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 TERMINÉ 

Cell-Cell fusion in fertilization and developmental biology: a structural biology approach (Celcelfus)

Date du début: 1 mars 2014, Date de fin: 28 févr. 2019,

My group has made seminal contributions in the past toward understanding the mechanism of membrane fusion used by enveloped viruses to infect a cell. This aim of this ERC grant proposal is to achieve similar breakthroughs in understanding fusion between cells, both during fertilization and organogenesis. This proposal is based in recent important results not yet published.We have determined the cr ...
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 1

 TERMINÉ 

Tree growth, forest carbon storage and climate change in a Canadian boreal region using a model-data fusion approach (MAIDEN-SPRUCE)

Date du début: 1 oct. 2015, Date de fin: 30 sept. 2017,

The boreal forest is one of the most important global carbon sinks but its carbon fluxes and total amount of sequestered carbon depend on the regional climate variability. Because of this sensitivity to climate, boreal trees are also important natural archives of current and past climate change. During this project, we will use a data-model approach to improve our understanding of the links betwee ...
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 1

 TERMINÉ 

Lung cancEr fusiOn geNes: a new dIagnostic Device (LEONID)

Date du début: 1 juil. 2015, Date de fin: 31 déc. 2016,

The main scope of LEONID project is the development and validation of the clinical performance of a new diagnostic Nanostring-based device against existing standards (FISH and IHC) for the detection of in vitro biomarkers with predictive power of response to tyrosin kinase inhibitors used for lung cancer treatment. The device will be the first CE-IVD kit that detects all ALK, ROS1 and RET rearrang ...
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 3

 TERMINÉ 

Controlled fusion of liposomes and cells: a new pathway for direct drug delivery (DirectDelivery)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2014,

Inspired by the natural membrane fusion machinery, the aim of this research line is to design a synthetic analogue in order to: 1) Understand the process of the peptide-controlled fusion of two membranes at the atomic, molecular and mesoscopic level. 2) Developing a new generic method for the controlled delivery of any (bio)molecule directly into the cytoplasm of a cell thereby omitting endocytoti ...
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 1

 TERMINÉ 

Cultural Fusion: Finding a common language

Date du début: 1 août 2012,

Cultural Fusion is an arts & culture youth exchange that will take place in Georgia. The YE will last for 8 days. 32 participants and 2-4 group leaders will come together from 2 EU countries and 2 Partner countries in the Caucasus.The project aims to create an environment where participants move beyond the cultural / national boundaries which divide them while finding new ways of interacting and c ...
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 4

 TERMINÉ 

Cognitive distortions in eating disorders: Development and application of a model for thought-shape fusion (Thought-Shape Fusion)

Date du début: 25 mai 2010, Date de fin: 24 oct. 2011,

Cognitive distortions are characterized by faulty, irrational thought processes, and are characteristic of psychopathology. Within the past decade, new research has emerged that suggests that there is a specific cognitive distortion associated with eating disorders. This distortion has been identified as ‘thought-shape fusion’ (TSF), and is associated with the belief that just thinking about eatin ...
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 1

 TERMINÉ 

Organelle homeostasis: How are membrane fission and fusion machineries coordinated to regulate size and copy number of a lysosomal compartment? (ORGANELL)

Date du début: 1 sept. 2009, Date de fin: 31 août 2015,

Yeast vacuoles (lysosomes) will serve as an excellent model system: Vacuoles change copy number and size in the cell cycle and upon shifts of media; due to their large diameter (up to 5 µm) these changes can be assayed by fluorescence microscopy and are amenable to genetic screening. Moreover, an in vitro system for vacuole fusion exists and we recently succeeded in reconstituting also cell-free v ...
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 1

 TERMINÉ 

Implementation of activities described in the Roadmap to Fusion during Horizon 2020 through a Joint programme of the members of the EUROfusion consortium (EUROfusion)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,

A Roadmap to the realization of fusion energy was adopted by the EFDA system at the end of 2012. The roadmap aims at achieving all the necessary know-how to start the construction of a demonstration power plant (DEMO) by 2030, in order to reach the goal of fusion electricity in the grid by 2050. The roadmap has been articulated in eight different Missions. The present proposal has the goal of impl ...
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 31

 TERMINÉ 

Fusion Youth!

Date du début: 20 juin 2014, Date de fin: 19 déc. 2014,

Fusion Youth! is a Multilateral Youth Exchange to perform in Guadarrama , Madrid, from 19 to 28 September 2014 , in which 40 young people from four countries in the euro area (Spain , Italy , Romania, Croatia and Estonia ), aged between 18 and 25 years work for ten days with the issue of unemployment , creativity and entrepreneurship as background activities . These issues will be worked through d ...
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 5

 TERMINÉ 

Unveiling the physics of cellular processes: new approaches to study macromolecules at work (MacromoleculesAtWork)

Date du début: 1 oct. 2008, Date de fin: 30 sept. 2010,

The objective of this proposal is to combine different computational methods to study the physics of specific cellular components and processes which involve biological macromolecules. We will especially concentrate on the study of polyelectrolye DNA chains and analogous biopolymers and will investigate on their interaction with cellular structures and on the mechanisms of modifications of their p ...
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 1

 TERMINÉ 

Advanced Networking for Nuclear Education and Training and Transfer of Expertise (ANNETTE)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

The present situation of nuclear energy in Europe asks for a continuing effort in the field of Education and Training aimed to assure a qualified workforce in the next decades. In this scenario, the present proposal is aimed at enhancing and networking the Europe-wide efforts initiated in the past decades by different organisations belonging to academia, research centres and industry to maintain a ...
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 25

 TERMINÉ 

Multi-Modal Situation Assessment & Analytics Platform (MOSAIC)

Date du début: 1 avr. 2011, Date de fin: 31 juil. 2014,

"MOSAIC Platform will involve multi-modal data intelligence capture and analytics including video and text collaterals etc. The distributed intelligence within the platform enables decision support for automated detection, recognition, geo-location and mapping, including intelligent decision support at various levels to enhance situation awareness, surveillance targeting and camera handover; these ...
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 9

 TERMINÉ 

Recovery of dredged SEDIments of the PORT of Ravenna and SILicon extraction (SEDI.PORT.SIL)

Date du début: 1 sept. 2010, Date de fin: 28 févr. 2013,

Background Many European ports and harbours have a tendency to silt up over time in the face of natural environmental factors. Port authorities often have to remove deposited materials to maintain the needed depths in harbour channels and basins to meet the requirements of shipping and tourism. These materials then have to be disposed of appropriately. T ...
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 8

 TERMINÉ 

Sichtbar werden: Jugend und öffentlicher Raum - Kreative Raumstrategien als innovative Werkzeuge in der Jugendarbeit. Trainingskurs für kreativ-künstlerisch arbeitende Menschen, die in der Jugendarbeit tätig sind.

Date du début: 1 août 2014, Date de fin: 31 déc. 2014,

Attaining Visibility! Youth and public space – Creative space strategies as innovative tools in youthwork The project responds to the need of young people to attain visibility in public space and, by this means, to increase their influence and impact in the formation of public opinion and in the sphere of the political discourse. Young people and youth workers from different programme and partner ...
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 11

 TERMINÉ 

Pico-second Silicon photomultiplier-Electronics- & Crystal research-Marie-Curie-Network (PicoSEC-MCNet)

Date du début: 1 déc. 2011, Date de fin: 30 nov. 2015,

We propose to establish a special detector-training network aiming to extend the application of cutting-edge technologies developed in High Energy Physics (HEP) to other domains, such as medical imaging. A large number of detector techniques, developed for and used in particle physics experiments, has been transferred successfully to other fields. Most prominent are their applications in medicine, ...
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 11

 TERMINÉ 

Five Challenges in Computational Anatomy (FCCA)

Date du début: 1 mai 2011, Date de fin: 30 avr. 2017,

New medical imaging technologies encode human anatomy in a wide variety of data structures. Computational Anatomy (CA) offers an approach to synthesize this plethora of data by comparison of anatomical features using smooth invertible transformations specific to the data structure.This proposal is for work to develop new mathematical and numerical methods for image analysis in the framework of CA, ...
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 2

 TERMINÉ 

Manipulation of topological phases with cold atoms (TopoCold)

Date du début: 1 févr. 2017, Date de fin: 31 janv. 2022,

Topological states of matter constitute one of the hottest disciplines in quantum physics, demonstrating a remarkable fusion between elegant mathematical theories and technological applications. However, solid-state experiments only provide a limited set of physical systems and probes that can reveal non-trivial topological order. It is thus appealing to seek for alternative setups exhibiting topo ...
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 1

 TERMINÉ 

PERICA

Date du début: 1 juin 2014, Date de fin: 31 mai 2015,

The EPLEFPA Perigord led European projects for over 10 years with the aim to develop and strengthen the chances of further study and on the labor market of its students mainly from disadvantaged areas and economically, socially and culturally. He now aim to continue the actions directed mainly towards technical training and expand its activities to general education . To achieve the institution mu ...
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 3

 TERMINÉ 

ENgineering COMPASS (ENCOMPASS)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2019,

The ENCOMPASS project principally aims to create a fully digital integrated design decision support (IDDS) system to cover the whole manufacturing chain for a laser powder bed fusion (L-PBF) process encompassing all individual processes within in. The ENCOMPASS concept takes a comprehensive view of the L-PBF process chain through synergising and optimising the key stages. The integration at digita ...
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 11

 TERMINÉ 

Combined application of targeted therapy and immunotherapy in chronic myeloid leukaemia (immunotherapy in CML)

Chronic myeloid leukaemia (CML) is a disease of the haemopoietic stem cell, arising from a translocation t(9;22)(q34;q11). This translocation gives rise to a Philadelphia chromosome together with a BCR-ABL fusion gene that codes for a fusion protein with greatly enhanced tyrosine kinase activity. CML is a paradigm for the use of immunotherapy as well as being a model disease for the use of molecul ...
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 2

 TERMINÉ 

Presynaptic Regulatory Principles in Synaptic Plasticity, Neuronal Network Function, and Behaviour (SYNPRIME)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

Neuronal signalling via synaptic vesicle (SV) fusion is the fastest membrane fusion event in mammalian cells. Its speed and the ability of presynapses to sustain SV fusion at high stimulation rates are key requirements for brain function. Plastic changes of SV fusion rates have long been thought to control complex brain processes such as working memory, but the link between presynaptic plasticity ...
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 1

 TERMINÉ 

DYNAMICAL SYSTEMS AND THEIR APPLICATIONS (DynSysApll)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

The main objective of this project is to create fundamental understanding in dynamical systems theory and to apply this theory in formulating and analyzing real world models met especially in Neuroscience, Plasma Physics and Medicine. The specific objectives, tasks and methodology of this proposal are contained in the 5 WPs of the project. In WP1 we want to develop new methods for the center and i ...
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 10

 TERMINÉ 

European High Power Laser Energy Research Facility (Preparatory Phase Study) (HIPER)

Date du début: 28 avr. 2008, Date de fin: 27 avr. 2013,

HiPER is a multi-national laser facility designed to allow Europe to take a leading position in the pursuit of Inertial Fusion Energy, whilst offering an internationally unique capability for science in extreme conditions. It will open up entirely new areas of research, providing access to physics regimes which cannot be explored on any other science facility. It has been formally endorsed by 6 Eu ...
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 20

 TERMINÉ 

BackPlayers

Date du début: 1 sept. 2015, Date de fin: 31 mai 2016,

The "BackPlayers" project born with the idea to use the language of the game and the charm of the journey as suitable tools to spread awareness among the youth around good practice to intervene actively in society. Objective of the project is to increase the sensitivity on the issue of sustainability, and equip young participants with the tools to disseminate in their territory the project's resul ...
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 3

 TERMINÉ 

Nature inspired energy generation system for urban distributed power (Windtree)

Date du début: 1 nov. 2016, Date de fin: 28 févr. 2017,

NewWind R&D is a company, created in 2011 by engineers and designers, specialised in energy harvesting technologies for distributed power generation from a natural biomimetic approach.By 2040 energy demand worldwide will grow by 37%. 1.6 billion of new consumers will need electricity, 70% of whom will live in cities compared to the current 50%. These consumers rely on energy prices and security s ...
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 1

 TERMINÉ 

Regulation of Macroautophagy by viral Pathogens (Fluphagy)

Date du début: 1 mars 2014, Date de fin: 28 févr. 2017,

Influenza infections kill around 300.000 people each year. Due to its ability to reassort with viruses from other animal species and its mutational drift, society is in great need of novel vaccination strategies. Autophagy is involved in the delivery and processing of antigens derived from different viruses. Influenza and other viruses often target this important mechanism to evade immune recognit ...
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 1

 TERMINÉ 

High-throughput Production of FunctIonal 3D images of the brain (HIGH PROFILE)

Date du début: 1 avr. 2011, Date de fin: 30 juin 2014,

"HIGH PROFILE combines industrial and clinical driven R&D activities dealing with image diagnostic platforms for the central nervous system. The project’s approach is to progress state-of-the-art by integrating imaging equipment for diagnostics –including algorithms, equipment and infrastructure for massive image processing and simulation– to support combinations of images from different medical e ...
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 20

 TERMINÉ 

Global and local star formation with state-of-the-art physics (AdvancedStarForm)

Date du début: 1 sept. 2015, Date de fin: 31 août 2017,

New stars form within large turbulent complexes harboring several thousands of solar masses of cold gas: the molecular clouds. The diffuse gas collapses gravitationally and heats up via compression until nuclear fusion reactions ignite and the star comes to life. The full description involves an intricate interplay between large-scale environmental factors and small-scale processes close to the st ...
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 1

 TERMINÉ 

Collaborative, Complex and Critical Decision-Support in Evolving Crises (TRIDEC)

Date du début: 1 sept. 2010, Date de fin: 31 oct. 2013,

Description TRIDEC focuses on new technologies for real-time intelligent information management in collaborative, complex critical decision processes in earth management. Key challenge is the construction of a communication infrastructure of interoperable services through which intelligent management of dynamically increasing volumes and dim ...
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 11

 TERMINÉ 

Building body representations: An investigation of the formation and maintenance of body representations (BODYBUILDING)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

"The body is ubiquitous in perceptual experience and is central to our sense of self and personal identity. Disordered body representations are central to several serious psychiatric and neurological disorders. Thus, identifying factors which contribute to the formation and maintenance of body representations is crucial for understanding how body representation goes awry in disease, and how it mig ...
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 2

 TERMINÉ 

Solar Sailing for Space Situational Awareness In the Lunar System (S4ILS)

Date du début: 8 août 2015, Date de fin: 7 févr. 2018,

Solar Sailing for Space Situational Awareness In the Lunar System (S4ILS) will deliver radically new orbits in space by exploiting the potential of solar sailing, an exciting new type of spacecraft propulsion. As a flight-proven technology, a solar sail spacecraft rides on sunlight the way that sailboats ride on the wind. Its renewable attribute makes solar sailing a truly mission enabling technol ...
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 1

 TERMINÉ 

Enabling Grids for E-sciencE III (EGEE-III)

Date du début: 1 mai 2008, Date de fin: 30 avr. 2010,

A globally distributed computing Grid now plays an essential role for large-scale, data intensive science in many fields of research. The concept has been proven viable through the Enabling Grids for E-sciencE project (EGEE and EGEE-II, 2004-2008) and its related projects. EGEE-II is consolidating the operations and middleware of this Grid for use by a wide range of scientific communities, such as ...
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 167

 TERMINÉ 

Mitochondrial deficiency and cardiomyopathy. Role of Reactive Oxygen Species (ROLROS)

Date du début: 2 avr. 2012, Date de fin: 1 avr. 2016,

"Mitochondrial diseases are now considered to be among the most common forms of genetic disorders, with a minimum prevalence of 1 in 5000 individuals. They can be caused by mutations in either the nuclear or the mitochondrial DNA (mtDNA). One of the most well characterized clinical presentations is neuromuscular dysfunction, followed by cardiomyopathy, generally in the form of hypertrophic cardiom ...
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 1

 TERMINÉ 

Advanced imaging and measurement for multiphase flow (AIMMF)

Date du début: 14 sept. 2009, Date de fin: 13 sept. 2010,

The principal aim of the research is to develop a new generation of a non-invasive flow instrument for the measurement of flowrates and imaging of the internal structure of complex, unsteady two- or three-phase flows. The research is multi disciplinary covering the aspects of flow mechanics and metering, process tomography, signal processing and multi-variable data fusion. The instrument, based on ...
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 1

 TERMINÉ 

Future Service Oriented Networks (FUSION)

Date du début: 1 janv. 2013, Date de fin: 30 juin 2016,

The Future Service Oriented Networks (FUSION) project will develop a new networking architecture designed to natively support efficient provisioning, discovery and execution of service components distributed over the network. Today's cloud computing architectures are centralised and network-agnostic. This makes them unfit for geographically distributed services with tight QoS-constraints and high ...
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 5

 TERMINÉ 

Fusing Far-Infrared and Near-Infrared Imaging for Pedestrian Injury Mitigation (FNIR)

Date du début: 1 janv. 2008, Date de fin: 31 oct. 2010,

Road accidents involving pedestrians are far more frequent at night than during the day. More than 12 000 pedestrians and cyclists are killed and almost 300 000 are seriously injured in the EU every year. The most important factor is the driver's dramatically reduced range of vision. Fewer pedestrians will be killed or seriously injured through improved driver warning strategies enabled by Night V ...
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 8

 TERMINÉ 

Computational Methods for Fusion Technology (COMFUS)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2015,

The simulation of multidisciplinary applications use very often a combination of heterogeneous and disjoint numerical techniques that are hard to put together by the user, and whose mathematical foundation is obscure. An example of this situation is the numerical modeling of the physical processes taking place in nuclear fusion reactors. This problem, which can be modeled by a set of partial diffe ...
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 1

 TERMINÉ 

European Control System Security Incident Analysis Network (ECOSSIAN)

Date du début: 1 juin 2014, Date de fin: 31 mai 2017,

The protection of critical infrastructures increasingly demands solutions which support incident detection and management at the levels of individual CI, across CIs which are depending on each other, and across borders. An approach is required which really integrates functionalities across all these levels. Cooperation of privately operated CIs and public bodies (governments and EU) is difficult b ...
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 22

 TERMINÉ 

Genome-wide identification of factors controlling the telomere damage response and telomere-driven genomic instability (Telomeres)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2017,

Telomeres are specialized nucleoprotein complexes that protect chromosome ends against recognition as DNA breaks. In somatic cells telomeres shorten every cell division, eventually compromising telomere function. This leads to activation of a DNA damage response that induces irreversible growth arrest or cell death and serves to suppress tumorigenesis by preventing outgrowth of incipient cancer ce ...
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 1

 TERMINÉ 

"Neural coding, specification, design and test of message passing neural machines" (NEUCOD)

Date du début: 1 févr. 2012, Date de fin: 31 janv. 2017,

"The way information is represented, stored, recalled and processed in the neocortex is assuredly one of the most puzzling enigmas that science will have to solve during this century. Setting the basic principles of the Mental Information Theory is a high challenge potentially opening huge fields of research and progress in various domains.This research project is at the crossroads of neuroscience ...
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 1