4 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
The roles of juvenile NMDA receptors in synapse maturation and elimination and their association with cognition (NMDAR-synprun)
Date du début: 1 mars 2013, Date de fin: 28 févr. 2015,
The aim of the project is to understand how the NMDA receptor subunit NR3A is involved in selective synapse elimination (“pruning”) during development and how the abnormal expression of NR3A found in mental disorders such as Schizophrenia, Alzheimer´s disease and Huntington correlates with the reduction of functional synapses and deficits in the cognitive function. Importantly, the Host lab has al ...
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TERMINÉ
Toxic protein aggregation in neurodegeneration (ToPAG)
Date du début: 1 juin 2013, Date de fin: 31 mai 2019,
Formation of amyloid-like protein aggregates is the hallmark of a number of neurodegenerative diseases, but how the aggregation process is linked with cytotoxicity and cell death remains unclear. The goal of this pro¬ject is to elucidate the basic mechanisms of aggregate toxicity and how it affects the biological system in its entirety. We will analyse cell culture and mouse models of Huntington’s ...
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TERMINÉ
Repeat polymorphisms as genetic modifiers of brain function in healthy subjects and Huntington disease mutation carriers (BRAIN REPEATS)
Date du début: 1 oct. 2016, Date de fin: 30 sept. 2017,
Neuropsychiatric disorders such as dementia and depression are among the leading causes of disability and exert a dramatic burden on Europe’s healthcare systems. In order to devise more effective therapies it is essential to elucidate their genetic basis. However, to date genetic association studies have only identified a small fraction of the genetic determinants, possibly due to neglect of some ...
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TERMINÉ
European HD Youth Camp 2016
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2016,
...pean HD Youth Camp 2016 is an arrangement for adolescents/young adults who share heavy challenges living with HD in the family. They have a parent who has the hereditary, neurodegenerative disease - Huntington's disease (HD). Many children growing up with a sick parent take a lot of responsibility to take care of their parent. At the same time they have 50% risk of having inherited the disease t ...
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