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39 projets européens trouvés

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 TERMINÉ 

European Initiative for basic research in Microbiology and Infectious Diseases - IAPP (EIMID-IAPP)

Date du début: 1 déc. 2008, Date de fin: 30 nov. 2012,

"The EIMID-IAPP training programme is part of the European Initiative for Basic Research in Microbiology and Infectious Diseases (EIMID), created in 2003 by scientists of five European centres of excellence (the Max Planck Institute for Infection Biology in Berlin, the CMMI at Imperial College in London, the Institut Pasteur in Paris, the Karolinska Institutet in Stockholm; and the vaccine company...
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 7

 TERMINÉ 

Transcriptional mutagenesis in mammalian cell systems: p53 signaling as a probe of cellular effects (TMP53COMPMIX)

Date du début: 1 mai 2010, Date de fin: 30 avr. 2014,

"The process of misincorporation of incorrect bases into the nascent RNA as a result of DNA-lesion bypass by RNA polymerases during transcription is referred to as transcriptional mutagenesis (TM). Although this has been shown to alter the subsequent proteins function, the relative importance of TM in human health is virtually untouched. I propose to study the cellular effects and biological signi...
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 1

 TERMINÉ 

Alterations in Memory Networks in Mild Cognitive Impairment and Alzheimer’s disease: Relating the Impact of Amyloid Burden with PIB-PET on Neuronal Activation as Assessed with fMRI (MCI_AD PIB-PET_fMRI)

Date du début: 1 août 2009, Date de fin: 31 mai 2014,

The main objective of this first 2-year period as a post-doctoral research fellow at BWH/MGH Harvard Medical School is to get training in novel Magnetic Resonance Imaging (MRI) and Pittsburgh Compound B–Positron Emission Tomography (PIB-PET) techniques, their analysis methods, and applications to aging and age-related neurodegenerative diseases. The final purpose is to advance the candidate’s prof...
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 1

 TERMINÉ 

The biological clock and cancer (CANCERTIME)

Date du début: 1 févr. 2011, Date de fin: 31 janv. 2014,

"The circadian clock generates and regulates many daily physiological and behavioural rhythms and thereby also influences the health of the organism. This knowledge has been useful for treating various diseases including cancer. In cancer therapy, survival rate and secondary effects can be improved by applying the treatment at the right time of day. However, the mechanisms by which the clock influ...
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 1

 TERMINÉ 

Communication of Food, Fisheries, Agriculture and Biotechnologies research – a network to support EU-funded research projects (CommFABnet)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2014,

The effective communication of research results of EC funded research projects to end users is hampered by a number of factors including• Lack of confidence and communication skills within the scientific community• Inherent difficulties in effectively reaching out to the media and other multipliers with research resultsPoor dissemination of research results significantly reduces the potential proj...
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 5

 TERMINÉ 

Human iPS cell therapy for spinal cord injury (human iPS in SCI)

Date du début: 3 oct. 2011, Date de fin: 2 oct. 2013,

Human iPS cell therapy for Spinal Cord Injury with Acronym: “Human iPS in SCI”Our overall aim is to develop a clinically safe and effective neural cell therapy, combining novel biomaterials and human neural progenitor cells, to improve functional outcome after spinal cord injury (SCI). We have the unique possibility to compare neuro-rescue potentials of human induced pluripotent stem (iPS) cells a...
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 1

 TERMINÉ 

Asian Regional Capacity Development for Research on Social Determinants of Health (ARCADE RSDH)

Date du début: 1 déc. 2011, Date de fin: 30 nov. 2015,

"This project will add new research training capacity at low and middle-income countries (LMICs) in Asia, for promoting research on social determinants of health (RSDH). The focus is doctoral and post doctoral training, institutional strengthening for education, financial and administrative research management, and LMICs-based network building. Novel capacity building approaches will reduce brain ...
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 14

 TERMINÉ 

Unrestricted Leveraging of Targets for Research Advancement and Drug Discovery (ULTRA-DD)

Date du début: 1 mars 2015, Date de fin: 29 févr. 2020,

ULTRA-DD (Unrestricted Leveraging of Targets for Research Advancement and Drug Discovery) will be an European-wide, highly collaborative and inclusive consortium, to validate new targets for drug discovery by (1) generating high quality research tools, with an emphasis on chemical probes; (2) generating the chemical probes in the most cost-effective manner, using structure-guided methods and harne...
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 10

 TERMINÉ 

Advanced Regional Translation of Excellence into Medical Innovations for Delayed Aging (ARTEMIDA)

Date du début: 1 juin 2015, Date de fin: 31 mai 2016,

Our vision is to become by 2020 a Central and South-East European (CSEE) Centre of Excellence for Translational Medicine (CETM), coordinated by the Faculty of Medicine, University of Ljubljana that will harness, develop, exploit and market the significant potential for research and innovation in the region. The vision of CETM is to form the hub of an alliance of biomedical and health-related resea...
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 3

 TERMINÉ 

DNA Origami for drug delivery (VECTORIGAMI)

Date du début: 1 juin 2015, Date de fin: 31 mai 2017,

The main objective of this project is to produce innovative DNA self-assembled nanostructures with the goal of evolving new approaches for drug delivery. The properties of the DNA nanostructures will be tuned by introducing new elements into the nanostructures improving their versatility and structural integrity. This project will aim to:• build and characterise DNA nanostructures using long oligo...
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 1

 TERMINÉ 

Validation of a conceptually new treatment for glioblastoma multiforme with an IP protected small molecule (GlioVac)

Date du début: 1 mars 2015, Date de fin: 31 août 2016,

Glioblastoma multiforme (GBM) is the most aggressive form of brain cancer with marginal life expectancy even with the most aggressive available therapy. We have identified a previously unanticipated vulnerability of GSCs which when targeted, leads to a rapid and complete cell death of all tumor cells isolated from nine different patients diagnosed with GBM. The cellular mechanism has been identifi...
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 1

 TERMINÉ 

Boost Brittle Bones Before Birth (BOOSTB4)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Osteogenesis imperfecta (OI) is, in its severe forms, a devastating inherited disorder characterised by brittle bones. A person with severe OI is affected throughout their lifetime with repeated, multiple fractures, considerable pain and handicap. There is no curative or effective treatment for OI. Our preclinical studies and initial clinical cases have demonstrated that transplantation of fetal m...
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 13

 TERMINÉ 

TWINNING ON DNA-BASED CANCER VACCINES (VACTRAIN)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2018,

The objective of this Twinning project is to significantly strengthen the research in Riga Stradins University (RSU; Latvia) in the smart specialization area of Latvia “bio-medicine, medical technologies, and biotechnologies” with application to immunotherapy of cancer through building an up-rising connections with two internationally leading research institutions, Institute of Microbiology, Tumor...
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 4

 TERMINÉ 

Self and others in the sensorimotor system: a computational neuroanatomy of sensory attenuation (TICKLE ME)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2018,

Why can’t you tickle yourself? Previous behavioural and neuroimaging evidence suggests that when we move one hand to touch the other, the resulting tactile sensation is perceived as less intense compared to identical touches of external origin. This sensory attenuation (SA) phenomenon is hypothesized to arise because our brains use internal information about the motor command (efference copy) to p...
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 1

 TERMINÉ 

Higher education student and staff mobility project

Date du début: 1 juin 2014, Date de fin: 31 mai 2016,

In the Karolinska Institutet (KI) institutional strategy (Strategy 2020), our Erasmus Policy Statement and our Action Plan for Internationalisation of First Cycle and Second Cycle Education 2014-2017, the importance of internationalisation is stressed. The overall aim of KI is to improve people's health through research and education. Internationalisation, i e all activities bringing an internatio...
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 1

 TERMINÉ 

Crimean-Congo Haemorrhagic Fever Vaccine (CCHFVaccine)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2022,

Natural epidemics and outbreaks of emerging viral epidemics are growing problems internationally. The general aim of the CCHFVaccine project is to develop and deliver a vaccine, which can significantly increase our capacity to control the situation of Crimean Congo Haemorrhagic fever (CCHF) disease on a global basis. The proposed work program on CCHF virus aims to build a multidisciplinary researc...
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 15

 TERMINÉ 

Illuminating GENome Organization through integrated MIcroscopy and Sequencing (GENOMIS)

Date du début: 1 janv. 2018, Date de fin: 31 déc. 2022,

In human cells, two meters of DNA sequence are compressed into a nucleus whose linear size is five orders of magnitude smaller. Deciphering how this amazing structural organization is achieved and how DNA functions can ensue in the environment of a cell’s nucleus represent central questions for contemporary biology.Here, I embrace this challenge by establishing a comprehensive framework of microsc...
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 1

 TERMINÉ 

Chromatin dynamics resolved by rapid protein labeling and bioorthogonal capture (RAPID)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Histone proteins provide a dynamic packaging system for the eukaryotic genome. Chromatin integrates a multitude of signals to control gene expression, only some of which have the propensity to be maintained through replication and cell division. For our understanding of cellular memory and epigenetic inheritance we need to know what features characterize a stable, heritable chromatin state through...
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 1

 TERMINÉ 

European Sudden Cardiac Arrest network: towards Prevention, Education and NEw Treatment (ESCAPE-NET)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

Sudden cardiac arrest (SCA) causes ~20% of all deaths in Europe. SCA is lethal within minutes if left untreated and survival rates are presently only 5-20%. Therefore, there is a large medical need to improve SCA prevention and treatment. Designing effective individualized prevention and treatment strategies requires knowledge on genetic and environmental risk factors. So far, these efforts have b...
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 17

 TERMINÉ 

Multiple manifestations of genetic and non-genetic factors in Multiple Sclerosis disentangled with a multi-omics approach to accelerate personalised medicine (MultipleMS)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

The complex interactions between genetic and non-genetic factors produce heterogeneities in patients as reflected in the diversity of pathophysiology, clinical manifestations, response to therapies, disease development and progression. Yet, the full potential of personalized medicine entails biomarker-guided delivery of efficient therapies in stratified patient populations.MultipleMS will therefor...
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 25

 TERMINÉ 

An Integrated European ‘Flagship’ Program Driving Mechanism-based Toxicity Testing and Risk Assessment for the 21st Century (EU-ToxRisk)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2021,

The vision of EU-ToxRisk is to drive a paradigm shift in toxicology towards an animal-free, mechanism-based integrated approach to chemical safety assessment. The project will unite all relevant disciplines and stakeholders to establish: i) pragmatic, solid read-across procedures incorporating mechanistic and toxicokinetic knowledge; and ii) ab initio hazard and risk assessment strategies of chemi...
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 43

 TERMINÉ 

Exploration and promotion of neurogenesis in the adult brain (Neurogenesis)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,

It is now well established that new neurons are added to certain regions of the adult brain. There is today considerable interest in the development of regenerative therapies based on modulating endogenous neurogenesis, but it is necessary to better understand these events to assess whether this is rational and realistic. This application takes its initiation in two recent discoveries that we have...
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 1

 TERMINÉ 

Children and Adolescents with PaRental mental Illness: Understanding the ‘who’ and ‘how’ of targeting interventions (CAPRI)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2021,

At least 10% of mothers and 5% of fathers have a mental illness. Family, educational and social lives of children and adolescents with parental mental illness (CAPRI) are disrupted by deprivation and repeated hospitalisation. This is an urgent political and public health concern. The Child and Adolescent Mental Health in Europe (CAMHEE) report urges us ‘to acknowledge and attend to the needs of ch...
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 2

 TERMINÉ 

Reversing the epigenetic state of oligodendrocyte precursors cells in multiple sclerosis (EPIScOPE)

Date du début: 1 sept. 2016, Date de fin: 31 août 2021,

Oligodendrocytes (OL) are glial cells that mediate myelination of neurons, a process that is defective in multiple sclerosis (MS). Although OL precursor cells (OPCs) can initially promote remyelination in MS, this regenerative mechanism eventually fails in progressive MS. OPCs go through several epigenetic states that ultimately define their potential to differentiate and myelinate. OPCs in progre...
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 1

 TERMINÉ 

Restoration of tumor suppressor function by induction of translational read-through of premature termination codons - a strategy for improved cancer therapy (TRANSREAD)

Date du début: 1 sept. 2016, Date de fin: 31 août 2021,

Tumor suppressor genes such as TP53, RB1, PTEN and APC are frequently inactivated in sporadic and inherited human tumors. A significant fraction of the mutations in these genes are nonsense mutations that lead to premature termination of translation and expression of truncated unstable and non-functional proteins. We will identify and characterize novel molecules that can induce translational read...
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 1

 TERMINÉ 

Functional connectome of brainstem circuits that control locomotion (LocomotorIntegration)

Date du début: 1 août 2016, Date de fin: 31 juil. 2021,

Locomotion is a complex motor act that is used in many daily life activities and is the output measures of a plethora of brain behaviors. The planning and initiation of locomotion take place in the brain and brainstem, while the execution is accomplished by activity in neuronal networks in the spinal cord itself. Recent experiments have provided significant insight to the organization of the execu...
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 1

 TERMINÉ 

Targeting oxidative repair proteins for treatment of cancer and inflammation (TAROX)

Date du début: 1 août 2016, Date de fin: 31 juil. 2021,

Oxidative damage and defects in DNA repair are frequently underlying many diseases, e.g., cancer, autoimmune diseases, ischemia/reperfusion injury, neurodegenerative disorders, viral diseases and ageing. Although some molecular understanding into oxidative DNA lesions and repair proteins exist, a thorough understanding on the link to diseases is largely missing, and therapies exploiting oxidative ...
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 1

 TERMINÉ 

Understanding microbe-induced stomach cancer – the key to a workable strategy for worldwide prevention (PreventStoCan)

Date du début: 1 juil. 2016, Date de fin: 30 juin 2021,

Stomach cancer is the 4th most common cancer and 2nd leading cause of cancer-related death worldwide. The aim of this proposal is to deepen the understanding of mechanisms involved in microbe-induced gastric carcinogenesis, which will facilitate risk stratification for identification of high-risk groups and may offer new opportunities for pharmacological and probiotic prevention. We hypothesize th...
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 1

 TERMINÉ 

Shaping of the Human Immune System by Primal Environmental Exposures In the Newborn Child (Born-Immune)

Date du début: 1 juil. 2016, Date de fin: 30 juin 2021,

Immune systems are highly variable, but the sources of this variation are poorly understood. Genetic variation only explains a minor fraction of this, and we are unable to accurately predict the risk of immune mediated disease or severe infection in any given individual. I recently found that immune cells and proteins in healthy twins vary because of non-heritable influences (infections, vaccines,...
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 1

 TERMINÉ 

Therapeutic and Biomarker Potential of long non-coding RNAs in Vascular Disease (NORVAS)

Date du début: 1 mai 2016, Date de fin: 30 avr. 2021,

The contribution of cardiovascular disease to human morbidity and mortality continues to steadily increase in our aging European society. In response, extraordinary efforts have been launched to determine the molecular and pathophysiological characteristics of its etiology. The collective work of multiple research groups has uncovered a complex transcriptional and post-transcriptional regulatory m...
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 1

 TERMINÉ 

RECAP: Research on European Children and Adults born Preterm (RECAP)

Date du début: 1 janv. 2017, Date de fin: 31 mars 2021,

The project’s overall aim is to improve the health, development and quality of life of children and adults born very preterm (VPT, < 32 weeks of gestation) or very low birth weight (VLBW, < 1500g) – approximately 50 000 births each year in Europe – by establishing an ICT platform to integrate, harmonise and exploit the wealth of data from 20 European cohorts of VPT/VLBW children and adults and the...
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 21

 TERMINÉ 

Towards enduring mouse resources and services advancing research into human health and disease (INFRAFRONTIER2020)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

The INFRAFRONTIER RI integrates European Mouse Clinics and the European Mouse Mutant Archive with the common goal to ensure access to mouse models for basic research of human health and disease, and to translate this knowledge into therapeutic approaches for the benefit of the European society. The expanded INFRAFRONTIER2020 network, coordinated by the INFRAFRONTIER GmbH, includes 3 SMEs and is st...
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 33

 TERMINÉ 

Paediatric Clinical Research Infrastructure Network (PedCRIN)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

Children’s health is a major societal challenge for Europe and the world, requiring development of paediatric medicines and treatments strategies based on evidence derived from clinical trials demonstrating efficacy and safety in infants and children, rather than on uncritical extrapolation from adult data (over 50 % of the medicines used for children had not been tested in this specific age group...
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 16

 TERMINÉ 

Releasing the full potential of Instruct to expand and consolidate infrastructure services for integrated structural life science research (INSTRUCT-ULTRA)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

Instruct-Ultra aims to advance the scope and efficiency of implementation of Instruct and consolidate the foundations for long-term sustainability. This will be achieved through specific objectives: expand Instruct membership to new Member States and increase global links; engage new user communities; improve efficiencies in service delivery; improve data capture and management; adjust the scale a...
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 19

 TERMINÉ 

Implementation of cost-optimized childhood vision and hearing screening programmes in middle-income countries in Europe (EUSCREEN)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

Screening for vision and hearing disorders in children has shown to be highly effective. EU-directive 16620/11 invites EU-member states to give priority to such screening programmes. Early detection and treatment of a lazy eye (prevalence 3%) prevents lifelong visual impairment. Early detection and treatment of hearing impairment (prevalence 0.15%) prevents delayed speech and language development....
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 10

 TERMINÉ 

TRANSlating the role of Mitochondria in Tumorigenesis (TRANSMIT)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,

The consolidation of the knowledge that cancer is not only a genetic, but also a metabolic disease, has led scientists to investigate the intricate metabolic plasticity that transformed cells must undergo to survive the adverse tumor microenvironment conditions, and the contribution of oncogenes and tumor suppressors in shaping metabolism. In this scenario, genetic, biochemical and clinical eviden...
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 10

 TERMINÉ 

Ubiquitous Pharmacogenomics (U-PGx): Making actionable pharmacogenomic data and effective treatment optimization accessible to every European citizen (U-PGx)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Pharmacogenomics is the study of genetic variability affecting an individual’s response to a drug. Its use allows personalized medicine and reduction in ‘trial and error’ prescribing leading to more efficacious, safer and cost-effective drug therapy. The U-PGx consortium will investigate a pre-emptive genotyping approach (that is: multiple pharmacogenomic variants are collected prospectively and ...
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 16

 TERMINÉ 

European HIV Vaccine Alliance (EHVA): a EU platform for the discovery and evaluation of novel prophylactic and therapeutic vaccine candidates (EHVA)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Many HIV vaccine concepts and several efficacy trials have been conducted in the prophylactic and therapeutic fields with limited success. There is an urgent need to develop better vaccines and tools predictive of immunogenicity and of correlates of protection at early stage of vaccine development to mitigate the risks of failure. To address these complex and challenging scientific issues, the Eur...
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 43

 TERMINÉ 

Comorbid Conditions of Attention deficit / hyperactivity disorder (CoCA)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Understanding mechanisms underlying comorbid disorders poses a challenge for developing precision medicine tools. Psychiatric disorders are highly comorbid, and are among the last areas of medicine, where classification is driven by phenomenology rather than pathophysiology. We will study comorbidity between the most frequent psychiatric conditions, ADHD, mood/anxiety, and substance use disorders,...
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 17