Plus de 40 projets européens trouvés
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TERMINÉ
Brain image processing with Alpha-Stable distributions. Applications to intensity normalization, segmentation and diagnosis of Parkinsonian syndrome and Alzheimer's disease (ALPHA-BRAIN-IMAGING)
Date du début: 16 juil. 2014, Date de fin: 3 mai 2017,
In this project, D. Salas-Gonzalez proposes to develop brain image processing with alpha-stable distributions with applications to intensity normalization, segmentation and diagnosis of Parkinsonian syndrome and Alzheimer's disease. The expected results of this interdisciplinary project will definitely have applications and impact in the European society and its health, which is an objective of th ...
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TERMINÉ
Linking aggregation of alpha-synuclein to proteasomal dysfunction; an investigation of the causes leading to Parkinson's disease (PROTEASOME-AMYLOID)
Date du début: 1 oct. 2010, Date de fin: 30 sept. 2012,
"Parkinson’s disease (PD) is a severe neurodegenerative disease affecting more than 800000 people in Europe. Aggregation of the brain protein alpha-synuclein (aS) and its deposition into intracellular inclusions is a crucial event in the pathway leading to the onset of this tremendous disease. This process is triggered by alterations of the delicate homeostasis between production, aggregation and ...
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1
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TERMINÉ
Effects of posttranslational modifications of alpha-synuclein on dopaminergic neurodegeneration in a novel viral vector mediated in vivo model of Parkinson’s disease (modifyPD)
Date du début: 1 nov. 2010, Date de fin: 31 oct. 2012,
One of the major pathological hallmarks of Parkinson´s disease (PD) is the progressive loss of specific dopaminergic projection neurons, especially those located in the substantia nigra pars compacta. The neurodegeneration is accompanied by the presence of cytoplasmic inclusions called Lewy bodies, which invariably contain the α-synuclein (α-syn) protein as a major component. Aggregation of α-syn ...
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1
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TERMINÉ
Structural characterisation of early alpha-synuclein amyloidogenic species relevant to Parkinson's disease: Validation as therapeutic targets (Early amyloid states)
Date du début: 1 janv. 2010, Date de fin: 31 déc. 2011,
Alpha-synuclein (AS) is the major constituent of Lewy bodies, a pathological signature of Parkinson’s disease (PD). Amyloid-like deposits of AS are generated by toxic pre-fibrillar species of the protein which are now considered to be a major cause of cell death in PD. The mechanisms by which oxidative stress is linked to AS aggregation are not yet known and are a subject of intense research in th ...
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1
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TERMINÉ
Alpha-synuclein and mitochondrial dysfunction: key links between Gaucher’s disease and Parkinson’s? (MitSyn)
Date du début: 13 avr. 2015, Date de fin: 12 avr. 2017,
Recent studies have highlighted a strong genetic association between Parkinson’s disease (PD) and Gaucher’s disease (GD), a lysosomal storage disorder that causes severe neurodegeneration in children and shares some pathophysiological features of PD. GD results from mutations that reduce activity of the enzyme glucocerebrosidase (GCase), causing impaired lysosomal function. It was recently shown t ...
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1
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TERMINÉ
Elucidating the Role of Phosphorylation by Polo-like kinases in Modulating Alpha-Synuclein Aggregation and Toxicity in Parkinson's disease and Related Disorders (Plks in PD)
Date du début: 1 mai 2009, Date de fin: 30 avr. 2011,
Increasing evidence suggest that alpha-synuclein (a-syn) phosphorylation plays an important role in the regulation of a-syn aggregation, Lewy Bodies (LBs) formation and neurotoxicity in Parkinson’s disease (PD) and related synucleopathies. However, the exact kinase(s) responsible for phosphorylating a-syn and the relationships between phosphorylation, a-syn fibrillogenesis, LB formation and cell d ...
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1
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TERMINÉ
Deformable Surface Tracking and Alpha Matting for the Automation of Post-production Workflows (AutoPost)
Date du début: 1 janv. 2015, Date de fin: 30 juin 2016,
In today´s era of automation and intelligent systems, a huge amount of video and film post-production work can still only be completed manually by specialized artists. In the case of visual effects (VFX) and 2D/3D conversion, artists spend about 20%-40% of their time doing labour-intensive additive and subtracting retouching.To address this issue, AutoPost will develop productive end-user solution ...
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6
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TERMINÉ
The premium green multi-cloud management and optimization tool (NUVEA)
Date du début: 1 mai 2015, Date de fin: 31 oct. 2015,
Feasibility study - NUVEA is carried out by the SME New Generation SR, an innovative start-up active in the field of digital technologies and infrastructures. The objective of the overall project is to bring to customers an on-line platform that allows them to take over, manage, benchmark and optimize permanently their distributed IT infrastructure (at the web- and entreprise-grade), independently ...
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1
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TERMINÉ
Smart PArallel Robotic Kinematics (SPARK)
Date du début: 1 févr. 2015, Date de fin: 31 juil. 2015,
Founded in 1994 in the province of Brescia, Italy, we, ALPHA-PROGETTI offer our customers in the sectors of industrial automation customized industrial machinery design and development as well as services in the field of new product development, business development and commercialization. Thanks to our 20 years’ experience and on-going development works, we have devised a promising business opport ...
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2
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TERMINÉ
The Dark Energy Imprint on the Baryon Acoustic Oscillations (DEBAO)
Date du début: 28 mars 2013, Date de fin: 26 avr. 2016,
This work programme addresses pressing issues in both observational and theoretical cosmology. The main goal is to use the Baryon Acoustic Scale of Oscillations (BAO) to pin down the nature of the Dark Energy (DE) component.The BAO scale is a powerful probe of DE properties. It constrains geometrical as well as dynamical tracers of the Universe’s evolution, and can break the long-standing degenera ...
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2
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TERMINÉ
Construction of microcompartments in thermophilic Geobacillus thermoglucosidasius as nano-bioreactors for advanced biofuels production at high temperature (THERMCP)
Date du début: 9 mai 2016, Date de fin: 8 mai 2018,
Geobacillus spp are thermophilic Gram positive bacteria which are specialists in the degradation of hemicellulose derived from renewable biological feedstocks and the supervisor’s group has recently engineered strains able to degrade cellulose. Some of the strains are facultative anaerobes which can grow anaerobically and produce fermentation products such as lactate and ethanol. Hence they are an ...
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1
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TERMINÉ
In-cell NMR monitoring of alpha-Synuclein aggregation in neuronal cells (NeuroInCellNMR)
Date du début: 1 nov. 2015, Date de fin: 31 oct. 2020,
Intracellular aggregation of the human amyloid protein alpha-synuclein is causally involved in Parkinson’s disease, a debilitating neurodegenerative disorder. The goal of this project is to combine low-resolution, fluorescence-imaging methods with high-resolution in-cell NMR and EPR spectroscopy techniques to derive macroscopic and microscopic insights into alpha-synuclein aggregate structures dir ...
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1
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TERMINÉ
Multichannel Investigation of Solar Modulation Effects in Galactic Cosmic Rays (MAtISSE)
Date du début: 5 mai 2016, Date de fin: 4 mai 2018,
The topic of the MAtISSE project is the Multichannel Investigation of Solar Modulation Effects in Galactic Cosmic Rays (CRs). When entering the heliosphere, CRs encounter a turbulent flowing plasma, the solar wind, which modulates their energy spectra. The solar modulation is expected to be different for positive and negative particles (due to charge-sign dependent effects) or for leptons and nucl ...
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1
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TERMINÉ
Imaging Innate Immunity of Staphylococcal Infections (PSMS-IN-INFLAMMATION)
Date du début: 9 avr. 2014, Date de fin: 8 avr. 2017,
"Staphylococcus aureus community-acquired (CA)-MRSA strains are highly virulent and can cause infections in otherwise healthy individuals and are a leading cause of death worldwide. Innate immunity is our primary defense against invading staphylococci. Blood-neutrophils migrate to the site of infection where they, in concert with the complement system, engulf and kill bacteria in a process called ...
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1
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TERMINÉ
Validation of diagnostic and prognostic biomarkers for Parkinson disease (Biomarkers for PD)
Date du début: 1 sept. 2015, Date de fin: 29 févr. 2016,
Parkinson’s disease (PD) is one of the most prevalent neurodegenerative disorders and a disease with a significant unmet medical need. World-wide, more than 4.6 million individuals over the age of 50 suffer from PD and it is estimated that the number will more than double by 2030. The economic impact of the disease is enormous and the estimated annual European cost of PD is 14 billion euros. At pr ...
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1
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TERMINÉ
Understanding the balance between functional and deleterious interactions of alpha-synuclein with lipid bilayers (toxiclipasyn)
Date du début: 1 mai 2017, Date de fin: 30 avr. 2019,
Proteins are among the most essential molecules of life. In order to fulfil their native function(s) they need to adopt a well-defined three-dimensional structure. However, under some circumstances, proteins can misfold and/or form toxic amyloid structures, which are the hallmark of a range of diseases including type 2 diabetes and neurodegenerative diseases. In particular, the small pre-synaptic ...
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1
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TERMINÉ
Stabilising Protein-Protein Interactions: A Target-Guided Fragment-Based Approach (TaGFrag)
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2018,
This action aims to discover novel, synthetically tractable small-molecule stabilisers of the therapeutically important 14-3-3δ – estrogen receptor alpha (ERα) protein-protein interaction (PPI). To achieve this a rational target-guided chemical biology approach will be developed that combines the concepts of fragment-based drug discovery with bioorthogonal synthesis. The significances of achieving ...
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1
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TERMINÉ
An Ultra-sensitive Assay to Measure Oligomer Induced Toxicity in Human Cerebrospinal Fluid (Neurotoxic)
Date du début: 1 août 2016, Date de fin: 31 juil. 2018,
The study of protein aggregates and how they damage neuronal cells is important in order to understand the initiation and progression of several neurodegenerative diseases - including Alzheimer’s disease (AD), Parkinson’s disease (PD). The aggregation from the native monomeric proteins to beta sheet containing amyloid structures involves the formation of different species - misfolded proteins, sma ...
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1
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TERMINÉ
Spectroscopy of Trapped Antihydrogen (hbar12)
Date du début: 1 mai 2013, Date de fin: 30 avr. 2018,
Antihydrogen is the only stable, neutral antimatter system available for laboratory study. Recently, the ALPHA Collaboration at CERN has succeeded in synthesizing and trapping antihydrogen atoms, storing them for up to 1000 s, and performing the first resonant spectroscopy, using microwaves, on trapped antihydrogen. This last, historic result paves the way for precision microwave and laser spect ...
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1
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TERMINÉ
Catalysts for change: Alpha volunteers
Date du début: 1 mars 2015, Date de fin: 30 nov. 2015,
The main objective of the project „Catalysts for Change: ALPHA Volunteers” is developing social cohesion, solidarity and mutual understanding between young volunteers and young people with disabilities, but also promoting active citizenship among young people; effectuating activities, non-formal learning experiences to improve skills for personal development and to facilitate young volunteers prof ...
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2
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TERMINÉ
Nauczyciele 2.0 tworzą nową jakość szkoły.
Date du début: 1 sept. 2016, Date de fin: 31 janv. 2018,
This Project is the answer to growing demand of our teachers, who understand that employing of new technologies in the teaching process is an essential factor which enables to maximize teacher efficacy as well as makes the lessons more attractive and straightforward for the students. Teachers are aware that a new curriculum for extra classes is needed for students’ better development. Our teachers ...
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1
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TERMINÉ
Huddle in Broby 2016/2017
Date du début: 1 août 2016, Date de fin: 31 juil. 2017,
For Huddle in Broby, we invite two upcoming young leaders from Europe to participate in a process of change. The aim is to create a community of young adults from Europe, who live together, share experiences and get inspiration that they can take with them through life. The Christian community who volunteers will stay and be a part of, will be a meeting place and an open house for young people in ...
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3
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TERMINÉ
Modern Iskola - Modern Módszerek
Date du début: 1 juin 2016, Date de fin: 31 mai 2017,
Our Erasmus-group and the management of the school together have set the goals and areas where we have to ensure professional development. These areas are: the teaching of English as a foreign language, the instruction of subjects in English in the bilingual program and the use of ICT tools in the teaching process. The teaching of English is the most important priority of our school. This is the b ...
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1
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TERMINÉ
Globalisering-Forlagt Undervisning og Praktik
Date du début: 1 juin 2015, Date de fin: 31 mai 2017,
The project (GLOFUP) consists of two elements, partly a 2-week study visit to Malaga in Spain or Dublin in Ireland and a one-week work placement in a company/institution/organization in Malaga/Dublin. The participants in the study visit are 40 third-year students from HHX (Higher Commercial Course) GLOFUP helps to improve the students’ ability to interact successfully with representatives from ot ...
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3
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TERMINÉ
TATAMI - Tanulva Taníts Mindig
Date du début: 1 juin 2015, Date de fin: 31 mai 2016,
The title - Always Teach by Learning - summarises the objectives of the project in a few words: the basis of good education is always the teacher, who besides loving and respecting their subject, is able to learn continually, renew in his/her profession so as to stay enthusiastic and up-to-date. Only this kind of professional teacher can be authentic for students.
The areas where our institution h ...
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1
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TERMINÉ
Színes Európa - minden nyelv a tudás felé vezet
Date du début: 31 déc. 2014, Date de fin: 30 déc. 2015,
There were four institutions taking part in the project called " Színes Európa" or "Colourful Europe", : our school the Székesfehérári Vasvári Pál Secondary Grammar School, Torre di Babele in Rome, Alpha College in Dublin an IPC in Exeter.
With the consent of all our teachers we deputed the following three colleagues to take part in the foreign teachertraining courses sponsored by Erasmus +: Csa ...
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1
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TERMINÉ
Training ABI-Acquired Brain Injury
Date du début: 1 août 2014, Date de fin: 31 juil. 2015,
The project promotes the European dimension in vocational training. At this mobility will participate 30 professionals and volunteers, who are working in the field of socio-professional integration of people with disabilities. 2 specialists will go to a job shadowing to “Human Profess” from Hungary and they will explore innovative ways in working with people with diseases caused by a brain injury, ...
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2
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TERMINÉ
A shared mobility On-Demand Service (SHOTL)
Date du début: 1 déc. 2016, Date de fin: 31 mai 2017,
SHOTL (www.shotl.com) is an on-demand collective transport service that re-defines the daily commute. Comprising a fleet of minivans and intelligent routing software, SHOTL will enable millions of people living and working in ‘first-mile’ and ‘last-mile’ areas to reach their daily destinations, offering a convenient and affordable alternative to private cars.Every day around 60M Europeans commute ...
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1
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TERMINÉ
A rapid, low-cost, cervical cancer screening platform (HoloCyt)
Date du début: 1 janv. 2017, Date de fin: 30 juin 2017,
Cervical cancer causes 13.000 deaths and 34.000 new cases in the European Union. 200M tests are performed worldwide per year representing a $3,4B market.Today two tests are performed to diagnose cervical cancer. Firstly, a cervical smear is analysed by a pathologist via a visual subjective inspection using traditional microscopy. This is an 8-step process performed by several persons at different ...
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1
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TERMINÉ
ARCING AND NEXT GENERATION ELECTRICAL AIRPLANE POWER HAZARD ABATEMENT (ARCANGEL-ALPHA)
Date du début: 1 mars 2011, Date de fin: 30 avr. 2014,
"The More Electric Aircraft (MEA) concept promises lower fuel consumption, lower emissions, and reduced operating costs. Fundamental to MEA is the replacement of the inefficient and maintenance intensive hydraulic, pneumatic and bleed air powered systems present on today’s aircraft with electrically powered systems. New aircraft designs are beginning to implement 230 volt variable frequency AC a ...
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1
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TERMINÉ
Nuclear reaction studies relevant to the astrophysical p-process nucleosynthesis (ATOMKI-PPROCESS)
Date du début: 1 juil. 2008, Date de fin: 30 juin 2013,
The astrophysical p-process, the stellar production mechanism of the heavy, proton rich isotopes (p-isotopes), is one of the least studied processes in nucleosynthesis. The astrophysical site(s) for the p-process could not yet be clearly identified. In order to reproduce the natural abundances of the p-isotopes, the p-process models must take into account a huge nuclear reaction network. A precise ...
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1
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TERMINÉ
The magnetism of the chromosphere: combining theory and observations (ChroMag)
Date du début: 29 oct. 2007, Date de fin: 28 oct. 2010,
H-alpha spectroheliograms revealed already in the early twentieth century the beauty and the huge variety of magnetic structures in the chromosphere. However, a comprehensive description of this important layer, coupling the photosphere to the corona, is still missing. The key for a deeper understanding of the chromosphere lies in the reliable determination of the vector magnetic field. The low ma ...
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2
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TERMINÉ
Modeling signaling pathways in cartilage degeneration (MOSPAIC)
Date du début: 1 sept. 2007, Date de fin: 31 août 2009,
Osteoarthritis (OA) and Rheumatoid Arthritis (RA) are painful and debilitating diseases characterized by cartilage degeneration, swelling, and decreased function of the synovial joints. It is the leading cause of disability in the developed countries affecting one of every six people and resulting in a significant cost on health and social care systems. Cartilage degeneration can be characterized ...
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1
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TERMINÉ
The origin of mitochondria and the root of the eukaryotic tree (MitEukRoot)
Date du début: 1 janv. 2009, Date de fin: 31 déc. 2010,
"The origins of eukaryotes and mitochondria are among the most fundamental questions in biology and are central to understanding eukaryotic genomic and cellular evolution. It is now accepted that the mitochondrion was ancestrally present in all eukaryotic groups and that it derives from an alpha-proteobacterium, although the precise identity of the original endosymbiont is unknown. In this project ...
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1
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TERMINÉ
Architectures for fLexible Photonic Home and Access networks (ALPHA)
Date du début: 1 janv. 2008, Date de fin: 31 mars 2011,
The ALPHA project addresses the challenges of building the future access and all types of in-building networks for home and office environments. The proposal supports the evolution towards a cognitive network by dynamically utilising the resources of an optical network infrastructure to support a heterogeneous environment of wired and wireless technologies.The project investigates innovative archi ...
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17
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TERMINÉ
Precision lattice QCD calculations (Precision LatticeQCD)
Date du début: 1 juin 2010, Date de fin: 31 mai 2014,
The research project aims to further unveil the structure of hadrons and to perform precision determination of the strong coupling constant. This will be mainly done by means of Monte Carlo simulations of lattice QCD with either N(f)=2 or N(f)=2+1 clover-type Wilson fermions.Our investigation of the hadronic structure will focus on moments of distribution amplitudes, for example, of the Lambda or ...
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1
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TERMINÉ
Cellular and structural determinants of amyloid toxicity (Amyloid Hot Spots)
Date du début: 1 mai 2010, Date de fin: 30 avr. 2012,
Neurodegenerative disorders such as Alzehimer´s or Parkinson´s affect millions of people in Europe and are linked to the misfolding and aggregation of proteins in the form of amyloid fibrils. The molecular pathways of amyloid aggregation are complex and poorly understood, and involve the population of oligomeric intermediates before fibrils form. Little is known about the role in vivo of amyloid i ...
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2
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TERMINÉ
Alpha-Catenin regulatory properties and functions during Zebrafish development (Alpha-Catenin roles)
Date du début: 1 sept. 2009, Date de fin: 31 oct. 2012,
Adherens junctions (AJ) play key roles in cell-cell adhesion, cell migration and cell signaling in a variety of biological processes. AJ are dynamic structures composed of cell-cell adhesion proteins (cadherin super-family), associated adaptor proteins (alpha-, and beta-catenin) and other proteins (p120) that locally regulate the actin cytoskeleton. The functions of two components of the AJ, cadhe ...
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1
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TERMINÉ
The Role of Molecular Chaperones in Parkinson' s Disease (Chaperones in ND)
Date du début: 1 avr. 2008, Date de fin: 30 nov. 2010,
Parkinson's disease is a severe human neurodegenerative disorder that affects mainly the aging generation. It is characterized by the loss of dopaminergic neurons from the substantia nigra, and the formation Lewy bodies, intraneuronal inclusions which are primarily composed of fibrillar alpha-synuclein. Several lines of evidence support a role for molecular chaperones as modulators of alpha-synucl ...
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1
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TERMINÉ
Academic-Industrial Training Network on Alpha-Synuclein-related Brain Diseases (NEURASYNC)
Date du début: 1 nov. 2009, Date de fin: 31 oct. 2013,
"Parkinson’s Disease (PD) is the second most common neurodegenerative disorder. It is characterized pathologically by the accumulation of aggregated conformations of the presynaptic protein alpha-synuclein (ASYN) in cytoplasmic inclusions termed Lewy Bodies (LBs). Furthermore, aberrant aggregated species of ASYN accumulate in various disease states, such as Multiple System Atrophy, Diffuse LB Dise ...
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