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23 projets européens trouvés

Recherche sur 125080 projets européens

 TERMINÉ 

Targeting cancer using evolutionary refined pathogen derived antigens (MalOnco)

Date du début: 1 sept. 2014, Date de fin: 31 août 2019,

We have recently discovered a malaria protein which has shown a high potential in cancer treatment. In pregnant women, malaria infected red blood cells express a protein that binds to a distinct carbohydrate structure present only on cells of the maternal side of the placental circulation, but not elsewhere in the vasculature. This highly evolved binding system enables the parasite to evade cleara ...
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 2

 TERMINÉ 

Arctic Sea Ice and Greenland Ice Sheet Sensitivity (Ice2Ice)

Date du début: 1 août 2014, Date de fin: 31 juil. 2019,

The cryosphere is in fast transition. The possibility that the ongoing rapid demise of Arctic sea ice may instigate abrupt changes on the Greenland Ice Sheet (GIS) is not tackled by current research. Ice cores from the GIS show clear evidence of past abrupt warm events,up to 15 degrees warming in less than a decade, possibly caused by disappearing se ice in the Nordic Seas..Arctic sea ice extent w ...
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 4

 TERMINÉ 

Multipartite Quantum Information Theory (QMULT)

Date du début: 1 sept. 2013, Date de fin: 31 mai 2019,

Quantum information theory studies the way information is stored, transmitted and processed in quantum devices. Mathematically, quantum information theory extends Shannon's theory of information but differs from it by allowing both for stronger correlations known as entanglement and for non-commutative effects resulting in measurement uncertainty as required by the laws of quantum physics. Entangl ...
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 2

 TERMINÉ 

Insect Pathogens as Endophytes – New Tools for Pest Control? (ENDOPEST)

Date du début: 28 févr. 2014, Date de fin: 20 mai 2019,

Plants harbor fungi asymptomatically within their tissues, called endophytes, which may protect the host plant against herbivores. The fungus Beauveria bassiana is an entomopathogen infecting insects, but it has recently also been demonstrated to grow as an endophyte within several plants. In this project I will evaluate the potential of the entomopathogenic fungus B. bassiana as an endophyte for ...
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 1

 TERMINÉ 

Diagnostic Imaging Strategies for Patients with Stable Chest Pain and Intermediate Risk of Coronary Artery Disease: Comparative Effectiveness Research of Existing Technologies (DISCHARGE)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

Coronary artery disease (CAD) is the leading cause of death in high-income countries. Invasive coronary angiography (ICA) is the reference standard for the diagnosis of CAD and allows immediate therapy. However, only 40% of patients undergoing ICA actually have obstructive CAD and ICA has relatively rare but considerable risks. Coronary computed tomography (CT) is the most accurate diagnostic test ...
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 38

 TERMINÉ 

PREVention of diabetes through lifestyle Intervention and population studies in Europe and around the World (PREVIEW)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2018,

"The primary goal of PREVIEW is to identify the most efficient lifestyle pattern for the prevention of type-2 diabetes in a population of pre-diabetic overweight or obese individuals. The project comprises two distinct lines of evidence, both embracing European and overseas countries:1) A multicentre, clinical randomized intervention trial with a total of 2,500 pre-diabetic participants, including ...
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 16

 TERMINÉ 

Designing microProteins to alter growth processes in crop plants (miPDesign)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2018,

The directed control of protein activity plays a crucial role in the regulation of growth and development of multicellular organisms. Different post-translational control mechanisms are known to influence the activity of proteins. Here, I am proposing a novel way to control the activity of proteins that function as multimeric complexes. MicroProteins, are small single-domain protein species that c ...
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 2

 TERMINÉ 

Plant Tissue Cultures as New Production Platforms for Terpenoid Based Anti-Cancer Drugs (DrugTissueCult)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2018,

Plants produce a vast diversity of specialized and bioactive compounds. For thousands of years, mankind has used extracts from plants containing bioactive compounds as part of traditional herbal medicines. More recently anticancer properties of some bioactive compounds have been discovered and are now leads for new pharmaceutical drugs to combat cancers. In DrugTissueCult we focus on two bioactive ...
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 2

 TERMINÉ 

Synthesis of systematic resources (SYNTHESYS3)

Date du début: 1 sept. 2013, Date de fin: 31 août 2017,

SYNTHESYS3 will create an accessible, integrated European resource for researchers in the natural sciences in Europe and globally. Building on the success of the previous SYNTHESYS IA, the NA will focus on improving collections management of new physical and virtual collections. By focusing the JRA on extracting and enhancing data from digitised collections, SYNTHESYS3 will increase the accessibil ...
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 21

 TERMINÉ 

Xenobiotic-induced thyroid and steroid hormone disruption in wildlife (XENROID)

Date du début: 1 juin 2014, Date de fin: 12 juil. 2017,

By applying cutting-edge technologies at the very forefront of endocrine-disruption research, this XENROID project will investigate environmental xenobiotics that pose a threat to three highly sensitive vertebrate indicator species; African clawed frog (Xenopus laevis), California sea lion (Zalophus californianus) and polar bear (Ursus maritimus). Thyroid and steroid hormone systems are most often ...
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 1

 TERMINÉ 

Bacterial Persistence (PERSIST)

Date du début: 1 mai 2012, Date de fin: 30 avr. 2017,

"Almost all bacterial species generate persisters, individual cells that are tolerant to antibiotics. Persisters have entered a dormant or slow growing state in which they are recalcitrant to the killing activity of most known antibiotics. The molecular mechanisms underlying bacterial persistence are unknown and there is a pressing need to develop new methods and approaches to study the phenomenon ...
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 2

 TERMINÉ 

Cone snail toxins as therapeutic agents: Decoding biological mechanisms of conotoxin folding (CONBIOS)

Date du début: 1 mai 2013, Date de fin: 31 mars 2017,

"Predatory marine cone snails use extraordinarily complex venoms to capture prey. Most of the ~500,000 biologically active venom components are small, disulfide-rich peptides called conotoxins. They target receptors and ion channels of the nervous system with remarkable potency and specificity. Due to their enormous diversity and target specificity, conotoxins have become invaluable tools in molec ...
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 1

 TERMINÉ 

It takes two to tango: A longitudinal study of the development of infant-mother attachment and stress- regulation capacities (ORIGIN OF ATTACHMENT)

Date du début: 1 avr. 2015, Date de fin: 31 mars 2017,

Infant attachment is one of the key factors for child mental health. Whereas secure attachment predicts social competence and resilience, insecure and disorganized attachment are risk factors for later mental problems. These long-term effects can be explained by the importance of early attachment for children’s stress-regulation capacities. Securely attached children are confident that the parent ...
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 1

 TERMINÉ 

Clinical development of a VAR2CSA-based placental malaria vaccine (PLACMALVAC)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2017,

Placental malaria, a special form of malaria targeting pregnant women, causes the death of 200,000 infants and 10,000 pregnant women each year. Placental malaria has no sustainable cure. The overall success criterion of the proposed project is to enable the manufacture of a vaccine, which protects fetus and mother against the adverse effects of malaria during pregnancy. Administered to women befor ...
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 6

 TERMINÉ 

Characterization of epithelial wound repair at the molecular level for revealing epithelial aspects of inflammatory bowel disease (EpiREP)

Date du début: 26 févr. 2015, Date de fin: 25 févr. 2017,

Inflammatory bowel disease (IBD) affects millions of people worldwide. The incidence and the prevalence are rising every year. This chronic disease not only decreases patient's quality of life but also creates a huge socio-economic burden for society. For establishment of a curative therapy, it is critical to understand the pathophysiology of IBD and this requires comprehensive understanding of in ...
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 1

 TERMINÉ 

Responsive and Flexible: Living and learning researcher career development framework (REFLEX)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2016,

Systematic and focused career development is becoming increasingly important for both researchers and their employers. Variety of career management tools is currently available to help them with this challenge. Although many of these tools are very effective in certain contexts they are not simply transferable to another. REFLEX project will try to address this problem through bottom-up approach b ...
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 5

 TERMINÉ 

Self-Assembly in Confined Space (SACS)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,

Supramolecular chemistry studies chemistry beyond individual molecules, where molecules or macromolecules form larger entities by spontaneous self-assembly or by self-organisation. The resulting supramolecular architectures are held together by covalent bonds and a variety of non-covalent intermolecular interactions (hydrogen bonding, metal coordination, hydrophobic interactions etc). Spatially, t ...
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 10

 TERMINÉ 

Cancer Associated Fibroblasts (CAF) Function in Tumor Expansion and Invasion (CAFFEIN)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

"Aim of the CAFFEIN network is to provide 10 early stage researchers (ESRs) and 2 exprerienced researchers (ERs) with excellent training in an industry relevant area of cancer research, complementary skills required for pharmaceutical industry, and knowledge in setting up biomedical start-up companies. To this end, the network comprises two full industrial partners: the established pharmaceutical ...
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 11

 TERMINÉ 

Design & Engineering of Photosynthetic Communities for Industrial Cultivation (PHOTO.COMM)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

The generation of young biotechnologists is of paramount importance for Europe´s future. PHOTO.COMM will train primarily early stage researchers who have demonstrated high ambitions and talents in a unique platform based on emerging technology and science that would shape the forefront of future European biotechnology. PHOTO.COMM involves the utilization of microalgae for the conversion of carbon ...
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 11

 TERMINÉ 

Training and Research AImed at Novel Antibacterial Solutions in Animals and People (TRAIN-ASAP)

Date du début: 1 janv. 2012, Date de fin: 30 sept. 2016,

TRAIN-ASAP addresses a very urgent public health issue. The lack of effective antibacterial drugs against resistant bacteria poses a serious threat to human health and has huge economical consequences to the healthcare system. The objective of this ITN is to fill the current gap between the burden of infections due to resistant bacteria and the strong need for alternative solutions to combat antib ...
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 9

 TERMINÉ 

The role of ubiquitin and ubiquitin-like modifiers in replication stress (UBIREPS)

Date du début: 1 avr. 2014, Date de fin: 31 mars 2016,

Accurate DNA replication is an essential prerequisite of genome stability, and nature has evolved numerous mechanisms to ensure precise and complete genome duplication. Subversion of these protective mechanism results in genome instability, the hallmark of cancer and many human developmental syndromes. Paradoxically, recent evidence suggests that pharmacological interference with these mechanisms ...
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 1

 TERMINÉ 

Identifying long non-coding RNAs with a role in Oncogenic-Induced Senescence (NONCOSENSE)

Date du début: 1 mars 2014, Date de fin: 29 févr. 2016,

The sequencing of the human genome has revealed that protein-coding genes correspond only to approximately 2% of the genome. Despite of this, the vast majority of the mammalian genome is actively transcribed. Thus, it is intriguing what this non-coding RNA (ncRNA), which was previously considered as transcriptional “noise”, is doing in the cell. New high-throughput technologies and novel RNA metho ...
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 1

 TERMINÉ 

Novel platform for combinatorial genetic libraries by recombination (COLIBRI)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2015,

Assembly of combinatorial genetic libraries for identification of biomolecules with novel or improved properties requires high fidelity and efficiency to produce the greatest spectrum of genetically diverse clones. We have been developing homologous recombination (HR) as a platform for the production of combinatorial genetic libraries for affinity maturation and diversification of human therapeuti ...
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 1