"""PRO –SENESCENCE” THERAPY IN PEDIATRIC BRAIN TUMORS"
(Senescence Therapy)
Date du début: 23 févr. 2009,
Date de fin: 22 févr. 2013
PROJET
TERMINÉ
The irreversible cell growth arrest, termed cellular senescence, is emerging as an intrinsic tumour suppressive mechanism, which restricts progression of early cancerous lesions in humans. We have recently reported, a new type of cellular senescence, which occurs after the acute inactivation of the tumour suppressor Pten and significantly opposes tumorigenesis in vivo. Pten induced cellular senescence (PICS) occurs at early time points after Pten inactivation even in absence of cellular proliferation and DNA Damage. I will discuss the mechanism that trigger PICS in cancer, hailing the potential therapeutic implication of p53 stabilizing drugs and Pten inhibitors. Importantly, I will discuss how the oncogenic stress induced by complete loss of Pten can still triggers senescence in cells with low proliferative potential, such as cancer stem cells. I propose to apply this model to the treatment of pediatric brain tumors.
Accédez au prémier réseau pour la cooperation européenne
Se connecter
ou
Créer un compte
Pour accéder à toutes les informations disponibles
Coordinateur
Ente Ospedaliero Cantonale
€ 100 000,00- Gianfranco Bozzini
- Vialle Officina 3 CH-6500 Bellinzona (Switzerland)
Details
- 100% € 100 000,00
-
FP7-PEOPLE
- Projet sur CORDIS platform
1 Participants partenaires
- Vittorio Cirucci
- Via Cassia 600 00189 ROMA (Italy)