3 projets européens trouvés
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TERMINÉ
Social Participation for improving emotional, mental, and physical wellbeing in independently living older adults (DREAM)
Date du début: 1 févr. 2016, Date de fin: 31 janv. 2019,
The combination of longer life expectancy, evolving socio-economical norms and conditions, and new technologies are dramatically changing life after retirement, and not always for the better. In more and more countries, pensioners find themselves with many years in front of them, some of them likely characterized by reduced physical and cognitive abilities. For older adults, this span of time out ...
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3
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TERMINÉ
Manipulation of senescence pathways for cancer therapy: from experimental models to clinic (PICS therapy)
Date du début: 1 avr. 2011, Date de fin: 31 mars 2016,
This proposal aims to harness a novel type of senescence that we have identified in response to acute Pten inactivation, and which we believe offers a radical therapeutic approach to target the quiescent cancer stem cell in vivo. In characterizing Pten loss Induced Cellular Senescence, which we have named PICS for short, we have discovered that PICS is distinct from other forms of cellular senesce ...
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1
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TERMINÉ
"""PRO –SENESCENCE” THERAPY IN PEDIATRIC BRAIN TUMORS" (Senescence Therapy)
Date du début: 23 févr. 2009, Date de fin: 22 févr. 2013,
The irreversible cell growth arrest, termed cellular senescence, is emerging as an intrinsic tumour suppressive mechanism, which restricts progression of early cancerous lesions in humans. We have recently reported, a new type of cellular senescence, which occurs after the acute inactivation of the tumour suppressor Pten and significantly opposes tumorigenesis in vivo. Pten induced cellular senesc ...
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