Tobacco use is the leading preventable cause of death in the world. Nicotine, which is the addictive ingredient of tobacco, exerts its addictive effect through nicotinic acetylcholine receptors (nAChRs) in the central nervous system (CNS). Besides mediating nicotine addiction, nAChRs have been implicated in Alzheimer’s disease, Parkinson’s disease, learning and memory, autism, anxiety disorders, d ...