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21 projets européens trouvés

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 EN COURS 

Molecule-to-man pain network (PAIN-Net)

Date du début: 1 févr. 2017, Date de fin: 31 janv. 2021,

Neuropathic pain affects 5% of the general population and 40% of patients with neurological diseases, and has a key role in the pathophysiology of cancer pain that affects up to 50% of patients in the early disease stage and 30% of survivors, causing an enormous social burden. Treatments are inadequate with less than 50% of patients achieving 50% of pain relief at best, while up to 30% of cancer p ...
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 13

 EN COURS 
The research in which the young scientists of the EU-GliaPhD consortium will be trained is centred on the role of neuron-glia interactions in brain function and pathology.Prompted by exciting discoveries of recent years, many academic research groups are currently focussing their research on the field of neuron-glia interactions for a better understanding of brain function. Also the private sector ...
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 13

 TERMINÉ 

Ageing Trajectories of Health: Longitudinal Opportunities and Synergies (ATHLOS)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2020,

The objective of the ATHLOS Project is to achieve a better understanding of ageing by identifying patterns of healthy ageing pathways or trajectories, the determinants of those patterns, the critical points in time when changes in trajectories are produced, and to propose timely clinical and public health interventions to optimise healthy ageing. Moreover, a new definition of ‘old age’ based on ma ...
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 15

 TERMINÉ 

Data-driven models for Progression Of Neurological Disease (EuroPOND)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

EuroPOND will develop a data-driven statistical and computational modeling framework for neurological disease progression. This will enable major advances in differential and personalized diagnosis, prognosis, monitoring, and treatment and care decisions, positioning Europe as world leaders in one of the biggest societal challenges of 21st century healthcare. The inherent complexity of neurologica ...
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 9

 TERMINÉ 
The decision-making in chemotherapy nowadays depends on standard methods that are liquid chromatography (LC-MS/MS) followed by mass spectrometry or capillary electrophoresis; both are labour- and cost-intensive and can be performed only in dedicated hospitals and laboratories. This lead to a minimal therapeutic drug monitoring in patients and hence that 30-60% of drugs are administered without cli ...
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 9

 TERMINÉ 

Microbubble driven multimodal imaging and theranostics for gliomas (THERAGLIO)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

Microbubbles (MBs) are used as contrast agent in ultrasound (US) imaging for a variety of tumours while little has been done for glioblastomas, a rare cancer. Intraoperative Contrast-Enhanced US-imaging (CEUS) using lipidic MBs hold promises in increasing extent of resection of such tumors. Furthermore, MBs gained recently interest as a delivery system for drugs. We will develop a new generation o ...
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 12

 TERMINÉ 
DESIRE will focus on epileptogenic developmental disorders EDD, i.e. early onset epilepsies whose origin is closely related to developmental brain processes. A major cause of EDD are malformations of cortical development (MCD), either macroscopic or subtle. EDD are often manifested as epileptic encephalopathies (EE), i.e. conditions in which epileptic activity itself may contribute to severe cogni ...
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 29

 TERMINÉ 
Mitochondria are the major source of ATP, synthesized by the mitochondrial respiratory chain (MRC) through the process of oxidative phosphorylation. ATP deficiency leads to cellular dysfunction and ultimately death. In mammals, 13 mitochondrial DNA (mtDNA)-encoded subunits interact with over 70 nuclear-encoded subunits to form four of the five MRC complexes. Many additional factors are essential f ...
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 3

 TERMINÉ 

Mental Health Training through Research Network in Europe (MARATONE)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2017,

"MARATONE is a Marie Curie Initial Training Network proposal that directly addresses the need for high-level training and career pathways in mental health to increase the inter-sectorial and trans-national employability of young scientists in the academic, public and private sectors to meet the enormous challenge of the 2009 EU Parliament Resolution on Mental Health. The Resolution set out recomme ...
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 14

 TERMINÉ 

Mitochondrial European Educational Training (MEET)

Date du début: 14 janv. 2013, Date de fin: 13 janv. 2017,

"The expanding diversification and specialization of knowledge and the growing complexity of contemporary research in translational research warrant the creation of cooperative multi-disciplinary networks including both basic and medically oriented expertise. This notion is especially true for Mitochondrial Medicine which aims at understanding the physiopathological mechanisms sharing the features ...
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 10

 TERMINÉ 

PROBING THE ROLE OF SODIUM CHANNELS IN PAINFUL NEUROPATHIES (PROPANE STUDY)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2016,

Neuropathic pain is a frequent feature of peripheral neuropathy adversely impacting patients’ quality of life and increasing health care costs. Not all individuals with neuropathy develop pain and it is not possible to predict who is more or less susceptible among those with similar risk exposure. Inability to identify high-risk individuals and drug-responder patients and lack of drugs acting on t ...
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 9

 TERMINÉ 

Treat Iron-Related Childhood-Onset Neurodegeneration (TIRCON)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,

Neurodegeneration with brain iron accumulation (NBIA) is a heterogeneous group of rare hereditary neurodegenerative disorders characterized by high levels of brain iron. The most common form is pantothenate kinase-associated neurodegeneration (PKAN). Classic PKAN and most other NBIA cases are characterised by early childhood onset and rapid progression. Currently, there is no proven therapy to hal ...
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 14

 TERMINÉ 

European Friedreich's Ataxia Consortium for Translational Studies (EFACTS)

Date du début: 1 mai 2010, Date de fin: 30 avr. 2015,

EFACTS (the European Friedreich’s Ataxia Consortium for Translational Studies) assembles a body of expertise to adopt a translational research strategy for the rare autosomal recessive neurological disease, Friedreich’s ataxia (FRDA). FRDA is a severely debilitating disease that leads to loss of the ability to walk and dependency for all activities. Some patients have cardiomyopathy that can cause ...
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 15

 TERMINÉ 

Active Constraints Technologies for Ill-defined or Volatile Environments (ACTIVE)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2015,

Description Active Constraints Technologies in Neurosurgery for Ill-defined or Volatile Environments The ACTIVE project exploits ICT and other engineering methods and technologies for the design and development of an integrated redundant robotic platform for neurosurgery. A light and agile redunda ...
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 19

 TERMINÉ 
"Myasthenia Gravis (MG) is a heterogeneous rare autoimmune neurological disease affecting the neuromuscular junction (NMJ). The molecular events causing and maintaining MG are still unknown and current treatments do not lead to remission and entail considerable side-effects stressing the need for improved therapies. We will address the: 1. Natural course of disease: determine factors associated wi ...
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 13

 TERMINÉ 
Leukodystrophies (LDs) are inherited rare neurodegenerative diseases of the white matter and its main component, the myelin, that are affecting predominantly children. Severity of the disease is related to the axonal dysfunction due to myelin deficiency or destruction. Despite the achievement of remarkable advances made in the past decade, there is no current curative therapy. The development of t ...
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 25

 TERMINÉ 

RICHE – a platform and inventory for child health research in Europe (RICHE)

Date du début: 1 févr. 2010, Date de fin: 31 juil. 2013,

"The European Commission and other funding agencies make a large investment in child health research. The health of our children is satisfactory, but there are serious concerns, for example, obesity, mental health, alcohol abuse, and sexuality. We know that there are strong links between the health of young people and their social inclusion and level of education. Our objective is to establish a s ...
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 27

 TERMINÉ 

Psychosocial fActors Relevant to BrAin DISorders in Europe (PARADISE)

Date du début: 1 janv. 2010, Date de fin: 30 juin 2013,

The overall prevalence of brain disorders – both neurological and psychiatric – is very high in Europe. Although it is well known that the burden and costs of these disorders are high, there is evidence that the overall, personal, social and economic costs of brain disorders have been underestimated because of the lack of valid and reliable information regarding the full range of psychosocial diff ...
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 10

 TERMINÉ 

COURAGE in Europe - COllaborative Research on AGEing in Europe (COURAGE IN EUROPE)

Date du début: 1 mai 2009, Date de fin: 31 déc. 2012,

The European Commission has identified the challenge of population ageing as the most pressing policy issue in the 21st century. As Europeans live longer and disabilities in this population increase, valid and comparable longitudinal data on their health is essential for evidence based policy making. Valid data requires better measurement instruments and methodologies for longitudinal and cross-po ...
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 13

 TERMINÉ 
"Nothing defines the function of a neuron better than it's connections" (Mesulam)In the last two decades impressive advances in understanding brain function with new neuroimaging methods have been made, however to understand brain function, it is also very important to characterise its structure and connections. The recent development of diffusion MR methods that map white matter tissue structur ...
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 10

 TERMINÉ 
The proposal aims at the development and clinical validation of advanced non-invasive optical methodologies for in-vivo diagnosis, monitoring, and prognosis of major neurological diseases (stroke, epilepsy, ischemia), based on diffuse optical imaging by pulsed near infrared light. Established diagnostic imaging modalities (e.g. X-ray Computed Tomography, Magnetic Resonance Imaging, Positron Emissi ...
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 14