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14 projets européens trouvés

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 TERMINÉ 

Consortium on Organ Preservation in Europe (COPE)

Date du début: 1 janv. 2013, Date de fin: 30 juin 2018,

The discrepancy between organ supply and demand remains the biggest challenge facing the transplant community today. In order to increase the amount of available donor organs, transplant specialists are increasingly turning to sub-optimal donor organs. Organs from such donors, usually have normal or near normal function before death, but retrieval, storage and transplantation cause progressive inj ...
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 16

 TERMINÉ 

European Medical Information Framework (EMIF)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

In response to the need to tackle increasingly complex medical research questions, a growing amount of human health data is being collected, either in routine Electronic Healthcare Record (EHR) databases, through research-driven cohort studies, in biobanks or related efforts. However, data sources are typically fragmented and contain information gaps which prevent their full exploitation. EMIF aim ...
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 64

 TERMINÉ 

Calcium- and light signals in photosynthetic organisms (CALIPSO)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

"CALIPSO is a genuine interdisciplinary and intersectorial research network composed of nine academic research institutions and three industrial partners, thus presenting an example of true translational research and training of young researchers in communicating and transferring achievements from different model organisms directly to industrial partners. CALIPSO aims at identifying environmentall ...
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 11

 TERMINÉ 

Overcoming translational barriers to gene therapy by novel vector design (RETINAL-GENE-THERAPY)

Date du début: 1 mai 2013, Date de fin: 30 avr. 2017,

"Inherited retinal degenerations are a primary clinical focus of adeno-associated virus (AAV) mediated gene therapy. These diseases mostly involve pathogenic mutations in the retinal pigment epithelium or photoreceptor transcripts leading to cell death and progressively lead to blindness. Current delivery methods are efficient for gene delivery to these cells as well as other therapeutically relev ...
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 1

 TERMINÉ 

A Multi-Stage Malaria Vaccine (MultiMalVax)

Date du début: 1 oct. 2012, Date de fin: 31 mars 2017,

A highly effective malaria vaccine is a major goal of global health research and will likely require a multi-stage product. MultiMalVax will develop a highly effective multi-stage malaria vaccine to the point of proof-of-concept phase II testing in Europe, prior to trials in malaria-endemic areas.Remarkable recent advances in vaccine design for all four stages of the P. falciparum parasite’s life- ...
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 6

 TERMINÉ 

Orphans Unite: chILD better together – European Management Platform for Childhood Interstitial Lung Diseases (CHILD-EU)

Date du début: 1 déc. 2012, Date de fin: 30 nov. 2016,

Children with diffuse lung disease, also called childhood interstitial lung diseases (chILD), may have one of more than 200 entities, the biggest group of respiratory orphan lung diseases. Frequently undiagnosed because of lack of awareness or complex differential diagnosis, they lead to much morbidity, mortality (about 15%) and psychosocial stress for the families. Current lack of evidence based ...
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 10

 TERMINÉ 

Advanced Studies towards Knowledge on Lyssavirus Encephalitis Pathogenesis Improving Options for Survival (ASKLEPIOS)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2016,

The overall aim of ASKLEPIOS is to unravel and increase our understanding of the mechanisms that govern pathogenesis of rabies virus (RABV) infection, in pursuit of the rational identification of novel therapeutic leads for rabies encephalitis. Several studies have been conducted over the past decades attempting to unravel the pathogenesis of this deadly disease, however with limited success. New ...
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 9

 TERMINÉ 

Environmental Acclimation of Photosynthesis (ACCLIPHOT)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

AccliPhot is an interdisciplinary, intersectorial research andtraining network devoted to study photosynthetic acclimation processesin plants and algae. We will train 13 early-stage researchers (ESRs)and 1 experienced researcher (ER) in cutting-edge experimentaltechnologies, modern modelling approaches, industrial applications anda wide spectrum of complementary and industry-relevant skills. In th ...
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 13

 TERMINÉ 

A Gateway to European Kidney Research Resources - KidneyConnect (KidneyConnect)

Date du début: 1 août 2013, Date de fin: 31 juil. 2016,

Diabetes, Cardiovascular and Chronic kidney (DCC) -diseases are relentlessly increasing globally, causing enormous human suffering, premature deaths and unsustainable costs. Leading European research has indisputably pointed that the kidney filtration barrier and its epithelial cell, the podocyte, is a common denominator for the DCC-diseases. However, European excellence and expertise have remaine ...
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 19

 TERMINÉ 

The European Network for Translational Research in Atrial Fibrillation (EUTRAF)

Date du début: 1 nov. 2010, Date de fin: 31 oct. 2015,

"The initiation and perpetuation of atrial fibrillation (AF) can be regarded as a complication of a progressive transformation of the structure and functional properties of the atria. This transformation is the result of complex and multiple changes at the molecular, cellular and organ levels which interact to form the basis for proarrhythmic mechanisms in AF. Numerous individual and environmental ...
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 20

 TERMINÉ 

Visualizing tolerance induction: behavior and function of regulatory T cells during the establishment of materno/fetal tolerance (VISTO)

Date du début: 1 mars 2012, Date de fin: 28 févr. 2014,

The presence of foreign (allogenic) tissue in a host yields an immune response with the goal to destroy the tissue. During pregnancy, however, the semiallogenic fetus is allowed to grow within the maternal uterus. This ‘immunological paradox of pregnancy’ has received much attention because of its therapeutic implications in organ transplantation and autoimmune diseases.While it has recently been ...
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 1

 TERMINÉ 

NANOPARTICLES FOR THERAPY AND DIAGNOSIS OF ALZHEIMER DISEASE (NAD)

Date du début: 1 sept. 2008, Date de fin: 31 août 2013,

The search for effective therapies and early detection strategies for Alzheimer’s Disease (AD), the major cause of dementia in Europe, is imperative. It is known that β-amyloid (Aβ) peptide plays a central role in neurodegeneration. In AD brain, Aβ is released in a soluble form that progressively becomes insoluble forming aggregates; extracellular plaques mainly composed of Aβ are a hallmark of po ...
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 19

 TERMINÉ 

Understanding and combating human age-related muscle weakness (MYOAGE)

Date du début: 1 janv. 2009, Date de fin: 30 juin 2013,

Ageing of skeletal muscle results in a progressive loss of mobility that decreases the quality of life and has major economic and social consequences for society at large. Increasing muscle weakness is a major component of muscle ageing. In the elderly muscles become atrophic (loss in muscle mass) and weaker (loss in muscle force), more susceptible to damage and consequently regenerate and recover ...
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 18

 TERMINÉ 

A road map for European ageing research (WhyWeAge)

Date du début: 1 janv. 2009, Date de fin: 31 déc. 2010,

The rapid increase of life expectancy in Europe is essentially a positive outcome from improved health care and socioeconomic progress. However age-related deteriorations of health greatly impinge upon the health care and social security systems. This fosters an increasing necessity of keeping as long as possible the elderly in relatively healthy conditions. Unravelling the fundamental mechanisms ...
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 15