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 EN COURS 

A Systems medicine approach to chronic inflammatory disease (SYSCID)

Date du début: 1 janv. 2017, Date de fin: 31 mars 2022,

"The SYSCID consortium aims to develop a systems medicine approach for disease prediction in CID. We will focus on three major CID indications with distinct characteristics, yet a large overlap of their molecular risk map: inflammatory bowel disease, systemic lupus erythematodes and rheumatoid arthritis. We have joined 15 partners from major cohorts and initiatives in Europe (e.g.IHEC, ICGC, Twins ...
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 16

 EN COURS 

Brain-Specific, Modular and Active RNA Therapeutics (B-SMART)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

The overall objective of B-SMART is: 1. to design modular nanoparticles, 2. to manufacture them via a quality-by-design protocol, 3. to achieve delivery of therapeutic RNAs to the brain and treat neurodegenerative diseases. I. To design modular nanoparticles consisting of o an active RNA payloado established (lipid-based), emerging (trigger-responsive polymer-based) or exploratory (extracellular v ...
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 9

 EN COURS 

Linking genetic resources, genomes and phenotypes of Solanaceous crops (G2P-SOL)

Date du début: 1 mars 2016, Date de fin: 28 févr. 2021,

G2P-SOL is a research alliance bringing together the major European and International repositories of germplasm with public and private institutions active in genomics, phenotyping and breeding in the four major Solanaceous crops: potato, tomato, pepper and eggplant. These four crops constitute 66% of the value of European horticultural production, and over 65,000 accessions are available within t ...
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 20

 TERMINÉ 
The world demographic growth and global climate change are major challenges for human society,hence the need to design new strategies for maintaining high crop yield in unprecedented environmental conditions.The objective of TomGEM is to design new strategies aiming to maintain high yields of fruit and vegetables at harsh temperature conditions, using tomato as a reference fleshy fruit crop.As yie ...
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 18

 TERMINÉ 
The main objective of GoodBerry is to provide the necessary knowledge and procedures to facilitate the development of highly productive and top quality berry fruits, even under multiple suboptimal growth conditions, at a competitive cost. The project is based on an integrative multi-actor approach, from cultivation techniques to molecular studies, aiming the development and validation of a range o ...
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 19

 TERMINÉ 

Chimeric Antigen Receptors (CARs) for Advanced Therapies (CARAT)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

Chimeric antigen receptors (CARs) are artificial surface receptors that can be introduced into somatic cells by genetic engineering and that act as recognition molecules like antibodies or T-cell receptors. In this respect, CARs are increasingly used for cellular therapy to redirect T-cells specifically towards killing of cancer cells. Recent success stories of cancer therapy with CAR modified T-c ...
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 9

 TERMINÉ 
The objective of MYOCURE is to develop an innovative gene therapy platform to cure rare hereditary muscle disorders, specifically focusing on myotubular myopathy (MTM) and glycogen storage disorder (GSD) type II. These are attractive diseases for gene therapy since they compromise a diverse family of rare genetic diseases typically caused by single gene defects that often provoke significant morbi ...
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 8

 TERMINÉ 

Systems Medicine of Mitochondrial Parkinson’s Disease (SysMedPD)

Date du début: 1 déc. 2015, Date de fin: 30 nov. 2019,

The overall objective of this project is to identify novel drug candidates capable of slowing down the progression of neurodegeneration in the subset of Parkinson’s disease (PD) patients with overt mitochondrial dysfunction. Multi-modal phenotypic characterisation of cohorts of monogenic PD patients with overt mitochondrial dysfunction will be used as an anchor for the discovery of two extreme coh ...
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 8

 TERMINÉ 

The European IPR Helpdesk (European IPR Helpdesk)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,

"The European IPR Helpdesk, funded under the Horizon 2020 programme, supports at an EU level cross-border SME and research activities to: manage, diffuse and valorise technologies and other Intellectual Property (IP) Rights and IP Assets. It provides support products and services, including: support to candidates and participants in programmes such as Horizon 2020 and COSME on their IP needs, fre ...
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 4

 TERMINÉ 
The aim of CoMMiTMenT is the development of combined imaging technologies based on optofluidic microscopy and scanning ion conductance microscopy. An integrated, completely simultaneous device named µCOSMOS will be used as a proof-of-principle for therapeutic interventions in rare anaemias. Both techniques rely on molecular detection: optofluidic microscopy relies on molecular biomarkers, and scan ...
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 9

 TERMINÉ 
The rise of the system complexity, the rapid changing of consumers demand require the European industry to produce more customized products with a better use of resources.The main objective of IMPROVE is to create a virtual Factory of the Future, which provides services for user support, especially on optimization and monitoring. By monitoring anomalous behaviour will be detected before it leads t ...
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 13

 TERMINÉ 
The overall ambition of MOVE is to provide a research-informed contribution towards an improvement of the conditions of the mobility of young people in Europe and a reduction of the negative impacts of mobility through the identification of ways of good practice thus fostering sustainable development and wellbeing. The consortium of MOVE is built up of nine partners within six countries: Luxembour ...
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 9

 TERMINÉ 
Tomato is the second most consumed vegetable in the EU and a major dietary source of many nutrients, vitamins and antioxidants. Consumers complaints about the loss of flavour in modern tomatoes, provide an opportunity for the valorisation of traditional tomato varieties, in order to protect them from genetic erosion and the replacement by higher-yielding, pest resistant modern cultivars. Genetic, ...
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 16

 TERMINÉ 
The multi-disciplinary CUPESSE project carries out a comparative analysis of both the demand and supply side of youth unemployment in eleven Member States of the EU and Associated Countries (i.e. Austria, Czech Republic, Denmark, Germany, Greece, Hungary, Italy, Spain, Switzerland, Turkey, and the United Kingdom). These ten countries represent the main empirical scope of the project, but whenever ...
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 14

 TERMINÉ 
The main objective of PneumoNP is the development of a theragnostic system for the treatment of lung Gram-negative bacterial infections. As a proof of concept PneumoNP will focus the attention on Klebsiella pneumoniae caused infections. A diagnostic kit will be developed to enable a rapid and precise identification of the bacteria strain causing the infection and avoid the use of wide spectrum a ...
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 11

 TERMINÉ 

Synthetic Cellular Signaling Circuits (SynSignal)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,

Cellular signaling systems are crucially important for a broad range of critical health and disease areas and high value industrial applications. Signaling systems are the target for more than half of the medicines marketed by the pharmaceutical industry, and form the main R&D area for the nutrition, flavour and fragrance industries. SynSignal is a multidisciplinary high-tech consortium working in ...
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 10

 TERMINÉ 
"Plant natural products have been utilised by human civilisation for millennia, providing vital medicines and essential dietary components. More recently bioactive compounds from plant sources have been used in cosmetics, as health supplements and are important components of feedstuffs. Despite significant investments new activities and new sustainable biosources are required to alleviate our reli ...
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 15

 TERMINÉ 
Fit for Health 2.0 aims to promote and enhance a sustainable participation of European industry in the Health-related sector of Horizon 2020 (H2020). Focusing on research-intensive, high technology SMEs the project offers targeted support measures, covering the entire innovation cycle of research projects. Key assets are highly qualified advice and support including a mentoring and coaching approa ...
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 11

 TERMINÉ 
Neuro-immune alterations in the peripheral and central nervous system play a role in the pathophysiology of chronic pain, and non-coding RNAs (ncRNAs) regulate both immune and neuronal processes. Therefore, ncRNAPain proposes that ncRNAs are critically important master switches for chronic pain.ncRNAPain represents a multidisciplinary consortium of clinical partners, molecular and systems-level n ...
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 12

 TERMINÉ 
Developing robust, reproducible, interoperable and collaborative hyper-models of diseases and normal physiology is a sine qua non necessity if rational, coherent and comprehensive exploitation of the invaluable information hidden within human multiscale biological data is envisaged. Responding to this imperative in the context of both the broad Virtual Physiological Human (VPH) initiative and the ...
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 17

 TERMINÉ 

Innovation Management Support for SMEs (Innosupport)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2016,

The general objective of the described actions is to contribute to smart growth in the European Union by increasing the efficiency and effectiveness of investments in research, development and innovation and by contributing to a better and more efficient connection of actors along the innovation chain.To achieve the above mentioned objectives the proposed grant shall:a) Identify bottlenecks to the ...
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 4

 TERMINÉ 
SENSIndoor aims at the development of novel nanotechnology based intelligent sensor systems for selective monitoring of Volatile Organic Compounds (VOC) for demand controlled ventilation in indoor environments. Greatly reduced energy consumption without adverse health effects caused by the Sick Building Syndrome requires optimized ventilation schemes adapted to specific application scenarios like ...
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 10

 TERMINÉ 
Goals: We will carry out a regenerative medicine clinical trial of the therapeutic system OSTEOGROW for regenerating bone through harnessing a novel bone regenerative product to accelerate and enhance bone repair.The osteogenic regenerative product is composed of an autologous carrier and a biologically active recombinant human protein offering a therapeutic solution in bone regeneration superior ...
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 11

 TERMINÉ 

A BLUEPRINT of Haematopoietic Epigenomes (BLUEPRINT)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2016,

In response to the call for a high impact initiative on the human epigenome, the BLUEPRINT Consortium has been formed with the aim of generating at least 100 reference epigenomes and studying them to advance and exploit knowledge of the underlying biological processes and mechanisms in health and disease. BLUEPRINT will focus on distinct types of haematopoietic cells from healthy individuals and o ...
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 45

 TERMINÉ 
The overall strategic objective of MultiBioPro is to exploit natural resources from genetic varieties of two industry-utilized plant species, poplar and the tobacco tree Nicotiana glauca, for direct applicability to novel industrial end products. The consortium will explore already existing poplar and N. glauca genotypes in parallel with innovative state-of-the-art translational research from the ...
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 12

 TERMINÉ 

Next Generation Genome Based High Resolution Tracing of Pathogens (PathoNgen-Trace)

Date du début: 1 janv. 2012, Date de fin: 30 juin 2016,

"Next generation sequencing (NGS) has fundamentally altered genomic research. New developments will bring NGS costs and performance down to an everybody's technology with extreme potential for ultra fast and accurate molecular typing and diagnostic as it provides the ultimate whole genome information. However, technical and bioinformatics constraints, restrict the application of NGS to few highly ...
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 8

 TERMINÉ 
"NOTOX will develop and establish a spectrum of systems biological tools including experimental and computational methods for i) organotypic human cell cultures suitable for long term toxicity testing and ii) the identification and analysis of pathways of toxicological relevance. NOTOX will initially use available human HepaRG and primary liver cells as well as mouse small intestine cultures in 3D ...
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 13

 TERMINÉ 

New Technologies and Production Tools for Complex Protein Biologics (ComplexINC)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,

ComplexINC conceptualizes and systematically generates advanced tool-kits to enable high-throughput assembly of complex biologics and metabolic pathways in eukaryotic expression systems, for micro- to large scale production of high-quality protein specimens for drug discovery and as bio-therapeutics. Essential parts of these tool-kits will be innovative next-generation HT DNA assembly pipelines fo ...
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 8

 TERMINÉ 

Economic iNsTRuments to Achieve Climate Targets in Europe (ENTRACTE)

Date du début: 1 sept. 2012, Date de fin: 30 sept. 2015,

The ENTRACTE research project assesses the EU’s climate policy portfolio. While the EU ETS is key to promote the transition towards a low-carbon economy, ambitious GHG emissions reductions will be reached only if this scheme is improved and supported by complementary policies. A carefully considered policy design has to take into account existing market failures other than the climate externality, ...
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 9

 TERMINÉ 

From data sharing and integration via VPH models to personalised medicine (p-medicine)

Date du début: 1 févr. 2011, Date de fin: 31 juil. 2015,

Medicine is undergoing a revolution that is transforming the nature of healthcare from reactive to preventive. The changes are catalyzed by a new systems approach to disease which focuses on integrated diagnosis, treatment and prevention of disease in individuals. This will replace our current mode of medicine over the coming years with a personalized predictive treatment . While the goal is clea ...
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 19

 TERMINÉ 

Sugar Alcohol based Materials for Seasonal Storage Applications (SAM.SSA)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2015,

The SAM.SSA project aims at developing new phase change materials (PCM) for thermal energy seasonal storage applications (STES) in the range of medium temperatures. The generated materials shall provide:• Low cost, environmentally sound and safe solutions for seasonal storage applications• Easy adjustment of the melting point for optimal ”tuning” to the required applications• Energy densities > 20 ...
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 9

 TERMINÉ 
Major objective: It is our aim to develop a lipid based diet that is able to delay or prevent onset of Alzheimer’s disease and related diseases and has a stabilizing effect on cognitive performance in aging. Multiple lines of evidence suggest that there is a large overlap between risk factor of these three diseases. Importantly, there is equally strong evidence that prevention and treatment of the ...
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 19

 TERMINÉ 

Innovation Management Support for SMEs (Innosupport)

Date du début: 1 juil. 2014, Date de fin: 31 déc. 2014,

The general objective of the described actions is to contribute to smart growth in the European Union by increasing the efficiency and effectiveness of investments in research, development and innovation and by contributing to a better and more efficient connection of actors along the innovation chain.To achieve the above mentioned objectives the proposed grant shall: a) Identify bottlenecks to th ...
Voir le projet

 2

 TERMINÉ 
"The ARISTOTEL project challenge is ensuring aircraft safety and aims to reduce the aircraft and rotorcraft accidents caused by a particularly unfavourable category of phenomena: aircraft-pilot-couplings and rotorcraft-pilot-couplings (A/RPCs). Generally, A/RPCs are defined as “inadvertent, sustained aircraft oscillations which are a consequence of an abnormal joint enterprise between the aircraft ...
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 10

 TERMINÉ 
"INTRODUCTION. RAMSES comprises partner institutions from Germany (FMC), Romania (ICBP) and Egypt (CU) in order to promote closer S&T cooperation opportunities between Europe and Egypt. The concept of RAMSES is to build capacities by improving scientific relationships, networking and development of the S&T Human Potential, exchanging of know-how and experience between the participating partners, a ...
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 4

 TERMINÉ 
Buruli ulcer disease (BUD), caused by Mycobacterium ulcerans, is a neglected bacterial infection of the poor in remote rural areas, mostly affecting children. BUD, the third most common mycobacterial disease in immunocompetent humans after tuberculosis and leprosy, is most endemic in West Africa, but cases have been reported from more than 30 countries. BUD is a mutilating disease leading to sever ...
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 16

 TERMINÉ 
"The majority of compounds used to treat diseases come from a single group of organisms, the actinomycetes. This over-reliance on a single organism to produce the worlds drugs is a major problem for the development of compounds with alternative modes of action which can overcome and delay the onset of drug resistance. To address this problem we will form an international multi-disciplinary group o ...
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 6

 TERMINÉ 
Astroglial cells are now recognized as active elements in the brain that sense and integrate synaptic signals and, by releasing gliotransmitters, regulate synaptic efficacy and cerebral blood flow. Despite accrued knowledge, many fundamental aspects of neuron-astroglia partnerships remain open, or have been poorly addressed in a functional context in vivo. For example, does astroglia heterogeneity ...
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 8

 TERMINÉ 

European network for global cooperation in the field of AIDS & TB (EUCO-Net)

Date du début: 1 nov. 2008, Date de fin: 30 avr. 2010,

Background Tuberculosis and HIV/AIDS are on the rise worldwide, representing a global public health problem with considerable mutual interaction: TB is the leading cause of mortality for people living with HIV/AIDS, and HIV is the most potent force driving the TB epidemic in countries with a high prevalence of HIV . Especially in rural areas of Africa, Latin America, India and Russia both diseases ...
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 14

 TERMINÉ 
To meet growing demand for high-level professional translation, especially in candidate countries, the Master in Translation project will develop and test the first European master programme in translation, collaborating with social partners in the industry. The project further expects to serve as an example of good practice in developing a European joint degree. Alongside the creation of a traini ...
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 20