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29 projets européens trouvés

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 TERMINÉ 

Targeting novel lipid pathways for treatment of cardiovascular disease (Athero-Flux)

Date du début: 1 sept. 2013, Date de fin: 31 août 2018,

Lipid lowering has significantly reduced cardiovascular disease (CVD) mortality in EU. However, the aim to abolish CVD in EU is far from achieved and attempts to improve on the benefits of statins with new agents have not yet delivered new therapeutics. The Consortium Athero-Flux builds on FP7-generated large-scale lipidomics data showing that specific sphingolipids and in particular distinct cer ...
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 12

 TERMINÉ 

Transferring NOn autonomous cell degeneration models between EU and USA for development of effective therapies for Motor Neuron Diseases (MND) (NO-MND)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2018,

"Amyotrophic lateral sclerosis (ALS) and Spinal Muscular Atrophy (SMA) are fatal diseases characterized by selective degeneration of motor neurons without any effective treatment. Non-neuronal cells like astrocytes play a key role in the pathogenesis of ALS and SMA. Understanding the mechanisms of cell death caused by non-neuronal cells is a major research target and it has been proposed that tran ...
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 3

 TERMINÉ 

Systems Biology to Identify Molecular Targets for Vascular Disease Treatment (SYSVASC)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2018,

Asymptomatic vascular damage accumulates for years before patients are identified and subjected to therapeutic measures. The limited knowledge on early vascular disease pathophysiology is reflected in the lack of therapeutic options. SysVasc aims to overcome this limitation by mounting a comprehensive systems medicine approach to elucidate pathological mechanisms, which will yield molecular target ...
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 19

 TERMINÉ 

Personalized diagnostics and treatment of high risk coronary artery disease patients (RISKYCAD)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2017,

Although the accurate diagnosis and prevention of coronary artery disease (CAD), acute myocardial infarction (AMI) and death is a major public health issue, risk stratification for CAD with current diagnostic tools is not properly supporting clinical decision making. RiskyCAD’s overall goal is to identify novel biomarkers for asymptomatic patients in high risk of major coronary events, and develop ...
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 12

 TERMINÉ 

Clinical and system –omics for the identification of the MOlecular DEterminants of established Chronic Kidney Disease (iMODE-CKD)

Date du début: 1 sept. 2013, Date de fin: 31 août 2017,

iMODE-CKD integrates multi-disciplinary expertise in proteomics, metabolomics, transcriptomics, bioinformatics, pathology, and clinical science from leading academic and industrial investigators, establishing a unique training platform on biomarker research and Systems Biology. Special emphasis is placed on the application of a wide range of –omics and bioinformatics techniques to clinical researc ...
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 10

 TERMINÉ 

NOX enzymes as mediators of inflammation-triggered neurodegeneration: modulating NOX enzymes as novel therapies (NEURINOX)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2016,

NEURINOX aims at elucidating the role of NADPH oxidases (NOX) in neuroinflammation and its progression to neurodegenerative diseases (ND), as well as evaluating the potential of novel ND therapeutics approaches targeting NOX activity. NOX generate reactive oxygen species (ROS) and have emerged as regulators of neuroinflammation. Their role is complex: ROS generated by NOX lead to tissue damage in ...
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 15

 TERMINÉ 

Micro-ring resonator-based biophotonic system for food analysis (BIOFOS)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2016,

Current methodologies for detection of food contamination based on heavy analytical tools cannot guarantee a safe and stable food supply. The reasons are the complexity, the long time-to-result (2-3 days) and the cost of these tools, which limit the number of samples that can be practically analyzed at food processing and storage sites. The need for screening tools that will be still reliable but ...
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 12

 TERMINÉ 

THALAssaemia MOdular Stratification System for personalized therapy of beta-thalassemia (THALAMOSS)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,

THALAMOSS is aimed at development of universal sets of markers and techniques for stratification of β-thalassaemia patients into treatment subgroups for (a) onset and frequency of blood transfusions, (b) choice of iron chelation, (c) induction of fetal hemoglobin, (d) prospective efficacy of gene-therapy. At present, no framework exists to guide therapeutic decisions and personalised treatment of ...
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 14

 TERMINÉ 

Molecular Medicine for Bladder Cancer (BCMolMed)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

BCMolMed integrates complementary and multi-disciplinary expertise of two main (research-intensive SME-academia) and five associate partners with the objective to generate a state of the art training platform on application-oriented biomarker research and systems biology. Special emphasis is placed on the efficient employment of proteomics and bioinformatics techniques to clinical research, and un ...
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 3

 TERMINÉ 

Translation of novel Biomarkers for Bladder Cancer for clinical outcome prediction (TransBioBC)

Date du début: 1 sept. 2013, Date de fin: 31 août 2016,

Currently, clinical diagnosis and monitoring of bladder cancer (BC) relies on invasive, highly costly cystoscopy. Additionally, due to high recurrence rates BC treatment is associated with frequent follow-up of patients, making BC one of the most costly types of cancer in terms of management cost. Thus there is a clear clinical need for the development of new approaches for early detection of recu ...
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 5

 TERMINÉ 

A Gateway to European Kidney Research Resources - KidneyConnect (KidneyConnect)

Date du début: 1 août 2013, Date de fin: 31 juil. 2016,

Diabetes, Cardiovascular and Chronic kidney (DCC) -diseases are relentlessly increasing globally, causing enormous human suffering, premature deaths and unsustainable costs. Leading European research has indisputably pointed that the kidney filtration barrier and its epithelial cell, the podocyte, is a common denominator for the DCC-diseases. However, European excellence and expertise have remaine ...
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 19

 TERMINÉ 

Post-infectious immune reprogramming and its association with persistence and chronicity of respiratory allergic diseases (PreDicta)

Date du début: 1 oct. 2010, Date de fin: 31 mars 2016,

Chronic inflammatory diseases associated with allergy, including asthma and rhinitis, constitute a major and continuously growing public health concern for Europe. However, the causative factors and mechanisms converting a physiological inflammatory reaction to a chronic response triggering allergic disease remain elusive.Viral infections, particularly those caused by human rhinoviruses (RV) are t ...
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 13

 TERMINÉ 

Immune mechanisms of osteopontin-mediated protection in allergic airway disease (OPN-IMMUNOREGULATION)

Date du début: 1 déc. 2009, Date de fin: 30 nov. 2015,

In allergic asthma, an important health problem, disease is driven by allergen-specific Th2 immune responses. Differentiation of Th2 cells depends on their early interactions with antigen presenting cells, such as dendritic cells (DCs), and cytokines are crucial for this process. Osteopontin (Opn) was originally identified as an important cytokine for Th1 immunity and autoimmunity. Our group recen ...
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 2

 TERMINÉ 

Modulating motor output in the mammalian spinal cord (MODULATIONSPINALCORD)

Date du début: 1 sept. 2011, Date de fin: 31 août 2015,

The executive component of movement – the task of determining which muscles to activate, how intensely, and for how long – depends on neural circuits located in the spinal cord. At the core of these circuits are local interneurons (INTs) that regulate the pattern and frequency of motor neuron (MN) firing. Spinal motor activity is shaped by a combination of amino acid mediated excitation and inhibi ...
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 2

 TERMINÉ 

Identification and therapeutic targeting of common arrhythmia trigger mechanisms (EUTRIGTREAT)

Date du début: 1 oct. 2009, Date de fin: 31 mars 2015,

Arrhythmias are common manifestations of heart disease which frequently cause sudden cardiac death (SCD) or other devastating health problems. In Europe, prevention of SCD by device and drug therapy is expensive and increasingly strains public health resources due to a growing population at risk. However, identification of patients at increased risk for SCD is ineffective, and SCD prevention strat ...
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 15

 TERMINÉ 

The emergence of bioenergetic diversity in prokaryotes (EBioDiP)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2015,

Prokaryotes are characterised by an amazing metabolic diversity, which allows them to persist in diverse and often extreme habitats. Some are able to use light or organic matter to harvest energy and fix carbon, while others utilise chemo- or lithotrophic modes which use theredox potential of molecules found in their particular environment to harness energy for their survival. Molecular evolution ...
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 2

 TERMINÉ 

The role of mRNA-processing bodies in ageing (PAGE)

Date du début: 1 sept. 2008, Date de fin: 31 août 2014,

Recently, we and others have revealed that, in the nematode Caenorhabditis elegans, reduction of protein synthesis rates in somatic cells extends lifespan. Based on this, we postulate that the molecular factors and mechanisms that control the mRNA metabolism in post-mitotic cells are critical determinants of ageing. This project will validate this hypothesis using C. elegans as main model system, ...
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 2

 TERMINÉ 

MicroEncapsDelivery

Date du début: 1 sept. 2012, Date de fin: 31 août 2014,

In this multidisciplinary research proposal we aim to develop a new therapeutic platform for hepatocellular carcinoma (HCC). HCC is the third leading cause of cancer death worldwide with a death rate greater than 600,000 persons annually. Currently the main curative treatments include resection, liver transplantation, or percutaneous local ablative treatment. However, all these approaches are prim ...
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 2

 TERMINÉ 

Development and Neuromodulation of Intrinsic Cortical Activity (INTRICA)

Date du début: 1 juil. 2010, Date de fin: 30 juin 2014,

"We propose to study intrinsic cortical network activity in-vitro. It is already known that the cerebral cortex, both in-vivo and in-vitro, produces spontaneous patterns of electrical activity independently of extrinsic inputs. These consist of network-induced prolonged depolarizations & action potentials (UP states), alternating with periods of synaptic withdrawal, membrane hyperpolarization and ...
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 2

 TERMINÉ 

Targeting the mutated PI3Kα isoform for the development of novel anti-cancer agents (Comput Drug Design)

Date du début: 1 mai 2010, Date de fin: 30 avr. 2014,

The application of rational drug design is proven to be more efficient than the traditional way of drug discovery since it aims to understand the molecular basis of a disease. The aim of this project is to deactivate the mutated cancerous PI3Kα protein with small molecule inhibitors. It was recently established that PIK3CA, the gene encoding the catalytic p110α subunit of PI3K, is frequently mutat ...
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 2

 TERMINÉ 

European Collaborative Project on Inflamation and Vascular Wall Remodelling in Atherosclerosis (ATHEROREMO)

Date du début: 1 mai 2008, Date de fin: 31 oct. 2013,

"The health of the EC population has never been better. However, serious public health problems remain, which cannot be ignored including high levels of premature death due to cardiovascular diseases. Thus, new preventive, diagnostic and therapeutic strategies against atherosclerotic cardiovascular diseases are needed. The atherosclerotic changes of the vascular wall are central in the developmen ...
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 19

 TERMINÉ 

European Project on Mendelian Forms of Parkinson’s Disease (MEFOPA)

Date du début: 1 avr. 2010, Date de fin: 30 sept. 2013,

"The Collaborative Project on Mendelian Forms of Parkinson’s Disease (MEFOPA) will bring together the major groups in Europe with a track-record in basic and clinical research on rare Mendelian forms of Parkinson’s disease (PD) in order to identify and validate relevant disease-related molecular pathways, drug-targets and biomarkers for disease susceptibility and progression.. Over the last years ...
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 27

 TERMINÉ 

Targeted Amphoteric Carriers in ImmunoTherapy (TACIT)

Date du début: 1 août 2009, Date de fin: 31 juil. 2013,

"The past year has been exciting for oligonucleotide-based drug discovery and development. The Nobel Prize was awarded to Mello and Fire for discovering RNA interference. There was also big investment from the Pharmaceutical industry to Biotechnology companies-pioneers in oligonucleotide therapeutics such as Sirna, Alnylam and Isis, all US-based. High expectations were therefore raised but further ...
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 4

 TERMINÉ 

Translating basic research findings in major human diseases (TranSMed)

Date du début: 1 janv. 2010, Date de fin: 30 juin 2013,

Improvement of human health requires translation of the basic research discoveries into practical applications for human disease, including biomarker identification, novel clinical tools, and medications. The scope of TranSMed is to support the development of a center of excellence in the EU target area of “translational research for major human diseases”, in the convergence region of Attica, Gree ...
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 2

 TERMINÉ 

Markers of prenatal metabolic plasticity and assessment of their reversibility by postnatal interventions (Metabolic Plasticity)

Date du début: 1 juil. 2010, Date de fin: 30 juin 2013,

Inactivity and nutritional aberrations result in an expanding population of individuals with compromised metabolic function including obesity and insulin resistance. From this pool of individuals an increasing percentage develops overt diabetes leading to vast personal and social burden. Natural interventions are beneficial and exercise accompanied by weight loss can reverse insulin resistance, at ...
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 2

 TERMINÉ 

Stem Cells and Cancer Stem Cells in Mouse Mammary Glands (MG stem)

Date du début: 25 mai 2009, Date de fin: 24 mai 2013,

It is thought that, although cancer stem cells are a small minority in the tumor cell population, they can escape the toxicity of drugs used for treatment, as they are relatively quiescent, i.e. chemotherapy can lead effectively to remission, but not frequently to a cure. An important question that cannot be answered at present and should certainly be addressed is whether a therapeutic window can ...
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 2

 TERMINÉ 

Novel MS-based strategies to Discover and Evaluate Cancer Biomarkers in urine: Application to Diagnosis of Bladder Cancer (DECanBio)

Date du début: 1 mars 2008, Date de fin: 31 juil. 2012,

In clinical studies, proteomics and transcriptomics allow the comparison of samples from different patients and hold special promise for the discovery of novel biomarkers and the development of “personalized medicine” approaches. Yet, translating recent discoveries into daily medical practice takes time and despite intensified researchers’ interest and investments, the rate of introduction of nove ...
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 9

 TERMINÉ 

Nano-Actuators and Nano-Sensors for Medical Applications (NANOMA)

Date du début: 1 juin 2008, Date de fin: 30 sept. 2011,

The NANOMA project aims at proposing novel controlled nanorobotic delivery systems which will be designed to improve the administration of drugs in the treatment and diagnosis of breast cancer. Breast cancer is diagnosed in 1.2 million men and women globally every year and kills 500,000. The NANOMA project proposes a magnetic nanocapsule steering approach that relies on improved gradient coils for ...
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 9

 TERMINÉ 

Biobanking and Biomolecular Resources Research Infrastructure (BBMRI)

Date du début: 1 févr. 2008, Date de fin: 31 janv. 2011,

The Preparatory Phase for a pan-European Biobanking and Biomolecular Resources Research Infrastructure (BBMRI) will focus on technical, legal, governance, and financial issues to • prepare to construct BBMRI, building on existing biobanks, resources and technologies, specifically complemented with innovative components and properly embedded into European scientific, ethical, legal and societal fra ...
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 55