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 TERMINÉ 

Quantum Computer Lab (QC-LAB)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2019,

The world of atoms is governed by the rules of quantum mechanics. Over the past century, quantum-mechanical phenomena such as superposition and entanglement have been observed and studied with great precision. Today, we are entering a new era in which we can hope to explore quantum mechanics in larger objects. The science of quantum mechanics in more complex objects is barely known and as a result ...
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 2

 TERMINÉ 
Aggression inflicts a huge personal, psychological and financial burden on affected individuals, their relatives, and society at large. Despite large scientific, preventive, and treatment investments, no decrease in aggressive behavior is seen. This calls for a shift to new approaches. By capitalising on comprehensive longitudinal cohorts, recent advances in genetic, biological, epidemiological, a ...
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 12

 TERMINÉ 

Sequencing biological molecules with graphene (BIOGRAPHENE)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2019,

Graphene – a one atom thin material – has the potential to act as a sensor, primarily the surface and the edges of graphene. This proposal aims at exploring new biosensing routes by exploiting the unique surface and edge chemistry of graphene.
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 1

 TERMINÉ 
The formation and evolution of clusters and proto-clusters of galaxies will be studied using unique diagnostic tools provided by the new pan-European radio telescope LOFAR and the APERTIF phased arrays on WSRT radio telescope. Combined with new ultra low frequency antennas (an extension to LOFAR here proposed), these new facilities will for the first time enable sensitive observations from the low ...
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 1

 TERMINÉ 

Vaccination In Atherosclerosis (VIA)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2018,

"Cardiovascular disease (CVD) is still a leading cause of death in the European Union (EU) accounting for nearly half of all deaths in Europe (48%). In addition, CVD complications lead to a vast number of hospitalizations and thus to a great burden of health care costs in the EU. Atherosclerosis and its final complication, plaque rupture and subsequent infarct in heart or brain, is the main underl ...
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 12

 TERMINÉ 
Cancers are genetic disease arising from the accumulation of multiple molecular alterations in affected cells. Large-scale genomic, transcriptomic and proteomic analyses have established comprehensive catalogues of molecules which are altered in their structure and/or abundance in malignant tumors as compared to healthy tissues. Far less developed are concepts and methods to integrate data from di ...
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 18

 TERMINÉ 

Light-activatable ruthenium-based anticancer prodrugs (RuProLight)

Date du début: 1 juin 2013, Date de fin: 31 mai 2018,

Chemotherapy is, after surgery, the second most efficient therapy against cancer. However, it has many side effects for cancer patients because anticancer drugs kill cancer cells but also healthy ones. My project aims at synthesizing new metal-containing compounds that 1) are poorly toxic in the dark; 2) can be attached via a light-sensitive bond to liposomes that will carry them into cancer cells ...
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 1

 TERMINÉ 
Patients suffering from triple-negative breast cancer (TNBC) have a poor prognosis as these tumors frequently confer resistance against chemotherapeutic agents and lack drug targets such as estrogen receptor, progesterone receptor, and epidermal growth factor receptor 2. Insufficient knowledge on the biology of this specific breast tumor type and its heterogeneity hinder the identification of pot ...
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 3

 TERMINÉ 

European Lead Factory (EUC²LID)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

The European Lead Factory concept proposed by the EUC2LID Consortium relates to the discovery of novel small molecule candidates to serve as starting points for subsequent optimization to either drug candidates or high-quality pharmacological tools for the experimental validation of targets. The concept intends to bridge academic and applied research interests. The European Lead Factory will provi ...
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 34

 TERMINÉ 

Kinetics for Drug Discovery (K4DD) (K4DD)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2017,

There is mounting evidence that the often ignored kinetic aspects of the interaction between a drug and its target are highly relevant for clinical success. This ignorance may be one of the reasons for the high attrition rates in drug discovery, as it has been analyzed that many recently marketed drugs had indeed improved kinetic profiles. This hindsight knowledge needs to be converted into data-d ...
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 21

 TERMINÉ 
Most biopharmaceuticals (BP) currently on the market are recombinant proteins which are parenterally administered. These would benefit from more patient-friendly routes of administration. Moreover, new classes of BP (e.g. siRNA, miRNA, DARPins) with specificity for intracellular targets hold promise but await the advent of efficient delivery systems before their potential can be realised into ther ...
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 22

 TERMINÉ 

Global Research in Paediatrics (GRiP)

Date du début: 1 janv. 2011, Date de fin: 30 juin 2017,

Paediatric drugs (PD) lack appropriate testing. Most drugs have inadequate information about dosing regimen, dose adjustment and how to administer them. These are longstanding problems that unquestionably require concerted efforts at the international level. Both the US and the EU have introduced paediatric legislation that facilitates participation of children in research and pharmaceutical innov ...
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 24

 TERMINÉ 

Gaia European Network for Improved data User Services (GENIUS)

Date du début: 20 sept. 2013, Date de fin: 1 avr. 2017,

GENIUS is designed to boost the impact of the next European breakthrough in astrophysics, the Gaia astrometric mission. Gaia is an ESA Cornerstone mission scheduled for launch in October 2013 and aims at producing the most accurate andcomplete 3D map of the Milky Way to date. A pan-European consortium named DPAC is working on the implementation of the Gaia data processing, of which the final resul ...
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 14

 TERMINÉ 

Identifying host factors involved in staphylococcal infection (STAPHYLOMICS)

Date du début: 1 févr. 2015, Date de fin: 31 janv. 2017,

"Staphylococcus aureus is able to cause a wide range of diseases, with no vaccine available and common antibiotic resistance. It is therefore essential to better understand S. aureus pathogenesis. Accumulating evidence indicates that an intracellular infection stage is an important step in the disease progression. However, the mechanism of S. aureus phagocyte parasitism is currently unknown. A key ...
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 1

 TERMINÉ 
The current test systems employed by Industry are poorly predictive for Drug induced liver injury (DILI). The ‘MIP-DILI’ project will address this situation by the development of innovative preclinical test systems which are both mechanism-based and of physiological, pharmacological and pathological relevance to DILI in humans. An iterative, tiered approach with respect to test compounds, test sys ...
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 29

 TERMINÉ 

Optical Infrared Co-ordination Network for Astronomy (OPTICON)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,

Optical-infrared astronomy in Europe is in a state of transition and opportunity, with the goal of a viable structured European scale community in sight. A strong astronomical community requires access to state of the art infrastructures (telescopes), equipped with the best possible instrumentation, and with that access being open to all on a basis of competitive excellence. Further, the community ...
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 26

 TERMINÉ 

Carbon emission mitigation by Consumption-based Accounting and Policy (CARBON CAP)

Date du début: 1 oct. 2013, Date de fin: 31 déc. 2016,

Climate change mitigation now focus on production, where upward drivers of GHG emissions come from consumption. Demand side oriented policies hence can complement domestic GHG reduction efforts. The core aim of this project is to1. Stimulate innovative demand side oriented climate policies by improved shared insight in consumption emissions.2. Realize a more effective policy mix for achieving the ...
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 11

 TERMINÉ 

Foundational Research on MULTIlevel comPLEX networks and systems (MULTIPLEX)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,

Future advancements in ICT domain are closely linked to the understanding about how multi-level complex systems function. Indeed, multi-level dependencies may amplify cascade failures or make more sudden the collapse of the entire system. Recent large-scale blackouts resulting from cascades in the power-grid coupled to the control communication system witness this point very clearly. A better unde ...
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 24

 TERMINÉ 

Drug Disease Model Resources (DDMORE)

Date du début: 1 mars 2011, Date de fin: 31 août 2016,

Model based-drug development (MBDD) is accepted as a vital approach in understanding patient risk/benefit and attrition. At the core of MBDD lies Modelling and Simulation (M&S), a technology providing the basis for informed, quantitative decision-making.M&S facilitates the continuous integration of available information related to a drug or disease into constantly-evolving mathematical models capa ...
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 28

 TERMINÉ 

DEferiprone Evaluation in Paediatrics (DEEP)

Date du début: 1 janv. 2011, Date de fin: 31 août 2016,

"β-thalassaemia major is one of the most severe forms of chronic congenital anaemia. The recommended treatment consists in regular blood transfusions combined with chelating therapy to remove harmful iron accumulation in the body. The use of deferoxamine, the first chelating agent only available for subcutaneous administration is limited due to toxicity and the lack of compliance, despite its sat ...
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 18

 TERMINÉ 

Teaching Enquiry with Mysteries Incorporated (TEMI)

Date du début: 1 févr. 2013, Date de fin: 31 juil. 2016,

The aim of this teacher training project is to help transform science and mathematics teaching practice across Europe by giving teachers new skills to engage with their students, exciting new resources and the extended support needed to effectively introduce enquiry based learning into their classrooms. We will do this by working with teacher training institutions and teacher networks across Europ ...
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 15

 TERMINÉ 
"150 years from the Origin and we have yet to unravel how ecological speciation works, and how it leads to spectacular adaptive radiations. The process has two components: adaptation to ecological niches and production of new species. My aim is to make breakthroughs in understanding ecological speciation by the study of geographically parallel adaptive radiations in mycalesine butterflies that hav ...
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 2

 TERMINÉ 
"DESIRE will develop and apply an optimal set of indicators to monitor European progress towards resource-efficiency. We propose a combination of time series of environmentally extended input output data (EE IO) and the DPSIR framework to construct the indicator set. Only this approach will use a single data set that allows for consistent construction of resource efficiency indicators capturing th ...
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 12

 TERMINÉ 

Integrated research on DEvelopmental determinants of Aging and Longevity (IDEAL)

Date du début: 1 févr. 2011, Date de fin: 31 janv. 2016,

"IDEAL will obtain insight into the role of early life conditions affecting late-life health, disease and aging, and the role of epigenetic regulation therein. IDEAL will identify the determinants and targets of this epigenetic regulation utilizing a resource of unique human cohorts and animal studies that allow testing of hypotheses on the link between development and aging.Key objectives of IDEA ...
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 16

 TERMINÉ 
Infectious diseases caused by pathogenic micro-organisms are major causes of death, disability, and social and economic disruption for millions of people. During evolution these pathogens have developed intricate strategies to manipulate host defence mechanisms and outwit the immune system. To reduce the burden of infectious diseases it is important to increase understanding of these host-pathogen ...
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 10

 TERMINÉ 
... ata mining provide a powerful emerging technology platform to enable systems biology of the living cell. These imaging technologies, here referred to as “Systems microscopy”, will be a cornerstone for next-generation systems biology to elucidate and understand complex and dynamic molecular, sub-cellular and cellular networks. As a paradigm to enable systems biology at the cellular scale of biologi ...
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 11

 TERMINÉ 
"Assessment of repeated dose toxicity is a standard requirement in human safety evaluation and relies on animal testing as no alternatives are currently accepted for regulatory purposes. An integrated research strategy for the replacement of animal tests needs to comprise the development of biomarkers of long-term toxicity in human target cells. To this aim, the DETECTIVE project will set up a scr ...
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 15

 TERMINÉ 
Users of NGS technologies, producing large and numerous distinct types of omics data, demands statistical methods to combat data and knowledge fragmentation and inappropriate procedures for data analysis. Yet, the current a gap between the available tools for analysis of a single omics data-type versus the requirement of biomedical scientists to understand the integrated results derived from sever ...
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 11

 TERMINÉ 
Metabolomics is an important phenotyping technique for molecular biology and medicine. It assesses the molecular state of an organism or collections of organisms through the comprehensive quantitative and qualitative analysis of all small molecules in cells, tissues, and body fluids. Metabolic processes are at the core of physiology. Consequently, metabolomics is ideally suited as a medical tool t ...
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 16

 TERMINÉ 
People in Europe acknowledge that nature is important to them and to society at large. Economists have shown that indeed, biodiversity has total economic values running into the trillions of euros worldwide and hundreds of millions even for ‘minor’ ecosystem services on local scales. In spite of these immense values, politicians and the general public in Europe do not appear to really act for natu ...
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 8

 TERMINÉ 

Latin Amercian Chinese European Galaxy Formation Network (LACEGAL)

Date du début: 15 mai 2011, Date de fin: 14 mai 2015,

The focus in cosmology is shifting from the determination of the basic cosmological parameters to developing an understanding of how galaxies formed. Progress in this field has been driven by a combination of computer simulation and observational breakthroughs. Over the next few years, groundbreaking new facilities will come online and will provide data of unprecedented quality with which to test ...
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 9

 TERMINÉ 
Cardiovascular disease (CDV) is a serious health issue and one of the main causes of death in developed countries. The connection between lipids and the disease progress has been established in the past years. Particularly, lipid composition in blood circulating lipoproteins may have a significant correlation with CVD and CVD risk. However, although in the past years lipidomics-based platforms hav ...
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 1

 TERMINÉ 

Environmental Macro Indicators of Innovation (EMININN)

Date du début: 1 nov. 2011, Date de fin: 30 avr. 2015,

EMInInn aims at assessing the environmental impacts associated with innovation.In a first step EMInInn will assemble and set out coherently, on the one hand, macro-indicators and data of environmental impacts and, on the other hand, indicators and data to measure innovations. The definitions and delineations will be the basis for selecting appropriate analytical frameworks to operationalize assess ...
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 7

 TERMINÉ 

Nature Inspired Computation and its Applications (NICaiA)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2015,

The proposed exchange programme will allow us to strengthen the infrastructure of intellectual exchange between the EU (UK, Netherlands and Spain) and China. The short-term transfer of academic staff will facilitate the mutual exchange of domain specific knowledge and know-how, and by means of seminars and workshops, we intend to widen the scope of the programme, including as many (self-supported) ...
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 4

 TERMINÉ 
The ChemBioFight project aims towards the exploration of natural resources to the discovery of bioactive therapeutic molecules against leishmania and Chagas disease. This will be accomplished through the establishment of an extended scientific network between European and South American research entities. Already assembled, highly diverse chemical libraries will be employed for the determination o ...
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 5

 TERMINÉ 

The Collective Experience of Empathic Data Systems (CEEDs)

Date du début: 1 sept. 2010, Date de fin: 28 févr. 2015,

The Collective Experience of Empathic Data Systems (CEEDS) project will develop novel, integrated technologies to support human experience, analysis and understanding of very large datasets.Making use of humans' implicit processing abilitiesCEEDS will develop innovative tools to exploit theories showing that discovery is the identification of patterns in complex data sets by the implicit informati ...
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 17

 TERMINÉ 

Gaia Research for European Astronomy Training - ITN (GREAT)

Date du début: 1 mars 2011, Date de fin: 28 févr. 2015,

Gaia is the ESA cornerstone mission set to revolutionise our understanding of the Milky Way. This proposal will shape a critical mass of new expertise with the fundamental skills required to power the scientific exploitation of Gaia over the coming decade and beyond.The GREAT-ITN research theme is 'Unravelling the Milky Way' focused on four fundamental problems: unravelling the origin and history ...
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 13

 TERMINÉ 

ZF-Delivery (ZF-DELIVERY)

Date du début: 1 mars 2014, Date de fin: 28 févr. 2015,

Within our ERC Starting Grant “Direct Drug Delivery”, we developed a method controlled fusion of liposomes and cells: a new pathway for direct drug delivery.Our method of membrane fusion is inspired by natural occurring SNARE proteins, which control this process in-vivo. A set of complementary peptide amphiphiles were designed and these are able to induce the rapid and efficient fusion between two ...
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 1

 TERMINÉ 
"NATURALISM is a philosophical viewpoint according to which everything arises from natural properties, and supernatural explanations are just excluded. This proposal is a by-product of this definition. It will contribute to the understanding of the origin of life in the universe by unravelling experimentally the chemical reaction schemes leading to large and complex molecules in interstellar ice a ...
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 1

 TERMINÉ 

International Desktop Grid Federation – Support Project (IDGF-SP)

Date du début: 1 nov. 2012, Date de fin: 31 janv. 2015,

There are over a billion PCs in the world. Most of these PCs can be found in citizens' homes and, to a lesser extent, in universities. Most of these computers remain idle most of the time. About 1 million of them are active in supporting science in a volunteer computing grid and use their idle time to run scientific applications.The potential growth of this computing capacity is enormous. Many Des ...
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 7