13 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Smart Biologics: Developing New Tools in Glycobiology (SWEETOOLS)
Date du début: 1 févr. 2016, Date de fin: 31 janv. 2021,
Glycans are ubiquitous biomolecules found throughout all kingdoms of life. Early studies contributed considerably to our appreciation of glycan functions by showing that abnormalities in the glycosylation can develop into pathogenesis and severe dysfunctions. Despite the crucial role of sugars in many biological events we still do not have adequate tools to decipher their complexity. To unveil the ...
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1
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TERMINÉ
ELIXIR-EXCELERATE: Fast-track ELIXIR implementation and drive early user exploitation across the life-sciences. (ELIXIR-EXCELERATE)
Date du début: 1 sept. 2015, Date de fin: 31 août 2019,
The life sciences are undergoing a transformation. Modern experimental tools study the molecules, reactions, and organisation of life in unprecedented detail. The precipitous drop in costs for high-throughput biology has enabled European research laboratories to produce an ever-increasing amount of data. Life scientists are rapidly generating the most complex and heterogeneous datasets that scienc ...
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47
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TERMINÉ
Click Chemistry for Future Gene Therapies to Benefit Citizens, Researchers and Industry (ClickGene)
Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,
Gene therapy is expected to play a key role in next-generation medicine by correcting the underlying genetic causes of disease, thereby facilitating personalised medicine. Current gene therapy methods possess undesirable side effects, including insertional mutagenesis, toxicity, low efficiency and off-target cutting. Questions also remain regarding the optimal methods for delivering nucleases into ...
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9
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TERMINÉ
"FLUOR21 : Synthesis, structure and function of fluorinated systems" (FLUOR21)
Date du début: 1 mars 2014, Date de fin: 28 févr. 2018,
"Organofluorine chemistry has played a significant role in the majority of the spectacular scientific and technological developments of thepast century although this is not widely recognised even by the scientific community. Fluoroorganic molecules are key components in anever increasing number of high-value commercially important products particularly in the life science industries. The use of fl ...
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9
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TERMINÉ
Substrate specificity, mechanism and biological roles of rhomboid intramembrane proteases (Rhomboid substrates)
Date du début: 1 mars 2013, Date de fin: 1 mai 2017,
Rhomboids are widely conserved intramembrane proteases. They are known to control important biological processes in model insect, worm, yeast and protozoan species, but their functions in most organisms including mammals and bacteria are unknown. The key to the understanding of rhomboid functions are their natural substrates, but it has been unclear how these are selected and recognized and method ...
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1
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TERMINÉ
Systems biology of Mycobacterium tuberculosis (SYSTEMTB)
Date du début: 1 avr. 2010, Date de fin: 30 sept. 2014,
Tuberculosis (TB) is a re-emerging global health threat caused by Mycobacterium tuberculosis (Mtb). One third of the world's population is infected with Mtb and new infections occur at a rate of one per second. Despite global research efforts, mechanisms underlying pathogenesis, virulence and persistence of Mtb infection remain poorly understood. Simple reductionist approaches are insufficient to ...
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14
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TERMINÉ
Regular Arrays of Artificial Surface-Mounted Dipolar Molecular Rotors (DIPOLAR ROTOR ARRAY)
Date du début: 1 févr. 2009, Date de fin: 31 juil. 2014,
We propose a feasibility demonstration of an unprecedented concept: preparation of regular two-dimensional arrays of artificial surface-mounted dipolar molecular rotors and control of their coherent motion by the application of an outside electric field. The proposal involves a highly interdisciplinary endeavor, which requires experience in synthesis (preparation of molecular rotors), surface che ...
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1
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TERMINÉ
DEVELOPMENT OF DIAMOND INTRACELLULAR NANOPROBES FOR ONCOGEN TRANSFORMATION DYNAMICS MONITORING IN LIVING CELLS (DINAMO)
Date du début: 1 mai 2010, Date de fin: 30 avr. 2013,
Dynamic information about biomolecular processes in living cells is important for fundamental understanding of cellular functions, which is one of the primary targets of molecular cell-biology with important applications to pharmacology. However fur further progress in this field, and this specifically for monitoring genomic processes, there is immense need for developing sensing and detection tec ...
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8
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TERMINÉ
New Horizons for Mass Spectrometry (HORIZOMS)
Date du début: 1 juil. 2009, Date de fin: 31 mars 2013,
This project of basic research in chemistry tackles the challenge to close the wide gap between chemical and physical processes occurring in liquid solution and sophisticated studies of model systems in the idealized gas phase. By such the project aims to reach a convergence between the microscopic and macroscopic world. To this end, the planned research will span the range from isolated atoms in ...
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1
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TERMINÉ
Multi-scale Formation of Functional Nanocrystal-Molecule Assemblies and Architectures (FUNMOL)
Date du début: 1 oct. 2008, Date de fin: 31 mars 2012,
Recent developments in the design and synthesis of nanoscale building blocks as active elements in opto- or bio-electronic devices with tailored electronic functionality have the potential to open up new horizons in nanoscience and also revolutionise multi-billion dollar markets across multiple technology sectors including healthcare, printable electronics, and security. Ligand-stabilised inorgani ...
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10
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TERMINÉ
"TARGETING HIV INTEGRATION CO-FACTORS, TARGETING CELLULAR PROTEINS DURING NUCLEAR IMPORT OR INTEGRATION OF HIV" (THINC)
Date du début: 1 mars 2008, Date de fin: 29 févr. 2012,
"Standard therapy of infection with the human immunodeficiency virus type 1 (HIV-1) is based on potent cocktails of drugs targeting viral proteins. This treatment is associated with severe side effects and is almost unaffordable for the patients living in sub-Saharan Africa. Incomplete suppression of HIV replication results in drug-resistance. Therefore, a continued research effort is required to ...
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11
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TERMINÉ
"Effects of temperature, dynamics, and media on magnetic resonance parameters in endohedral fullerenes and confined Xe atom systems." (MRTDM)
Date du début: 1 nov. 2008, Date de fin: 31 oct. 2011,
"Proposal concentrates on applying and testing computational methodology for accurate calculations of magnetic resonance parameters with inclusion of the relevant physical effects, such as electron correlation, relativity, dynamics, temperature, and media effects, in the calculation. This will be done by combination of the electronic structure theory methods with the simulation approaches, such as ...
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1
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TERMINÉ
Targeting assembly of infectious HIV particles (HIV ACE)
Date du début: 1 mars 2008, Date de fin: 31 août 2011,
"AIDS remains one of the major life threatening infectious diseases in the world today. A constant supply of novel antiretrovirals (ARVs) is needed to respond to the limitations of current drugs. By the end of 2007, the therapeutic arsenal against HIV is expected to comprise ARVs blocking all major steps of HIV replication, except for particle assembly and budding. Members of HIV-ACE were instrume ...
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