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 TERMINÉ 

Liaison in Scientific Training for European auditory Neuroscience (LISTEN)

Date du début: 1 déc. 2016, Date de fin: 30 nov. 2020,

This ITN will train 10 ESRs to meet the urgent need for translation of Auditory Neuroscience into commercial and pharmaceutical products to treat hearing disorders including tinnitus. Tinnitus is the debilitating perception of imaginary sound that is often associated with hearing loss. This Liaison in Scientific Training for European auditory Neuroscience (LISTEN) is a consortium of top hearing sc ...
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 9

 TERMINÉ 

Clinical development of a dendritic-cell vaccine therapy for acute myeloid leukaemia (AML-VACCiN)

Date du début: 1 janv. 2016, Date de fin: 31 mars 2020,

Eradicating minimal residual disease (MRD) in patients with acute myeloid leukaemia (AML) is an area of high unmet medical need. AML is a deadly rare disease that affects both children and adults. Approximately 45% of younger AML patients who are treated will be cured, and in older patients (>60 years of age), 85% will relapse and die within 2 years.Immunotherapy has great potential for treating M ...
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 12

 TERMINÉ 

Elucidating Pathways of Steatohepatitis (EPoS)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2019,

Strongly associated with the epidemics of obesity and type 2 diabetes mellitus (T2DM) that are testing healthcare systems worldwide, Non-Alcoholic Fatty Liver Disease (NAFLD) is an increasingly common cause of advanced liver disease in the aging population of Europe. NAFLD is a spectrum of hepatic fat accumulation (steatosis); steatosis plus inflammation (non-alcoholic steatohepatitis, NASH); fibr ...
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 13

 TERMINÉ 

PanCare Studies in Fertility and Ototoxicity to Improve Quality of Life after Cancer during Childhood, Adolescence and Young Adulthood (PANCARELIFE)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

Survival rates after childhood cancer now reach nearly 80% in developed European countries as a result of more effective therapies and better supportive care, leading to a steady increase in the number of survivors in the population. However, the treatments that have improved survival are harsh and cause serious side-effects that can greatly impact survivors’ quality of life in the long term. The ...
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 19

 TERMINÉ 

Lipid Signaling at the Glutamatergic Synapse: Involvement in Brain Network Function and Psychiatric Disorders (LiPsyD)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2018,

We have recently reported on a novel mode of modulation of neuronal transmission at the glutamatergic junction. This signaling pathway involves lysophosphatidic acid (LPA) acting via presynaptic LPA2 receptors. This is in turn controlled by a molecule which we named plasticity related gene-1 (PRG-1, Bräuer et al., Nat Neurosci 2003) from the postsynaptic side (Trimbuch et al., Cell 2009). PRG-1 is ...
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 1

 TERMINÉ 

European Consortium for the Study of a Topical Treatment of iCRVO to prevent Neovascular Glaucoma (STRONG)

Date du début: 1 oct. 2012, Date de fin: 31 mars 2018,

Neovascular glaucoma (NVG) is a very aggressive and rare type of glaucoma: yet, it contributes disproportionately to blindness from all eye diseases. NVG is also the second most common cause for the removal of the eye-ball across all eye diseases, usually because of intractable pain. The major cause of NVG is Ischaemic Central Retinal Vein Occlusion (CRVO) leading to neovascularisation, obstructio ...
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 9

 TERMINÉ 

NutrImmune: Nutrient-controlled molecular pathways instructing development and function of mucosa-associated innate lymphocytes (NUTRIMMUNE)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2018,

The last decade has witnessed an explosion of research into the molecular networks ensuring maintenance of a mutualistic relationship between microbes and host cell networks at mucosal surfaces. Failure of such homeostatic or adaptive programs lead to susceptibility to intestinal infections or to chronic inflammation causing debilitating human diseases such as inflammatory bowel diseases or inflam ...
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 2

 TERMINÉ 

Non-coding RNAs in neurogenic and neuropathic pain mechanisms and their application for risk assessment, patient stratification and personalised pain medicine (NCRNAPAIN)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

Neuro-immune alterations in the peripheral and central nervous system play a role in the pathophysiology of chronic pain, and non-coding RNAs (ncRNAs) regulate both immune and neuronal processes. Therefore, ncRNAPain proposes that ncRNAs are critically important master switches for chronic pain.ncRNAPain represents a multidisciplinary consortium of clinical partners, molecular and systems-level n ...
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 12

 TERMINÉ 

Quantitative Imaging of Liver Fibrosis and Fibrogenesis (LiverFibrosisImaging)

Date du début: 1 août 2012, Date de fin: 31 juil. 2017,

Chronic liver disease can progress to cirrhosis, with death due to liver failure and cancer. Cirrhosis prevalence in the EU is 0.5%-1%. However, development of therapies that prevent progression to cirrhosis is hampered by the lack of a sensitive, non-invasive method to quantify fibrosis or fibrosis progression (fibrogenesis). Liver biopsy 1) is risky, 2) shows high sampling variability, and 3) is ...
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 3

 TERMINÉ 

Chronotherapeutic lifestyle intervention for diabetes and obesity to reset the circadian rhythm and improve cardiometabolic risk in the European working population (EURHYTHDIA)

Date du début: 1 oct. 2011, Date de fin: 30 juin 2017,

Modern lifestyle has dramatically changed the daily rhythms of life. Physical activity, diet and light exposure are no longer restricted to daytime hours, as technical and economical de-mands fuel the necessity to work outside usual working hours. Recent studies show that al-tered light exposure, shifted exercise patterns and untimely food intake following extended active periods into the night di ...
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 17

 TERMINÉ 

Open Project for the European Radiation Research Area (OPERRA)

Date du début: 1 juin 2013, Date de fin: 31 mai 2017,

"Within the OPERRA project, it is proposed that the MELODI Association, as a well-advanced network, takes the lead in establishing the necessary structures able to manage the long-term European research programmes in radiation protection, also taking advantage of the valuable experience gathered through the DoReMi network of excellence. Whilst in fields adjacent to low-dose risk research (radioeco ...
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 71

 TERMINÉ 

Initial Training Network for Neurogical disorders orchestrated by cytoKines (NEUROKINE)

Date du début: 1 janv. 2013, Date de fin: 31 mai 2017,

Neuroinflammatory disease, in particular multiple sclerosis affects more than 700.000 people within Europe alone. European countries are at the forefront of neuroimmunological research and students in medicine and biology are greatly attracted by the field. Neuroimmunology research further impacts our understanding of the ethiopathology of other CNS-disorders including Alzheimer’s Dementia and Mor ...
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 13

 TERMINÉ 

Role of the mitochondrial anti-viral signaling protein in sepsis (MAVS)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2017,

"Severe sepsis is an important complication of infections and one of the leading causes of morbidity and mortality. For the countries of the European Union it is estimated that approximately 600,000 cases and more than 150,000 deaths occur from sepsis per year. Currently, no approved treatment options are available for the therapy of septic shock in humans.This research proposal intends to investi ...
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 1

 TERMINÉ 

Epidemiological study to quantify risks for paediatric computerized tomography and to optimise doses (EPI-CT)

Date du début: 1 févr. 2011, Date de fin: 31 janv. 2017,

Diagnostic radiation represents an indispensable, sometimes life-saving, tool in modern medicine. However, the growing use of computerized tomography (CT) is a topic of concern in radiological protection, especially for children and adolescents. Children are generally more sensitive to the carcinogenic effects of ionizing radiation than adults. In addition, they have a longer life-span to express ...
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 22

 TERMINÉ 

PanCare Childhood and Adolescent Cancer Survivor Care and Follow-up Studies (PanCareSurFup)

Date du début: 1 févr. 2011, Date de fin: 31 janv. 2017,

Over the last 40 years, treatment for childhood and adolescent cancer has improved greatly; 5- year survival after childhood cancer is now 80% in developed countries. Approximately 1 individual in 750 of young adults is now a childhood cancer survivor. Epidemiologic data on the number of European childhood cancer long-term survivors are not available, but estimates suggest a number between 300,000 ...
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 18

 TERMINÉ 

Orphans Unite: chILD better together – European Management Platform for Childhood Interstitial Lung Diseases (CHILD-EU)

Date du début: 1 déc. 2012, Date de fin: 30 nov. 2016,

Children with diffuse lung disease, also called childhood interstitial lung diseases (chILD), may have one of more than 200 entities, the biggest group of respiratory orphan lung diseases. Frequently undiagnosed because of lack of awareness or complex differential diagnosis, they lead to much morbidity, mortality (about 15%) and psychosocial stress for the families. Current lack of evidence based ...
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 10

 TERMINÉ 

Morphogenetically active blood vessels: Proof-of-Concept (MorphoVES-PoC)

Date du début: 1 avr. 2015, Date de fin: 30 sept. 2016,

"Cardiovascular diseases are the leading causes of mortality in Europe and worldwide. Currently, synthetic prostheses used in bypass vascular surgery are produced from polyethylene terephthalate [PET] and expanded polytetrafluoroethylene [ePTFE]. Those materials show less than optimal, insufficient biocompatibility and durability properties, especially if used for SMALL DIAMETER BLOOD VESSELS. Wit ...
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 1

 TERMINÉ 

BlueGenics – From gene to bioactive product: Exploiting marine genomics for an innovative and sustainable European blue biotechnology industry (BlueGenics)

Date du début: 1 août 2012, Date de fin: 31 juil. 2016,

Marine organisms, in particular sponges and their associated microorganisms, are an inexhaustible source of novel bioactive (lead) compounds for biomedical application. Industrial exploitation of this natural resource using traditional approaches is, however, hampered, with a few exceptions, by unsolvable supply problems - despite of numerous efforts in the past. Therefore, there is, very likely, ...
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 18

 TERMINÉ 

Natural inorganic polymers and smart functionalized micro-units applied in customized rapid prototyping of bioactive scaffolds (Bio-Scaffolds)

Date du début: 1 juin 2013, Date de fin: 31 mai 2016,

The application of rapid prototyping techniques has become a new trend in the fabrication of customized scaffolds for tissue regeneration or repair. The aim of the proposed project is to provide novel solutions for bottle-neck problems currently faced in establishing the corresponding processing chain, which encounter, among others, the extraction of essential geometry data of the damaged tissue f ...
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 5

 TERMINÉ 

From gene to biomineral: Biosynthesis and application of sponge biosilica (BIOSILICA)

Date du début: 1 juin 2011, Date de fin: 31 mai 2016,

"During the last decade, the principles of biomineralization have increasingly attracted multidisciplinary scientific attention, not only because they touch the interface between the organic/inorganic world but also because they offer fascinating bioinspired solutions to notorious problems in the fields of biotechnology and medicine. However, only one group of animals has the necessary genetic/enz ...
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 1

 TERMINÉ 

Biomarker for Cardiovascular Risk Assessment in Europe (BiomarCaRE)

Date du début: 1 oct. 2011, Date de fin: 31 mars 2016,

Biomarkers are considered as tools to enhance cardiovascular risk estimation. However, the value of biomarkers on risk estimation beyond European risk scores, their comparative impact among different European regions and their role in the drive towards personalised medicine remains uncertain.Based on harmonised and standardised European population cohorts we have built significant research collabo ...
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 31

 TERMINÉ 

Marine nanobiotechnology: Manganese oxide-containing core-shell materials formed by proteins from marine organisms for biomedical and environmental applications (CoreShell)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2015,

Core-shell materials are of enormous interest for many applications in nanotechnology and nanomedicine. Only recently, due to the achievements of the consortium, the generation of such nanoparticles by applying unique proteins from marine organisms has become possible. In this IAPP, based on a long-term and very successful cooperation between groups in Germany and Croatia, well known in the field ...
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 3

 TERMINÉ 

European-Chinese Research Staff Exchange Cluster on Marine Biotechnology (MARBIOTEC*EU-CN*)

Date du début: 1 août 2010, Date de fin: 31 juil. 2015,

Marine biotechnology is one of the most exciting emerging fields of technology. It becomes more and more important in many areas of application such as the production of new drugs, food ingredients, agrochemicals, and cosmetics. More recently, it was found that some products of marine organisms are also of extreme importance in the rapidly growing field of nano(bio)technology, another technology o ...
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 3

 TERMINÉ 

Neuronal NanoCarbon Interfacing Structures (NeuroCare)

Date du début: 1 mars 2012, Date de fin: 28 févr. 2015,

NeuroCare aims to create better retinal, cortical and cochlear implantable devices through the use of improved interfacing between the electronic implants and living cells. The NeuroCare concept involves low-cost, carbon-based materials, well-adapted for medical implants, because they (i) offer wide range of electronic properties (metal, semiconductor and insulator), (ii) are bio-inert and (iii) a ...
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 14

 TERMINÉ 

The role of Toll-Like Receptors Signaling in Angiogenesis and its Potential Applications in Promoting Vascularization in Regenerative Medicine (RTSAPA)

Date du début: 15 janv. 2013, Date de fin: 14 janv. 2015,

"The creation of adequate tissue constructs and other therapeutic products in tissue engineering and regenerative medicine is a highly challenging task. Adequate vascularization of tissue engineering constructs is an important prerequisite, which could be promoted by allowing stem cells or progenitor cells to reach the site of injury/replacement for tissue repair. The development of new approaches ...
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 1

 TERMINÉ 

Novel strategies for wound management (KOALA)

Date du début: 1 févr. 2012, Date de fin: 31 juil. 2014,

"The objective of the proposed research is the exchange of staff between Europe and Australia for the development of intelligent, bio-responsive materials that will SIGNAL and TREAT INFECTION in wounds as well as SUPPLY valuable medication “on demand” for rapid healing. Wound healing is a worldwide challenge and is, in its basic requirements, common to all people. Different areas of the world, how ...
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 6

 TERMINÉ 

Active wound dressings based on biological mimicry (BacterioSafe)

Date du début: 1 juil. 2010, Date de fin: 30 juin 2014,

The aim of the Bacteriosafe consortium is to construct, test and develop a unique active wound dressing, which incorporates novel colourimetric sensor and active therapeutic processes for detecting and counteracting pathogenic bacteria in wounds. The inspiration for this project is the natural nano-biological mechanism of bacterial attack on healthy cells. The outer cell walls are ruptured by an a ...
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 11

 TERMINÉ 

Clinical development of Enzyme Replacement Therapy in alpha-Mannosidosis patients using recombinant human enzyme (ALPHA-MAN)

Date du début: 1 oct. 2010, Date de fin: 31 mars 2014,

Alpha-Mannosidosis is a rare Lysosomal Storage Disorder with a worldwide incidence of about 1:500 000. This orphan and devastating disease is caused by the deficiency of the lysosomal alpha-mannosidase (LAMAN) which is responsible for the intralysosomal degradation of mannosyl linked oligosaccharides. To date no causative treatment for alpha-Mannosidosis is available and since most of the children ...
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 12

 TERMINÉ 

Silica-based Nanobiomedical Approaches for Treatment of Bone Diseases: Proof-of-Concept (SI-BONE-POC)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2013,

Silicatein is a unique enzyme from siliceous sponges that is able to catalyze the formation of an inorganic material, silica or “biosilica” which forms the inorganic skeleton of these sponges. Another exceptional property of this protein is its dual function, as we discovered for the first time in the ERC Advanced Grant “BIOSILICA” (Grant no. 268476): silicatein both (i) acts as an enzyme (biosili ...
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 1

 TERMINÉ 

Sponge Enzymes and Cells for Innovative AppLications (SPECIAL)

Date du début: 1 déc. 2010, Date de fin: 30 nov. 2013,

"The SPECIAL project aims at delivering breakthrough technologies for the biotechnological production of cellular metabolites and extracellular biomaterials from marine sponges. These include a platform technology to produce secondary metabolites from a wide range of sponge species, a novel in vitro method for the production of biosilica and recombinant technology for the production of marine coll ...
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 11

 TERMINÉ 

Therapeutic challenge in Leukodystrophies: Translational and ethical research towards clinical trials (LEUKOTREAT)

Date du début: 1 mars 2010, Date de fin: 31 août 2013,

Leukodystrophies (LDs) are inherited rare neurodegenerative diseases of the white matter and its main component, the myelin, that are affecting predominantly children. Severity of the disease is related to the axonal dysfunction due to myelin deficiency or destruction. Despite the achievement of remarkable advances made in the past decade, there is no current curative therapy. The development of t ...
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 25

 TERMINÉ 

Microbial-induced Angiogenesis in the Gut (MicAG)

Date du début: 1 juil. 2010, Date de fin: 30 juin 2013,

Objective: The mammalian gut is colonized by trillions of bacteria. These gut microbes (microbiota) have coevolved with the host and developed traits that affects host physiology. Interestingly, germ-free (GF) mice exhibit arrested intestinal vascularisation if compared to littermates that were raised in a non-sterile environment (CONV-R, conventional-raised). Intestinal colonization with a normal ...
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 2

 TERMINÉ 

Novel biofunctional high porous polymer scaffolds and techniques controlling angiogenesis for the regeneration and repair of the degenerated intervertebral disc (Disc Regeneration)

Date du début: 1 nov. 2008, Date de fin: 31 oct. 2012,

30% of European workers experience back pain, and it is the most frequently reported work-related disorder. The proposed work seeks to provide a cure for lower back pain by developing porous scaffolds and technology which will repair a damaged intervertebral disc (IVD) by enabling its regeneration to a natural healthy state or better. Injectable acellular and cell-loaded bioactive polymer-based sc ...
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 17

 TERMINÉ 

Biomineralization: Understanding of basic mechanisms for the design of novel strategies in nanobiotechnology (BIOMINTEC)

Date du début: 1 sept. 2008, Date de fin: 31 août 2012,

"Biomineralization is the formation of minerals by living cells and organisms. To understand the processes involved in biomineralization, at the cutting edge between inorganic and organic world, the cooperation between molecular and cell biologists, inorganic chemists, and physical chemists, but also computational scientists is required. The products formed by biomineralization are often composite ...
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 10

 TERMINÉ 

MORMED: Multilingual Organic Information Management in the Medical Domain (MORMED)

Date du début: 1 mars 2010, Date de fin: 31 août 2012,

MORMED proposes a multilingual community platform combining Web 2.0 social software applications with semantic interpretation of domain relevant content, enhanced with automatic translation capabilities, fine-tuned for a specific domain. MORMED will be piloted upon the community interested in Lupus or Antiphospholipid Syndrome (Hughes Syndrome), involving researchers, medical doctors, general prac ...
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 6

 TERMINÉ 

Search for new therapeutic agents against complicated obesity by reprofiling existing drugs (REPROBESITY)

Date du début: 1 déc. 2008, Date de fin: 31 mai 2012,

"Obesity is one of the most serious and fast-growing health problem in the European Union, and a leading cause of diabetes. The main barrier for approval of an anti-obesity drug is the safety requirements. We propose to overcome this barrier by discovering phenotypes and biomarkers that identify subsets of patients with safe and efficacious responses to drugs, and by identifying new indications of ...
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 7

 TERMINÉ 

High-Density Peptide MicroArrays and Parallel On-line Detection of Peptide-Ligand Interactions (PepChipOmics)

Date du début: 1 oct. 2008, Date de fin: 31 mars 2012,

"Proteins are crucial structural and functional elements of life, and frequent targets of intervention. Short protein sequences, conventionally defined as peptides, have emerged as indispensable tools in biotechnology: peptides may represent short linear protein structures, and in some cases they even mimic more complex discontinuous structures. Custom-made synthetic peptides cost down to ca. 30 E ...
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 7

 TERMINÉ 

Development and analysis of polymer based multi-functional bactericidal materials (EMBEK1)

Date du début: 1 août 2008, Date de fin: 31 juil. 2011,

90% of bacteria are found attached to solid surfaces forming structures (bio-films), that are inaccessible to drugs and antibiotics. These bio-films represent a major problem in European society in both industry and health care. Currently, however, we understand little about how these bio-films form and, more importantly, how they can be prevented. This lack of understanding means that patients of ...
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 11

 TERMINÉ 

Healthcare Interoperability Testing and Conformance Harmonization (HITCH)

Date du début: 1 janv. 2010, Date de fin: 30 juin 2011,

"eHealth, the beneficial application of ICT-based systems and solutions, has been identified as potentially the key enabler to fundamentally improve patient safety in clinical contexts" . However, with ICT becoming a mission critical component of healthcare processes, the interoperability of the multitude of systems that together form the eHealth infrastructure of a hospital, region or nation, is ...
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 13

 TERMINÉ 

A European Consortium for Lysosomal Disorders (EUCLYD)

Date du début: 1 mai 2008, Date de fin: 30 avr. 2011,

"The EUCLYD consortium aims at developing a scientific network among outstanding communities of basic and clinical investigators in five European countries (Italy, Netherlands, UK, Sweden and Germany) to study various aspects of lysosomal storage diseases (LSD). LSDs are rare disorders (overall prevalence of 1/5000 to 1/8000), each due to a specific lysosomal enzyme deficiency, leading to intracel ...
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 6