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19 projets européens trouvés

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 TERMINÉ 

Epigenetic Training Network - Innovative techniques and models to understand epigenetic regulation in the pathogenesis of common diseases (EPITRAIN)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2017,

"Despite the past century witnessing considerable advances in our understanding of genetics, the success of genome-wide association studies (GWAS) in detecting putative causal variants has been tinged with disappointment as the effects found have been modest. Epigenetics promises a novel biological foundation of a new way of looking at common diseases because it responds to the environment and gov ...
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 6

 TERMINÉ 

Vascular Endothelial interactionS and SpEciaLization (Vessel)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,

The vascular network plays essential roles in animal biology. Local disruption or impaired function of the vascular network is known to cause various pathological conditions, such as ischemic heart disease and stroke. The angiogenic growth of blood vessels is critically required during development, growth and regeneration, but it can also promote the growth of cancer cells and contribute to diabet ...
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 9

 TERMINÉ 

Sustainable Lifestyles 2.0: End User Integration, Innovation and Entrepreneurship (EU-INNOVATE)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2016,

Typically, end users or “consumers” are perceived as adopters of sustainable products and services, developed by companies. Thus, a lot of attention is paid to the (non-) diffusion of sustainable products and services. From this perspective end users are seen as – more or less – passive recipients of sustainable products and services.We propose to investigate the active roles of end users in shapi ...
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 14

 TERMINÉ 

Innovation in Action: Studying Innovation in Times of Crisis (INNO-ACT)

Date du début: 1 mars 2014, Date de fin: 20 déc. 2016,

INNO-ACT brings sociocultural anthropology and innovation studies together to tackle the following interrelated questions: (i) How did innovation arise to its current prominence, particularly in the European Union? (ii) What are the different meanings, discourses, and values used by different actors when referencing innovation? and (iii) Under which circumstances does innovation emerge and make a ...
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 1

 TERMINÉ 

ADenoViruses as novel clinical treatments (ADVANCE)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2016,

ADVance is designed to integrate 8 leading academic centres and 4 private companies under a single umbrella to create an opportunity to train young scientists in adenovirus (AdV) research. Our full partners and industrial partners represent internationally leading academic centres of excellence in key facets of research into the basic biology of AdV and their application as vectors for clinical p ...
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 13

 TERMINÉ 

The Role of the RPL11/p53 Checkpoint in the Development and Treatment of DBA (DBA-Checkpoints)

Date du début: 1 mars 2012, Date de fin: 29 févr. 2016,

Extensive studies have demonstrated that the underlying cause of Diamond Blackfan anemia (DBA) is hypomorphic mutations in ribosomal protein (rp) genes. Patients with this disease present with an erythroid anemia, which has the propensity to progress to a wide range of cancers, particularly acute myeloid leukemia and osteosarcomas. Recently our laboratory has provided a model to explain the anemia ...
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 1

 TERMINÉ 

Creativity in learning through Social Computing and Game Mechanics in the Enterprise (COLLAGE)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2015,

Description Social creativity in learningMuch social creativity involves human collaboration through and about artefacts that embody collective knowledge resulting from the collaboration. It can be a catalyst to enable European SMEs and large organizations to adopt and sustain new approaches to learning by fostering non-linear and non-sta ...
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 9

 TERMINÉ 

Use of adoptive T cell transfer in combination with oncolytic adenoviruses for cancer treatment (Cancer therapies)

Date du début: 1 mai 2011, Date de fin: 31 août 2015,

Metastatic cancer remains an incurable disease in the majority of cases and thus development of novel treatment strategies is required. Adoptive T cell therapy is a promising therapy for patients with a wide range of cancers. This therapy involves ex vivo activation and expansion of T cells followed by infusion into patients. Peripheral blood CD4+ and CD8+ T cells can be redirected against tumor-a ...
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 2

 TERMINÉ 

Role of human papillomavirus infection and other co-factors in the aetiology of head and neck cancer in India and Europe (HPV-AHEAD)

Date du début: 1 sept. 2011, Date de fin: 31 août 2015,

Human papillomavirus (HPV) is responsible for approximately 25% of head and neck cancer (HNC) worldwide and appears to be associated with a better response to treatment and improved prognosis. Evidence suggests that HPV-induced HNC has steadily increased in the USA and some European countries in the last decades. However, whether this is a worldwide phenomenon and specific risk factors are associa ...
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 11

 TERMINÉ 

Systems biology towards novel chronic kidney disease diagnosis and treatment (SysKID)

Date du début: 1 janv. 2010, Date de fin: 31 déc. 2014,

Chronic kidney disease (CKD) affects up to 10% of the population. Besides eventual progression towards end stage renal disease CKD impacts the patient’s quality of life by causing serious comorbidities including cardiovascular complications and bone metabolism disorders. On the everyday clinical level early stage diagnosis and tailored treatment of CKD are still inadequate. In addition, CKD seems ...
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 30

 TERMINÉ 

Development of OPN-305 as an orphan drug for the treatment of Delayed Graft Function post solid organ transplantation (MABSOT)

Date du début: 1 déc. 2010, Date de fin: 30 sept. 2014,

Delayed graft function (DGF) is defined as the need for dialysis within seven days of renal transplantation (DGF promotes allograft rejection, requires prolonged dialysis and hospitalisation, and increases the likelihood of graft failure and ultimately the duration of renal graft survival-expectancy. The incidence of DGF occurs in 21-44% of cases following cadaveric renal graft. Several rare dise ...
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 10

 TERMINÉ 

Immunomodulatory Effects of Exercise in Type 1 Diabetes (IMMEEDIA)

Date du début: 1 juil. 2010, Date de fin: 30 juin 2014,

"Diabetes is a major metabolic disease with huge costs for healthcare system throughout the EU and worldwide. Type 1 Diabetes (T1DM) is a chronic condition in which pancreas produces little or no insulin, believed to result from a disorder of immunoregulation. For decades it has been known that regular aerobic exercise improves insulin sensitivity in diabetic patients, reducing insulin requirement ...
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 5

 TERMINÉ 

Chromatin diseases: from basic mechanisms to therapy (DisChrom)

Date du début: 1 nov. 2009, Date de fin: 31 oct. 2013,

The scope of this ITN is to promote research and training in the field of chromatin diseases. Chromatin diseases (CD) are genetic pathologies resulting from mutations in structural components of chromatin or in enzymes that biochemically modify chromatin, altering chromatin status and thereby causing drastic effects on gene expression. CD frequency ranges from very rare to quite common pathologies ...
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 11

 TERMINÉ 

Therapeutic challenge in Leukodystrophies: Translational and ethical research towards clinical trials (LEUKOTREAT)

Date du début: 1 mars 2010, Date de fin: 31 août 2013,

Leukodystrophies (LDs) are inherited rare neurodegenerative diseases of the white matter and its main component, the myelin, that are affecting predominantly children. Severity of the disease is related to the axonal dysfunction due to myelin deficiency or destruction. Despite the achievement of remarkable advances made in the past decade, there is no current curative therapy. The development of t ...
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 25

 TERMINÉ 

Assembly of a prostate cancer genome-wide molecular interactome for the identification of the key regulatory genes of malignant transformation and new targets for therapeutic intervention (PC interactome)

Date du début: 2 août 2010, Date de fin: 14 août 2013,

A major issue in the translation of findings from mouse models to clinical practice is the lack of appropriate tools to identify causal mechanisms of oncogenesis, tumor progression, and drug activity. The multidisciplinary project here proposed will characterize fundamental mechanisms and signaling pathways deregulated in prostate cancer through the assembly of a prostate cancer interactome, which ...
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 1

 TERMINÉ 

health-economic modelling of PREvention strategies for Hpv-related Diseases in European CounTries (PREHDICT)

Date du début: 1 mai 2010, Date de fin: 30 avr. 2013,

"The goals of the PREHDICT study are to determine prerequisites and strategies for vaccination in European countries and to predict the impact of vaccination on screening programmes. To achieve these goals, a multiple HPV type transmission model will be built to describe the type-specific incidence and clearance of HPV infections. This model will be linked to an individual-based simulation model u ...
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 14

 TERMINÉ 

Breaking Tolerance - Combination of Virotherapy and Immunotherapy for Cancer Treatment (Viral&Immune Therapy)

Date du début: 1 févr. 2011, Date de fin: 31 janv. 2013,

The aim of this project is to enhance the efficacy of a tumour killing virus and break tolerance within the tumour to induce an immune response against the primary tumour and metastatic deposits. The proposed strategy requires three steps. First, the tumour immunological microenvironment needs to be reset as tumours utilize a variety of mechanisms to escape host immune system. Here, we propose to ...
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 1

 TERMINÉ 

Modelling cancer in Caenorhabditis elegans (canceromics)

Date du début: 1 oct. 2007, Date de fin: 31 mars 2012,

Cancer is a complex disease that results from accumulation of diverse alterations in the genome. There are more than 300 genes identified as “cancer genes” although it is estimated that there are many more involved in cancer development that could be significant during tumorigenesis and putative targets for drugs therapies. Several scientific groups are performing a comprehensive sequencing of gen ...
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 2

 TERMINÉ 

PlayMancer: A European Serious Gaming 3D Environment (PlayMancer)

Date du début: 1 nov. 2007, Date de fin: 31 mai 2011,

PlayMancer will implement a new Serious Game environment, by augmenting existing 3D gaming engines with new possibilities. The objectives of the project are four-fold:1.\tto construct a next generation networked gaming environment, mainly augmenting the gaming experience with innovative ICT modes of interaction between the player and the game world,2.\tto allow for a shorter and most cost-effectiv ...
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 9