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 TERMINÉ 

Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI)

Date du début: 1 oct. 2013, Date de fin: 31 mars 2020,

Traumatic Brain Injury (TBI) is a major cause of death and disability, leading to great personal suffering to victim and relatives, as well as huge direct and indirect costs to society. Strong ethical, medical, social and health economic reasons therefore exist for improving treatment. The CENTER-TBI project will collect a prospective, contemporary, highly granular, observational dataset of 5400 p ...
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 44

 TERMINÉ 

Neurobiology and Treatment of Adolescent Female Conduct Disorder: The Central Role of Emotion Processing (FEMNAT-CD)

Date du début: 1 sept. 2013, Date de fin: 28 févr. 2018,

Conduct Disorder (CD) and Oppositional Defiant Disorder with symptoms of Conduct Disorder (which is included among the abbreviation “CD” throughout the proposal) has a highly negative impact for the affected individual as well as for families and society. Although the number of females exhibiting serious aggressive behaviours is growing, the majority of studies on aetiology and treatment of CD hav ...
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 19

 TERMINÉ 

Biomarker Research Alliance for Diagnosing Heart Disease in the Ageing European Population (BESTAGEING)

Date du début: 1 févr. 2013, Date de fin: 31 janv. 2018,

The ageing of the European population represents a rapidly rising social and economic challenge. Especially cardiovascular morbidity increases with age, but unfortunately, elderly patients are often difficult to diagnose due to confounding factors, leading to uncertainties in clinical decision making with huge impact on patients’ outcomes. Hence, there is an unmet need for novel biomarkers for mor ...
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 22

 TERMINÉ 

Immunostimulatory Agonist antibodies for Cancer Therapy (IACT)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,

"This concerted action aims at providing new treatment options for cancer patients through boosting innovative drug development by European academia and industry. A wealth of preclinical data shows that the therapeutic impact of cytotoxic regimens is enhanced by simultaneous application of drugs that strengthen the immune system. The recent FDA-approval of Ipilimumab demonstrated that cancer immun ...
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 11

 TERMINÉ 

Non-coding RNAs in neurogenic and neuropathic pain mechanisms and their application for risk assessment, patient stratification and personalised pain medicine (NCRNAPAIN)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

Neuro-immune alterations in the peripheral and central nervous system play a role in the pathophysiology of chronic pain, and non-coding RNAs (ncRNAs) regulate both immune and neuronal processes. Therefore, ncRNAPain proposes that ncRNAs are critically important master switches for chronic pain.ncRNAPain represents a multidisciplinary consortium of clinical partners, molecular and systems-level n ...
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 12

 TERMINÉ 

European Consortium for High-Throughput Research in Rare Kidney Diseases (EURENOMICS)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2017,

EURenOmics will integrate several established consortia devoted to rare kidney diseases with eminent need and potential for diagnostic and therapeutic progress (i.e. steroid resistant nephrotic syndrome, membranous nephropathy, tubulopathies, complement disorders such a haemolytic uraemic syndrome, and congenital kidney malformations). The Consortium has access to the largest clinical cohorts asse ...
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 29

 TERMINÉ 

Cystic Fibrosis Microbiome-determined Antibiotic Therapy Trial in Exacerbations: Results Stratified (CFMATTERS)

Date du début: 1 oct. 2013, Date de fin: 30 juin 2017,

Antimicrobial resistance is arguably the most significant challenge facing the EU health care system. The unnecessary use of antibiotics is a key driver in the development of antibiotic resistance. Cystic Fibrosis (CF) represents a unique disease model to study bacterial resistance and to explore therapeutic strategies for same, as chronic lung infection overlaps with acute lung exacerbations caus ...
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 15

 TERMINÉ 

Intelligent control of swimming pool disinfection with reduction and treatment of harmful by- products (INTELLIPOOL)

Date du début: 1 sept. 2014, Date de fin: 31 mai 2017,

The 4 SME Participants in the INTELLIPOOL project – ULTRAAQUA, VES, Electrocell and Swan aim to develop technology solutions to eliminate the severe adverse health effects caused by chlorinated disinfection by-products (DBP) in recreational bathing water facilities and simultaneously save energy, chemicals and water associated with pool water sanitation. We will create a toolbox of analytical/desi ...
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 10

 TERMINÉ 

Receptor signalling mediating malaria parasite motility (ParaMotSig)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2017,

Plasmodium sporozoites are the motile forms of the malaria parasite injected into the host by a mosquito. Sporozoite motility is essential for tissue penetration as well as host cell invasion and thus pathogenesis suggesting that blocking motility could potentially add a new way in controlling malaria. It is dependent on a parasite specific myosin, a highly divergent actin and plasma membrane prot ...
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 1

 TERMINÉ 

International Research Consortium on Dengue Risk Assessment, Management, and Surveillance (IDAMS)

Date du début: 1 sept. 2011, Date de fin: 28 févr. 2017,

The overall concept of this research project is to assemble a consortium of international experts working together to develop new and innovative tools to be applied to the control of dengue in a global context. The core of the application focuses on parallel strategies aimed at:• improving diagnosis and clinical management of dengue through two linked work packages designed a) to identify readily ...
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 18

 TERMINÉ 

European multicentre, randomised, phase III clinical trial of hypothermia plus best medical treatment versus best medical treatment alone for acute ischaemic stroke (EuroHYP-1)

Date du début: 1 févr. 2012, Date de fin: 31 janv. 2017,

The consortium led by UKER and EuroHYP, the European Stroke Research Network for Hypothermia, proposes a large, multicentre clinical trial which will assess mild hypothermia as a novel treatment for ischemic stroke.Stroke is the second cause of death world-wide and the second cause of lost disability-adjusted life years in high-income countries. Stroke incidence rises exponentially with age, so it ...
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 38

 TERMINÉ 

Generation of Novel Cardiotropic AAV-Based Serotypes to Evade Human Humoral Immunity (ImEvAAV)

Date du début: 1 oct. 2014, Date de fin: 30 sept. 2016,

Cardiovascular diseases remain the primary cause of morbidity and mortality in the western countries. Pharmacological treatment improves survival and quality of life, but does not reverse disease progression. Gene therapy could fill this void, owing to its ability to treat the underlying cause. Adeno-associated viruses (AAV) emanated in the past decade as potent vectors, owing to their tropism for ...
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 1

 TERMINÉ 

OPtimization of Treatment and Management of Schizophrenia in Europe (OPTiMiSE) (OPTiMiSE)

Date du début: 1 févr. 2010, Date de fin: 31 juil. 2016,

OPTiMiSE (OPtimization of Treatment and Management of Schizophrenia in Europe) will focus on two goals: optimising current treatments in Schizophrenia and explore novel therapeutic options for schizophrenia. The project intends to both address basic, but so far unanswered, questions in the treatment of schizophrenia and develop new and experimental interventions. It is expected that the project wi ...
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 25

 TERMINÉ 

The MEtabolic Road to DIAstolic Heart Failure (MEDIA)

Date du début: 1 janv. 2011, Date de fin: 30 juin 2016,

More than 50% of heart failure (HF) patients present without a major deficit of left ventricular (LV) systolic function and are presumed to suffer from diastolic HF (DHF) because diastolic LV distensibility is usually impaired in these patients. The vast majority (~80%) of DHF patients is exposed to metabolic risk factors. The MEDIA consortium therefore investigates:1) how metabolic derangements c ...
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 23

 TERMINÉ 

Formulating new Goals for global health, and proposing new Governance for global health that will allow the achievement of these goals (GO4HEALTH)

Date du début: 1 sept. 2012, Date de fin: 29 févr. 2016,

The MDGs succeeded in generating consensus on and mobilising resources towards agreed goals. They were less successful at clarifying responsibilities for achieving them. The MDG target on sharing global health innovation is particularly ambiguous about the allocation of responsibilities.The members of the consortium behind this proposal assume that the new goals for global health will need to be b ...
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 14

 TERMINÉ 

European Training and Research in Peritoneal Dialysis (EUTRIPD)

Date du début: 1 déc. 2011, Date de fin: 30 nov. 2015,

Peritoneal dialysis (PD) and haemodialysis (HD) are life-saving renal replacement therapies for more than 200,000 patients with chronic kidney disease in Europe, and this number increases annually. Although PD and HD have similar mortality rates, PD offers major advantages in terms of quality of life, costs, home-based treatment opportunities and early patient survival. Moreover, PD, rather than H ...
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 13

 TERMINÉ 

Role of human papillomavirus infection and other co-factors in the aetiology of head and neck cancer in India and Europe (HPV-AHEAD)

Date du début: 1 sept. 2011, Date de fin: 31 août 2015,

Human papillomavirus (HPV) is responsible for approximately 25% of head and neck cancer (HNC) worldwide and appears to be associated with a better response to treatment and improved prognosis. Evidence suggests that HPV-induced HNC has steadily increased in the USA and some European countries in the last decades. However, whether this is a worldwide phenomenon and specific risk factors are associa ...
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 11

 TERMINÉ 

Overcoming clinical relapse in multiple myeloma by understanding and targeting the molecular causes of drug resistance (OVER-MYR)

Date du début: 1 janv. 2012, Date de fin: 30 juin 2015,

Multiple Myeloma (MM) is a currently incurable rare malignant plasma cell disease, which invariably relapses despite therapy. The objective of OVER-MYR is to understand the causes of drug resistance and relapse, develop novel strategies to overcome these, provide proof of principal for phase I/II trial, and thus impact on MM-patient’s survival.Currently-used drugs target both MM cells (MMC) and c ...
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 11

 TERMINÉ 

Small-molecule Inhibitor Leads Versus emerging and neglected RNA viruses (SILVER)

Date du début: 1 oct. 2010, Date de fin: 31 mars 2015,

RNA virus infections kill millions of humans annually, largely due to the lack of suitable vaccines and drugs to control them. This problem is addressed in this FP7 call and in response a consortium of Europe’s and Asia’s leading molecular virologists, structural biologists, medicinal chemists and bioinformaticians has been brought together to generate a state-of-the-art drug discovery and design ...
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 25

 TERMINÉ 

New Algorithms for Host Pathogen Systems Biology (SYSPATHO)

Date du début: 1 oct. 2010, Date de fin: 31 mars 2015,

SYSPATHO focuses on the development of novel and generally applicable mathematical methods and algorithms for systems biology. These methods and algorithms will be applied to study the complex interactions of hepatitis C virus (HCV), a human-pathogenic virus of high medical relevance, with its host at the systems level. Using a multidisciplinary, integrative approach, PATHOSYS will (a) develop met ...
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 11

 TERMINÉ 

THERAPEUTIC AND PREVENTIVE IMPACT OF NUTRITIONAL LIPIDS ON NEURONAL AND COGNITIVE PERFORMANCE IN AGING, ALZHEIMER’S DISEASE AND VASCULAR DEMENTIA (LIPIDIDIET)

Date du début: 1 août 2008, Date de fin: 31 mars 2015,

Major objective: It is our aim to develop a lipid based diet that is able to delay or prevent onset of Alzheimer’s disease and related diseases and has a stabilizing effect on cognitive performance in aging. Multiple lines of evidence suggest that there is a large overlap between risk factor of these three diseases. Importantly, there is equally strong evidence that prevention and treatment of the ...
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 19

 TERMINÉ 

Tailored implementation for chronic diseases (TICD)

Date du début: 1 févr. 2011, Date de fin: 28 févr. 2015,

Project aim. Chronic diseases represent an important challenge facing healthcare systems. Research has consistently shown gaps between knowledge and practice for chronic illness care. Tailoring implementation interventions implies that the choice and content of implementation interventions are based on assessment of local barriers and enabling factors. It is widely believed that tailoring contribu ...
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 7

 TERMINÉ 

European Training Network on (+)RNA Virus Replication and Antiviral Drug Development (EUVIRNA)

Date du début: 1 mars 2011, Date de fin: 28 févr. 2015,

Virus infections remain a major cause of disease, with dramatic costs in mortality, morbidity, and economic loss worldwide. There is an unmet need for potent antiviral drugs, in particular against viruses with a (+)RNA genome which include many important pathogens of humans and animals.Antiviral drug development requires a detailed understanding of virus replication and effective translation of th ...
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 12

 TERMINÉ 

A Modular Nanosystems Platform for Advanced Cancer Management: Nano-vehicles; Tumor Targeting and Penetration Agents; Molecular Imaging, Degradome based Therapy (SAVEME)

Date du début: 1 mars 2011, Date de fin: 28 févr. 2015,

SaveMe project will address current urgent needs for pancreatic cancer diagnosis and treatment by exploiting partners’ expertise and most recent research achievements for the design and development of novel modular nanosystems platform integrating new functionalized nano-core particles and active agents. The modular platform will enable the design of diverse active nanosystems per diagnostic or th ...
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 23

 TERMINÉ 

Research Training in 3D Digital Imaging for Cancer Radiation Therapy (ENTERVISION)

Date du début: 1 févr. 2011, Date de fin: 31 janv. 2015,

The vision on a future high-precision radiation therapy utilizing either particle or photon beams is a treatment on a technological level which allows for: (1) obtaining information on relevant tumour parameters (volume, position, topology, density - also of the surrounding tissue) during every moment of therapeutic irradiation; (2) adapting the treatment plan in real time; and (3) initiating the ...
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 12

 TERMINÉ 

An integrated surveillance system for infectious disease in rural China: generating evidence for early detection of disease epidemics in resource-poor settings (ISSC)

Date du début: 1 mars 2010, Date de fin: 31 déc. 2014,

Background A crucial goal of infectious disease surveillance is the early detection of epidemics, which is essential for disease control. In China, the current surveillance system is based on confirmed case reports and only covers notifiable diseases. In rural China, it is not practical for health units to perform laboratory tests to confirm disease and people are more likely to get 'old' and emer ...
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 5

 TERMINÉ 

TOWARDS THE ESTABLISHMENT OF A FRAMEWORK IN MALARIA BETWEEN THE AMRN AND EVIMALAR (Ozmalnet)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2014,

54 partners from 34 institutes have formed an EC-funded Network of Excellence (NoE) in basic malaria research, the European Virtual Institute for Malaria Research (EVIMalaR). Over the previous >5 years as the NoE Biomalpar these partners successfully broke down many barriers to cooperation pursuing a programme of integrated research. This was greatly assisted by the Biomalpar PhD School whose stud ...
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 14

 TERMINÉ 

Regeneration and Target Reinnervation after Spinal Cord Injury (Axon Regeneration)

Date du début: 1 oct. 2010, Date de fin: 30 sept. 2014,

Recent studies have indicated that combinatorial treatments that target multiple mechanisms are necessary to address the limited regenerative capacity in the adult nervous system. We have shown that chemotropic guidance by growth factor gradients, activation of cell-intrinsic regenerative programs and suitable cellular bridges at a lesion site allow for axons to extend across a lesion site in the ...
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 1

 TERMINÉ 

European NoVel Imaging Systems for ION therapy (ENVISION)

Date du début: 1 févr. 2010, Date de fin: 31 juil. 2014,

Following the pioneering experiences which lasted several decades, particle therapy has become a recognized way of curing cancer. 2 new European dual-ion facilities (Heidelberg, Pavia) will soon become operational, followed by several others which are today at different stages of planning and construction. Hadron therapy faces the challenge of improving treatment outcomes with tools able to provid ...
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 16

 TERMINÉ 

Glycomics by High-throughput Integrated Technologies (GlycoHIT)

Date du début: 1 janv. 2011, Date de fin: 30 juin 2014,

Protein glycosylation is a post-translational phenomenon that is involved in most physiological and disease processes including cancer. Most of the known cancer-associated glycobiomarkers were discovered individually using liquid chromatography and mass spectroscopy. Though valuable, there is room for improvement in these approaches for the discovery phase. There is also a critical need for innova ...
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 16

 TERMINÉ 

T Helper cell lineages and their Cytokines in Autoimmune SKin Disease (THC-ASKID)

Date du début: 1 juin 2011, Date de fin: 31 mai 2014,

"Autoimmune skin diseases like psoriasis and atopic dermatitis are in part CD4 T cell mediated. After stimulation, CD4 T cells differentiate into different T helper cell lineages with distinct cytokine profiles. While in atopic dermatitis for example skin infiltrating T cells mainly show a Th2-polarization, in psoriasis, which is mediated by autoreactive T cells of the Th1-phenotype, recent eviden ...
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 1

 TERMINÉ 

Quality of maternal and prenatal care: bridging the know-do gap (QUALMAT)

Date du début: 1 mai 2009, Date de fin: 30 avr. 2014,

Besides a dramatic lack of financial and human resources in developing countries, health care is additionally endangered by quality deficiencies caused by low staff motivation. This lack of motivation leads to an insufficient translation of knowledge into optimal utilization of resources. The “know-do” gap represents a challenge that must be addressed to strengthen health services performance towa ...
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 6

 TERMINÉ 

Research capacity for the implementation of genetic control of mosquitoes (INFRAVEC)

Date du début: 1 sept. 2009, Date de fin: 28 févr. 2014,

Mosquitoes transmit a variety of infectious diseases that cause a tremendous burden to public health. Due to climate changes and to the increase in international trade and tourism the threats posed by mosquitoes are increasingly affecting large parts of Europe, causing understandable concerns among the populations of many Member States. Control methods, mainly based on insecticide usage, are strug ...
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 31

 TERMINÉ 

INtegrated HEart Research In TrANslational genetics of dilated Cardiomyopathies in Europe (INHERITANCE)

Date du début: 1 janv. 2010, Date de fin: 31 déc. 2013,

"Inherited dilated cardiomyopathies (DCM) are monogenic disorders caused by mutations in more than 30 genes, characterised by substantial phenotype heterogeneity. DCM affects 1:2.500 individuals and is the major cause of heart transplantation and death for non-ischaemic heart failure in adolescents and young adults. Currently, less than 1% of patients with familial DCM are genotyped in Europe. The ...
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 11

 TERMINÉ 

BrainTrain: Integrative neuroscience school on brain function and disease (BrainTrain)

Date du début: 1 nov. 2009, Date de fin: 31 oct. 2013,

Brain disorders, in particular neurodegenerative diseases and mental illnesses are among the most prevalent and debilitating diseases. Because they are chronic, quality of life and socio-economic prospects are dramatically impaired. Increased life expectancy further enhances the impact of brain dysfunction on society. In coming decades this burden will grow into one of most pressing and costly pro ...
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 14

 TERMINÉ 

Affording Recovery In Stroke (ARISE)

Date du début: 1 mars 2008, Date de fin: 31 août 2013,

"Stroke poses a massive clinical, social and economic burden, yet we have very limited effective therapies. This inadequacy is in spite of intensive research efforts and numerous failed clinical trials. Leading European stroke researchers and clinicians with a track record of established cooperation will share their complementary expertise, and team up with SME partners with high profile R&D and o ...
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 17

 TERMINÉ 

Compliance and effectiveness in HF and CHD closed-loop management (HeartCycle)

Date du début: 1 mars 2008, Date de fin: 31 août 2013,

Each year Cardiovascular Disease (CVD) causes over 1.9 million deaths in the EU, causing direct health costs of €105 billion. Coronary Heart Disease (CHD), half of all CVD deaths, is the single most cause of death in Europe. Heart Failure (HF) – a CHD being the most frequent cause of hospitalization for people over 65 – has 10 million patients in the EU. Current treatment of HF entails recommendat ...
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 22

 TERMINÉ 

Personalised and intergrated cardiac care: \nPatient-specific Cardiovascular Modelling and Simulation for In Silico Disease Understanding and Management (euHeart)

Date du début: 1 juin 2008, Date de fin: 30 nov. 2012,

Cardiovascular disease (CVD) has a significant impact on the European society in terms of mortality, morbidity and allied healthcare costs. The opportunity of multi-scale modelling spanning, sub-cellular level up to whole heart is to improve CVD outcomes by providing a consistent, biophysically-based framework for the integration of the huge amount of fragmented and inhomogeneous data currently av ...
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 21

 TERMINÉ 

Particle Training Network for European Radiotherapy (PARTNER)

Date du début: 1 oct. 2008, Date de fin: 30 sept. 2012,

"A Particle Training Network for European Radiotherapy (PARTNER) will be established in response to the critical need for reinforcing research in ion therapy and the training of professionals in the rapidly emerging field of hadron therapy. This is an interdisciplinary, multinational initiative, which has the primary goal of training researchers who will help to improve the overall efficiency of i ...
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 10

 TERMINÉ 

Intervention strategies against malaria (InterMalTraining)

Date du début: 1 oct. 2008, Date de fin: 30 sept. 2012,

Malaria exacts a devastating social and economic cost across the globe. Europe is at the forefront of the battle against this disease. It contains many of the leading malaria research groups, most of which are members of at least one of two consortia; BioMalPar, a Network of Excellence focused on basic research into the biology and pathology of malaria; and AntiMal, an integrated project aiming ...
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 13