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 EN COURS 

A Systems medicine approach to chronic inflammatory disease (SYSCID)

Date du début: 1 janv. 2017, Date de fin: 31 mars 2022,

"The SYSCID consortium aims to develop a systems medicine approach for disease prediction in CID. We will focus on three major CID indications with distinct characteristics, yet a large overlap of their molecular risk map: inflammatory bowel disease, systemic lupus erythematodes and rheumatoid arthritis. We have joined 15 partners from major cohorts and initiatives in Europe (e.g.IHEC, ICGC, Twins ...
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 16

 EN COURS 

GALAXY: Gut-and-liver axis in alcoholic liver fibrosis (GALAXY)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2021,

Alcohol overuse is an important societal challenge with annual healthcare costs of over €22 billion in Europe. Alcohol is the main cause of liver cirrhosis, which is the 5th and 7th most common cause of life years lost in respectively Eastern and Western Europe. Cirrhosis is considered irreversible but its precursor, liver fibrosis, is reversible when detected before disease progression. GALAXY pr ...
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 12

 EN COURS 

The European network for observing our changing planet (ERA-PLANET)

Date du début: 1 févr. 2016, Date de fin: 31 janv. 2021,

In the last decade a significant number of projects and programmes in different domains of environmental monitoring and Earth observation have generated a substantial amount of data and knowledge on different aspects related to environmental quality and sustainability. Big data generated by in-situ or satellite platforms are being collected and archived with a plethora of systems and instruments m ...
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 38

 EN COURS 

Translational Research Network in Prostate Cancer (TransPot)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

The Translational Research Network for Prostate Cancer (TransPot) program adopts an innovative, multidisciplinary approach, providing highly sought-after, effective solutions for incurable prostate cancer (PC).The TransPot scientific objective is to obtain an unmatched depth of molecular, mechanistic and informatics systems-level disease understanding in order to improve the prognosis and treatmen ...
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 11

 EN COURS 

Big data against childhood Obesity (BigO)

Date du début: 1 déc. 2016, Date de fin: 30 nov. 2020,

Childhood and adolescent obesity is a major global and European public health problem. Currently, public actions are detached from local needs, mostly including indiscriminate blanket policies and single-element strategies, limiting their efficacy and effectiveness. The need for community-targeted actions has long been obvious, but the lack of monitoring and evaluation framework and the methodolog ...
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 14

 TERMINÉ 
Current diagnostic options for cancer treatment monitoring rely on imaging techniques and cannot guarantee proper assessment of therapeutic response. This project aims to develop a disruptive Point of Care (PoC) device for cancer early diagnosis and treatment monitoring as a companion diagnostics tool. One of the scientific breakthroughs of this project is the development of a “cancer stem cells” ...
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 8

 TERMINÉ 
Cardiovascular disease (VD) is the leading cause of mortality and morbidity in Europe and worldwide. The objective of the PRETREAT consortium is to generate a joint SME/academic European preclinical platform for providing services for detection of VD and drug development. This platform will combine the use of urinary and/or blood peptidomics in humans and in preclinical animal models of VD, togeth ...
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 6

 TERMINÉ 

Coordinated Research Infrastructures Building Enduring Life-science services (CORBEL)

Date du début: 1 sept. 2015, Date de fin: 31 août 2019,

The social and economic challenges of ageing populations and chronic disease can only be met by translation of biomedical discoveries to new, innovative and cost effective treatments. The ESFRI Biological and Medical Research Infrastructures (BMS RI) underpin every step in this process; effectively joining scientific capabilities and shared services will transform the understanding of biological m ...
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 39

 TERMINÉ 
... sh, operate and develop a Pan-European distributed research infrastructure in order to facilitate the access to biological resources as well as facilities and to support high quality biomolecular and biomedical research. The ADOPT BBMRI-ERIC proposal aims at boosting and accelerating implementation of BBMRI-ERIC and its services. Its main deliverables are designed to complete or launch the constr ...
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 22

 TERMINÉ 

Multimodal Imaging of rare Synucleinopathies (MultISyn)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

Despite remarkable progress in the understanding of the molecular pathogenesis of neurodegenerative diseases (NDD), no causative or disease-modifying treatment is currently available. Aggregation of misfolded proteins are thought to play a crucial role in the pathogenesis, but attempts to exploit this knowledge for novel treatments have not been successful. Also, pathogenetically relevant biomarke ...
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 9

 TERMINÉ 

Targeting novel lipid pathways for treatment of cardiovascular disease (Athero-Flux)

Date du début: 1 sept. 2013, Date de fin: 31 août 2018,

Lipid lowering has significantly reduced cardiovascular disease (CVD) mortality in EU. However, the aim to abolish CVD in EU is far from achieved and attempts to improve on the benefits of statins with new agents have not yet delivered new therapeutics. The Consortium Athero-Flux builds on FP7-generated large-scale lipidomics data showing that specific sphingolipids and in particular distinct cer ...
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 12

 TERMINÉ 
GEO-CRADLE brings together key players representing the whole (Balkans, N. Africa and M. East) region and the complete EO value chain with the overarching objective of establishing a multi-regional coordination network that will (i) support the effective integration of existing EO capacities (space/air-borne/in-situ monitoring networks, modelling and data exploitation skills, and past project expe ...
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 20

 TERMINÉ 

Systems Biology to Identify Molecular Targets for Vascular Disease Treatment (SYSVASC)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2018,

Asymptomatic vascular damage accumulates for years before patients are identified and subjected to therapeutic measures. The limited knowledge on early vascular disease pathophysiology is reflected in the lack of therapeutic options. SysVasc aims to overcome this limitation by mounting a comprehensive systems medicine approach to elucidate pathological mechanisms, which will yield molecular target ...
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 19

 TERMINÉ 
"Amyotrophic lateral sclerosis (ALS) and Spinal Muscular Atrophy (SMA) are fatal diseases characterized by selective degeneration of motor neurons without any effective treatment. Non-neuronal cells like astrocytes play a key role in the pathogenesis of ALS and SMA. Understanding the mechanisms of cell death caused by non-neuronal cells is a major research target and it has been proposed that tran ...
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 3

 TERMINÉ 
Although the accurate diagnosis and prevention of coronary artery disease (CAD), acute myocardial infarction (AMI) and death is a major public health issue, risk stratification for CAD with current diagnostic tools is not properly supporting clinical decision making. RiskyCAD’s overall goal is to identify novel biomarkers for asymptomatic patients in high risk of major coronary events, and develop ...
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 12

 TERMINÉ 
iMODE-CKD integrates multi-disciplinary expertise in proteomics, metabolomics, transcriptomics, bioinformatics, pathology, and clinical science from leading academic and industrial investigators, establishing a unique training platform on biomarker research and Systems Biology. Special emphasis is placed on the application of a wide range of –omics and bioinformatics techniques to clinical researc ...
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 10

 TERMINÉ 

BeTheCuRE (BTCURE)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2017,

BTCure is based on the recognition that RA is a heterogeneous disease where a major subset involves adaptive immunity, and that animal models have to develop the line with the different subsets of the human diseases in order to be optimally used for drug discovery and drug evaluation. Our aim is to develop an understanding of the early process in human arthritis subsets and the animal models that ...
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 41

 TERMINÉ 
NEURINOX aims at elucidating the role of NADPH oxidases (NOX) in neuroinflammation and its progression to neurodegenerative diseases (ND), as well as evaluating the potential of novel ND therapeutics approaches targeting NOX activity. NOX generate reactive oxygen species (ROS) and have emerged as regulators of neuroinflammation. Their role is complex: ROS generated by NOX lead to tissue damage in ...
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 15

 TERMINÉ 
... ara University, Italy), M. Kleanthous (The Cyprus Foundation for Muscular Dystrophy Research, Cyprus), S.Philipsen (Erasmus Universitair Medisch Centrum Rotterdam, The Netherlands), E.Katsantoni (Biomedical Research Foundation, Academy of Athens, Greece), S.Rivella (Cornell University, NY, USA - The Children's Hospital of Philadelphia, Philadelphia, USA), P.Holub (Masaryk University, Czech Republ ...
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 14

 TERMINÉ 

Molecular Medicine for Bladder Cancer (BCMolMed)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

BCMolMed integrates complementary and multi-disciplinary expertise of two main (research-intensive SME-academia) and five associate partners with the objective to generate a state of the art training platform on application-oriented biomarker research and systems biology. Special emphasis is placed on the efficient employment of proteomics and bioinformatics techniques to clinical research, and un ...
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 3

 TERMINÉ 
Currently, clinical diagnosis and monitoring of bladder cancer (BC) relies on invasive, highly costly cystoscopy. Additionally, due to high recurrence rates BC treatment is associated with frequent follow-up of patients, making BC one of the most costly types of cancer in terms of management cost. Thus there is a clear clinical need for the development of new approaches for early detection of recu ...
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 5

 TERMINÉ 

A Gateway to European Kidney Research Resources - KidneyConnect (KidneyConnect)

Date du début: 1 août 2013, Date de fin: 31 juil. 2016,

Diabetes, Cardiovascular and Chronic kidney (DCC) -diseases are relentlessly increasing globally, causing enormous human suffering, premature deaths and unsustainable costs. Leading European research has indisputably pointed that the kidney filtration barrier and its epithelial cell, the podocyte, is a common denominator for the DCC-diseases. However, European excellence and expertise have remaine ...
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 19

 TERMINÉ 
Chronic inflammatory diseases associated with allergy, including asthma and rhinitis, constitute a major and continuously growing public health concern for Europe. However, the causative factors and mechanisms converting a physiological inflammatory reaction to a chronic response triggering allergic disease remain elusive.Viral infections, particularly those caused by human rhinoviruses (RV) are t ...
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 13

 TERMINÉ 

hERG related risk assessment of botanicals (HERGSCREEN)

Date du début: 1 mars 2012, Date de fin: 29 févr. 2016,

The main goal of this project is the establishment of a network between European, South American, North American and South African educational and research entities. This attempt will be based on an innovative scientific project aiming towards the identification of hERG (human Ether-à-go-go Related Gene) channel blockers in commonly consumed botanicals and supplements. Blocking these ion channels ...
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 6

 TERMINÉ 
In allergic asthma, an important health problem, disease is driven by allergen-specific Th2 immune responses. Differentiation of Th2 cells depends on their early interactions with antigen presenting cells, such as dendritic cells (DCs), and cytokines are crucial for this process. Osteopontin (Opn) was originally identified as an important cytokine for Th1 immunity and autoimmunity. Our group recen ...
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 2

 TERMINÉ 

Modulating motor output in the mammalian spinal cord (MODULATIONSPINALCORD)

Date du début: 1 sept. 2011, Date de fin: 31 août 2015,

The executive component of movement – the task of determining which muscles to activate, how intensely, and for how long – depends on neural circuits located in the spinal cord. At the core of these circuits are local interneurons (INTs) that regulate the pattern and frequency of motor neuron (MN) firing. Spinal motor activity is shaped by a combination of amino acid mediated excitation and inhibi ...
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 2

 TERMINÉ 

Infrastructure for Systems Biology - Europe (ISBE)

Date du début: 1 août 2012, Date de fin: 31 juil. 2015,

The Infrastructure for Systems Biology in Europe (ISBE) programme comprises an infrastructure that is designed to meet the needs of European systems biology, in terms of development, applications and training. In order to address this requirement, we are proposing a distributed, interconnected infrastructure which primarily comprises three types of centres: Data Integration Centres (DICs), and sys ...
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 24

 TERMINÉ 
Arrhythmias are common manifestations of heart disease which frequently cause sudden cardiac death (SCD) or other devastating health problems. In Europe, prevention of SCD by device and drug therapy is expensive and increasingly strains public health resources due to a growing population at risk. However, identification of patients at increased risk for SCD is ineffective, and SCD prevention strat ...
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 15

 TERMINÉ 

The emergence of bioenergetic diversity in prokaryotes (EBioDiP)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2015,

Prokaryotes are characterised by an amazing metabolic diversity, which allows them to persist in diverse and often extreme habitats. Some are able to use light or organic matter to harvest energy and fix carbon, while others utilise chemo- or lithotrophic modes which use theredox potential of molecules found in their particular environment to harness energy for their survival. Molecular evolution ...
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 2

 TERMINÉ 

The role of mRNA-processing bodies in ageing (PAGE)

Date du début: 1 sept. 2008, Date de fin: 31 août 2014,

Recently, we and others have revealed that, in the nematode Caenorhabditis elegans, reduction of protein synthesis rates in somatic cells extends lifespan. Based on this, we postulate that the molecular factors and mechanisms that control the mRNA metabolism in post-mitotic cells are critical determinants of ageing. This project will validate this hypothesis using C. elegans as main model system, ...
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 2

 TERMINÉ 

MicroEncapsDelivery

Date du début: 1 sept. 2012, Date de fin: 31 août 2014,

In this multidisciplinary research proposal we aim to develop a new therapeutic platform for hepatocellular carcinoma (HCC). HCC is the third leading cause of cancer death worldwide with a death rate greater than 600,000 persons annually. Currently the main curative treatments include resection, liver transplantation, or percutaneous local ablative treatment. However, all these approaches are prim ...
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 2

 TERMINÉ 

Development and Neuromodulation of Intrinsic Cortical Activity (INTRICA)

Date du début: 1 juil. 2010, Date de fin: 30 juin 2014,

"We propose to study intrinsic cortical network activity in-vitro. It is already known that the cerebral cortex, both in-vivo and in-vitro, produces spontaneous patterns of electrical activity independently of extrinsic inputs. These consist of network-induced prolonged depolarizations & action potentials (UP states), alternating with periods of synaptic withdrawal, membrane hyperpolarization and ...
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 2

 TERMINÉ 
The number of patients with chronic kidney disease (CKD) is increasing steadily due to extended life expectancy, long lasting diabetes and obesity. Early unambiguous detection of patients at risk is both a clinical and scientific challenge. Capillary electrophoresis coupled to mass spectrometry (CE-MS), developed by Mosaiques Diagnostics (MD, SME, Germany), has been shown to be an excellent tool f ...
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 4

 TERMINÉ 
The application of rational drug design is proven to be more efficient than the traditional way of drug discovery since it aims to understand the molecular basis of a disease. The aim of this project is to deactivate the mutated cancerous PI3Kα protein with small molecule inhibitors. It was recently established that PIK3CA, the gene encoding the catalytic p110α subunit of PI3K, is frequently mutat ...
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 2

 TERMINÉ 
"Parkinson’s Disease (PD) is the second most common neurodegenerative disorder. It is characterized pathologically by the accumulation of aggregated conformations of the presynaptic protein alpha-synuclein (ASYN) in cytoplasmic inclusions termed Lewy Bodies (LBs). Furthermore, aberrant aggregated species of ASYN accumulate in various disease states, such as Multiple System Atrophy, Diffuse LB Dise ...
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 11

 TERMINÉ 
"The health of the EC population has never been better. However, serious public health problems remain, which cannot be ignored including high levels of premature death due to cardiovascular diseases. Thus, new preventive, diagnostic and therapeutic strategies against atherosclerotic cardiovascular diseases are needed. The atherosclerotic changes of the vascular wall are central in the developmen ...
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 19

 TERMINÉ 

European Project on Mendelian Forms of Parkinson’s Disease (MEFOPA)

Date du début: 1 avr. 2010, Date de fin: 30 sept. 2013,

"The Collaborative Project on Mendelian Forms of Parkinson’s Disease (MEFOPA) will bring together the major groups in Europe with a track-record in basic and clinical research on rare Mendelian forms of Parkinson’s disease (PD) in order to identify and validate relevant disease-related molecular pathways, drug-targets and biomarkers for disease susceptibility and progression.. Over the last years ...
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 27

 TERMINÉ 

Mastering Data-Intensive Collaboration and Decision Making (Dicode)

Date du début: 1 sept. 2010, Date de fin: 31 août 2013,

Description Exploiting a cloud infrastructure to augment collaboration and decision making in data-intensive and cognitively-complex settingsThe goal of the Dicode project is to facilitate and augment collaboration and decision making in data-intensive and cognitively-complex settings. To do so, it will exploit and build on the most promi ...
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 8

 TERMINÉ 

Targeted Amphoteric Carriers in ImmunoTherapy (TACIT)

Date du début: 1 août 2009, Date de fin: 31 juil. 2013,

"The past year has been exciting for oligonucleotide-based drug discovery and development. The Nobel Prize was awarded to Mello and Fire for discovering RNA interference. There was also big investment from the Pharmaceutical industry to Biotechnology companies-pioneers in oligonucleotide therapeutics such as Sirna, Alnylam and Isis, all US-based. High expectations were therefore raised but further ...
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 4

 TERMINÉ 
"The Mediterranean and Middle East, with a combined total population of more than 400 million people, are characterized by strong environmental gradients, climate extremes and diverse economic, social and cultural identities. It is expected that throughout the 21st century the region will experience substantial adverse climate changes and face major challenges in energy demand and supply, as well ...
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 8