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24 projets européens trouvés

Recherche sur 125080 projets européens

 TERMINÉ 

Anti-tick Vaccines to Prevent Tick-borne Diseases in Europe (ANTIDotE)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2018,

Background Ixodes ricinus transmits bacterial, protozoal and viral pathogens that cause Lyme borreliosis, babesiosis and tick-borne encephalitis respectively and exceedingly affect Central and Eastern Europe (CEE). During feeding, ticks introduce salivary proteins in the skin that interfere with host defense mechanisms. However, in animals repeated tick infestations as well as vaccination against ...
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 8

 TERMINÉ 

Metabolic requirements for prostate cancer cell fitness (CancerMetab)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

The actual view of cellular transformation and cancer progression supports the notion that cancer cells must undergo metabolic reprogramming in order to survive in a hostile environment. This field has experienced a renaissance in recent years, with the discovery of cancer genes regulating metabolic homeostasis, in turn being accepted as an emergent hallmark of cancer. Prostate cancer presents one ...
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 1

 TERMINÉ 

Unravelling the Nascent Code: Signals sensed and transmitted by the nascent chain to acquire its functional state or reprogram gene expression (THE NASCENT CODE)

Date du début: 14 juil. 2014, Date de fin: 13 juil. 2018,

"Emerging biochemical and biophysical data strongly suggest that the transformation of the potential set of proteins, encrypted in the genome, into its actual vital functional set, is a manifestation not just of the genetic code, but of an additional layer of information encoded within the newly synthesized polypeptide nascent chain. To date, we know that immediately upon the first steps of protei ...
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 1

 TERMINÉ 

Hierarchical Functionalization of Graphene for Multiple device fabrication (HIGRAPHEN)

Date du début: 1 mars 2014, Date de fin: 28 févr. 2018,

"This project is based on the application of layer-by-layer (LbL) technology for the development of a versatile and generic procedure for the fabrication of hybrid devices involving graphene and materials of a different nature such as polymeric, organic, and inorganic entities. The project aims to achieve the organization and integration of graphene sheets with heterogeneous components of differ ...
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 2

 TERMINÉ 

Nanotherapeutics to Treat Antibiotic Resistant Gram-Negative Pneumonia Infections (PNEUMONP)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2017,

The main objective of PneumoNP is the development of a theragnostic system for the treatment of lung Gram-negative bacterial infections. As a proof of concept PneumoNP will focus the attention on Klebsiella pneumoniae caused infections. A diagnostic kit will be developed to enable a rapid and precise identification of the bacteria strain causing the infection and avoid the use of wide spectrum a ...
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 11

 TERMINÉ 

Biomolecular Hydrogels – from Supramolecular Organization and Dynamics to Biological Function (JELLY)

Date du début: 1 déc. 2012, Date de fin: 30 nov. 2017,

Certain proteins and glycans self-organize in vivo into soft and strongly hydrated, dynamic and gel-like supramolecular assemblies. Among such biomolecular hydrogels are the jelly-like matrix that is formed around the egg during ovulation, mucosal membranes, slimy coats produced by bacteria in biofilms, and the nuclear pore permeability barrier.Even though biomolecular hydrogels play crucial roles ...
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 2

 TERMINÉ 

Design of a versatile and fast colloidal sensor based on virus modified particles (VIROMA)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,

"Viroma project aims to fabricate multiplexed bead-based arrays as sensing devices on the basis of virus capsid and virosome Layer by Layer-assisted assembly on colloidal carriers. The virosome based platform technology will be suitable for the detection of several analytes ranging from comparatively small molecules, of the size of dioxins to larger biomolecules such as small proteins. Such syst ...
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 4

 TERMINÉ 

Biological Foundation for the Safety Classification of Engineered Nanomaterials (ENM): Systems Biology Approaches to Understand Interactions of ENM with Living Organisms and the Environment (NANOSOLUTIONS)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2017,

The main objective of this research proposal is to identify and elaborate those characteristics of ENM that determine their biological hazard potential. This potential includes the ability of ENM to induce damage at the cellular, tissue, or organism levels by interacting with cellular structures leading to impairment of key cellular functions. These adverse effects may be mediated by ENM-induced a ...
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 40

 TERMINÉ 

Development of plasmonic quorum sensors for understanding bacterial-eukaryotic cell relations (PLASMAQUO)

Date du début: 1 mars 2011, Date de fin: 28 févr. 2017,

"This proposal aims at the development of novel nanostructured materials based on crystalline assemblies of anisotropic plasmonic (gold/silver) nanoparticles, to be used for the surface enhanced Raman scattering (SERS) detection of quorum sensing (QS) signaling molecules, and to the demonstration of applications of such materials to monitor population kinetics in bacterial colonies and the determi ...
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 2

 TERMINÉ 

Novel Upconversion Nanomaterials for Inorganic Photoactivated Chemotherapy (UCnanomat4iPACT)

Date du début: 15 janv. 2013, Date de fin: 14 janv. 2017,

Upconversion nanoparticles (UCNPs) have outstanding optical and magnetic properties, which make them extremely suited for application in cancer phototherapy and imaging. They efficiently convert low energy near infrared (NIR) light to higher energies in the visible. The so-generated upconverted luminescence can be exploited to photoactive anticancer metal complexes, a promising class of compounds ...
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 1

 TERMINÉ 

Translocation and Safe Design of Surface Engineered Metal oxide Nanoparticles (BRASINOEU)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,

"BRASINOEU aims to study the translocation and nanosafety issues of engineered metal oxide nanoparticles (NPs).The new scientific and technology developments of nanotechnology require a deeper knowledge of the effects of nanotechnology based products on human health. This knowledge is fundamental for the development of nanotechnology and to achieve its full acceptance. The concept of “safe by desi ...
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 7

 TERMINÉ 

Self-Assembly in Confined Space (SACS)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,

Supramolecular chemistry studies chemistry beyond individual molecules, where molecules or macromolecules form larger entities by spontaneous self-assembly or by self-organisation. The resulting supramolecular architectures are held together by covalent bonds and a variety of non-covalent intermolecular interactions (hydrogen bonding, metal coordination, hydrophobic interactions etc). Spatially, t ...
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 10

 TERMINÉ 

Innovative Radiochemistry to Advance Molecular Imaging (RADIOMI)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,

The RADIOMI Initial Training Network (ITN) has the goal of providing training in a superbly suited academic and industrial environment uniquely equipped to conduct a scientific research program that addresses one of the key aspects of functional imaging, the underpinning radiochemistry essential for preparation of radiotracers currently difficult or not possible to access. This will be exploited f ...
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 9

 TERMINÉ 

Implication of energy sensing pathways in prostate cancer biology (PTENLKB1)

Date du début: 2 janv. 2012, Date de fin: 1 janv. 2016,

"Prostate cancer is among the most prevalent forms of cancer in men and the fifth cause of dead from cancer in men worldwide. Therefore, the understanding of prostate cancer biology is a key step in the development of new effective therapeutic approaches. In this line, the use of genetically engineered mouse models has been critical in the understanding of the genetic cues that regulate the proces ...
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 1

 TERMINÉ 

Self-assembled virus-like vectors for stem cell phenotyping (SAVVY)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2015,

The Self-Assembled Virus-like Vectors for Stem Cell Phenotyping (SAVVY) project relies on hierarchical, multi-scale assembly of intrinsically dissimilar nanoparticles to develop novel types of multifunctional Raman probes for analysis and phenotyping of heterogeneous stem cell populations.Our project will address a large unmet need, as stem cells have great potential for a broad range of therapeut ...
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 8

 TERMINÉ 

European Soft Matter Infrastructure (ESMI)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2015,

The central objective of this ESMI proposal is to create a top-level interdisciplinary research infrastructure available to a broad European materials research community. This is of crucial importance to the EU in view of the European strategy for nanosciences and nanotechnology and its implementation report that identifies “a lack of leading interdisciplinary infrastructures”.ESMI offers the mos ...
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 18

 TERMINÉ 

European Research Training in the Ubiquitin Proteasome System (UPStream)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,

The main objective of the international training network UPStream is the training of a novel generation of European scientist in a critical and complex field of modern biology: the understanding of the regulation of the UPS and its potential use for drug development. The importance of this process is illustrated by the imperious necessity to destroy certain proteins during several phases of the ce ...
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 10

 TERMINÉ 

A pan-European infrastructure for quality in nanomaterials safety testing (QUALITYNANO)

Date du début: 1 févr. 2011, Date de fin: 31 juil. 2015,

Nanoscale objects interact with living organisms in a fundamentally new manner, ensuring that a fruitful marriage of nanotechnology and biology will long outlast short term imperatives. Therefore, investment in an infrastructure to drive scientific knowledge of the highest quality will have both immediate benefits of supporting the safety assessment of legacy nanomaterials, as well as pointing tow ...
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 33

 TERMINÉ 

Combined Highly Active Anti-retroviral Microbicides (CHAARM)

Date du début: 1 janv. 2010, Date de fin: 30 juin 2015,

This proposal is for a large scale collaborative project in which we propose both to develop novel microbicides directed against new intracellular targets and to investigate novel combinations of highly active anti-retroviral drugs which may be particularly effective as microbicides. Combinations may enhance efficacy but equally importantly will increase the genetic barrier to the development of r ...
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 34

 TERMINÉ 

"Combining supramolecular chemistry, physico-chemical characterization and theoretical modeling to understand multivalent interactions at the cell-hyaluronan matrix interface" (CELLMULTIVINT)

Date du début: 15 mars 2012, Date de fin: 14 mars 2015,

"Multivalent interactions are characterized by the simultaneous binding of multiple ligands on one entity to multiple receptors on another. Multivalency provides the basis for mechanisms of both agonizing and antagonizing biological interactions that are fundamentally different from those available in monovalent systems. Even though multivalent interactions occur broadly in biological systems, the ...
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 1

 TERMINÉ 

The nuclear pore permeability barrier – physical concepts and a biosynthetic approach to understand and exploit the unique selectivity of a natural macromolecular sieve (Nuclear Pore)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2015,

Nuclear pore complexes (NPCs) are the exclusive gate of entry/exit of macromolecules into and out of the nucleus of living cells. They exhibit a unique selectivity in transport, with respect to size and molecular species: very small molecules can diffuse efficiently through the pore, while larger objects are delayed/blocked unless they are bound to specialized proteins, so called nuclear transport ...
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 1

 TERMINÉ 

A Modular Nanosystems Platform for Advanced Cancer Management: Nano-vehicles; Tumor Targeting and Penetration Agents; Molecular Imaging, Degradome based Therapy (SAVEME)

Date du début: 1 mars 2011, Date de fin: 28 févr. 2015,

SaveMe project will address current urgent needs for pancreatic cancer diagnosis and treatment by exploiting partners’ expertise and most recent research achievements for the design and development of novel modular nanosystems platform integrating new functionalized nano-core particles and active agents. The modular platform will enable the design of diverse active nanosystems per diagnostic or th ...
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 23

 TERMINÉ 

Regenerable active polyelectrolyte nanofiltration membranes for water reuse and metal/acid recovery (LbLBRANE)

Date du début: 1 févr. 2012, Date de fin: 31 janv. 2015,

The shortage of drinking water in many regions on the planet constitutes a real problem and hazard. The use of seawater, brackish water and wastewater for human consumption is not a new concept. In spite of the success of membrane technology in water reclamation, membrane separation systems suffer from a serious problem: membrane fouling. The main downside is an inevitabe increase in operation and ...
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 13

 TERMINÉ 

Integration of Novel Nanoparticle based Technology for Therapeutics and Diagnosis of different types of Cancer (NANOTHER)

Date du début: 1 sept. 2008, Date de fin: 31 août 2012,

The breakthrough objective of NANOTHER is to develop & characterise a novel nanoparticle system that will be used as a therapeutic agent or diagnosis tool for breast cancer, colorectal cancer & bone metastasis. Theranostics, the development of nanoparticles with both functionalities, will also be carried out using the hyperthermic effect to kill tumour cells or to release the selected drug . The n ...
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 19