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 TERMINÉ 

A paradigm shift in cancer therapy – using mitochondria-powered chemiluminescence to non-invasively treat inaccessible tumours (Lumiblast)

Date du début: 1 oct. 2016, Date de fin: 31 mars 2021,

...required for the photosensitive agents to become activated, killing the tumour cells from the inside. Lumiblast requires a concerted interdisciplinary action. The project coordinator (Berg’s group, Oslo University Hospital, OUS) is world renowned in PDT and photomedicine, while the team from the University of Athens (Georgios Vougioukalakis’ group, UoA) is up and coming with high expertise in synt ...
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 6

 TERMINÉ 

Children’s Liver Tumour European Research Network (ChiLTERN)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Liver cancer in the paediatric population is rare with an incidence approximately 1-1.5 per million population. The commonest tumour seen in the childhood population is hepatoblastoma (HB), usually seen in young children and infants. Much rarer (about 10% of paediatric liver cancers) is hepatocellular carcinoma (HCC), usually seen in the teenage population and sometimes associated with underlying ...
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 21

 TERMINÉ 

Effect of ALlopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcome (ALBINO)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Neonatal hypoxic-ischemic encephalopathy (HIE) is a major cause of death or long-term disability in infants born at term in the western world, affecting about 1-4 per 1.000 life births and consequently about 5-20.000 infants per year in Europe.Hypothermic treatment became the only established therapy to improve outcome after perinatal hypoxic-ischemic insults. Despite hypothermia and neonatal inte ...
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 18

 TERMINÉ 

Training, Research and Raising of Public Awareness in Cell Biology and Pathology of Neuroglia (EU-GliaPhD)

Date du début: 1 déc. 2016, Date de fin: 30 nov. 2020,

The research in which the young scientists of the EU-GliaPhD consortium will be trained is centred on the role of neuron-glia interactions in brain function and pathology.Prompted by exciting discoveries of recent years, many academic research groups are currently focussing their research on the field of neuron-glia interactions for a better understanding of brain function. Also the private sector ...
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 13

 TERMINÉ 

High Performance Soft-tissue Navigation (HiPerNav)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2020,

Primary liver cancer, which consists predominantly of hepatocellular carcinoma (HCC), is the fifth most common cancer worldwide and the third most common cause of cancer mortality. A successful surgical resection of HCC requires complete removal of the tumour while sparing as much healthy tissue as possible. Due to technical and clinical difficulties relatively low percentage of patients are eligi ...
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 10

 TERMINÉ 

PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke (PRECIOUS)

Date du début: 1 juin 2015, Date de fin: 31 mai 2020,

Every year, 1.3 million Europeans have a stroke and one million ultimately die of stroke. One third of stroke patients remain dependent on the help of others. The annual costs for stroke care in Europe are estimated at € 64.1 billion. Stroke incidence increases almost exponentially with age, and the personal, societal, and economic burden of stroke is therefore largely driven by its frequent occur ...
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 20

 TERMINÉ 

Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI)

Date du début: 1 oct. 2013, Date de fin: 31 mars 2020,

Traumatic Brain Injury (TBI) is a major cause of death and disability, leading to great personal suffering to victim and relatives, as well as huge direct and indirect costs to society. Strong ethical, medical, social and health economic reasons therefore exist for improving treatment. The CENTER-TBI project will collect a prospective, contemporary, highly granular, observational dataset of 5400 p ...
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 44

 TERMINÉ 

Wireless In-Body Environment (WiBEC)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

WiBEC (Wireless In-Body Environment Communications) is an Innovative Training Network for 16 young researchers, who will be recruited and trained in coordinated manner by Academia, Industry, and Medical Centres. This training will address the Social, Health, and Technology challenges of the H2020:Wireless In-Body Devices. WiBEC’s main objective is to provide high quality and innovative doctoral tr ...
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 9

 TERMINÉ 

Cancer treatment and monitoring through identification of circulating tumour cells and tumour related nucleic acids in blood (CANCER-ID)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2019,

Blood-based biomarkers such as Circulating Tumor Cells (CTCs), circulating free tumor DNA (cfDNA) and microRNAs (miRNAs) have the potential to improve the development of personalized medicines for cancer patients. This is of particular importance when biopsies of the primary tumor or metastases are not accessible (e.g. at early disease stages or in minimal residual disease) or possible and the ass ...
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 34

 TERMINÉ 

INTEGRATED AND ADAPTIVE RESPONSES TO TOXIC EMERGENCIES FOR RAPID TRIAGE: ENGINEERING THE ROADMAP FROM CASUALTY TO PATIENT TO SURVIVOR. (TOXI-triage)

Date du début: 1 sept. 2015, Date de fin: 31 août 2019,

The seven specific objectives of TOXI-triage address the operational; technological; ethical and societal dimensions of CBRN response and recovery, and importantly the economic base from which sustainable CBRN and multi-use systems are derived.19 partners in 4 Task forces will deliver 9 Work Packages (WPs) that address: end user specifications; Design and delivery; Test and Validation; and, Impact ...
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 19

 TERMINÉ 

MELanoma GENetics - understanding and biomarking the genetic and immunological determinants of melanoma survival (MELGEN)

Date du début: 1 juin 2015, Date de fin: 31 mai 2019,

MELGEN (MELanoma GENetics) – understanding and biomarking the genetic and immunological determinants of melanoma survivalThe MELGEN European Training Network (ETN) will create an environment for long-term, collaborative, inter-sectorial cancer genetics research with the ultimate aim of improving precision (personalised) medicine. In a 2012 report the European Science Foundation identified the impo ...
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 7

 TERMINÉ 

Strategies towards Excellence in Immuno-Oncology (STREAM)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2018,

In 2013, the Science magazine announced Immunotherapy of cancer as the ‘Breakthrough of the Year’. The results of ongoing clinical studies with new cancer immunotherapeutics strongly support this enthusiasm. Following the lead of the top research groups, the Coordinator of the present proposal, Medical University of Warsaw (MUW) displays a predominant ambition of becoming a major player in the thr ...
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 7

 TERMINÉ 

Targeted Action for Curing Trauma Induced Coagulopathy (TACTIC)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

...gulopathic trauma patients, and potentially all patients with acute critical illness.TACTIC will recruit patients from a network of trauma centres in Amsterdam, Cologne, Copenhagen, London, Oslo and Oxford to compare the effectiveness of different current practices across Europe. It will deliver universal guidelines for how coagulaopathy should be monitored and treated, enabling the individualised ...
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 9

 TERMINÉ 

Development of a prophylactic treatment for the prevention of fetal/neonatal alloimmune thrombocytopenia (FNAIT) (PROFNAIT)

Date du début: 1 août 2012, Date de fin: 31 juil. 2018,

Objective--The project aims to develop an anti HPA-1a immunoglobulin (IgG), Tromplate® that can prevent post delivery immunisation of the mother against the Human Platelet Antigen-1a (HPA-1a). This prophylactic treatment will prevent Fetal/Neonatal Alloimmune Thrombocytopenia (FNAIT) in the fetus/newborn in subsequent pregnancies.FNAIT--FNAIT is a rare but potentially serious condition which affec ...
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 13

 TERMINÉ 

AusBildung wird Forschung - DKFZ-Auszubildende forschen europaweit

Date du début: 1 juil. 2016, Date de fin: 30 juin 2018,

In our 24 months project "AusBildung wird Forschung - DKFZ-Auszubildende forschen europaweit", the German Cancer Research Center will grant 32 apprentices the opportunity to partake in an internship as biological laboratory assistants, animal care takers, office clerks and qualified IT specialists. They will all finish the second year of training during the internship and they successfully complet ...
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 7

 TERMINÉ 

Effective Mobility II - Genuine Worklife Co-operation

Date du début: 1 juin 2016, Date de fin: 31 mai 2018,

Effective Mobility II – Genuine Worklife Co-operationThe objective of the mobility project is to enhance the co-operation with work-life partners in order to support the business target achievement of corporate and public sector organizations. This is achieved by effective co-operation within international mobility projects in full alignment with each participant organizations business equation. T ...
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 15

 TERMINÉ 

The effect of intracoronary reinfusion of bone marrow-derived mononuclear cells (BM-MNC) on all-cause mortality in acute myocardial infarction (BAMI)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2017,

Although the long term prognosis of patients suffering acute myocardial infarction (AMI) has improved since the introduction of reperfusion therapies and primary angioplasty, the 1 year mortality of patients with AMI and resultant left ventricular systolic dysfunction (LVSD) is still as high as 13%. A major reason for the high morbidity and mortality is that the heart has an inadequate regenerativ ...
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 23

 TERMINÉ 

Intelligent needle tracking using ultrasound imaging for improved minimally invasive interventions (INTUI-VIEW)

Date du début: 1 nov. 2015, Date de fin: 31 oct. 2017,

...blind”, using indirect measures as well as their anatomical experience to decide where they should inject. The INTUI-VIEW solution will change this.In the INTUI-VIEW project, Philips, B.Braun and Oslo University Hospital are partnering in order to bring an ultrasound tablet solution with needle tracking technology to the market. The solution is a revolutionary and new technique. It will speed up t ...
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 4

 TERMINÉ 

Epidemiological study to quantify risks for paediatric computerized tomography and to optimise doses (EPI-CT)

Date du début: 1 févr. 2011, Date de fin: 31 janv. 2017,

Diagnostic radiation represents an indispensable, sometimes life-saving, tool in modern medicine. However, the growing use of computerized tomography (CT) is a topic of concern in radiological protection, especially for children and adolescents. Children are generally more sensitive to the carcinogenic effects of ionizing radiation than adults. In addition, they have a longer life-span to express ...
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 22

 TERMINÉ 

A European Platform for Translational Cancer Research (EUROCANPLATFORM)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2016,

Europe has a number of advantages as regards developing translational cancer research, yet there is no clear European strategy to meet the increasing burden posed by cancer. The FP6 Eurocan+Plus project analysed the barriers underlying the increasing fragmentation of cancer research and stressed the need to improve collaboration between basic/preclinical and comprehensive cancer centres (CCCs), in ...
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 29

 TERMINÉ 

International study for treatment of childhood relapsed ALL 2010 with standard therapy, systematic integration of new agents, and establishment of standardized diagnostic and research (INTREALL)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2016,

Though survival of children with acute lymphoblastic leukaemia (ALL) has improved, relapse remains a leading cause of mortality in childhood cancer. Given the rarity of the disease, only a large international cooperative group can recruit sufficient patients for prospective studies with specific questions in biologic subgroups. Under the umbrella of the I-BFM SG all relevant mainly European study ...
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 29

 TERMINÉ 

Effective Mobility - Creating Tomorrows Working Life

Date du début: 1 août 2014, Date de fin: 31 juil. 2016,

Amiedu and the Ami Foundation have a long tradition of being a learning and developing organisation with a constant evolution path in accordance with changing customer needs. Our competence and excellence capability builds from a base of social responsibility. We have developed and provided services to support the unskilled and unemployed, provided qualification programmes and certificates and als ...
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 9

 TERMINÉ 

"Prevention and improved diagnosis of adolescent genital disease in schistosomiasis endemic KwaZulu-Natal, South Africa" (VIBE-FGS-EUSAN)

Date du début: 1 août 2011, Date de fin: 31 mars 2016,

"The VIBE-FGS-EUSAN project is a joint initiative by six partner universities in Europe and one partner university in Africa who have developed collaborative links in the last decade. This network of translational research aims to facilitate a strong collaboration between laboratories at the forefront of basic research and field projects trying to resolve tropical issues on the ground. In the poor ...
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 7

 TERMINÉ 

PAtients Leading and mANaging their healThcare through EHealth (PALANTE)

Date du début: 1 févr. 2012, Date de fin: 31 juil. 2015,

Patient empowerment is considered a potential tool to reduce healthcare costs and improve efficiency of the health systems, reinforcing healthcare quality. Patient empowerment has become an element of high priority in the EU health strategy, supported by national and regional health authorities.Building on already existing e-health platforms and services in the participating regions, the PALANTE p ...
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 21

 TERMINÉ 

Evaluation of the synergy between tamoxifen chemotherapy and hypericin photodynamic action, following mitochondrial complex III photo-inhibition: Towards a combinatorial anticancer treatment modality (HYPERTAM)

Date du début: 7 juin 2013, Date de fin: 22 juil. 2015,

In the present Marie Curie Intra European Fellowship application, HYPERTAM, we propose to combine our recent complementary findings in two separate anticancer therapeutic modalities, namely, photodynamic therapy of cancer (PDT) with hypericin or other phototoxins and tamoxifen chemotherapy, fusing them in one combinatorial treatment predicted to demonstrate enhanced antitumoural potency through sy ...
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 2

 TERMINÉ 

Magnetic Isolation and moleculaR Analysis of single CircuLating and disseminated tumor cElls on chip (MIRACLE)

Date du début: 1 sept. 2010, Date de fin: 31 mai 2015,

Cancer remains a prominent health concern afflicting modern societies. Continuous innovations and introduction of new technologies are essential to level or even reduce current healthcare spending. As the analysis of occult tumour cells (OTC) in blood or bone marrow is most promising in this respect, MIRACLE aims to develop a low-cost, fully automated, integrated lab-on-a-chip (LOC) system for the ...
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 15

 TERMINÉ 

Determining Optimal non-invasive Parameters for the Prediction of Left vEntricular morphologic and functional Remodeling in Chronic Ischemic Patients (DOPPLER-CIP)

Date du début: 1 mai 2009, Date de fin: 28 févr. 2015,

Coronary artery disease (CAD) remains the primary cause of cardiovascular morbidity and mortality in Europe. In current clinical practice, patients with chronic CAD are followed using non-invasive imaging methodologies for possible adverse morphologic remodelling and functional recovery of the myocardium before the decision for invasive examinations and treatments is taken. Technological developm ...
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 10

 TERMINÉ 

Intelligent Surgical Robotics (I-SUR)

Date du début: 1 mars 2011, Date de fin: 31 déc. 2014,

Description I-SUR will develop advanced technologies for automation in minimally invasive and open surgery. Currently, automation is not used in the operating room for a number of technical and legal reasons, but it may provide a solution to improve performance and efficiency without increasing operating costs. I-SUR aims at breaking new gro ...
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 9

 TERMINÉ 

Breast Cancer Somatic Genetics Study (BASIS)

Date du début: 1 juil. 2010, Date de fin: 31 déc. 2014,

"All cancers arise due to somatically acquired mutations in their genomes which alter the function of key cancer genes. Understanding these critical mutational events underlying cancer development is paramount for advancing prevention, early detection, monitoring and treatment of the disease. Breast cancer is the most common class of cancer diagnosed in women worldwide with more than one million c ...
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 16

 TERMINÉ 

Metastatic tumours facilitated by hypoxic tumour micro-environments (METOXIA)

Date du début: 1 févr. 2009, Date de fin: 31 juil. 2014,

"Recent research suggests that the hypoxic micro-environment of tumours is one of the major drivers of metastatic spread of cancer. Furthermore, hypoxic tumour micro-environments may result in treatment resistance of cancer cells, therefore causing a double effect of reducing the potential of a successful treatment of the cancer patient. This project seeks to clarify the roles and functions of the ...
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 21

 TERMINÉ 

Glycomics by High-throughput Integrated Technologies (GlycoHIT)

Date du début: 1 janv. 2011, Date de fin: 30 juin 2014,

Protein glycosylation is a post-translational phenomenon that is involved in most physiological and disease processes including cancer. Most of the known cancer-associated glycobiomarkers were discovered individually using liquid chromatography and mass spectroscopy. Though valuable, there is room for improvement in these approaches for the discovery phase. There is also a critical need for innova ...
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 16

 TERMINÉ 

"Myasthenias, a group of immune mediated neurological diseases: from etiology to therapy." (FIGHT-MG)

Date du début: 1 déc. 2009, Date de fin: 31 mai 2014,

"Myasthenia Gravis (MG) is a heterogeneous rare autoimmune neurological disease affecting the neuromuscular junction (NMJ). The molecular events causing and maintaining MG are still unknown and current treatments do not lead to remission and entail considerable side-effects stressing the need for improved therapies. We will address the: 1. Natural course of disease: determine factors associated wi ...
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 13

 TERMINÉ 

Treatment of reperfusion injury using a mitochondrial targeted approach: towards a better understanding of the disease (MITOCARE)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2013,

"Current interventional treatment of acute myocardial infarction (AMI) focused on re-establishing cardiac reperfusion has significantly improved clinical outcome by reducing infarct size and mortality due to cardiac ischemia.It is now recognized that events triggered at reperfusion also result in cell death and may account for as much as 50% of the infarct volume, this being termed ischemia-reperf ...
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 18

 TERMINÉ 

Innovative Intracranial Pressure and Volume Wave Monitoring System (DynICP)

Date du début: 1 déc. 2011, Date de fin: 30 nov. 2013,

In DynICP, we propose to develop an advanced, portable prototype of a non-invasive intracranial dynamic pressure (dynamic ICP) diagnosing and monitoring device which can be used at hospitals, point of care as well as at home. This device will consist of a wearable head gear capable of precise positioning of two ultrasonic transducers, software and hardware for dynamic ICP analysis and data communi ...
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 9

 TERMINÉ 

Integrated Interventional Imaging Operating System (IIIOS)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2013,

"The scope of the present consortium is to provide technology and training for the integration of ultrasound and biophotonics based imaging with magnetic resonance imaging (MRI), Computed Tomography (CT) and Positron Emission Tomography (PET) to define the specs of an Integrated Interventional Imaging Operating System (III OS) aimed at minimal invasive treatment of common life-threatening disorder ...
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 13

 TERMINÉ 

European Project on Mendelian Forms of Parkinson’s Disease (MEFOPA)

Date du début: 1 avr. 2010, Date de fin: 30 sept. 2013,

"The Collaborative Project on Mendelian Forms of Parkinson’s Disease (MEFOPA) will bring together the major groups in Europe with a track-record in basic and clinical research on rare Mendelian forms of Parkinson’s disease (PD) in order to identify and validate relevant disease-related molecular pathways, drug-targets and biomarkers for disease susceptibility and progression.. Over the last years ...
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 27

 TERMINÉ 

Smart Catheterization (SCATh)

Date du début: 1 févr. 2010, Date de fin: 31 janv. 2013,

Modern medicine is irreversibly shifting towards less invasive surgical procedures. Conventional open surgery approaches are systematically being replaced by interventions that reduce access trauma and thereby minimise pain and hospitalisation periods for patients. The downside of this approach is that it is highly demanding for the interventionalist, entailing unacceptable risks for the patient. ...
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 9

 TERMINÉ 

Multi-layer network modules to identify markers for personalized medication in complex diseases (MultiMod)

Date du début: 1 nov. 2008, Date de fin: 31 oct. 2012,

The symptoms of complex disease like allergy, obesity and cancer depend on the products of multiple interacting genes. High-throughput techniques have implicated hundreds of genes. There are also considerable individual variations. A clinical implication of this may be inadequate treatment response, which is increasingly recognized as a cause of increased suffering and costs. Ideally, physicians s ...
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 6

 TERMINÉ 

Invivo Ultrasonic Transponder System for Biomedical Applications (ULTRAsponder)

Date du début: 1 sept. 2008, Date de fin: 31 mars 2012,

The key objective of ULTRAsponder is to develop a novel telemetry technology for biomedical applications that will enable any kind of deeply implanted device (the transponder) to communicate and be powered wirelessly via acoustic waves with the external system (the control unit). The implanted transponder will include one or more sensors for monitoring a variety of parameters, such as temperature, ...
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 10

 TERMINÉ 

Elimination of secondary surgery for removal of internal fixations of fractured bones (FracFix)

Date du début: 1 nov. 2008, Date de fin: 31 juil. 2011,

Internal fixation components are widely used in fracture surgery. The medical implant industry is a part of the medical device market generates about €2.4 Bn in Europe and €1.5 Bn in the USA in 2008 and has an estimated annual growth of 10% per year, largely attributed to the aging population in the developed countries. Internal fixation devices market is an estimated €980 Mn in EU25. The total co ...
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 9