38 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Development of a more effective and safer therapeutic antibody for cancer treatment with a dual mechanism of action to eliminate CSCs and reactivate the tumour’s immune system. (CSC-IS)
Date du début: 1 juil. 2015, Date de fin: 31 déc. 2016,
...herefore urgent to develop more effective treatments against this fatal disease.There are two main reasons that explain the lack of success for the current treatments: In one hand, Cancer Stem cells (CSCs) are responsible from tumour initiation, maintenance, relapse and metastasis. On the other hand, the tumour has mechanisms to repress the patient’s immune system that attacks tumour cells. Our te ...
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2
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TERMINÉ
Semiconductor-based Ultrawideband Micromanipulation of CAncer STEm Cells (SUMCASTEC)
Date du début: 1 janv. 2017, Date de fin: 30 juin 2020,
SUMCASTEC explores radically new approach for cancer stem cells (CSCs) real time isolation (i.e. within minutes vs current 40 days) and neutralization. A novel micro-optofluidic lab-on-chip (LOC) platform will be developed through a joint and iterative effort by biologists, clinicians and engineers. For the first time, a single LOC will be capable of delivering ultra-wide broadband radiation to co ...
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6
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TERMINÉ
Molecular characterization and targeted elimination of metastatic pancreatic cancer stem cells (PA-CSC)
Date du début: 1 juil. 2009, Date de fin: 31 déc. 2014,
...t. We have identified and characterized pancreatic CSC in the context of tumour growth, metastasis, and resistance to chemotherapy. To eventually be able to develop a targeted therapy for eliminating CSCs as the root of the tumour, we will perform comparative functional and genomic analyses of the identified, highly purified human CSC populations, their more differentiated progenies, normal tissue ...
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1
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TERMINÉ
BUILDING FUTURES (BUFU)
Date du début: 31 déc. 2008, Date de fin: 30 déc. 2012,
... supported residents- 240 residents assisted through Information Advice & Guidance (IAG)- 120 residents achieving accredited training- 50 residents gaining Construction Skills Certification Scheme (CSCS) cards- Development of joint construction industry awareness sessions, training, support & practice guide.- Newsletters on partner websitesActivity 3- 50 work placements offered to upskilled reside ...
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4
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TERMINÉ
...ack to criminal behavior. During the project the Dutch partners will share their experiences, update the products and pilot the new products together with project partner in Portugal (ISQ) and Italy (CSCS – Centro Servizi “Cultura Sviluppo” Srl). Both partners are involved in training youngsters in prison. The pilots will be evaluated and lessons learned will be published.European dimension The si ...
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4
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TERMINÉ
...ers- To transfer, after having adapted the teaching materials and the license of the MIME® method to the context of each country involved in the MANAGE project. In this sense, DOCUMENTA (Spain), CSCS (Italy) and IREA (Romania) will be in charge of organizing and monitoring MIME® training sessions in their own countries, spreading the method geographically, preparing future trainers to MIME® and ma ...
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8
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TERMINÉ
EBBD BRiDGES
Date du début: 1 juil. 2014, Date de fin: 30 juin 2015,
...els Brock Business College, Copenhagen) and in organizations providing well organized and monitored work placements, which will be certified according to European standards (ECVET and Europass) by CSCS Pistoia, so that the participating students can meet the required standards and teachers can gain the necessary experience, improve their competences linked to teaching, provide a better quality of ...
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8
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TERMINÉ
Integrated European Model for Rehabilitation of Victim and Offender Children
Date du début: 1 sept. 2014, Date de fin: 31 déc. 2016,
...proffesionals and thus this leads to unhealthy and ineffective rehabilitation. Besides, lack of integrated Rehabilitation system seems a Europe-wide issue. Each partner across Europe (Diagrama- UK, CSCS- IT, FAMYLIAS- ES, Provest-TR), which has deep expertise in Juvenile Rehabilitation and VET, will analyze the current state of art and draw best practices across Europe. Then a handbook of best pra ...
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4
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TERMINÉ
Support Opportunities For Training Skills
Date du début: 1 févr. 2015, Date de fin: 1 déc. 2015,
... participants should be
activists, youth workers who have some experience in youth work willing to multiply the knowledge they get with other young
people with fewer opportunities in local community.
CSCS is a vocational training provider, active in the field of research on labour market and pedagogic innovation, as well as in the
promotion of transnational cooperation on technical education and t ...
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9
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TERMINÉ
SEGUIMOS CRECIENDO PARA EUROPA
Date du début: 1 juin 2015, Date de fin: 31 mai 2016,
...s and they developed skills acquired in Spain and the linguistic competence in Italian.
For Intermediate Vocational Training, students went in internship companies to Pistoia (Italy), by means of CSCS, which is a Vocational Training Provider. They were going to have the first work experience, developing autonomously their professional and personal duties. In this way, they were going to develop th ...
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3
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TERMINÉ
Tourism for VET
Date du début: 1 juin 2015, Date de fin: 31 mai 2017,
...y: The practices will be held for 90 days in Portugal: Lisbon, intermediary organization CCIP, 20 mobilities, 10 per year, Italy: 42 mobilities, intermediary organizations: Kara Bobowski, INPROGRESS, CSCS 21 per year, Greece: Crete, intermediary organization: ELI 14 mobilities, 7 per year, Bulgaria: Sandanski, intermediary organization: EUNI, 4 mobilities, 2 per year. Hospitality Center Mediterran ...
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7
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TERMINÉ
Learning in international internship
Date du début: 1 sept. 2015, Date de fin: 31 août 2017,
...ey), Srednja poklicna in strokovna sola Bezigrad - Ljubljana (Slovenia), Berufsförderungswerk e.V. des Bauindustrieverbandes Berlin-Brandenburg e.V (Germany) and Centro Studi “Cultura Sviluppo” (CSCS, Italy).
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7
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TERMINÉ
Mobilny mechanik na rynku europejskim
Date du début: 31 déc. 2015, Date de fin: 30 déc. 2016,
...undergo a 3-week-vocational training program in a car repair workshop in Italy. The organization (partner) in Italy which is responsible for preparation and execution of the tasks entrusted is CSCS with a registered office in Pistoia. The project activities related to mobility will be preceded by an English course and the preparation in the field of cultural differences. The implementation of the ...
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2
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TERMINÉ
ASENTADOS EN EUROPA
Date du début: 1 juil. 2016, Date de fin: 30 juin 2017,
... skills acquired in Spain and the linguistic competence in Italian.For Intermediate Vocational Training, students will go in internship companies to Pistoia (Italy) and Mosta (Malta), by means of CSCS and Paragon Europe, which are hosting partners and accomodation Providers. They are going to have the first work experience, developing autonomously their professional and personal duties. In this wa ...
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4
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TERMINÉ
Vocational Education and Training in the Construction programme
Date du début: 1 juin 2015, Date de fin: 31 mai 2016,
...s which was compared to the evaluation methods used at our receiving organisations.
The partners are the vocational school ESEDU in Pieksämäki, Finland, the vocational training- and researchcenter CSCS in Pistoia, Italy and the vocational education- and training center BZB in Krefeld, Germany. 13 students in autumn 2015 and 10 students in spring 2016 had placement, in a four week period. The fir ...
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4
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TERMINÉ
Integrated next-generation flow cytometry and sequencing to uncover the pathway of curability in multiple myeloma (MYELOMANEXT)
Date du début: 1 sept. 2016, Date de fin: 31 août 2021,
Multiple myeloma (MM) represents a unique model to investigate cancer stem cells (CSCs), circulating tumour cells (CTCs), and the mechanisms of malignant transformation and chemoresistance. Despite the substantial improvement in MM patients’ outcome, the vast majority of patients eventually relapse and the disease remains largely incurable. For those patients failing to achieve deep remissions, bi ...
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2
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TERMINÉ
Next-Generation Antibody-Drug Conjugates for safer and more effective cancer therapies (ADC)
Date du début: 1 mai 2016, Date de fin: 30 sept. 2016,
...of a systemic treatment and have the advantage of targeting only tumour sites within the same therapy. Oncolinx’s drugs are effective against drug resistant cancers, as well as cancer stem cells (CSCs)—cells directly responsible for drug-resistance, metastasis, and relapse. In addition, Oncolinx’s technology activates the immune system against the tumour, which is an integral hallmark of durable r ...
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1
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TERMINÉ
Identification of alternative splicing networks defining embryonic stem cell identity (SPLICE-STEM)
Date du début: 1 mars 2014, Date de fin: 28 févr. 2018,
...enewal and pluripotency is not only important to understand normal development but could also improve the clinical potential of adult stem cells, ESCs and iPSCs, and reveal novel strategies to target CSCs.Our objective is to identify novel mechanisms controlling the genetic programs that define the fate of ESCs. Along this line, we recently revealed a central role for alternative splicing (AS) in ...
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1
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TERMINÉ
Three Dimensional Single Cell Analysis of the Cancer Stem Cell Inducing Epithelial-Mesenchymal Transition Signaling Networks in Breast Cancer by Mass Cytometry (Signaling 3D)
Date du début: 1 mars 2014, Date de fin: 28 févr. 2019,
Tumor metastases, relapse, and resistance to therapy are the main causes of death in cancer patients. Cancer stem cells (CSCs) drive cancer growth, are likely responsible for cancer reoccurrence, and provide the potential to colonize a metastatic site. A cell plasticity process called epithelial-mesenchymal transition (EMT) generates CSCs from epithelial cancer cells and simultaneously equips thes ...
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1
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TERMINÉ
CO-OPTION OF THE NKG2D LYMPHOCYTE RECEPTOR AS AN ONCOPROTEIN PROMOTING CANCER STEM CELL TRANSDIFFERENTIATION AND CANCER AUTONOMY (NKG2D)
Date du début: 1 janv. 2014, Date de fin: 1 janv. 2018,
...ition (EMT), a cellular reprogramming process that leads to increased cancer cell motility and metastatic dissemination. Intertwined with EMT is the generation of self-renewing cancer stem cells (CSCs), which are main culprits of failed cancer therapies. These findings challenge current concepts as cancer cells may co-opt NKG2D as an oncoprotein serving their own benefit.In a preliminary assessmen ...
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1
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TERMINÉ
Inside mechanisms sustaining cancer stem cells (InMec)
Date du début: 1 juil. 2014, Date de fin: 30 juin 2019,
The “Cancer Stem Cell (CSC) Hypothesis” postulates that the capacity to maintain tumour growth is owned by rare cancer cells, the CSCs, endowed with self-renewal properties. This hypothesis implies that CSCs must be eliminated to achieve cancer cure. Nevertheless, direct proof is still lacking, and recent findings challenge our concepts of CSCs, showing the limits of the CSC-defining assay (transp ...
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1
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TERMINÉ
Cellular bioengineering by plasmonic enhanced laser nanosurgery (Light2NanoGene)
Date du début: 1 avr. 2014, Date de fin: 31 mars 2017,
...gration of the plasmonic nanosurgery tool towards in-vivo (i.e. living subject) applications. In-vitro cell transfection (i.e., introduction of siRNA through the membrane of breast cancer stem cells (CSCs)) is the specific nanosurgery application of the Light2NanoGene project. The latter, is driven by the remarkable ability of these undifferentiated cells within a tumor to self-renew and promote m ...
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1
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TERMINÉ
The importance of the epigenome in tumour development and recurrence (EpiBrain)
Date du début: 1 mai 2014, Date de fin: 30 avr. 2018,
I aim to develop methods to reverse epigenetic anomalies in cancer stem cells (CSCs) to switch off the unlimited cell division and cancer growth and to understand the involvement of epigenetics in tumour development and recurrence. Epigenetic alterations are observed at the earliest stages of neoplasia within stem cells. Importantly, the alterations are reversible and can potentially be “treated”. ...
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1
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TERMINÉ
Nano-technology enabled repositioning of Disulfiram as an anti-cancer stem cell agent (NANODISCAN)
Date du début: 5 juin 2014, Date de fin: 4 juin 2016,
Most cancers remain ‘incurable’ and life-thretening. Cancer stem cells (CSCs) are the source of chemo/radioresistance and responsible for cancer recurrence which suggests the urgent requirement of CSC-targeting drugs. Drug development is a slow (15 years/drug) and costly (US$1.5bn/drug) procedure with only 5-25% of new oncology drugs in clinical development actually reaching the market mainly due ...
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1
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TERMINÉ
Targeting Cancer Stem Cells (CSC) for the development of more effective treatments to cure cancer patients (Anti-CSC)
Date du début: 1 déc. 2012, Date de fin: 30 nov. 2013,
...d EU, is 14 months and its 5-yr survival less than 5%. It is therefore urgent to develop more effective treatments against this fatal disease.It has been recently demonstrated that Cancer Stem Cells (CSCs) are responsible from tumour initiation, maintenance, relapse and treatment resistance, and therefore therapies targeting CSC should eradicate the tumour. Our team has discovered a molecular path ...
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2
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TERMINÉ
Testing and validation of bispecific antibody combinations targeting treatment-resistant cancer stem cells using organoid-based screening tools: a new drug discovery paradigm (SUPPRESSTEM)
Date du début: 1 juin 2013, Date de fin: 30 nov. 2016,
...l colon physiology but also CSC maintenance. Deregulation of Wnt and other mitogenic pathways results in formation of aggressive tumours with metastatic potential. Novel combinatorial drugs targeting CSCs are required to address signalling redundancy and subvert resistance and escape mechanisms. However to test them effectively better drug screening tools must be developed. The high failure rate i ...
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5
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TERMINÉ
Evaluation of metastatic and angiogenic potential of cancer stem-like cells in distinct mouse models for lung and liver metastasis (Metastasis)
Date du début: 1 nov. 2011, Date de fin: 5 mars 2014,
...e growth and spread of a tumor. This research proposal is founded on the hypothesis that the CSC theory also applies to the metastasic process. The aims are to determine the relative contribution of CSCs to tumor cell homing, their ability to recruit BMDCs and induce angiogenesis. The final goals are to elucidate the mechanisms that participate in these phenomena and to develop novel therapeutic ...
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1
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TERMINÉ
THE EPIGENOME OF BREAST CANCER STEM CELLS (EPIGBRCASTEM)
Date du début: 1 mars 2012, Date de fin: 29 févr. 2016,
...o the pathophysiology of these cells and with the ultimate goal of developing therapeutic schemes that target them specifically.Accumulating evidence suggests that only a subset of cancer cells, the CSCs, have the ability of self-renewal and can support cancer progression, while the rest of the tumour cells have only limited proliferative capacity and do not significantly contribute to tumour gro ...
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1
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TERMINÉ
A study of TGF-beta effects on breast cancer stem cells (TGF-beta and BCSCs)
Date du début: 1 janv. 2010, Date de fin: 31 déc. 2011,
...everal pathways and genes required for normal stem-cell function are activated in cancer cells and play essential roles in tumourigenesis. However, the specific molecular mechanisms through which CSCs exert their tumourigenic effects remain unknown. The TGF-beta pathway is a key player in mammalian biology, and its misregulation can result in tumour development. Increasing evidences are starting t ...
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1
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TERMINÉ
Intestinal stem cells and their role in colorectal cancer progression (CSC program)
Date du début: 1 juin 2010, Date de fin: 31 mai 2012,
...o isolate different tumor sub-populations in order to characterize them in detail. Interestingly, only a rare sub-population of tumor cells in CRC patients, so-called “cancer stem cells” (CSCs), is able to re-establish tumor growth in immune-deficient animals. We seek to understand how these tumor-promoting cells are genetically and functionally related to Lgr5+ ISC and Lgr5+ cells in CRC. Our res ...
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2
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TERMINÉ
Bidirectional interactions between cardiomyocytes and cardiac stem cells in the adaptive response to physiological stress (CSC PHYSTRESS)
Date du début: 1 mars 2008, Date de fin: 29 févr. 2012,
...he treatment of many degenerative and life-threatening diseases has opened up a promising and exciting outlook for the future of medicine and drug therapy. The recent discovery of cardiac stem cells (CSCs) present in the adult mammalian heart, including the human, has stimulated a new and exciting field for cardiac biology. These resident cells express defined stem cell markers (i.e. c-kit), are c ...
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1
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TERMINÉ
Ready for Future+
Date du début: 1 juil. 2016, Date de fin: 30 juin 2018,
Da Vinci has a new organsational structure, with bigger sectors where courses are clustered.Each sector has to present its plan where international activities have to be part, this has to result that teams have their plans with activities. The goal is to get a curriculum that has an International context. This is a process that takes time, not because people do not want this but the pressure on th ...
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22
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TERMINÉ
Europe is laid out for you
Date du début: 1 juil. 2016, Date de fin: 30 juin 2018,
By means of this project ROC Ter AA would like to enable all students and professionals of various departments within the school access to internships abroad, where they can experience other (work) cultures. This experience will allow them to place themselves into their professional future and in the world.These students and professionals from the 7 colleges: construction and design, business, ser ...
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8
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TERMINÉ
Zagraniczna praktyka zawodowa - sprawdź wiedzę i umiejętności, dowiedz się więcej
Date du début: 1 sept. 2016, Date de fin: 30 juin 2018,
The project will enable a realization of vocational trainings abroad for our students who study to be logistics, computer scientists, qualified hairdresser, food and catering industry technician. The project includes the organization of four trainings. In every of these trainings we expect 16 participants. Two pedagogic teachers will take care of students during the students’ vocational trainin ...
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3
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TERMINÉ
IFA VET mobility+ 2016
Date du début: 1 juin 2016, Date de fin: 31 mai 2018,
The funding applied for within the framework of the project will be used to finance stays abroad for a total of 555 individuals and 8 accompanying persons.337 apprentices will complete a 2 to 6 week internship specifically suited to their profession, individual level of training, knowledge and skills at a company active in their professional field. IFA will organize internships in small groups sta ...
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76
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TERMINÉ
Sector Skills Alliance for Advanced Manufacturing in the Transport Sector
Date du début: 1 janv. 2015, Date de fin: 31 déc. 2017,
The Sector Skill Alliance for Advanced Manufacturing in the Transport Sector represents the one-stop-shop providing state of the art solutions to competencies and skills needs faced by the automotive, aerospace and train industries.The Sector Skills Alliance is promoted by a network of leading organizations, including Jaguar Land Rover and SAS, Scandinavian Airlines Systems, in cooperation with re ...
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11
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TERMINÉ
DEVELOPING SKILLS AND COMPETENCIES IN VOCATIONAL TRAINING
Date du début: 1 sept. 2016, Date de fin: 31 déc. 2017,
This project is designed and developed by IKASLAN, Association of public vocational training centres public of the country Basque, to enable students of average degree of vocational training cycles and from virtually all professional families that are taught in the CAV can make a stay in different European countries. It is a continuation of the projects that we perform as response wing demand of p ...
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38
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TERMINÉ
SHARING KNOWLEDGE IN INNOVATION PROJECTS
Date du début: 19 sept. 2016, Date de fin: 18 nov. 2017,
Our proposal is a consequence of the results of an analysis conducted jointly by the three organizations IKASLAN, TKNIKA and the Deputy Ministry of Vocational Training and Lifelong Learning of the Basque government . While the evolution otrainees´ mobility level has reached 10% of the total amount , teachers´ mobility is very low and does not meet the minimum desired .We need to boost the mobili ...
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