Plus de 40 projets européens trouvés
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TERMINÉ
Orchestrating the Transcriptome and Proteome in Time and Space: Quantitative Modeling of Protein Production, Degradation and Localization in Mammalian Systems (EXPRESSION DYNAMICS)
Date du début: 1 janv. 2014, Date de fin: 1 mars 2017,
Gene expression in mammalian cells is tightly controlled and depends on the interplay between the production, degradation and localization of RNA and proteins. Each of these processes is highly regulated, but it remains largely unclear which of these is the dominant process determining the final concentration of each protein in each cell state or time point on a genomic scale.In my outgoing phase, ...
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1
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TERMINÉ
...objectifs de développement et de progrès de la commune ont souhaité initier et mettre en œuvre un projet de coopération durable avec les îles de la Caraïbe. Ce projet intitulé « Un espace dexpression et de promotion des cultures caribéennes populaires » sarticule autour de trois piliers et dune manifestation internationale à inscrire dorénavant dans le calendrier des manifestations culturelles de ...
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1
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TERMINÉ
Quality control of gene expression: mechanisms for recognition and elimination of nonsense mRNA (mRNA quality)
Date du début: 1 juin 2008, Date de fin: 31 mai 2013,
Analogous to quality control checks along the assembly line in industrial manufacturing processes, cells possess multiple quality control systems that ensure accurate expression of the genetic information throughout the intricate chain of biochemical reactions. “Nonsense-mediated mRNA decay” (NMD) represents a quality control mechanism that recognizes and degrades mRNAs of which the protein coding ...
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1
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TERMINÉ
GenoChemetics: Gene eXpression enabling selective Chemical functionalisation of natural products (GCGXC)
Date du début: 1 juin 2014, Date de fin: 31 mai 2019,
"We aim to consolidate a trans-disciplinary research programme in which synthetic biology is harnessed to enable synthetic chemistry. We will utilise this approach to expeditiously access series of previously intractable natural product analogues.There is an urgent need for the discovery and development of new drugs and in particular new antibiotics. More than 13 million lives worldwide are curren ...
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1
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TERMINÉ
Analysis of natural-genetic variation controlling the timing of GIGANTEA expression in Arabidopsis (Diversity of rhythms)
Date du début: 1 avr. 2008, Date de fin: 31 mars 2010,
...any physiological and developmental processes in plants. The GIGANTEA (GI) protein plays a major role in the clock mechanism and controls important clock outputs including photoperiodic flowering. GI expression follows a circadian rhythm, with a peak in the evening, and changes in the timing of GI expression have dramatic effects on biological programs such as flowering. Natural-genetic variation ...
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2
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TERMINÉ
Bridging Non-Equilibrium Problems: From the Fourier Law to Gene Expression (BRIDGES)
Date du début: 1 avr. 2012, Date de fin: 31 mars 2017,
"My goal is to study several important open mathematical problems in non-equilibrium (NEQ) systems and to build a bridge between these problems and NEQ aspects of soft sciences, in particular biological questions. Traffic on this bridge is going to be two-way, the mathematics carrying a long history as a language of science towards the soft sciences, and the soft sciences fruitfully asking new que ...
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1
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TERMINÉ
Consolidate Communities of Cross-Border Region through Expression of History in Arts,Ethnic Identity (Arts,Ethnic Identity)
Date du début: 3 janv. 2010, Date de fin: 30 juin 2011,
This project involves cooperation between two music schools, one located in the Lithuanian town of Naujoji Akmene and one in the town of Auce in Latvia, only 15 km from one another. The project includes student exchanges between the two schools to facilitate the sharing of knowledge between students from different learning environments. Focus is also given to the involving of people with disabilit ...
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2
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TERMINÉ
The Integron Cassette Dynamics and the Integrase Gene Expression (ICADIGE)
Date du début: 1 oct. 2012, Date de fin: 30 sept. 2014,
"Bacterial antimicrobial resistance has become one of the major concerns in modern medicine. It is currently responsible in Europe for 15 times as many deaths as AIDS every year. Not surprisingly this phenomenon is one of the Top Six Health Topics for the eCDC.Bacteria have shown a remarkable evolvability towards resistance. One of the most worrisome mechanisms observed, is the integron, a highly ...
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1
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TERMINÉ
Expression is Empowerment
Date du début: 1 mai 2016, Date de fin: 31 mars 2017,
The Youth Exchange "Expression is Empowerment" will take place between three partner organisations: ISKCON London (UK), Drustvo za Duso (Slovenia) and Avadhuta (Croatia) in Ljubljana, Slovenia on July 18 - July 24, 2016. The main aims of the project are to combat youth unemployment and foster positive experiences and interactions with the EU, through friendships and fun, and expression of their ow ...
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3
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TERMINÉ
Molecular mechanisms of tumor suppressor functions of HECT-type E3 ligase Smurf2: roles in chromatin organization, dynamics, gene expression and DNA damage response and repair (Smurf2 in Cancer)
Date du début: 1 août 2013, Date de fin: 31 juil. 2017,
Cancer is a multifaceted disease in which dysregulated gene expression and other aberrant activities are crucial for neoplastic initiation, progression and tumor cell survival upon the treatment with anticancer modalities.One of the major mechanisms that regulate these processes is protein ubiquitination. This modification can impose diverse effects on gene products–proteins, ranging from proteoly ...
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1
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TERMINÉ
Post-transcriptional Control of the Aire-Driven expression of self-antigens in the Thymus (CADET)
Date du début: 1 août 2011, Date de fin: 31 juil. 2015,
...TR shortening of its sensitive transcripts in MECs, and that these cells show an accumulation of miRNAs. The goal of our project is to describe a post-transcriptional control of the Aire-driven expression in the thymus that leads to higher levels of Aire-dependent self-antigens, and to identify key molecular players involved in this mechanism. We first propose to confirm that Aire-induced transcri ...
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1
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TERMINÉ
Painting the landscape of translational control of gene expression through meta-analysis of genome wide data sets (TRANSLATOMICS)
Date du début: 1 avr. 2011, Date de fin: 31 mars 2015,
Translational control determines the rate at which mRNAs are synthesized into proteins; regulates biological processes ranging from apoptosis to memory; and shows deregulation in diseases such as fibrosis and cancer. In cancer, dysregulated translational control is associated with worse prognosis in most sold cancer. Despite this, integrated genome wide knowledge of translational control and its r ...
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1
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TERMINÉ
High resolution mapping of genetic loci underlying variation in gene expression using a heterogeneous stock of mice (HS GENOMICS)
Date du début: 1 août 2007, Date de fin: 31 juil. 2009,
...ful new tool for the molecular dissection of complex traits. Here I propose a project using the outbred, genetically heterogeneous stock (HS) of mice together with Prof. Flint in Oxford. By analyzing expression levels in 500 liver samples I will be able to map loci to intervals of approximately 250 kilobases, sufficient to identify the responsible genes. Importantly, by combining the information f ...
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1
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TERMINÉ
Microbial Expression Platform for Membrane Integrated Enzymes (MINT ENZYMES)
Date du début: 1 juil. 2012, Date de fin: 30 juin 2016,
...e for membrane proteins vary between kingdoms and affect protein production under different growth conditions - with an unprecedented systematic approach. At the core of biotechnology is heterologous expression of proteins, i.e. to transfer genes into foreign hosts like microorganisms for protein production. One of the key challenges in protein production relates to the degeneracy of the genetic c ...
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1
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TERMINÉ
Modelling human ageing: developing and interrogating an integrated model of ageing to identify causal relationships between hormonal changes and gene expression changes (INTEGRAGEING)
Date du début: 15 nov. 2012, Date de fin: 14 nov. 2014,
"Ageing has a profound impact on human society and modern medicine, yet it remains a major puzzle of biology. Both hormonal and gene expression changes have been implicated as causal mechanisms of ageing. It is not clear, however, which molecular or physiological changes are more important drivers of the process of ageing or how they influence each other. This project aims to develop and interroga ...
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1
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TERMINÉ
YE-Polish-Norwegian Week of Tolerance and Freedom of Expression 2014
Date du début: 15 juin 2014, Date de fin: 14 janv. 2015,
...shed to strenghen the contact.
In the frames of the 200 years anniversary of the Norwegian constitution and the long history of constitutional law in Poland common focus area in 2014 was Freedom of Expression, that is one of the paragraphs in our constitutions.
24 young people from Wegliniec Youth Group (Poland) and Hå Youth Council (Norway) carried out a bilateral youth exchange project for on ...
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2
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TERMINÉ
Expression regulatory networks: beyond promoters and transcription control (ERNBPTC)
Date du début: 1 sept. 2008, Date de fin: 31 août 2013,
"Gene expression in living cells is a most intricate molecular process, occurring in stages, each of which is regulated by a diversity of mechanisms. Among the various stages leading to gene expression, only transcription is relatively well understood, thanks to Genomics and bioinformatics. In contrast to the vast amounts of genome-wide data and a growing understanding of the structure of networks ...
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1
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TERMINÉ
The Power of Creativity & Expression : an Intercultural European Dialogue
Date du début: 1 mars 2015, Date de fin: 1 nov. 2015,
...previous Yoth Exchange Programmes, this year´s programme results in a new aim that focuses on output-effects: The shared experience of both their own and collective outputs, ranging from creative to expressionistic methods, does not become an end in itself but constitutes the methodological framework for the narration of one´s own biographical identity.
From July 27 until August 3rd, 40 participan ...
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4
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TERMINÉ
The artist within – Applied eMOTION Dance and art expression in formal and non-formal education for developing entrepreneur skills – best practice sharing between sectors and methods
Date du début: 1 sept. 2014, Date de fin: 31 août 2016,
Recently, we find more and more educational, and training activities using different ways of artistic expression (dance/movement, drawing, theatre, cartoons) to enable learning in an innovative and creative way. Our project aims at the development and integration of the different art modalities into the formal and non-formal educational activities. We intend to further support institutions to empo ...
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6
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TERMINÉ
Regulation of the expression of odorant receptor genes in mouse (ORGENECHOICE)
Date du début: 1 avr. 2010, Date de fin: 31 mars 2015,
...ele. The mechanisms of OR gene choice remain elusive. We will execute five specific aims that are interconnected but independent. We will search for homeodomain genes that we can link functionally to expression of a subset of OR genes; we will define promoter regions for the eight OR genes that are solitary, not belonging to a cluster; we will look for organizational principles among the repertoir ...
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2
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TERMINÉ
Narration, linguistic expression and discourse structure: explorations of orality in Occitan and French (EXPRESSIONARRATION)
Date du début: 1 avr. 2016, Date de fin: 31 mars 2018,
This project is an exploration of the linguistic complexities around the concept of ‘orality’, as attested in different expressions of ‘oral narrative’ in Occitan and French. It will be corpus-based and comparative, looking at a key set of temporal features in narratives collected in a traditional oral setting, in contemporary oral settings and in published ‘literary’ versions of oral narratives. ...
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TERMINÉ
"LICHen population gENetics and genOMICS - Gene expression, neutral and adaptive genetic variation in natural populations of Peltigera membranacea" (LICHENOMICS)
Date du début: 1 sept. 2012, Date de fin: 31 août 2014,
...arkers, offering valuable insight on whether the species is likely to spread to sites with suitable conditions under climate change (landscape genetics). An experiment will shed light on whether gene expression differs when thalli are grown at high and low temperatures (experimental transcriptomics). The ESR genes will be investigated with Next Generation Sequencing to identify SNPs with an associ ...
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1
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TERMINÉ
Genomic sequence variants that correlate with gene expression and different epigenetic patterns modify risk for mTLE+HS (mTLE-HS)
Date du début: 1 avr. 2010, Date de fin: 30 juin 2012,
...the results of GWA studies give little information about the underlying disease mechanisms. The proposed research project will try to identify those genomic sequence variants that correlate with gene expression and different epigenetic patterns that could modify risk for mTLE+HS. Starting with an already established epilepsy GWA study, we propose to obtain gene expression and methylation data from ...
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1
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TERMINÉ
FUNCTIONS OF CHROMATIN MARKS IN REGULATION OF GENE EXPRESSION (FAME)
Date du début: 1 mars 2013, Date de fin: 29 févr. 2016,
In multicellular organisms, during embryogenesis and tissue homeostasis the differentiation of pluripotent stem cells into a variety of specialized cell types is governed by diverse transcriptional programs, the establishment and maintenance of which rely on epigenetic mechanisms, such as chromatin modifications. Over the past years, a large number of post-translational modifications of histones a ...
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1
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TERMINÉ
Epigenetic regulation and monoallelic gene expression: the X-inactivation paradigm and beyond (EpigenetiX)
Date du début: 1 mai 2010, Date de fin: 31 oct. 2015,
... chromosome is silenced while its homologue, present in the same nucleus, remains active. Thus, in addition to being an epigenetics paradigm, XCI also represents a powerful model for monoallelic gene expression and could provide important insights into the mechanisms underlying other examples of random, monoallelic regulation. The key locus underlying the initiation of XCI is the X-inactivation ce ...
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1
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TERMINÉ
Controlling stochastic gene expression during development and stem cell differentiation (GeneNoiseControl)
Date du début: 1 avr. 2012, Date de fin: 31 mars 2017,
...ed to underlying genetic and environmental variation. However, even genetically identical organisms in homogenous environments vary, suggesting that randomness in developmental processes such as gene expression may also generate diversity. My laboratory has intensively studied stochastic gene expression in microbial systems and more recently started to apply these concepts to multicellular organis ...
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1
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TERMINÉ
Art and Activism : Creativity and Performance as Subversive Forms of Political Expression in Super-Diverse Cities (ARTIVISM)
Date du début: 1 sept. 2016, Date de fin: 31 août 2021,
ARTIVISM aims at exploring new artistic forms of political expression under difficult, precarious and/or oppressive conditions. It asks how social actors create belonging and multiple forms of resistance when they use art in activism or activism in art. What kind of alliances do these two forms of social practices generate in super-diverse places, in times of crisis and in precarious situations? T ...
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1
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TERMINÉ
Regulation of gene expression in mammalian mitochondria (GENEMIT)
Date du début: 1 mai 2011, Date de fin: 30 avr. 2016,
...tance of mitochondria is underscored by the fact that deficient oxidative phosphorylation causes a wide number of genetic diseases. It is also heavily implicated in age-associated disease and ageing. Expression of mammalian mtDNA is of key importance for maintaining mitochondrial oxidative phosphorylation but studies of the poorly understood regulation of mammalian mitochondrial gene expression of ...
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2
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TERMINÉ
Standarization and orthogonalization of the gene expression flow for robust engineering of NTN (new-to-nature) biological properties (ST-FLOW)
Date du début: 1 déc. 2011, Date de fin: 30 nov. 2015,
...to perfectly predictable functional properties of the resulting devices, modules and entire systems. ST-FLOW focuses on each of the steps that go from assembling a DNA sequence encoding all necessary expression signals in a prokaryotic host (by default, E. coli) all the way to the making of the final product or to the behaviour of single cells and populations. Two complementary approaches will be ...
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15
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TERMINÉ
European Light Expression Network
Date du début: 1 mai 2016, Date de fin: 19 oct. 2018,
European Light Expression Network (ENLIGHT)will enable artists to develop new skills working with technicians and scientists to create a series of accessible, large-scale public realm works realised through international collaborations for international audiences. Running for 32 months the project will deliver 2 international lab events, 6 international collaborative residencies, commission 6 majo ...
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4
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TERMINÉ
Wiring up visual circuits: Interplay between gene expression and spontaneous and experience-dependent activity (WIRINGVISION)
Date du début: 1 janv. 2012, Date de fin: 30 juin 2017,
A fundamental feature of the developing neural circuits is their ability to change in response to sensorial experience. This phenomenon has been particularly observed during the generation of cortical maps, where altering the pattern of sensory experience changes the spatial organization of sensory representations. The mechanisms underlying this form of plasticity include synaptic modification suc ...
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1
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TERMINÉ
Dynamics of human genome architecture in stable and transient gene expression changes (4D-GENOME)
Date du début: 1 juin 2014, Date de fin: 31 mai 2019,
...e genomes of distinct eukaryotic cell types in interphase to identify differences in the chromatin landscape. We will follow the time course of structural changes in response to cues that affect gene expression either permanently or transiently. We will analyze the changes in genome structure during the stable trans-differentiation of immortalized B cells to macrophages and during the transient ho ...
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2
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TERMINÉ
The impact of recent retrotransposon invasions on the evolution of human neural gene expression (Evolutionary Neurogenomics)
Date du début: 1 juin 2015, Date de fin: 31 mai 2017,
...ory pathways. Retrotransposons are an important source for evolutionary novelties, but the impact of thousands of human-specific retrotransposon-KZNF regulatory modules on the evolution of human gene expression patterns is unknown. There is increasing evidence that retrotransposons become reactivated during neural differentiation, suggesting that neuronal gene-regulatory networks may be extra sens ...
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1
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TERMINÉ
The endocrine control of histone acetylation in regulating gonadotropin gene expression (HATs)
Date du début: 1 févr. 2009, Date de fin: 31 janv. 2013,
The gonadotropin hormones regulate reproduction, showing dynamic fluctuations in their expression levels across the life cycle to determine reproductive potential. The principle determinant of their expression is the hypothalamic hormone, GnRH, which stimulates both their synthesis and secretion. Aberrant GnRH exposure can stimulate precocious puberty, and we have shown previously that GnRH is abl ...
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1
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TERMINÉ
In Vitro Derivation of Beta Cells by Ectopic Expression of Pancreatic Transcription Factors (TRANSBETA)
Date du début: 1 juin 2012, Date de fin: 31 mai 2016,
...ce towards a cure for the disease. The general objective of this proposal is to establish a method to transdifferentiate adult human cells to the beta cell phenotype by direct reprogramming by forced expression of an optimized set of pancreas specific transcription factors. The underlying experimental rationale is that sequential or combinatorial ectopic expression of transcription factors can ind ...
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1
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TERMINÉ
A Novel Level for the Regulation of Eukaryotic Gene Expression: Coupling Transcription to Translation (Regextra)
Date du début: 1 sept. 2008, Date de fin: 31 août 2013,
Eukaryotic gene expression is a highly regulated, fundamental cellular process encompassing distinct steps such as transcription, mRNA processing and nuclear export, translation and degradation of the mRNA. In this project a novel level in the regulation of gene expression will be analyzed. We propose that transcription and the correct processing as well as packaging of the newly synthesized mRNA ...
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1
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TERMINÉ
Regulation of alpha-v-beta-8 integrin expression and its role in intestinal immune homeostasis (ITGB8 REGULATION)
Date du début: 1 oct. 2013, Date de fin: 30 déc. 2015,
... ubiquitously expressed, TGF-b must be activated in order to enable subsequent signaling. TGF-b activation thus represents a major point of regulation of intestinal immune responses.I have shown that expression of alpha-v-beta-8 integrin (avb8) by dendritic cells (DCs) is required to activate TGF-b so that it can signal to T cells. Furthermore, I have shown that avb8 expression is restricted to in ...
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TERMINÉ
The mechanism by which cohesin controls gene expression (COHESIN CONTROL)
Date du début: 1 mai 2012, Date de fin: 30 avr. 2017,
How cells retain, lose, and regain developmental plasticity is poorly understood due to ignorance of the molecular mechanisms regulating gene expression. Each gene is regulated by a unique set of factors and as a consequence the trans-acting factors and cis-acting chromatin modification states regulating a given gene are extremely rare. Transcription is affected by events taking place many thousan ...
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1
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TERMINÉ
Gene Expression Regulation and Cancer (miSWI)
Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,
...cer remains the most predominant cause of premature death in Europe. It constitutes a major public health problem with 1.28 million predicted deaths in the European Union in 2011. Changes in the gene expression patterns are a key feature of cancer cell transformation through an increase in expression of genes that promote carcinogenesis (oncogenes) and/or a decrease in expression of genes that pre ...
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1
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TERMINÉ
Training-Action: The Intercultural Mode of Expression (IMOE)
Date du début: 1 août 2014, Date de fin: 31 mai 2015,
Organised in the training activities of the youth workers professional group "ornais", this action training course is build around cutural expression ways by serve intercultural meating. 23 youth structures are implicated from europe and also meda countries from november 22 to 30 in LA LAcelle , Basse Normandie Orne department (61). Participants are all professional youth workers, in pedagogic rel ...
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