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38 projets européens trouvés

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 EN COURS 

Postdoctoral Programme in Bioengineering Excellence Scientific Training (BEST)

Date du début: 1 févr. 2017, Date de fin: 31 janv. 2022,

The Institute of Bioengineering of Catalonia (IBEC) is a leading-edge multidisciplinary research centre based in Barcelona that conducts excellent interdisciplinary research at the frontiers of engineering and life sciences in order to generate new knowledge that helps to enhance quality of life, improve health and create wealth. It is currently located in Barcelona Science Park, has facilities co ...
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 1

 EN COURS 

Mechanical control of biological function (MECHANO-CONTROL)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Mechanical forces transmitted through specific molecular bonds drive biological function, and their understanding and control hold an uncharted potential in oncology, regenerative medicine and biomaterial design. However, this potential has not been realised, because it requires developing and integrating disparate technologies to measure and manipulate mechanical and adhesive properties from the ...
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 7

 EN COURS 

Diabetes Approach by Multi-Organ-on-a-Chip (DAMOC)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Insulin secretion and insulin action are critical for normal glucose homeostasis. Defects in both of these processes lead to type 2 diabetes (T2D). Unravelling the mechanisms that lead to T2D is fundamental in the search of new molecular drugs to prevent and control this disease. Organ-on-a-chip devices offer new approaches for T2D disease modelling and drug discovery by providing biologically rel ...
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 1

 EN COURS 
Advanced Microscopy techniques are widely recognized as one of the pillars onto which the research and manufacture of Nanotechnology based products is sustained. At present, the greatest challenge faced by these techniques is the realization of fast and non-destructive tomographic images with chemical composition sensitivity and with sub-10 nm spatial resolution, in both organic and inorganic mate ...
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 10

 EN COURS 

Engineering Complex Intestinal Epithelial Tissue Models (COMIET)

Date du début: 1 déc. 2015, Date de fin: 30 nov. 2020,

Epithelial barriers protect the body against physical, chemical, and microbial insults. Intestinal epithelium is one of the most actively renewing tissues in the body and a major site of carcinogenesis. Functional in vitro models of intestinal epithelium have been pursued for a long time. They are key elements in basic research, disease modelling, drug discovery, and tissue replacing and have beco ...
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 1

 EN COURS 

How to regenerate the mammalian kidney (REGMAMKID)

Date du début: 1 nov. 2015, Date de fin: 31 oct. 2020,

Kidney non-endocrine functions are primarily performed by millions of individual integral units called nephrons. Although the adults of simple vertebrates (fish, amphibians and reptiles) have the ability to regenerate entire nephrons by a process called “nephron neogenesis”, this capacity is absent in birds and mammals. In this regard we have observed, for the first time, that the murine neonatal ...
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 1

 TERMINÉ 

Multiscale regulation of epithelial tension (TensionControl)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2019,

Throughout development and adult life, the growth and remodelling of living tissues is determined by a complex interplay between chemical and physical cues. Among such physical cues, mechanical tension is emerging as central regulator of cellular fate and function. To explain tension regulation, current research emphasizes molecular mechanisms at an ever increasing level of detail. How these local ...
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 1

 TERMINÉ 

Laser Multiplexed Biosensor (GLAM)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2019,

Differential cancer diagnosis takes place daily in clinical settings for a better monitoring of patient responses to existing treatments. However outcome of this diagnosis is today still poor. Moreover, current technology to measure biomarker levels is expensive and sophisticated.Most cancer biomarker analysis use blood or biological tissues as the main source of material. These biopsies must be a ...
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 10

 TERMINÉ 

Human Brain Project Specific Grant Agreement 1 (HBP SGA1)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2018,

Understanding the human brain is one of the greatest scientific challenges of our time. Such an understanding can provide profound insights into our humanity, leading to fundamentally new computing technologies, and transforming the diagnosis and treatment of brain disorders. Modern ICT brings this prospect within reach. The HBP Flagship Initiative (HBP) thus proposes a unique strategy that uses I ...
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 126

 TERMINÉ 

Active microcleaners for water remediation (MICROCLEANERS)

Date du début: 1 sept. 2016, Date de fin: 28 févr. 2018,

We have witnessed a massive growth in industrial and agricultural activities, and a huge increment in the release of pollutants to our aqueous ecosystems. Centralized water suppliers look for systems energetically more viable than current ones and for onsite water purification systems which can be faster, more affordable and less aggressive. Here, we present a novel active self-mixing and multifun ...
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 1

 TERMINÉ 

Lab-in-a-tube and Nanorobotic biosensors (LT-NRBS)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

The goal of this project is to develop new types of biosensors based on two different approaches: (i) a new bioanalytic microsystem platform for cell growth, manipulation and analysis using on-chip integrated microtubes and (ii) the use of synthetic self-propelled nanomotors for bioanalytical and biosensing applications. Based on the novel “Lab-in-a-tube” concept, we will design a multifunctional ...
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 3

 TERMINÉ 

Coordination And Migration of Cells during 3D Vasculogenesis (CAMVAS)

Date du début: 1 oct. 2014, Date de fin: 30 sept. 2017,

"Cell migration is the core of myriad of phenomena in health and disease. Physical forces exerted during collective cellular motion trigger structural adaptations and signaling events that are of paramount importance in tissue engineering, stem cell differentiation and cancer. A spectacular example of coordinated movements towards a useful endpoint is vasculogenesis, the formation ""de novo"" of a ...
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 1

 TERMINÉ 
"High incidence of degenerative skeletal tissue disorders in a progressively aging human population make tissue engineering of cartilage and bone a focus of extensive research. Bone and joint disorders are the most common disease in Europe: more than 100 million European citizens suffer from arthritis and 19 million people have osteoporosis (one of three women and one of eight men are affected). T ...
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 7

 TERMINÉ 

Optopharmacological brain mapping of autism mouse models (OPTOFRAX)

Date du début: 1 juil. 2015, Date de fin: 30 juin 2017,

Manipulation of neurons with light-regulated proteins and drugs has opened unprecedented possibilities for phototherapies for neurological diseases. The host laboratory has developed a powerful new optopharmacological tool: a selective photoswitchable modulator of metabotropic glutamate receptors (mGluR). This drug can be activated or inactivated with light so that its action can be finely pattern ...
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 1

 TERMINÉ 
During our life’s, both privately and professionally, we exposed to a multitude of hazardous situations. And most of the time we are not (timely) aware of the dangerous situation. One of these silent killers is definitely carbon monoxide poisoning. There is a direct societal need for home and building automation (HABA) systems equipped with ultra-sensitive, reliable gas sensors (for hazardous gase ...
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 21

 TERMINÉ 

Microwave Nanotechnology for Semiconductor and Life Sciences (NANOMICROWAVE)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,

Current applications of microwave technologies in communications, remote sensing and in industry are based on the properties of the interaction of microwaves with matter at supra-wave length scales (above centimetres). The developments performed in Nanotechnology in recent years makes now conceivable to explore the interaction of microwaves with matter at much smaller scales, from micrometres to n ...
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 10

 TERMINÉ 

Tissue in Host Engineering Guided Regeneration of Arterial Intimal Layer (THE GRAIL)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2016,

"The concept of THE GRAIL project is the creation of an in vivo, in situ structured bioactive, selectively porous, bioresorbable scaffold that locally regenerates intima growth after endovascular treatment of the obstructed arteries in patients with atherosclerosis. Arterial obstruction due to arteriosclerosis is the cause of a wide spectrum of diseases, disabilities and death, because of induced ...
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 9

 TERMINÉ 
Advances in the fields of molecular and cell biology are strongly coupled to the implementation of photonic tools that allow highly-sensitive measurements in living cells at high molecular concentrations and at the nanometre scale. The goal of NANO-VISTA is to exploit novel concepts of photonic antennas to develop a new generation of bionanophotonic tools for ultrasensitive detection, nanoimaging ...
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 7

 TERMINÉ 

Finite element simulations of mechanobiology in tissue engineering (MECHANOBIO)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2016,

"The influence of mechanical stimuli on cell behaviour also known as mechanobiology has led to the development of mechano-regulation theories and finite element simulations that predict tissue formation in regenerative medicine. Computer simulations can explore mechanotransduction processes on the cellular level which are not possible to measure experimentally. However, most studies are limited to ...
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 2

 TERMINÉ 
This proposal presents a novel methodology to explore the mechanisms of different electron pathways in redox bio-molecular architectures at the single-molecule level. Single-molecule contacts have been shown to be experimentally realizable at room temperature. Scanning Probe Microscopies are the most employed techniques for creating contacts due to the high spatial resolution. A huge variety of m ...
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 1

 TERMINÉ 

Physical forces driving fibroblast-led cancer cell migration (CAFFORCE)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2015,

Cancer cell invasion and metastasis remain the leading cause of cancer-associated death. It is now clear that invasion is not simply a cancer cell autonomous process but the result of complex interaction between tumour cells and their microenvironment. A number of studies have now shown that the presence of Cancer Associated Fibroblasts (CAFs) in the tumour microenvironment enhance cancer cell inv ...
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 1

 TERMINÉ 
Polyacrylamide gel electrophoresis (PAGE) is the most widespread tool to separate and detect macromolecules based on their molecular weight. New generation PAGE assays miniaturize the technique to obtain high throughput performance and reduce sample volume, reagents and cost. Here, we present a novel technology that will improve the range, the resolution and the accuracy that these new generation ...
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 1

 TERMINÉ 
We aim at designing, prototyping, and validating a new generation of ICT hardware and software technologies inspired from plant roots, called PLANTOIDS, endowed with distributed sensing, actuation, and intelligence for tasks of environmental exploration and monitoring. PLANTOIDS take inspiration from, and aim at reproducing, the amazing penetration, exploration, and adaptation capabilities of plan ...
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 4

 TERMINÉ 
This project will produce a new tool, the Volumetric Scanning Microwave Microscope (VSMM), for non-destructive 3D nanoscale structural characterisation. Full development of this new tool will take place ready for commercial exploitation within the project duration. The consortium, comprising three SMEs, a Large Company, an RTD Performer and two Research Institutions, will develop and commercialise ...
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 8

 TERMINÉ 
Fundamental biological processes including morphogenesis, tissue repair, and tumour metastasis require collective cell motions, and to drive these motions cells exert traction forces on their surroundings. The mechanisms underlying this basic principle of health and disease have been debated intensively and, using a variety of methods in vivo, in vitro, and in silico, much conflicting evidence has ...
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 2

 TERMINÉ 

Therapeutic Applications of Light-Regulated Drugs (THERALIGHT)

Date du début: 1 août 2013, Date de fin: 30 nov. 2014,

One of the major drawbacks of pharmacological therapies is the difficulty to control drug kinetics and restrict drug action to the target organ. This in turn limits the efficacy of drugs and triggers undesired side effects for patients. We have developed an innovative approach to control the activity of drugs with light in cell culture systems. The PoC grant will allow going a step further by test ...
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 1

 TERMINÉ 
Description Improving the treatment of lower back painThe MySpine project aims to improve the treatment of lower back pain. Nowadays treatment and prognosis of spinal disc degeneration are still based on trial and error decisions from the surgeon, leading to numerous post treatment complications and eventual morbidity. MySpine is working ...
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 9

 TERMINÉ 

Single Molecule Activation and Computing (FOCUS)

Date du début: 1 janv. 2011, Date de fin: 31 mars 2014,

The present project, FOCUS, will build a novel generation of biologically inspired molecular devices (MDs) based on the developments of new photonic tools. These photonic tools will use Plasmon Polariton and two-photon technology, enabling focused light spots with a diameter around 10 nm. FOCUS will also develop new light sensitive molecules that will be selectively activated by our new photonic ...
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 8

 TERMINÉ 

European Robotic Surgery (EuRoSurge)

Date du début: 1 oct. 2011, Date de fin: 31 déc. 2013,

Description Computer and Robot Assisted Surgery (CRAS) is an area receiving broad attention worldwide, because of its strong potential to achieve new levels of healthcare. In Europe, the robotics and the cognitive science communities have been independently pursuing research in this field, making significant, but fragmented contributions. Fu ...
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 7

 TERMINÉ 
"Optical switches are photoisomerizable compounds that allow to remotely controlling the activity of proteins, cells and entire organisms with light. These tools are revolutionizing research in biology with their high selectivity and spatiotemporal resolution. Here we propose to develop and apply optical switches to investigate the fundamental processes of secretion, exocytosis and endocytosis, in ...
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 3

 TERMINÉ 
Angiogenesis underlies almost all biological processes of morphogenesis, including those in tissue repair and regeneration. Physiological angiogenesis is controlled by a complex interplay between cells and their environment: the extracellular matrix (ECM) provides signaling via numerous ECM adhesion molecules and growth factors bound to ECM polysaccharide components; and cells locally degrade and ...
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 33

 TERMINÉ 
30% of European workers experience back pain, and it is the most frequently reported work-related disorder. The proposed work seeks to provide a cure for lower back pain by developing porous scaffolds and technology which will repair a damaged intervertebral disc (IVD) by enabling its regeneration to a natural healthy state or better. Injectable acellular and cell-loaded bioactive polymer-based sc ...
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 17

 TERMINÉ 

Photo-activated voltage-sensing domain in voltage-sensing proteins (PAVSD)

Date du début: 1 avr. 2010, Date de fin: 31 mars 2012,

"Eukaryotic cells have voltage-gated ion channels that are directly activated by voltage but never by light. Voltage-gated ion channels contain a voltage-sensing domain (VSD) that responds to changes in membrane potential by gating the pore domain. VSD are functionally independent domains within canonical voltage-activated ion channels, but are also components of voltage-sensing enzymes and can al ...
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 1

 TERMINÉ 

Mechanistic and Evolutive Development of Spine Biomechanical Modelling (SEVBIOM)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2011,

"Lumbar spine finite element (FE) modelling can bring important information about load distributions in tissues involved in low back pain. However, current verifications of spine models cannot validate predictions at single tissue level (Noailly, 2007). Mechanistic models of spine tissues, respecting the link between composition, structure, and biophysical properties, can ensure accurate local pre ...
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 1

 TERMINÉ 
This proposal presents a new fundamental approach to study one of the most outstanding processes in nature at the single-molecule level; the photo-induced charge separation process on molecular photosynthetic systems. The last technical advances, especially on Scanning Probe Microscopies (SPM), have allowed approaching a number of relevant molecular processes to a single-molecule level, fact that ...
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 1

 TERMINÉ 
"The sensing of force by cells is determinant for processes like morphogenesis, wound healing, or tumour formation, and can control functions such as proliferation, differentiation, or gene expression. However, the specific mechanisms by which cells sense mechanical forces and respond accordingly remain largely unknown. The proposed project aims to characterize cell mechanotransduction through the ...
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 1

 TERMINÉ 
The lack of models for technology transfer at nanotechnology developments is of increasing concern for the sector. This CSA will fulfil this gap providing guidelines for technology transfer and rules for IPR and license agreements in nanotechnology developments. To achieve these objectives, a consortium is formed by: 1) Key European research centres in different areas of nano and converging techno ...
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 10

 TERMINÉ 

EUROpean scale infrastructure in NANOBIOtechnology (EuroNanoBio)

Date du début: 1 févr. 2009, Date de fin: 31 janv. 2010,

EuroNanoBio aims at defining the key features of the future EU capacity in nanobiotechnology and the roadmap to reach this goal. It will establish the features of the infrastructure, the role of the various stakeholders and the way to establish it. This Support Action is divided into three phases: 1) An analytical phase where the existing data, published or not, will be scrutinised and analysed ...
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 8