Massimiliano Mellone
:
24 mars 2023
En recherche de financements
A propos
I am senior scientist at AstraZeneca and Visitor Research Fellow at University of Southampton. I work as in vivo scientist in the Discovery Immuno-Oncology group at at AZ and I have an interest in the Cancer Associated Fibroblasts (CAF) present in the tumour microenvironment. I would like to know more about anything related to CAF and networking with scientists interested in CAFs
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Idées proposées
Biotechnologie
Biotechnologie médicale
Biologie
Non-responsiveness to immune-checkpoint blockade can result from limited T cell infiltration, mediated by the cells of the tumour microenvironment. Myofibroblastic cancer-associated fibroblasts (myoCAF)-rich tumours generally contain few T-cells and respond poorly to immune-checkpoint blockade. Although myoCAF are associated with poor outcome in most solid tumours, the molecular mechanisms regu...
Cambridge, United Kingdom
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