29 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Combatting Bacterial Resistance in Europe - Molecules against Gram Negative Infections (COMBACTE-MAGNET)
Date du début: 1 janv. 2015, Date de fin: 31 déc. 2021,
Antimicrobial resistance (AMR) is a major global public health threat, and most troublesome is the rapid emergence and dissemination of multidrug resistant (MDR) Enterobacteriaceae, Acinetobacter species and Pseudomonas aeruginosa. There is an unmet medical need to prevent P. aeruginosa infection in critically ill patients and to develop new antibiotics for infections caused by Gram-negative bacte ...
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44
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TERMINÉ
Paediatric Clinical Research Infrastructure Network (PedCRIN)
Date du début: 1 janv. 2017, Date de fin: 31 déc. 2020,
Children’s health is a major societal challenge for Europe and the world, requiring development of paediatric medicines and treatments strategies based on evidence derived from clinical trials demonstrating efficacy and safety in infants and children, rather than on uncritical extrapolation from adult data (over 50 % of the medicines used for children had not been tested in this specific age group ...
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16
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TERMINÉ
INtestinal Tissue ENgineering Solution (INTENS)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,
Short Bowel Syndrome (SBS) is a condition that occurs when part or the entire small intestine is missing or has been removed during surgery. This condition renders the bowel incapable of fulfilling its nutritional function (intestinal failure). There is no cure for SBS. Parenteral (intravenous) nutrition (PN) and bowel transplantation are currently the preferred options for nutrition in children a ...
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9
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TERMINÉ
Boost Brittle Bones Before Birth (BOOSTB4)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,
Osteogenesis imperfecta (OI) is, in its severe forms, a devastating inherited disorder characterised by brittle bones. A person with severe OI is affected throughout their lifetime with repeated, multiple fractures, considerable pain and handicap. There is no curative or effective treatment for OI. Our preclinical studies and initial clinical cases have demonstrated that transplantation of fetal m ...
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13
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TERMINÉ
Big data against childhood Obesity (BigO)
Date du début: 1 déc. 2016, Date de fin: 30 nov. 2020,
Childhood and adolescent obesity is a major global and European public health problem. Currently, public actions are detached from local needs, mostly including indiscriminate blanket policies and single-element strategies, limiting their efficacy and effectiveness. The need for community-targeted actions has long been obvious, but the lack of monitoring and evaluation framework and the methodolog ...
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14
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TERMINÉ
Harnessing Targeted Nanotheranostics to Reprogram Activated Leukocytes in Inflammatory Bowel Disease (LeukoTheranostics)
Date du début: 1 nov. 2015, Date de fin: 31 oct. 2020,
"Inflammatory bowel diseases (IBD) is a group of chronic inflammatory conditions of the gastrointestinal tract, including Crohn’s disease (CD) and Ulcerative Colitis (UC) that can impact both the large and small bowel. IBD affects approximately 3.7 million Europeans and its peak onset is in persons of 15 to 30 years of age. IBD imposes a significant burden on Europe with over €3B in annual health ...
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2
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TERMINÉ
DevelopIng Genetic medicines for Severe Combined Immunodeficiency (SCID) (SCIDNET)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,
Severe combined immunodeficiency (SCID) is a devastating rare disorder of immune system development. Affected infants are born without functional immune systems and die within the first year of life unless effective treatment is given. Treatment options are limited to allogeneic haematopoietic stem cell transplantation and autologous stem cell gene therapy. Over the last 15 years, gene therapy for ...
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13
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TERMINÉ
Treatment of late onset bacterial sepsis caused by vancomycin susceptible bacteria in neonates and infants aged under three months (NEOVANC)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,
Vancomycin is the critically important antibiotic to treat neonatal Late Onset Sepsis (LOS) due to Gram positive bacteria in neonates, including Coagulase Negative Staphylococci (CoNS) and Staphylococcus aureus. These organisms also create biofilms which are extremely resistant to antibiotics. The increased incidence of LOS due to bacteria such as CoNS and MRSA in NICUs has led to a marked increas ...
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14
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TERMINÉ
Models of Child Health Appraised (MOCHA)
Date du début: 1 juin 2015, Date de fin: 30 nov. 2018,
Children’s health affects the future of Europe – children are citizens, future workers, parents and carers. Children are dependent on society to provide effective health services (UN Convention on the Rights of the Child). Models of child primary health care vary widely across Europe based on two broad alternatives (primary care paediatricians or generic family doctors), and a variety of models of ...
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20
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TERMINÉ
On the job learning by using ICF-CY in Social Pediatrics
Date du début: 1 sept. 2015, Date de fin: 31 août 2018,
Background/Context
2 major interconnected initiatives in the field of persons with disabilites (PwD) - the UN-Convention on the Rights of PwD (1986) and the International Classification of Functionning, Disabilty and Health (2002) (CY= children/youth version) focus on the full participation of PwD, on the necessity of inclusive settings and on a common language for professionals in order to descri ...
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11
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TERMINÉ
European Medical Information Framework (EMIF)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,
In response to the need to tackle increasingly complex medical research questions, a growing amount of human health data is being collected, either in routine Electronic Healthcare Record (EHR) databases, through research-driven cohort studies, in biobanks or related efforts. However, data sources are typically fragmented and contain information gaps which prevent their full exploitation. EMIF aim ...
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64
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TERMINÉ
New approach to treatment of the blinding disease Retinopathy of Prematurity (ROP) (PREVENTROP)
Date du début: 1 oct. 2012, Date de fin: 30 sept. 2017,
"The overall objective is to develop a novel preventative intervention for the blinding disease retinopathy of prematurity (ROP) and other complications of prematurity. The PREVENTROP consortium proposes to conduct preclinical studies (pharmacological, pharmacodynamics, pharmacokinetics and toxicological) in models and/or clinical studies (including phase III clinical trial) of an EU designated o ...
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10
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TERMINÉ
Global Research in Paediatrics (GRiP)
Date du début: 1 janv. 2011, Date de fin: 30 juin 2017,
Paediatric drugs (PD) lack appropriate testing. Most drugs have inadequate information about dosing regimen, dose adjustment and how to administer them. These are longstanding problems that unquestionably require concerted efforts at the international level. Both the US and the EU have introduced paediatric legislation that facilitates participation of children in research and pharmaceutical innov ...
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24
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TERMINÉ
Improving the practical skills of health professionals for the improvement of health of Children with intellectual disabilities - with focus on PraderVili Syndrome
Date du début: 1 juin 2015, Date de fin: 31 mai 2017,
Obesity is a rapidly growing problem worldwide leading to series of devastating complications of the health of the individual. Easy access to cheap calorie foods and passive lifestyle are the two most important factors for the growth of diseases caused by obesity. In individuals with Prader-Willi and other conditions where there is association between mental disability and excessive obesity, the p ...
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2
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TERMINÉ
Integrated Approaches to Food Allergen and Allergy Risk Management (IFAAM)
Date du début: 1 mars 2013, Date de fin: 28 févr. 2017,
Up to 20 million European citizens suffer from food allergy. However management of both food allergy (by patients and health practitioners) and allergens (by industry) is thwarted by lack of evidence to either prevent food allergy developing or protect adequately those who are already allergic. iFAAM will develop evidence-based approaches and tools for MANAGEMENT of ALLERGENS in FOOD and integrate ...
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46
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TERMINÉ
PanCare Childhood and Adolescent Cancer Survivor Care and Follow-up Studies (PanCareSurFup)
Date du début: 1 févr. 2011, Date de fin: 31 janv. 2017,
Over the last 40 years, treatment for childhood and adolescent cancer has improved greatly; 5- year survival after childhood cancer is now 80% in developed countries. Approximately 1 individual in 750 of young adults is now a childhood cancer survivor. Epidemiologic data on the number of European childhood cancer long-term survivors are not available, but estimates suggest a number between 300,000 ...
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18
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TERMINÉ
THALAssaemia MOdular Stratification System for personalized therapy of beta-thalassemia (THALAMOSS)
Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,
...o patient subgroups and (b) guide conventional and novel therapeutical approaches for β-thalassaemia, including personalised medical treatments.Key researchers of THALAMOSS are R.Gambari (Ferrara University, Italy), M. Kleanthous (The Cyprus Foundation for Muscular Dystrophy Research, Cyprus), S.Philipsen (Erasmus Universitair Medisch Centrum Rotterdam, The Netherlands), E.Katsantoni (Biomedical R ...
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14
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TERMINÉ
A phase I/IIa clinical trial in Duchenne muscular dystrophy using systemically delivered morpholino antisense oligomer to skip exon 53 (SKIP-NMD)
Date du début: 1 nov. 2012, Date de fin: 30 avr. 2016,
Duchenne muscular dystrophy (DMD) is a progressive, lethal muscle degenerative condition arising from the absence of dystrophin in skeletal and cardiac muscles. 65% of DMD boys have out-of-frame deletions. Modulation of pre-mRNA splicing by exon skipping is the most promising molecular intervention in DMD. 2 Phase Ib and 2 Phase IIa clinical trials (MDEX Consortium in collaboration with Sarepta Th ...
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10
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TERMINÉ
Treat Iron-Related Childhood-Onset Neurodegeneration (TIRCON)
Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,
Neurodegeneration with brain iron accumulation (NBIA) is a heterogeneous group of rare hereditary neurodegenerative disorders characterized by high levels of brain iron. The most common form is pantothenate kinase-associated neurodegeneration (PKAN). Classic PKAN and most other NBIA cases are characterised by early childhood onset and rapid progression. Currently, there is no proven therapy to hal ...
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14
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TERMINÉ
European multicenter network to evaluate pharmacokinetics, safety and efficacy of Meropenem in neonatal sepsis and meningitis (NEOMERO)
Date du début: 1 janv. 2010, Date de fin: 30 juin 2015,
Previous studies have demonstrated the high frequency of bacterial sepsis in neonates and infants admitted to neonatal intensive care unit (NICU), often associated with serious complications or death. Many pathogens capable of causing nosocomial bacterial sepsis in neonates and young infants have developed resistance to the antibiotics considered of choice for treatment. Meropenem is an antibiotic ...
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12
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TERMINÉ
Suicidality: Treatment Occurring in Paediatrics (STOP)
Date du début: 1 nov. 2010, Date de fin: 30 avr. 2015,
The emergence of suicidality in patients receiving drug treatment is of concern because of the overall burden and the possible link with completed suicide. The lack of uniform requirements for defining, detecting and recording suicidality and the presence of disease related confounders create major problems. It is possible that Medication-Related Suicidality (MRS) differs from Psychopathology-Rela ...
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19
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TERMINÉ
Atopic diseases in changing climate, land use and air quality (ATOPICA)
Date du début: 1 oct. 2011, Date de fin: 31 mars 2015,
There is an urgent need to understand how global and regional climate, land use and air quality changes will impact human health. Our consortium constitutes an innovative and multidisciplinary approach to explore the combined pan-European impact of changes in climate, land use and air pollution on allergen pollen-induced diseases through a chain of quantitative physical and statistical models. We ...
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11
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TERMINÉ
Treatment of NEonatal seizures with Medication Off-patent: evaluation of efficacy and safety of bumetanide (NEMO)
Date du début: 1 oct. 2009, Date de fin: 31 mars 2015,
Neonatal hypoxic ischaemic encephalopathy (HIE) occurs in 2-3/1000 live births and is a major cause of both acute mortality and long-term neurodisability. Seizures are the hallmark of HIE. The clinical and electrographic seizure burden in babies with HIE can be considerable and is often not reduced by current antiepileptic drugs. Phenobarbitone remains the first line drug for neonatal seizures des ...
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15
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TERMINÉ
Gene- Environment Interactions in Heart Development (CHeartED)
Date du début: 1 janv. 2009, Date de fin: 31 déc. 2012,
Cardiovascular malformation (CVM) is the commonest cause of childhood death in developed countries. In the EU there are 51,000 new cases each year and two million affected individuals. Yet, despite intensive research, the cause of 80% of CVM remains elusive. The mission of CHeartED is to identify genetic and environmental pathways that can be modified with the goal of reducing preventable CVM inci ...
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11
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TERMINÉ
European Network for the Study of Orphan Nephropathies (EUNEFRON)
Date du début: 1 mai 2008, Date de fin: 30 avr. 2012,
"In this proposal, we have mobilized a critical mass of expertise to investigate, on a Europe-wide scale, the natural history and pathophysiology of rare inherited diseases affecting important structures of the kidney. The project will use and develop multiple models (in vitro and in vivo) with the aim to develop preventive, diagnostic and therapeutic interventions that should alleviate the burden ...
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10
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TERMINÉ
The HSA project will introduce an instrument for the qualitative analysis of human resources in the health sector, namely a Human System Audit (HSA). The primary target group of the project are professionals in the health sector with responsibility for the management of personnel within a hospital environment. Project partners will initially adapt the HSA to the characteristics of the hospital sec ...
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9
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TERMINÉ
The aim of the project was to align EU countries to provide standardised, accredited training for HCPs, and create transferable learning outcomes and credit points. The objective was to identify barriers and facilitators for the creation of the curriculum; to develop an EU accredited Certified Diabetes Educator Course (EU-CDEC) and establish an accreditation process aligned to ECVET principles. Th ...
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7
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TERMINÉ
The aim of the project was to develop a European Virtual learning Environment (VLE) which would act as the portal for the delivery of a structured online European Medical Postgraduate educational training programme to junior doctors who are training to be neonatal specialists. Having gained approval from the European Academy of Paediatrics it is anticipated that this innovation has the potential ...
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7
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TERMINÉ
The e-MEDICINimage project enabled the creation of a remote continuing education scheme in the health sector (medical biology) related to parasitology and medical mycology. These two training schemes are built exclusively on e-Learning techniques and each of them offers a unique curriculum available in 5 languages (English, Spanish, French, Polish and Portuguese). This scheme, associated with the ...
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