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Plus de 40 projets européens trouvés

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 TERMINÉ 

Finding noncoding cancer drivers (NONCODRIVERS)

Date du début: 1 déc. 2016, Date de fin: 30 nov. 2021,

Finding the mutations, genes and pathways directly involved in cancer is of paramount importance to understand the mechanisms of tumour development and devise therapeutic strategies to overcome the disease. Due to their role in cancer development and maintenance, the proteins encoded by cancer genes are candidate therapeutic targets. Indeed, in recent years we have witnessed the development of suc ...
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 2

 TERMINÉ 

European Academy for Biomedical Science (ENABLE)

Date du début: 1 juil. 2016, Date de fin: 31 déc. 2020,

The proposed European Academy for Biomedical Science (ENABLE) consortium will connect aspiring European researchers of tomorrow with prominent scientists of today, in particular to inspire and to give them the necessary tools to follow in their footsteps. ENABLE will organize peer-reviewed symposia celebrating European life science achievements from molecule to man/patient. These symposia will hav ...
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 6

 TERMINÉ 

European AIDS Vaccine Initiative 2020 (EAVI2020)

Date du début: 1 nov. 2015, Date de fin: 31 oct. 2020,

HIV-1 is responsible for a global pandemic of 35 million people, and continues to spread at a rate of >2 million new infections/year. It is widely acknowledged that a protective vaccine would be the most effective means to reduce HIV-1 spread and ultimately eliminate the pandemic, while a therapeutic vaccine may help mitigate the clinical course of disease and lead to strategies of viral eradicati ...
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 27

 TERMINÉ 

REgenerative Stem cell therapy for STroke in Europe (RESSTORE)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

Stroke is the second leading cause of death in the world population. When not fatal, stroke often results in disability, due to motor and cognitive impairments, and secondary health problems affecting not only patients but also their families. Building on emerging preclinical and pilot clinical evidences, RESSTORE will focus on the clinical assessment of regenerative cell therapy to improve stroke ...
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 29

 TERMINÉ 

iABC Programme (IABC PROGRAMME)

Date du début: 1 août 2015, Date de fin: 31 juil. 2020,

Cystic Fibrosis (CF) is a common fatal inherited disease with a frequency of 1 in 2500 live births, affecting approximately 36,000 (0.737/10,000) people in the EU. Chronic bacterial pulmonary infection leading to an irreversible decline in lung structure and function is the main cause of mortality and morbidity in patients with CF, with more than 95% of deaths due to respiratory failure. Pseudomon ...
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 21

 TERMINÉ 

Description of information transfer across macromolecules by concerted conformational changes (CONCERT)

Date du début: 1 juil. 2015, Date de fin: 30 juin 2020,

Signal transduction in biology relies on the transfer of information across biomolecules by concerted conformational changes that cannot currently be characterized experimentally at high resolution. In CONCERT we will develop a method based on the use of nuclear magnetic resonance spectroscopy in solution that will provide very detailed descriptions of such changes by using the information about s ...
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 2

 TERMINÉ 

Conservative iron chelation as a disease-modifying strategy in Parkinson’s disease: a multicentric, parallel-group, placebo-controlled, randomized clinical trial of deferiprone (FAIR-PARK-II)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2020,

Parkinson’s disease (PD) is a major, chronic, non-communicable disease and the 2nd most frequent neurodegenerative disorder worldwide. Excess iron is primarily detected in the substantia nigra pars compacta, where dopaminergic neurons are exposed to high levels of oxidative stress produced by mitochondrial disorders and dopamine metabolism. Our previous preclinical, translational and pilot clinica ...
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 17

 TERMINÉ 

Personalised Connected Care for Complex Chronic Patients (CONNECARE)

Date du début: 1 avr. 2016, Date de fin: 30 sept. 2019,

The ambition of the CONNECARE consortium is to co-design, develop, deploy, and evaluate a novel smart, adaptive integrated care system for chronic care management. This will save European healthcare organisations huge sums whilst improving patient outcomes. The consortium contains all the necessary partners to ensure success.Based on the concept of 4P medicine, CONNECARE will provide decision supp ...
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 10

 TERMINÉ 

ELIXIR-EXCELERATE: Fast-track ELIXIR implementation and drive early user exploitation across the life-sciences. (ELIXIR-EXCELERATE)

Date du début: 1 sept. 2015, Date de fin: 31 août 2019,

The life sciences are undergoing a transformation. Modern experimental tools study the molecules, reactions, and organisation of life in unprecedented detail. The precipitous drop in costs for high-throughput biology has enabled European research laboratories to produce an ever-increasing amount of data. Life scientists are rapidly generating the most complex and heterogeneous datasets that scienc ...
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 47

 TERMINÉ 

Dissecting gamma-TuRC composition and activity by Single Molecule Pull-down (GTR)

Date du début: 1 sept. 2017, Date de fin: 31 août 2019,

In this project I will use Single Molecule Pull-down (SiMPull) for studying activity and regulation of human gamma-tubulin ring complexes (gamma-TuRCs). Gamma-TuRCs are the main nucleators of microtubule (MT) polymerization. Additionally, gamma-TuRCs may play a role in modulating MT dynamics. Regulation of gamma-TuRC activity is key to organizing the dynamic MT arrays needed for essential processe ...
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 2

 TERMINÉ 

A genome editing-based approach to study the stem cell hierarchy of human colorectal cancers (editCRC)

Date du début: 1 avr. 2014, Date de fin: 31 mars 2019,

A hallmark of cancer is tumor cell heterogeneity, which results from combinations of multiple genetic and epigenetic alterations within an individual tumor. In contrast, we have recently discovered that most human colorectal cancers (CRCs) are composed of mixtures of phenotypically distinct tumor cells organized into a stem cell hierarchy that displays a striking resemblance to the healthy colonic ...
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 2

 TERMINÉ 

A systems pharmacology approach to the discovery of novel therapeutics in Alzheimer´s disease (SysPharmAD)

Date du début: 1 avr. 2014, Date de fin: 31 mars 2019,

Alzheimer´s disease (AD) is the most common form of dementia, with over 35 million people suffering from it worldwide, and it constitutes a personal and societal tragedy of immense proportions. Fifty years of intense research have revealed many key elements of the biology of this neurodegenerative disorder. However, our understanding of the molecular bases of the disease is still very limited, and ...
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 2

 TERMINÉ 

IRBLLEIDA International Postdoctoral Programme (IRBLLEIDA-IPP)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

"The aim of the Biomedical Research Institute of Lleida (IRBLleida) is to set up a trainingprogramme addressed to highly talented and motivated experienced researchers to givethem the opportunity to develop their research career at the Institute.The postdoctoral researchers will have the opportunity to join one or more research groupsat the Institute, and will follow an individual research project ...
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 1

 TERMINÉ 

Global BioImaging Project - International imaging infrastructure services for the life science community (Global BioImaging)

Date du début: 1 déc. 2015, Date de fin: 30 nov. 2018,

"The EC H2020 funded "Global BioImaging Project" enables Euro-BioImaging, the research infrastructure for access to biological and medical imaging technologies on the ESFRI roadmap, to work together with its international counterparts - the Australian Microscopy and Microanalysis Research Facility (AMMRF), the National Imaging Facility (Australia) and India-BioImaging - on concrete and sustainable ...
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 8

 TERMINÉ 

Centre of Excellence for Biomolecular Research (BioExcel)

Date du début: 1 nov. 2015, Date de fin: 31 oct. 2018,

Life Science research has become increasingly digital, and this development is accelerating rapidly. Biomolecular modelling techniques such as homology modelling, docking, and molecular simulation have advanced tremendously due to world-leading European research, resulting in extreme demands for better computational performance and throughput as these tools are used in applied research and industr ...
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 13

 TERMINÉ 

Multi-Scale Complex Genomics (MuG)

Date du début: 1 nov. 2015, Date de fin: 31 oct. 2018,

Genomics is probably the fastest evolving field in current science. A decade ago our main concern was to obtain the sequence (the 1D code) of the genome; but today the big challenges are to determine how genotype information is transferred into phenotype, and how pathological phenotypic changes can be predicted from genome alterations. While investigating these points, we have realized that a part ...
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 7

 TERMINÉ 

IRB Barcelona International Postdoctoral Programme 2.0 (IRBPostPro2.0)

Date du début: 2 avr. 2013, Date de fin: 1 avr. 2018,

IRB Barcelona is an independent, non-profit research institution engaged in basic and applied biomedical science at the interface between biology, chemistry and medicine, recently nominated a Severo Ochoa Centre of Excellence by the Spanish Ministry of Science and Innovation. One of the main missions of IRB Barcelona is to provide young life scientists with the opportunity to do training and resea ...
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 2

 TERMINÉ 

European Clinical Research Infrastructures Network - Integrating Activity (ECRIN-IA)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2017,

ECRIN is a distributed ESFRI-roadmap pan-European infrastructure designed to support multinational clinical research, making Europe a single area for clinical studies, taking advantage of its population size to access patients. Servicing multinational trials started during its preparatory phase, and it now applies for an ERIC status by 2011. The ERIC budget will be restricted to core activities re ...
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 48

 TERMINÉ 

Spatiotemporal regulation of epidermal stem cells by circadian rhythms: impact on homeostasis and aging (STEMCLOCK)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

"Most adult stem cells are compartmentalized in functionally deterministic niches where they self-renew and maintain homeostasis. From there, stem cells are instructed by combinations of signals and spatial tensile forces which they translate into a specific behavior. However how stem cells spatiotemporally coordinate their stem cell potential with niche- and systemic cues is poorly understood. Th ...
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 3

 TERMINÉ 

Early warning signals of ageing in human stem cells and age-related disorders (SYSTEMAGE)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

The regenerative power of a living organism is linked to the potential of its stem cells to replace the corresponding damaged tissue. Therefore organisms are as old as their stem cells. Whereas the vulnerability to cancer and chronic inflammation is associated with a decline of the immune system, the latter is in turn a sum product of interactions among hematopoietic stem cells (HSC), endothelial ...
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 11

 TERMINÉ 

Modelling Cancer Traits in Drosophila (FliesCan)

Date du début: 1 juil. 2012, Date de fin: 30 juin 2017,

Despite significant advance, cancer treatment remains suboptimal. Anatomical and physiological differences between humans and simple model organisms like Drosophila are many and major, and preclude the modelling of key aspects of the disease as it proceeds in vertebrates. However, malignant tumors in vertebrates and flies are made of cells that have derailed from their normal course of development ...
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 2

 TERMINÉ 

Advanced multiscale simulation of DNA (simDNA)

Date du début: 1 juil. 2012, Date de fin: 30 juin 2017,

The availability of new computers and software is making possible the theoretical representation of DNA, increasing then our knowledge on the behavior of one of the most relevant biological macromolecules. Unfortunately, current simulation procedures present two major problems, which handicapped their use: i) classical force-fields present well known biases, which limit their accuracy; ii) current ...
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 2

 TERMINÉ 

Signal integration and rewiring during tumor development (p38Cancer)

Date du début: 1 juil. 2012, Date de fin: 30 juin 2017,

Cell fate decisions rely on signaling pathways that integrate external signals to coordinate specific intracellular programs. One of these pathways leads to the activation of p38α MAPK, which plays key roles in cell responses to many types of stresses as well as chemotherapeutic agents and oncogenes. Importantly, p38α acts in a cell context-specific and cell type-specific manner to integrate signa ...
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 2

 TERMINÉ 

New Oral Nanomedicines: Transporting Therapeutic Macromolecules across the Intestinal Barrier (TRANS-INT)

Date du début: 1 mai 2012, Date de fin: 30 avr. 2017,

Despite the increasing number of macromolecules with potential impact in the treatment of devastating systemic diseases, these therapies have failed to deliver on their expectations because they cannot be administered in the fashion which is most cost efficient and has the highest patient compliance: the oral route. The availability of an oral form of administration could lead to a great improveme ...
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 20

 TERMINÉ 

New breast cancer therapies based on available p38 MAPK inhibitors (p38Cure)

Date du début: 1 oct. 2015, Date de fin: 31 mars 2017,

Breast tumors are classified by several grading systems and divided into four main molecular subtypes: Luminal A, Luminal B, Triple negative/basal-like and HER2+. Since luminal A tumors tend to be ER+, their treatment often includes hormonal therapy. HER2+ tumors can be treated with Trastuzumab, an anti-Her2 receptor antibody. Hormonal therapies or Trastuzumab cannot be used for triple negative tu ...
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 2

 TERMINÉ 

Testing and validation of bispecific antibody combinations targeting treatment-resistant cancer stem cells using organoid-based screening tools: a new drug discovery paradigm (SUPPRESSTEM)

Date du début: 1 juin 2013, Date de fin: 30 nov. 2016,

Colorectal cancer (CRC) was diagnosed in 1.23 million people worldwide (EU 333,000) in 2008 and 608,000 (EU 148,000) died of the disease. While some new treatments have been advanced in CRC many have failed clinical testing; metastatic CRC is still largely incurable.In CRC, Cancer Stem Cells (CSC) are responsible for tumour progression and resistant to standard chemotherapies. The Wnt signal trans ...
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 5

 TERMINÉ 

COLOStage : A new prognosis test for the prediction of metastasis in Colorectal Cancer and Hepatocellular Carcinoma (COLOStage)

Date du début: 1 mars 2015, Date de fin: 31 août 2016,

ColoStage is a new prognostic test, based on a novel gene expression signature, able to predict robustly the risk of disease relapse after therapeutic intervention in colorectal cancer (CRC) and potentially in hepatocellular carcinoma (HCC). We have previously demonstrated that CRC recurrence and metastasis strictly depend on high TGF-beta signaling (Calon et al., 2012). ColoStage is a gene expre ...
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 2

 TERMINÉ 

Computational Design of Highly Active Biocatalysts of Interest in the Chemical Industry (CompBiocatDesign)

Date du début: 1 mars 2013, Date de fin: 31 août 2016,

Developing new enzymes for catalyzing non natural reactions is a grand challenge for obtaining more efficient synthetic strategies for chemical industry as well as building complex molecules under enantioselective control with potential applications in medicine. Given the high specificity of natural enzymes for their substrates, new techniques are necessary for redesigning natural enzymes to perfo ...
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 2

 TERMINÉ 

Study of cis/trans proline isomerization as a novel regulatory mechanism of protein function (ProProteinRegulation)

Date du début: 1 sept. 2012, Date de fin: 31 août 2016,

Cellular processes are regulated through wide and complex signaling networks that require a tight spatial and temporal control over protein function. Recently a growing body of evidence has emerged supporting the role of prolyl cis-trans isomerization as a new intrinsic molecular regulatory mechanism with important consequences for protein function. Proline is the only amino acid in proteins that ...
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 2

 TERMINÉ 

Development of a new methodology for the synthesis of mercapto amino acids for protein synthesis by cysteine-free native chemical ligation (CYSTEINE-FREE NCL)

Date du début: 14 avr. 2014, Date de fin: 13 avr. 2016,

Proteins are in the heart of almost every single biological function and therefore are essential tools for drug discovery. Although the use of recombinant DNA techniques has been successfully applied to the synthesis of many proteins, the access to proteins bearing non natural amino acids, naturally obtained through post-translational modifications, remains limited. However, with the invention of ...
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 2

 TERMINÉ 

Addictions and Lifestyles In Contemporary Europe – Reframing Addictions Project (ALICE RAP)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2016,

ALICE RAP is a Europe wide project of 43 partner research institutions involving 107 researchers from 25 European countries providing 1000 months of a plurality of scientific endeavour to analyse the place and challenges of addictions and lifestyles to the cohesion, organization and functioning of contemporary European society. Through integrated multidisciplinary research, a wide range of factors ...
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 46

 TERMINÉ 

Mechanisms of prevention of type 2 diabetes by lifestyle intervention in subjects with pre-diabetes or at high-risk for progression (DEXLIFE)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

"Type 2 diabetes (T2DM) is preventable by sustained changes in diet and physical exercise. Despite this, modern societies are already approaching 10% population prevalence of diabetes, and another 15% with pre-diabetes. The costs of T2DM are huge, approaching 10% of all health costs. Prevention of diabetes is a priority for national healthcare agencies and for the health insurance industry. Inve ...
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 12

 TERMINÉ 

European Network of HIV/AIDS Cohort Studies to Coordinate at European and International Level Clinical Research on HIV/AIDS (EuroCoord)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2015,

Over the past 15 years, EU-funded cohorts and collaborations (EuroSIDA, CASCADE and PENTA), have played a central role in developing our understanding of HIV progression and the effects of ART, enabling European expertise to contribute directly to the advances in patient diagnosis and management worldwide, and providing a continued surveillance mechanism for detection of emerging problems at a Eur ...
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 26

 TERMINÉ 

European Researchers' Night: Researchers' For a Better Future (OurFuture)

Date du début: 1 avr. 2014, Date de fin: 31 oct. 2015,

The OurFuture: Researchers For a Better Future proposal consists in a two years proposal with different activities that are deeply related. The first activity consists of twelve main Events on the 26th September 2014 and 25th September 2015, organised by five universities, 3 public foundations, one scientific association, one autonomic government and a scientific installation around Spain as well ...
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 14

 TERMINÉ 

Generation of a new class of antiretrovirals targeting HIV-cellular cofactors interactions (HIVINNOV)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2015,

Highly active antiretroviral therapy is effective at controlling HIV-1 replication, however emergence and transmission of drug-resistant viruses is increasing, including viruses resistant to the newly developped integrase catalytic inhibitors. It is essential that new antiretrovirals (ARVs) become available. Most ARVs in development belong to the classes of viral enzyme inhibitors. Since HIV requi ...
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 7

 TERMINÉ 

IRB Barcelona International Postdoctoral Programme (IRBPostPro)

Date du début: 15 nov. 2010, Date de fin: 14 juil. 2015,

IRB Barcelona is an independent, non-profit research institution engaged in basic and applied biomedical science at the interface between biology, chemistry and medicine. One of the main missions of IRB Barcelona is to provide young life scientists with the opportunity to do training and research in a unique and multidisciplinary scientific environment. The Institute has a young but well-establish ...
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 2

 TERMINÉ 

Virtual Physiological Human: Sharing for Healthcare - A Research Environment (VPH-Share)

Date du début: 1 mars 2011, Date de fin: 31 mai 2015,

VPH-Share will develop the organisational fabric (the infostructure) and integrate the optimised services to (1) expose and share data and knowledge, (2) jointly develop multiscale models for the composition of new VPH workflows, (3) facilitate collaborations within the VPH community. Four flagship workflows (from @neurIST, euHeart, VPHOP, Virolab) provide existing data, tools and models, engage w ...
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 20

 TERMINÉ 

Study of the Determinants of Heterochromatin Formation and Maintenance (HETCHROMPROJECT)

Date du début: 1 juin 2011, Date de fin: 31 mai 2015,

Heterochromatin is a conserved organizational structure of the genetic material that is indispensable for cell viability. Heterochromatin is associated with the formation of functionally conserved centromeric and telomeric structures. These structures are both essential for the integrity and proper segregation of the genetic material during mitosis and meiosis. Heterochromatin structure is also im ...
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 2

 TERMINÉ 

Suicidality: Treatment Occurring in Paediatrics (STOP)

Date du début: 1 nov. 2010, Date de fin: 30 avr. 2015,

The emergence of suicidality in patients receiving drug treatment is of concern because of the overall burden and the possible link with completed suicide. The lack of uniform requirements for defining, detecting and recording suicidality and the presence of disease related confounders create major problems. It is possible that Medication-Related Suicidality (MRS) differs from Psychopathology-Rela ...
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 19

 TERMINÉ 

Paediatric European Risperidone Studies (PERS)

Date du début: 1 mai 2010, Date de fin: 30 avr. 2015,

"Second-generation antipsychotics are increasingly being prescribed to children and adolescents. Their use, however, is mostly off-label, and adequate and sufficient data about efficacy and particular safety are lacking. This proposal focuses on two indications, the use of risperidone in children and adolescents with conduct disorder who are not mentally retarded, and the use of risperidone in ado ...
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 22