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37 projets européens trouvés

Recherche sur 125080 projets européens

 TERMINÉ 

Collaboration on the Optimisation of Macromolecular Pharmaceutical Access to Cellular Targets (COMPACT)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2017,

Most biopharmaceuticals (BP) currently on the market are recombinant proteins which are parenterally administered. These would benefit from more patient-friendly routes of administration. Moreover, new classes of BP (e.g. siRNA, miRNA, DARPins) with specificity for intracellular targets hold promise but await the advent of efficient delivery systems before their potential can be realised into ther ...
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 22

 TERMINÉ 

Resistance in Gram-Negative Organisms: Studying Intervention Strategies (R-GNOSIS)

Date du début: 1 oct. 2011, Date de fin: 31 mars 2017,

Antibiotics are a mainstay of public health, but their use has increased exponentially leading to the emergence of antibiotic resistance. The R-GNOSIS (Resistance in Gram-Negative Organisms: Studying Intervention Strategies) project combines 5 international clinical studies, all supported by highly innovative microbiology, mathematical modelling and data-management, to determine - in the most rele ...
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 27

 TERMINÉ 

COLOR Ordering Templated by Hierarchized Supramolecular Porous FlatLANDS (COLORLANDS)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2016,

The idea of this research project is to take advantage of molecular self-assembly to create a new generation of periodically-organized porous organic materials that, acting as specific molecular hosts, can structurally control the positioning of multiple functional guests on surfaces, opening new horizons toward the understanding and development of rationale protocols for the patterning of unprece ...
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 2

 TERMINÉ 

Self-Assembly in Confined Space (SACS)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,

Supramolecular chemistry studies chemistry beyond individual molecules, where molecules or macromolecules form larger entities by spontaneous self-assembly or by self-organisation. The resulting supramolecular architectures are held together by covalent bonds and a variety of non-covalent intermolecular interactions (hydrogen bonding, metal coordination, hydrophobic interactions etc). Spatially, t ...
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 10

 TERMINÉ 

BARIUM CYCLING IN ANTARCTIC WATERS: UNDERSTANDING PRESENT AND PAST OCEAN PROCESSES (BARIUM)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

"Ice core records show that atmospheric carbon dioxide (pCO2), an important greenhouse gas that drives and amplifies climate change, varies naturally over a range of timescales. Biological productivity in the oceans is a major contributor to carbon drawdown, and an important factor controlling atmospheric pCO2. The Southern Ocean is linked with these climatic events, in part due to upwelling and ...
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 2

 TERMINÉ 

Cancer Diagnosis: Parallel Sensing of Prostate Cancer Biomarkers (PROSENSE)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

"The Marie Curie ITN ""Cancer Diagnostics: Parallel Sensing of Prostate Cancer Biomarkers"" (PROSENSE) aims at training a new generation of young scientists in the interdisciplinary techniques and methods required to meet the major challenges in the development of diagnostic tools for prostate cancer. It will bring together training by experts from the biosensor technology area and those from life ...
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 9

 TERMINÉ 

Development of RApid Point-of-Care test Platforms for Infectious Diseases (RAPP-ID)

Date du début: 1 avr. 2011, Date de fin: 30 sept. 2016,

RAPP-ID (“Development of RApid Point-of-Care test Platforms for Infectious Diseases”) will develop a Point-of-Care Test (POCT) for rapid (hospital
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 20

 TERMINÉ 

Integrating Economic Regional Impact Models (INTERIM)

Date du début: 1 juin 2013, Date de fin: 31 mai 2016,

With the ever-increasing turbulence of the modern global economy the need for better assessment of economic policy is imperative. National macroeconomic assessment has long been seen as one of the corner stones of good governance with all nations compiling vast amounts of data for analysis. What has not seen the same depth of analysis from Governments is the effect of economic policy on regions. T ...
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 1

 TERMINÉ 

New Models for Preclinical Evaluation of Drug Efficacy in Common Solid Tumours (PREDECT)

Date du début: 1 févr. 2011, Date de fin: 30 avr. 2016,

Traditional preclinical discovery methods, particularly for target validation, poorly predict drug efficacy, causing a high attrition rate in costly late-stage clinical trials. The PREDECT consortium will focus on complex but transferable, next generation in vitro and in vivo models for breast, prostate and lung cancers. Models will be investigated for their improved potential to validate novel th ...
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 23

 TERMINÉ 

Quantum fields and Curvature--Novel Constructive Approach via Operator Product Expansion (QC&C)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2016,

"It was realized already from the beginning that the theory of quantized fields (QFT) does not easily fit into known mathematical structures, and the quest for a satisfactory mathematical foundation continues to-day. Parts of this theory have already been tremendously successful, e.g. in the quantitative description of elementary particles, and ideas from QFT have revolutionized entire fields of m ...
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 2

 TERMINÉ 

Integrating Numerical Simulation and Geometric Design Technology (INSIST)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

The objective of this ITN is to develop the next generation methods integrating numerical simulation and geometric design technology. Currently, geometric design and simulation is based on different geometry representation hampering the effective design of Engineering structures, materials and components. Isogeometric analysis developed recently tries to remove those drawbacks by integrating CAD s ...
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 7

 TERMINÉ 

European Training and Research in Peritoneal Dialysis (EUTRIPD)

Date du début: 1 déc. 2011, Date de fin: 30 nov. 2015,

Peritoneal dialysis (PD) and haemodialysis (HD) are life-saving renal replacement therapies for more than 200,000 patients with chronic kidney disease in Europe, and this number increases annually. Although PD and HD have similar mortality rates, PD offers major advantages in terms of quality of life, costs, home-based treatment opportunities and early patient survival. Moreover, PD, rather than H ...
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 13

 TERMINÉ 

Finding the Ghost in the Genome: Assessing the contribution of epigenetics to environmental plasticity in the soil sentinel Lumbricus rubellus (EpiWorm)

Date du début: 1 sept. 2013, Date de fin: 31 août 2015,

It has been established that the epigenetic landscape (cytosine methylation, histone modification and non coding RNAs) impacts on the underlying genomic architecture thereby regulating the transcriptional machinery and modifying gene expression. These elegant mechanisms of control influence tissue differentiation, organism life spam and can coordinate biochemical pathways responses to stressors su ...
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 1

 TERMINÉ 

Euro-Mediterranean Urban Voids Ecology (EMUVE)

Date du début: 1 mars 2013, Date de fin: 9 juil. 2015,

The research project focus on the existing voids produced by current shrinking cities at theEuro-Mediterranean coastline. These cities, developed in the last 50 years as the main touristic destination of Europe, are now in many cases transformed in empty landscapes stopped by the present economic crisis. The voids of these abandoned territories are not more anomalous interferences within the urban ...
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 1

 TERMINÉ 

Multiscale Methods for Fracture (MultiFrac)

Date du début: 1 juil. 2011, Date de fin: 30 juin 2015,

The objective of this project is to setup and strengthen international collaborations in the field of 'multiscale modelling for fracture'. The scientific goal is to get a better understanding of how materials fail and to develop better predictive tools for Engineering applications. This requires the combination of knowledge from different areas, i.e. Computational Mechanics, Computational Material ...
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 2

 TERMINÉ 

Tailored Quantum Structures (TAQUS)

Date du début: 1 juin 2013, Date de fin: 31 mai 2015,

Self-assembled semiconductor quantum structures are the subject of world-wide interest because of their potential use in quantum information technologies and nanoscale optoelectronics. This project will advance this field by obtaining nanoscale movies of III-V quantum structure formation. This will be achieved by establishing a € 1 million Low Energy Electron Microscope (LEEM) which is the only in ...
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 1

 TERMINÉ 

Assessing the Toxicity of nitrates in a host-Parasite system (Para-Tox)

Date du début: 8 avr. 2013, Date de fin: 7 avr. 2015,

Anthropogenic nitrate contamination has increased significantly in recent decades but its effects on aquatic species are still poorly understood. The toxicity of nitrates has long been underestimated compared to ammonia and nitrites. However, new evidence indicates that long-term nitrate exposure not only impairs growth, fertilization and fecundity, but also weakens the immune response decreasing ...
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 1

 TERMINÉ 

COMPREHENSIVE APPROACH TO ENHANCE QUALITY AND SAFETY OF READY TO EAT FRESH PRODUCTS (QUAFETY)

Date du début: 1 janv. 2012, Date de fin: 31 mars 2015,

This proposal aims to improve safety and quality of RTE fresh produce throughout the whole chain by developing new predictive and probabilistic models and decision-making tools, by exploring rapid and non-destructive methods for quality evaluation and prediction, and by experimenting novel technologies, in order to quantify and manage spoilage and pathogen microorganisms, minimize risks to consume ...
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 14

 TERMINÉ 

High Potency Dermatologicals (HIPODERM)

Date du début: 1 mars 2011, Date de fin: 28 févr. 2015,

"The HIPODERM application seeks support under the Marie Curie Industry-Academia Partnerships and Pathways scheme to facilitate the growth of a dynamic research team for 'the development of novel dermal-translocation, high-potency drug delivery systems'. Our aim is to develop a core scientific platform from which novel non-invasive drug delivery systems can be developed and clinically assessed. At ...
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 4

 TERMINÉ 

The role of the Calcium Sensing Receptor (CaSR) in health and disease, implications for translational medicine (MULTIFACETED CASR)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2014,

The identification of the extracellular calcium sensing receptor (CaSR) was a crucial step in understanding nutrient sensing in mammals. In mammalian organisms the CaSR has multiple roles: besides calcium homeostasis, it is involved in protection against osteoporosis, blood vessel calcification, prevention against colorectal cancer, is involved in metastasis of breast and prostate cancer cells to ...
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 9

 TERMINÉ 

Mesoporous Graphitic Carbon Nitrides Supported Noble Metal Nanoparticles for Green Catalysis under Visible Light (NOMGCNP)

Date du début: 1 sept. 2012, Date de fin: 31 août 2014,

"The present synthetic methodologies in chemical industry must be significantly improved to enable producing many chemicals by employing environmental-friendly and sustainable procedures. One of the main challenges for establishing a sustainable society is to mimic natural photosynthesis and develop stable and efficient photocatalysts for various chemical transformations under visible light irradi ...
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 1

 TERMINÉ 

Targeting common mechanisms of pathogenesis in diseases of sterol homeostasis associated with lysosome dysfunction; development of novel and rapidly translatable clinical therapies (STEROLOSOME)

Date du début: 1 juin 2012, Date de fin: 31 mai 2014,

"We have recently discovered a link at the cellular level between two rare pediatric diseases, Niemann-Pick C (NPC) and Smith-Lemli-Opitz Syndrome (SLOS). NPC is a disease where cholesterol and other lipids accumulate within the lysosome. SLOS is a multimalformation disease attributed to an inborn error of cholesterol synthesis, characterised by severe birth defects and neurological decline. Our d ...
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 1

 TERMINÉ 

Diaminations of Alkenes using Metal-free Chemistry (DIALMEC)

Date du début: 1 mai 2012, Date de fin: 30 avr. 2014,

"Organic molecules of all shapes and sizes are required for a multitude of applications eg. in the biomedical, pharmaceutical, and agrochemical industries. Organic synthesis allows an insight into the way in which bonds between atoms can be formed or broken and how molecules can react with each other. Chemists are still faced with the challenge of converting simple, readily available molecules int ...
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 1

 TERMINÉ 

Novel low cost catalyst for direct hydrogen peroxide synthesis (LOWCOSTPEROXIDE)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2014,

"The discovery of the catalytic properties of gold has advanced understanding of the fundamental properties of catalyst materials and has opened new avenues for catalyst design and reaction control. However, the price of gold is a significant barrier to commercial uptake and implementation. A discovery arising from the ERC Advanced grant ‘After the Goldrush’ (ERC-2011-AdG-291319) offers the pros ...
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 1

 TERMINÉ 

Microelectromechanical Systems from Nanocrystalline Diamond (DIAMEMS)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2014,

"This project aims to develop high frequency, high quality factor micro and nano – electromechanical systems (MEMS) from nanocrystalline diamond (NCD). NCD offers superior performance to silicon for MEMS due to its extreme Young’s modulus, but it is also compatible with silicon CMOS technologies, offering a key advantage over other potential MEMS materials. High performance NCD growth and planariz ...
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 1

 TERMINÉ 

Probing the Fate of Stem Cells through the Development of a Multiplex Coherent Anti-Stokes Raman Scattering Imaging Technique (CARSforSTEM)

Date du début: 1 mars 2011, Date de fin: 28 févr. 2014,

Stem cell science and technology hold a great deal of promise within the context of tissue repair and regeneration. Whilst we know a lot about the function and response of stem cells in the laboratory, we know very little about their behaviour in tissues within individuals, delaying their applicability to the clinics. A major barrier has been the inability to accurately track cell lineages and to ...
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 1

 TERMINÉ 

Knowledge brokerage to promote sustainable food consumption and production: linking scientists, policymakers and civil society organisations (FOODLINKS)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2013,

The policy issue central to this project is food as many of today’s sustainability problems (e.g. water shortage, GHG emissions, pollution of soil and water, decrease of biodiversity, urban waste) are related to the prevailing pattern of food production and consumption (including processing and distribution). Hence, developing more sustainable food production and consumption patterns will have a s ...
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 14

 TERMINÉ 

IMGAME Commercial (IMCOM)

Date du début: 1 juin 2012, Date de fin: 30 nov. 2013,

The idea is to bring to pre-commercial stage two marketable versions of the research software that has been built for use in Prof Collins’ ERC Advanced Grant ‘IMGAME’ (ERC-2010-AdG-269463):1) A new academic IMGAME Research Tool, potentially to be sold under licence to universities and other organisations engaged in social sciences research; and2) A popular game, with the working name Masquerade, w ...
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 1

 TERMINÉ 

The role of host personality and stress responses in parasite dynamics (Para-PeSt)

Date du début: 1 sept. 2011, Date de fin: 31 août 2013,

The study of personality - consistent individual differences in animal behaviour - is a rapidly expanding research field. Like humans, animals may be categorized on personality axes such as bold-shy and aggressive-passive. These traits have both costs and benefits. However, the mechanisms underlying individual variation in personality and the consequences for evolutionary fitness are largely unkno ...
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 1

 TERMINÉ 

The role of altered monocyte activity in the long-term potential of peritoneal dialysis as a therapy (ROAMinPD)

Date du début: 1 août 2011, Date de fin: 31 juil. 2013,

Recurrent infection remains the major reason for treatment failure in patients treated for renal failure with peritoneal dialysis (PD). The underlying hypothesis of this study is that modification of peritoneal monocyte/macrophage biology by PD alters tissue homeostasis, susceptibility to infection and the development of immunity to re-infection, compromising the long-term potential of peritoneal ...
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 1

 TERMINÉ 

Ethnic Conflict, Cross-Community Practices & Transversal Assemblages (Transversal Politics)

Date du début: 1 août 2010, Date de fin: 31 juil. 2013,

The research aims at the elaboration of a philosophy of transformative action for ethnically segregated, conflict-ridden societies, in order to explain the challenge posed by existing practices of cross-community cooperation. This new approach to ethnic conflict draws on the tradition of transversal critical thought and on Gilles Deleuze & Félix Guattari’s (D&G) theory of assemblages. It focuses o ...
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 1

 TERMINÉ 

"Characterisation, synthesis and functional investigation of epidermal lipoxygenase products in inflammation" (LOXEPI)

Date du début: 1 juil. 2010, Date de fin: 30 juin 2013,

"The skin has many protective functions, acting as a barrier to physical and biological threats from the external environment while regulating water loss and body temperature. Loss of the normal skin function results in inflammation and associated diseases such as psoriasis, alopecia and ichthyosis. The skin is highly-enriched in lipids and fatty acids, which can be converted by lipoxygenase (LOX) ...
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 1

 TERMINÉ 

Spectral analysis of graph-coupled systems (GRAPH-COUPL)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2012,

"The analysis of thin branched structures has become very popular in Mathematical Physics during recent years. One reason is the increasing technological feasability of manufacturing nano-structures at an atomic level, making a detailed quantum mechanical analysis of the problem necessary. Thin branched structures occur e.g. inmicro-electronics or in opto-electronics; and a theoretical analysis ...
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 1

 TERMINÉ 

Enlightened or just less threatened: Education and anti-immigrant attitudes (educationimmigration)

Date du début: 1 oct. 2010, Date de fin: 30 sept. 2012,

This research proposal combines the strengths of sociology and social psychology to investigate the effect of education on anti-immigrant attitudes. Many studies in the last fifty years have found that the higher educated have less negative anti-immigrant attitudes. Anti-immigrant prejudice can have many negative consequences for social integration in communities but also for EU integration. Howev ...
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 1

 TERMINÉ 

Enabling the interoperability of cytometric data – a novel bioinformatics approach for revealing systems level understanding of cell cycle dynamics (Cellular Informatics)

Date du début: 1 avr. 2010, Date de fin: 30 sept. 2012,

The fellowship addresses a growing area of the life sciences interests of the EU community – understanding biological processes at the system level. Availability of high-quality quantitative data constitutes a bottleneck in this area and the fellowship addresses a specific problem. Ongoing efforts to converge genomic and proteomic data aiming to enlarge the systems view through bioinformatics. The ...
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 1

 TERMINÉ 

Routes to arousal: a simultaneous EEG-FMRI investigation of pharmacological sedation in humans (Routes to Arousal)

Date du début: 15 sept. 2010, Date de fin: 14 sept. 2012,

Functional Magnetic Resonance Imaging studies have progressed from identifying areas of the brain involved in a given task to investigating the temporal correlation or ‘functional connectivity’ between signals from different brain regions. This permits spatial and temporal characterisation of cortical and subcortical functional circuits during the execution of tasks and at rest. Combining informat ...
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 1

 TERMINÉ 

Novel Organoselenium Catalysts for Green Chemistry (NOSCat)

Date du début: 1 mai 2010, Date de fin: 30 avr. 2012,

Organic Chemistry is mainly dealing with the synthesis of molecules. In order to be able to do this efficiently, one must have reasonable insight into the way in which bonds between atoms can be formed or broken and how molecules can react with each other. In our research proposal we make use of the special properties of an interesting class of molecules containing selenium atoms. The properties o ...
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 1