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17 projets européens trouvés

Recherche sur 125080 projets européens

 TERMINÉ 

Integrative Analysis of Gene Functions in Cellular and Animal Models of Pancreatic Cancer (CAM-PAC)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

Cancers are genetic disease arising from the accumulation of multiple molecular alterations in affected cells. Large-scale genomic, transcriptomic and proteomic analyses have established comprehensive catalogues of molecules which are altered in their structure and/or abundance in malignant tumors as compared to healthy tissues. Far less developed are concepts and methods to integrate data from di ...
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 18

 TERMINÉ 

DNA Damage Response (DDR) signaling in tumor formation and therapeutic resistance of gliomas (GLIDD)

Date du début: 1 juil. 2014, Date de fin: 30 juin 2018,

"The gliomas are a large group of brain tumors and Glioblastoma Multiforme (GBM) is the most common and lethal primary central nervous system (CNS) tumor in adults. Despite the recent advances in treatment modalities, GBM patients generally respond poorly to all therapeutic approaches and prognosis remain dismal. Standard therapy for GBMs includes resection of the tumor mass, followed by concurren ...
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 1

 TERMINÉ 

Bioinformatics and Integrative Genomics for a Novel Personalized Cancer Therapy (PERSMEDOMICS)

Date du début: 1 juil. 2013, Date de fin: 30 juin 2017,

"The dawn of the age of personalized cancer treatment provides the promise to identify the right drug for the individual that will greatly improve the patient’s outcome. It is well known that cancer drugs work only in small subset of patients. For many of these agents, there are putative markers of response in the literature but very few are been used in clinical practice. More importantly, new ...
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 1

 TERMINÉ 

Risk, Stem Cells and Tissue Kinetics – Ionising Radiation (RISK - IR)

Date du début: 1 nov. 2012, Date de fin: 30 avr. 2017,

The magnitude of cancer risk in humans exposed to low radiation doses (
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 16

 TERMINÉ 

A European Platform for Translational Cancer Research (EUROCANPLATFORM)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2016,

Europe has a number of advantages as regards developing translational cancer research, yet there is no clear European strategy to meet the increasing burden posed by cancer. The FP6 Eurocan+Plus project analysed the barriers underlying the increasing fragmentation of cancer research and stressed the need to improve collaboration between basic/preclinical and comprehensive cancer centres (CCCs), in ...
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 29

 TERMINÉ 

Joint training and research network on Chromatin Dynamics and the DNA Damage Response (ADDRESS)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

DNA is tightly wrapped around histones to form chromatin, a highly dynamic structure that can adopt different conformations with contrasting degrees of compaction. Essential processes of DNA metabolism, such as DNA repair, replication or transcription operate in the context of chromatin and higher order chromosomal organization. Understanding how modulation of chromatin structure and repair influe ...
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 10

 TERMINÉ 

Systems Biology of Mitosis (MitoSys)

Date du début: 1 juin 2010, Date de fin: 31 mai 2015,

"MitoSys will generate a comprehensive mathematical understanding of mitotic division in human cells, a process of fundamental importance for human health. To create the critical mass and multidisciplinarity that is needed to achieve this ambitious goal, internationally leading mathematicians, biochemists/biophysicists and biologists working at twelve universities, research institutes, internation ...
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 14

 TERMINÉ 

Improving the selectivity of kinase inhibitors: Characterizing binding mechanisms of inhibitors targeting inactive states and allosteric sites (KIBinding)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2015,

Kinase proteins are key to signaling in eukaryotic cells, so it is not surprising that their dysfunction has been implicated in human diseases such as cancer and inflammatory disorders. As a result, kinases have become important targets for drug discovery. The majority of kinase inhibitors bind to the ATP-binding site, which is highly conserved among the different kinases. In order to increase ...
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 2

 TERMINÉ 

Development of novel diagnostic and therapeutic approaches to improve patient outcome in lung and pancreatic tumours (CANCERALIA)

Date du début: 1 avr. 2011, Date de fin: 30 sept. 2014,

Lung and pancreatic cancers still have a mortality rate over 85% at 5 years of diagnosis, a clear demonstration of the actual treatment failure and the need for improved clinical management. This involves better tools for diagnosis, prognosis, and selection of sensitive and resistant patients to current conventional therapies or improved innovative treatments as well as the development of novel th ...
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 8

 TERMINÉ 

Role of the protein kinase Mastl in Cell Division and Cancer (Mastl CDC)

Date du début: 1 sept. 2012, Date de fin: 31 août 2014,

The cell division cycle is an essential step in living organisms. Different studies have led to a model where cell cycle kinases act as major engines to promote cell cycle progression throughout the different phases of the cell cycle. In addition to Cyclin- dependent kinases (Cdks), Polo-like and Aurora kinases, other kinases have recently emerged as important regulators of cell cycle progression. ...
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 1

 TERMINÉ 

Rational designing of new meganucleases as molecular scissors for genomic tailoring (SMARTBREAKER)

Date du début: 1 juil. 2011, Date de fin: 30 juin 2014,

"Regenerative medicine using gene targeting by homologous recombination is one of the most powerful methods to achieve precise genome modifications. In the absence of double strand breaks the frequency of homologues recombination events at a target site is very low. A wide range of molecular tools are used to achieve targeting double strand breaks to increase the efficiency of homologues recombina ...
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 1

 TERMINÉ 

Genome Maintenance in the Context of Chromatin (CHROMOREPAIR)

Date du début: 1 déc. 2008, Date de fin: 30 nov. 2013,

"With the availability of the essentially complete sequence of the human genome, as well as a rapid development of massive sequencing techniques, the research efforts to understand genetics and disease from a cis standpoint will soon reach an endpoint. However, our emerging knowledge of gene regulation networks reveals that epigenetic regulation of the hereditary information plays crucial roles in ...
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 1

 TERMINÉ 

Nucleosome Structure & Function across Biological Scales and Biological Function (NUCLEOSOME4D)

Date du début: 1 nov. 2009, Date de fin: 31 oct. 2013,

Chromatin packages a few meters of DNA into a nucleus measuring a few microns. This tight folding occurs by assembling DNA with histones into so-called nucleosomes, thus ensuring the mechanical stability of our genome. On the flipside, this makes nucleosomes a formidable obstacle to the machines that read, copy or repair its DNA message. One of the fundamental questions in biology is to understand ...
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 17

 TERMINÉ 

ROLE OF HISTONE MODIFICATIONS IN DNA DAMAGE RESPONSE IN MAMMALS (HISTONEDDR)

Date du début: 1 déc. 2009, Date de fin: 1 oct. 2013,

"After DNA damage a signal must be created to recruit DNA repair factors to the lesion. Then the repair machinery needs to gain access to DNA and chromatin should be properly reassembled. DNA assembly with histones to form chromatin creates a physically limits the access to DNA. Alterations of chromatin that do not affect the DNA sequence constitute the epigenetic level of regulation of DNA metabo ...
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 1

 TERMINÉ 

Clonal analysis in pancreatic development, differentiation and carcinogenesis (PanClon)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2013,

The knowledge about pancreas development and the establishment of pancreatic cell lineages has exploded in recent years. These studies are important in developing strategies for regenerative medicine. On the other hand, pancreatic ductal adenocarcinoma (PDAC) is the tumor with the worst prognosis in humans: its incidence rate is equivalent to its mortality rate, with a median survival of less than ...
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 1

 TERMINÉ 

Safer gene repair and targeting based on the monomeric meganuclease I-DmoI by design of homologous-recombination-inducing nickase activity (DmoNickaseDesign)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2013,

An important aspect of cancer therapy is the specificity of the treatment. Significant progress has been made in drug design. However, gene therapy by direct targeting of oncogenes has not yet met equal success. Among the most valuable tools are meganucleases, also known as homing endonucleases (HE). These enzymes recognize and cleave long (around 20bp) DNA sequences and have been shown to induce ...
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 1

 TERMINÉ 

The role of activation-induced cytidine deaminase in inflammation-induced carcinogenesis (InflAIDCan)

Date du début: 1 mars 2010, Date de fin: 31 août 2011,

Activation-induced cytidine deaminase (AID) is a DNA-modifying enzyme essential for somatic hypermutation and class switch recombination in B cells. However, deregulation of AID can induce mutations and chromosomal translocations in B cells thus promoting neoplastic transformation and cancer development. AID expression is controlled by several transcription factors like those of the Rel/NF-kappa B ...
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 1