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 TERMINÉ 

Worm power: Can helminths modify the development of colorectal cancer? (WORMTUMORS)

Date du début: 1 août 2015, Date de fin: 31 juil. 2018,

The incidence of cancer is significantly lower in developing areas such as Africa, than in the Western world. These developing regions have a high incidence of helminth infection, which can protect against immune-mediated diseases and are currently being successfully used within clinical trials as novel therapeutics to treat inflammatory bowel disease. As Africa develops, lifestyle and dietary c ...
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 1

 TERMINÉ 

Hook a Worm to Catch a Man: Tracking Historical and Recent Human Settlement, Land use and Migration in Neotropical Rainforests using Ecosystem Engineers (HOOKaWORM)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2018,

The anthropologic and archaeological study of pre-Columbian people of the Amazonian basin has revealed sophisticated agriculture practices. Notwithstanding the absence of historical written records the biological evidence of these practices remains in the remarkable biodiversity of the Amazonian 'dark earths' (ADEs) or “Terra Preta do Indio” produced by ancient civilisations to promote highly prod ...
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 1

 TERMINÉ 

SpinCo, new energy saving worm gear technology by gear rolling contacts (SpinCo)

Date du début: 1 août 2016, Date de fin: 30 nov. 2016,

...BV has developed, tested and patented a new energy saving power transfer technology that is uniquely versatile and adaptive to hundreds of applications in nearly every gear market segment. The SpinCo worm gear improves efficiency, acceleration and power density as compared with conventional worm gearing. The invention is to use rolling contact between gear mating surfaces, replacing the rubbing an ...
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 1

 TERMINÉ 

Site-directed RNA Editing to Manipulate RNA and Protein Function (RNArepair)

Date du début: 1 août 2015, Date de fin: 31 juil. 2020,

...tool by lentiviral vectors and stabilized mRNAs. We further aim to create cell lines expressing the artificial editing machinery under conditional control. We will repair reporter genes in developing worm oocytes, and we want to reconstitute mutations that cause neuro-diseases. We also wish to establish new features including photocontrol and the application of editing to steer protein localizatio ...
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 1

 TERMINÉ 

RNA-Mediated Inheritance of Acquired Traits (TransgenerationalRNA)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

...rit an acquired trait, antiviral resistance, through transgenerational transmission of antiviral small RNAs (viRNAs), which mediate RNA interference (RNAi) (Cell, 2011). viRNAs, which protect the worm from viral propagation, pass down to many ensuing generations in a non-Mendelian manner, in the absence of their DNA template, and thus defend RNAi-deficient progeny from viral propagation. Here I su ...
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 1

 TERMINÉ 

Substrate specificity, mechanism and biological roles of rhomboid intramembrane proteases (Rhomboid substrates)

Date du début: 1 mars 2013, Date de fin: 1 mai 2017,

Rhomboids are widely conserved intramembrane proteases. They are known to control important biological processes in model insect, worm, yeast and protozoan species, but their functions in most organisms including mammals and bacteria are unknown. The key to the understanding of rhomboid functions are their natural substrates, but it has been unclear how these are selected and recognized and method ...
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 1

 TERMINÉ 

Prenylated protein regulation in the Caenorhabditis elegans brain (PPRITCEB)

Date du début: 1 août 2013, Date de fin: 31 juil. 2017,

... from the ER to the outer segments of cones and rods cells. Thus may play a critical role in normal vision physiology. PDE6D is conserved and has homologs across the animal kingdom. In the C. elegans worm, RNAi experiments against the PDE6D homolog pdl-1 failed to produce any abnormalities in the nematode physiology or behavior. However, we isolated a pdl-1 suppressor mutant that inhibits the fast ...
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 1

 TERMINÉ 

PECKLES

Date du début: 25 nov. 2015, Date de fin: 24 mai 2019,

...s to take flight with her best friends Stewy, Pedro, and Sylvia-a.k.a., the Wild Bunch. Peckles is determined, quirky, and always entertaining as she leads the Wild Bunch where no bird, squirrel, worm, and badger have gone before!Every story starts with Peckles, who, sparked by everyday occurrences, town events, and neighborhood legends summons the Wild Bunch to action via tin can phone: “Wild Buu ...
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 1

 TERMINÉ 

Restoration of inland dunes and psammophyle heathland in the North-western Veluwe (Wuthering heaths)

Date du début: 1 sept. 2011, Date de fin: 31 déc. 2016,

...ns and mushrooms species, several of which are classified as Red List species. The project area is also important for reptiles such as the sand lizard (Lacerta viridis), adder (Vipera berus) and slow worm (Anguis fragilis). Other species found in the project area include the stag beetle (Lucanus cervus) and giant earwig (Labidura riparia). The sand drift areas, however, have been severely reduced ...
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 1

 TERMINÉ 

Development of a new gearbox without lubricants for low OM costs, higher efficiency, and oiless applications (SMARTGEARBOX)

Date du début: 1 nov. 2014, Date de fin: 28 févr. 2015,

...w us to penetrate new markets such as food processing and medical, where the use of lubricants is prohibited. This project, called Smart GearBox, aims at integrating our developments on our worm-wheel gearboxes for commercialization, achieving a long-term profitability for both our customers and our company: increase of sales margin by 11% and sales by 42%, leading to an additional 6.3 million of ...
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 1

 TERMINÉ 

Nodding Syndrome: a trans-disciplinary approach to identify the cause and decrease the incidence of river epilepsy (NSETHIO)

Date du début: 1 oct. 2015, Date de fin: 30 sept. 2020,

...lic of the Congo (DRC), we gathered epidemiological evidence that supports the hypothesis that NS is a disease caused by a pathogen transmitted by blackflies, the vectors that transmit the parasitic worm that causes onchocerciasis. This pathogen could be an unknown neurotropic virus or another pathogen that is transmitted either independently or as a symbiont of the worm. We postulate that this ...
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 3

 TERMINÉ 

Development of a new gearbox without lubricants for low OM costs, higher efficiency, and oiless applications (SMARTGEARBOX)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2017,

...w us to penetrate new markets such as food processing and medical, where the use of lubricants is prohibited. This project, called Smart GearBox, aims at integrating our developments on our worm-wheel gearboxes for commercialization, achieving a long-term profitability for both our customers and our company: increase of sales margin by 11% and sales by 42%, leading to an additional 6.3 million of ...
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 1

 TERMINÉ 

CYPRES the ICS and SCADA security companion (CYPRES)

Date du début: 1 sept. 2015, Date de fin: 28 févr. 2018,

Industrial Automation and control systems are vital for city critical infrastructures which are soft targets by excellence. Awareness of their vulnerability arose since 2009 with the worm Stuxnet damaging Iranian nuclear sites. Most National Security Agencies reinforce the obligation to protect vital importance soft targets. So far, most solutions are partial and unsatisfying, and limited to Corpo ...
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 2

 TERMINÉ 

Establishing genetic code expansion as a tool to study neuronal circuit function in an animal (UAAWORM)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2021,

...neered technologies that allow the site-specific introduction of chemically synthesized unnatural amino acids (UAA) into a chosen protein within the context of a multicellular organism - the nematode worm C. elegans. The foundational technology for this advance is genetic code expansion. In its most simple form, genetic code expansion to incorporate UAA into proteins requires an orthogonal aminoac ...
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 1

 TERMINÉ 

Microfluidic systems for the study of living roundworms (Caenorhabditis elegans) and tissues (MEMSforLife)

Date du début: 1 mai 2013, Date de fin: 30 avr. 2018,

This proposal situated at the interfaces of the microengineering, biological and medical fields aims to develop microfluidic chips for studying living roundworms (Caenorhabditis elegans), living cultured liver tissue slices obtained from mice, and formaldehyde/paraffin-fixed human breast cancer tissue slices and tumors. Each type of microfluidic chip will be the central component of a computer-con ...
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 1

 TERMINÉ 

circular RNA Biology Training Network: from biogenesis to biomarkers (circRTrain)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

...tegrate various technologies (sequencing, single-molecule and whole-organism imaging, RNA knockdown/delivery, CRISPR/CAS9), disciplines (biochemistry, computational biology, genetics), model systems (worm, fly, mouse, human) and medical applications (biomarkers, new therapeutic strategies). CircRTrain will combine these diverse approaches and industrial technologies by training 15 early stage rese ...
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 8

 TERMINÉ 

Ciencioteca: transformar o futuro

Date du début: 31 déc. 2016, Date de fin: 30 déc. 2017,

... exhibits aligned with the issues on energy and environmental responsibility, a current strategic priority for the European Union - 2020, and the historical and ecological heritage for the silk worm. In the next two years the Centre faces, as objectives: (i) Exhibition contents renewal and photo exhibition related with the memory of the Micro-Hydroelectric Central (in the context of the project Ec ...
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 1

 TERMINÉ 

AcceSVE

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2016,

...elation to the possibilities offered by the method "learning by doing" in the subjects we work with.These activities materialize in: Morning activities from 10:00 to 14:00 (The early bird catches the worm); initiation in organization's management, organizing and finding resources for art workshops, dealing with other local organizations in person or online (skype, e-mail, social networks...) and w ...
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 3

 TERMINÉ 

Raising standards by sharing our Myths and Legends

Date du début: 1 sept. 2015, Date de fin: 31 août 2017,

... comic strip for a joint publication as part of an enterprise project. • Produce a collaborative newspaper during the project. • Design a badge and logo to belong the ‘Erasmus+ Book Worm Club’ • celebrate World Book Day, - a day full of reading and writing activities • Perform a myth or legend for younger pupils by using puppets to tell the tale • read and depict, through literacy, drama, art, and ...
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 6

 TERMINÉ 

My Small Permaculture Life - Benim Küçük Permakültür Yaşamım

Date du début: 20 janv. 2015, Date de fin: 19 juil. 2015,

...Detecting fields for permacultural ecological agriculture and soil production types, production of ecological fertilizer, making an amateur mill on a stream, and design of electiricity manufacture of worm compost, types of cherry and almond vaccination, tree pruning and ecological consumtion, ecological food at permaculture, creating a permacultural ecological agriculture and a garden, Youthpass c ...
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 4

 TERMINÉ 

Мотивация, квалификация, реализация- основни фактори за управлениe на промените в образованието

Date du début: 1 juin 2014, Date de fin: 31 mai 2015,

...provement of the quality of education and higher motivation which corresponds to the legislative reforms in Bulgarian Education. The expected results of this Project are believed to receive a worm welcome from both teachers and students after sharing and applying the innovative techniques and methods in class. New methods of teaching and higher quality of education are key components in the concep ...
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 2

 TERMINÉ 

Helminth-induced regulatory mechanisms that prevent the onset of diabetes (HELMINTH & DIABETES)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2015,

... pathology representing one of the biggest cost factors for the health care system. The ultimate goal of this proposal is to develop a novel immunomodulatory diabetes therapy by identifying parasitic worm (helminth) regulatory mechanisms which protect against autoimmune diseases. The applicants’ previous work has shown that infection with the filarial helminth Litomosoides sigmodontis prevents Typ ...
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 1

 TERMINÉ 

Quantitative pathway analysis of natural variation in complex disease signaling in C. elegans (PANACEA)

Date du début: 1 janv. 2009, Date de fin: 31 mars 2013,

...rtance of natural variation in disease signaling pathways of complex human diseases remains largely unknown. PANACEA will investigate the influence of natural variation in genetic pathways in the worm Caenorhabditis elegans. C. elegans is an important model for the identification and characterization of genes associated with cancer in humans. Therefore PANACEA focuses on cancer signaling pathway ...
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 5

 TERMINÉ 

Molecular Basis of Neuronal Ageing (NEURONAGE)

Date du début: 1 mai 2009, Date de fin: 30 avr. 2015,

Ageing is associated with marked decrease of neuronal function and increased susceptibility to neurodegeneration, in organisms as diverse as the lowly worm Caenorhabditis elegans and humans. Although, age-related deterioration of the nervous system is a universal phenomenon, its cellular and molecular underpinnings remain obscure. What mechanisms are responsible for the detrimental effects of agei ...
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 1

 TERMINÉ 

Colloidal Liquid Crystals of Flexible Particles: Theory and Simulation (COLCFLEX)

Date du début: 1 sept. 2008, Date de fin: 31 août 2010,

...r, structural and dynamical properties will be investigated as a function of the degree of internal particle flexibility. A more general virial theory for the isotropic-to-nematic phase transition in worm-like rods, which includes the third virial term in the excess free energy expression, will be formulated and worked out. This theory will be extended to inhomogeneous phases, such as smectic and ...
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 1

 TERMINÉ 

Dissecting the Immunological Interplay between Poverty Related Diseases and Helminth Infections: An African-European Research Initiative (IDEA)

Date du début: 1 mars 2010, Date de fin: 31 août 2015,

Worm infections are receiving increased attention due to: the wide geographic overlap in occurrence between worms and HIV, TB and malaria; the large proportion of individuals (minimal estimates around 25%) co-infected with worms and HIV/TB/ malaria; the potential risk of increasing disease burden; the very limited understanding of the impact by worm infections on HIV-, TB- and malaria-specific imm ...
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 23

 TERMINÉ 

Enhanced Protective Immunity Against Filariasis (E PIAF)

Date du début: 1 mars 2010, Date de fin: 31 août 2014,

...lth problem in West and Central Africa. Three filarial species are involved: Onchocerca volvulus (onchocerciasis or river blindness); Wuchereria bancrofti (lymphatic filariasis); and Loa loa (the eye worm). Treatment of onchocerciasis with ivermectin has been successful in many situations but emergence of drug resistance and risk of severe adverse reactions associated with L loa co-infections is r ...
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 11

 TERMINÉ 

MALCODE: Malicious Code Detection using Emulation (MALCODE)

Date du début: 1 juil. 2010, Date de fin: 30 juin 2013,

...e of the most common methods for malware propagation, exposing significant limitations in current state-of-the-art attack detection systems. For instance, the recent massive outbreak of the Conficker worm in the beginning of 2009 resulted to more than 10 million infected machines worldwide. Malicious web sites also launch code injection attacks against unsuspecting visitors by exploiting vulnerabi ...
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 1

 TERMINÉ 

Renovation and re-use of Salzano spinning mill for cultural purposes

Date du début: 31 déc. 2002, Date de fin: 29 sept. 2004,

... activity intends to preserve this mine of history and tradition, an ideal place to undertake cultural activities which find their source of inspiration here and in the cultivation of mulberry trees, worm-raising and silk production. The first renovation intervention is the construction of a new entrance to the spinning mill. Part of the ground floor will be used for cultural and social activities ...
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 1

 TERMINÉ 

Moonlight-dependent Hormones Orchestrating Lunar Reproductive Periodicity and Regeneration (HOR.MOON)

Date du début: 1 déc. 2010, Date de fin: 31 juil. 2016,

...ions, close to nothing is known about the molecular processes that underly these lunar reproductive cycles.We will take advantage of the recent advance in molecular resources and tools in the bristle worm Platynereis dumerilii, which has long served as a key model for classical experimental studies on lunar periodicity. The combination of modern techniques with well-founded classical observations ...
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 1

 TERMINÉ 

Deep Ocean Dispersal and Evolution (DODE)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2013,

... most abundant and species-rich groups, the polychaetes. To answer questions of dispersal and evolution in the deep sea we will study three contrasting groups of polychaetes. Firstly, polynoid (scale-worm) polychaetes are mobile with pelagic larvae that can drift some distances in ocean currents, although some polynoid species brood their offspring. Secondly, dorvilleid polychaetes which are mobil ...
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 1

 TERMINÉ 

Printable memory solutions for sensor, ID, and media applications (PriMeBits)

Date du début: 1 janv. 2008, Date de fin: 31 déc. 2010,

...s are unsuited. To overcome the shortcomings of prior-art approaches, printable inorganic metal-oxide-nanoparticle-based ferroelectric FRAM memory and a resistive metallic-based write-once-read-many (WORM) memory will be developed. To print the ferroelectric memory, new printing inks based on, for example, barium titanate (BaTiO3) nanoparticles will be developed. For the WORM memory, the project w ...
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 11

 TERMINÉ 

Controlling stochastic gene expression during development and stem cell differentiation (GeneNoiseControl)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2017,

...lly selected. The overarching goal of this proposal is to the understand how stochastic gene expression is controlled, or utilized, during development and stem cell differentiation using the nematode worm Caenorhabditis elegans and murine embryonic stem cells as experimental model systems. To obtain this goal we will use a combination of quantitative experiments, theoretical and computational appr ...
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 1

 TERMINÉ 

Protein damage control: regulation of toxic protein aggregation in aging-associated neurodegenerative diseases (PDcontrol)

Date du début: 1 déc. 2011, Date de fin: 30 nov. 2016,

...toxicity).Opening up such exciting new avenues for research is our recent identification of a modifier of aggregation, which we named MOAG-4, as a general regulator of age-related proteotoxicity in worm (C. elegans) models for neurodegenerative diseases. MOAG-4 and its human counterpart SERF act independently of classical pathways that degrade proteins or prevent their aggregation, but their molec ...
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 1

 TERMINÉ 

Cybersecurity on SCADA: risk prediction, analysis and reaction tools for Critical Infrastructures (CockpitCI)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2014,

... attacks could be performed blocking communication from central SCADA to local equipments or inserting fake commands/measurements in the SCADA-field equipment communications (as happened with STUXNET worm). The paradox is that critical infrastructures massively rely on the newest interconnected (and vulnerable) ICT technologies, while the control equipment is typically old, legacy software/hardwar ...
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 14

 TERMINÉ 

Innovative and sustainable strategies to mitigate the impact of global change on helminth infections in ruminants (GLOWORM)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2014,

"Infections with parasitic worms (nematodes and trematodes) represent a significant economic and welfare burden to the European ruminant livestock industry. The increasing prevalence of anthelmintic resistance means that current control programmes are costly and unsustainable in the long term. Recent changes in the epidemiology, seasonality and geographic distribution of helminth infections have b ...
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 14

 TERMINÉ 

Emulating the C. elegans nervous system: A blueprint for brain-inspired computational architectures (Si elegans)

Date du début: 1 avr. 2013, Date de fin: 30 sept. 2016,

...repancy between artificial systems and brains in seemingly simple orientation and navigation tasks. In fact, no system exists that can faithfully reproduce the rich behavioural repertoire of the tiny worm Caenorhabditis elegans which features one of the simplest nervous systems in nature made of 302 neurons and about 8000 connections. Si elegans aims at providing this missing link. We propose to d ...
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 5

 TERMINÉ 

Polymerisation-induced self-assembly (PISA)

Date du début: 1 févr. 2013, Date de fin: 31 janv. 2018,

...) novel polymer colloids. More specifically, the PI will work closely with four post-doctoral scientists and a PhD student to design a series of diblock copolymer nanoparticles with either spherical, worm-like or vesicular morphologies under dispersion polymerisation conditions in either water, alcohol or n-alkanes. This exciting and timely fundamental research programme will produce world-leading ...
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 1

 TERMINÉ 

Quantifying behavioural phenotype space: chemistry-to-gene screens and combination therapies (PHENOSPACE)

Date du début: 1 déc. 2016, Date de fin: 30 nov. 2021,

...complex phenotypes. To take full advantage of this potentially powerful model system, we will develop high-throughput tracking technology, both hardware and software, and use it to measure changes in worm behaviour in response to treatment with small molecules and genome-wide RNA interference. The result will be an unprecedented view of a multidimensional phenotype space in a genetically tractable ...
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 2

 TERMINÉ 

Epigenetic Regulation of Ageing (EpiAge)

Date du début: 1 août 2012, Date de fin: 31 juil. 2016,

...esearch in C. elegans has focussed on the characterization of signalling pathways involved in ageing. It is was demonstrated that the gene expression of old nematodes differs significantly from young worms, however, the molecular mechanisms that govern the regulation of genes have not been addressed in the context of ageing. The central questions for the proposed project are therefore, which epige ...
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 1