities
Date du début: 1 août 2016, Date de fin: 31 janv. 2017,
...e specialized in training and providing job opportunities for people with disabilities, especially, people with intellectual disabilities. Persons with disability are almost twice as likely to be inactive in the labour market as non-disabled people. The work program will schedule the following activities: energizers, presentation, press conference, evaluation, intercultural night, team building ac ...
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12
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TERMINÉ
Move for Health
Date du début: 1 juin 2015, Date de fin: 31 juil. 2016,
...ers, integration and diversity;
- to encourage the integration of young people with fewer opportunities;
- to encourage young people to lead an active life in a society where people are sedentary and inactive;
- to promote the knowledge of other cultures and the comparison on the different behaviours and habits about nutrition and physical activity;
- to support young people in creating a lifestyl ...
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5
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TERMINÉ
H.A.Y.P v2
Date du début: 7 août 2015, Date de fin: 6 déc. 2015,
...nt cultures: how a healthy and active life style is taught in families, at schools and in the community. What is more encouraged : competition/recreation. What are the dangers for young people (inactive way of living, alcohol, drugs, …)
All the activities will be a challenge to young people themselves to grow spiritually, physically, mentally. Focusing not only on the debate, but also on the invol ...
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2
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TERMINÉ
New high-performance excipients in pharmaceutical industry: an innovative solution for a more efficient and sustainable drug manufacturing process. (HPE1)
Date du début: 1 déc. 2016, Date de fin: 30 avr. 2017,
"Pharma73 SA is a Portuguese start-up dedicated to the development, production and commercialization of a new generation of High Functionality Excipients (HFEs). Excipients are inactive ingredients used together with active ingredients to formulate drugs into finished dosage forms. Ranging from 15% to 95% of the total weight of a given drug, excipients are extremely important in terms of procureme ...
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1
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TERMINÉ
DISKOmice (DISKOMICE)
Date du début: 1 sept. 2012, Date de fin: 30 août 2016,
...proposed research activities will focus on: mice models of gene invalidation particularly regarding the HIF pathway (HIF-1α, HIF-2α and Von Hippel Lindau tumor suppressor protein). To specifically inactive these genes during embryonic development, growth or aging, conditional and inducible KO will be generated using Cre or Cre-ERT2 strategies and promoters for Foxa2 (notochordal cells) or aggreca ...
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1
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TERMINÉ
Learning Map
Date du début: 1 déc. 2016, Date de fin: 31 mars 2018,
...ing by 2020. Indeed, there are major challenges to be confronted. At European level, challenges are:· Significantly increasing rates of adult participation in learning, especially for economically inactive, unemployed, older and less skilled adults;· Substantially reducing the number of adults who have only a lower secondary qualification. With this project we intend to work towards and contribute ...
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4
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TERMINÉ
TimeLapseReader for Quality Control of Immune Cells used for Cell-Based Therapies (Quality2Cells)
Date du début: 1 août 2016, Date de fin: 31 janv. 2017,
...roduction of therapeutic immune cells is expensive and associated with remaining risks. In particular, it is known that only actively migrating immune cells are efficient against tumours cells, while inactive therapeutic cells can elicit adverse effects. Yet, there is no quality control (QC) regarding motility of therapeutic cells before patient treatment. The goal of the proposal is to promote an ...
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1
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TERMINÉ
Porous Silicon Carbide as a support for Co metal nanoparticles in Fischer–Tropsch synthesis (SiCCatalysis)
Date du début: 1 juil. 2012, Date de fin: 30 juin 2014,
...o 40 bars). At these stress conditions the chemical nature of the support material plays an important role. Significant support interaction is observed for Al2O3 and TiO2 leading to the formation of inactive compounds (so-called SMSI effect). SiO2 support exhibits a weaker interaction. However, its low thermal conductivity provokes overheating of the metals due to a high exothermic nature of the F ...
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4
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TERMINÉ
European-Fitness Badge - an effective way promoting the awareness of the importance of health enhancing physical activity
Date du début: 1 janv. 2015, Date de fin: 30 juin 2017,
...mplementation of the EU Physical Activity Guidelines, and a tool that can be replicated and taken up by other stakeholders throughout and bayond the project lifetime.Sustainable behaviour change from inactive to active passes several stages. The Fitness Badge can be s sustainable module on the way to change the behaviour. Especially from the stage “thinking about/making plans” to the stage of “exp ...
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7
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TERMINÉ
Ανταγωνιστικές Δράσεις στον Αγροτουριστικό Τομέα - Competitive Actions in Agrotourism
Date du début: 1 juin 2015, Date de fin: 31 mai 2017,
...economy relies heavily on tourism. Unfortunately, the tourist season lasts 3-4 months, mainly during the summer months. The remainder of the year, hostels and small hotel accommodations remain either inactive or barely functioning, with obvious effects on the local economy and workforce employment. It is therefore necessary that touristic season should be extended as much as possible and preferabl ...
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4
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TERMINÉ
...ng prime strategic priorities of adaptation of European training system to become a world reference. The long term impact of this will be increased employment rates of BPS people who are currently inactive in the labour market and have low or no work experience or vocational training. This will lead to greater independence and financial security, allowing them to become fully active members of so ...
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4
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TERMINÉ
ADAptive circuit techniques for current-mode ultra low-power diGItal Integrated Circuits (ADAGIO)
Date du début: 10 mai 2009, Date de fin: 9 mai 2011,
...te bias current to compensate the inevitably large delay variations, adapt the power consumption to the available energy and the required performance, as well as to suppress the power contribution of inactive blocks. Accordingly, criteria and methods to design MCML standard cell libraries and use them in standard CAD design flows will be developed. To further reduce the consumption, an ultra-low v ...
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1
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TERMINÉ
...physical, intellectual or psychiatric disabilities usually face barriers of stigma and anxieties. The dominant idea - even by parents and professional staff – is that they are or should be sexually inactive and consequently do not need to learn about sexuality. The regular education system and a lot of parents as the prime sexual educator do not offer sufficient sex education for them. Most person ...
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4
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TERMINÉ
By-products for Building Materials (By-BM)
Date du début: 25 avr. 2016, Date de fin: 24 avr. 2018,
...ion including BMs. The By-BM project will develop innovative, environmentally-safe geopolymer building materials – which integrate waste materials, yet comply with necessary safety standards. Inactive leaching studies will also be carried out to investigate the possibilities of By-BM geopolymers in Radioactive Waste Cementation. The project brings together a leading research group in geopolymer co ...
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1
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TERMINÉ
Structural studies of ligand-induced conformational changes in G protein-coupled receptors (GPCR conformations)
Date du début: 1 juin 2011, Date de fin: 31 mai 2013,
...hroughput differential scanning fluorimetry or radioligand-binding assays. These results will be used in engineering of GPCR mutants that are more stable and locked in the specific (eg, activated or inactive) conformational state. Ligand-binding to the stabilised mutants and their functionality will be monitored by fluorescence anisotropy titrations, as well as by radioactive assays using the cor ...
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1
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TERMINÉ
Role of the PI3Kbeta isoform in signalling and cancer invasion (PIKbeta/cancer)
Date du début: 1 avr. 2011, Date de fin: 28 sept. 2013,
...ion. This will be achieved combining both cell-based in vitro 3D-invasion techniques using p110beta-selective pharmacological inhibitors and in vivo models of cancer invasion using mice expressing an inactive p110beta. An siRNA screen as well and advanced techniques of microscopy, biochemistry and cell biology will be performed. The results of these studies have implications for the fundamental un ...
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1
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TERMINÉ
Epigenetic regulation and monoallelic gene expression: the X-inactivation paradigm and beyond (EpigenetiX)
Date du début: 1 mai 2010, Date de fin: 31 oct. 2015,
X-chromosome inactivation (XCI) represents a classic example of epigenetics in mammals. In this process, one of the two X chromosomes in females is converted from an active into a clonally heritable, inactive, state during early embryonic development, to ensure dosage compensation between the sexes. This process is also remarkable in that an entire chromosome is silenced while its homologue, prese ...
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1
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TERMINÉ
Determining the roles of the nuclear periphery in mammalian genome function (FunctionalEdge)
Date du début: 1 mars 2010, Date de fin: 29 févr. 2016,
...ms to determine the functional significance of positioning specific genome regions at the edge of the nucleus in mammalian cells. The nuclear periphery has conventionally been considered as a zone of inactive chromatin and transcriptional repression. Several regulatory gene loci move away from the nuclear periphery as they are activated during differentiation. Novel approaches, developed by oursel ...
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