7 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Control of metabolic and inflammatory pathways by nuclear receptors (NR-NET)
Date du début: 1 sept. 2013, Date de fin: 31 août 2017,
NR-NET is a multidisciplinary consortium, whose activities are directed towards the understanding of the role of Nuclear Receptors (NRs) and coregulators in metaflammatory disease. Metaflammation - metabolic disorders linked to chronic inflammation – is an emerging concept explaining the pathogenesis of a wide-spectrum of diseases. Since several nuclear receptors can directly sense metabolic alter ...
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11
Participants partenaires
TERMINÉ
Molecular Basis of Mammalian Egg-Sperm Interaction (GAMETE RECOGNITION)
Date du début: 1 janv. 2011, Date de fin: 31 déc. 2015,
At the dawn of the 21st century, our knowledge of the molecular mechanism of mammalianfertilization remains very limited. Different lines of evidence indicate that initial gamete recognitiondepends on interaction between a few distinct proteins on sperm and ZP3, a major component of theextracellular coat of oocytes, the zona pellucida (ZP). On the other hand, recent findings suggest analternative ...
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1
Participant partenaire
TERMINÉ
Microbes in Allergy and Autoimmunity Related to the Skin (MAARS)
Date du début: 1 avr. 2011, Date de fin: 31 mars 2015,
"Allergy and autoimmunity cause increasing burden to societies worldwide. We study the effect of microbiome on the skin, the forefront barrier to environment, on autoimmunity and allergy, using atopic dermatitis (AD) and psoriasis (PSO) as paradigmatic examples. We have detailed information about the genetic risk factors, as well as the molecular and cellular players in AD and PSO, but we know ver ...
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10
Participants partenaires
TERMINÉ
The role of Lgr6 as a marker of progenitor cells and cancer-initiating cells in the mammary gland (Lgr6MammarySC)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2014,
The epithelial compartments of the mammary gland are thought to be derived from a tissue stem cell capable of self-renewal and differentiating into all cellular lineages of the mammary gland. Detailed studies of normal and tumorigenic breast stem cells have proven rather cumbersome since these cells are rare and a high degree of purification is needed. Several approaches to isolate mammary stem c ...
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1
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TERMINÉ
Broadening the Bioinformatics Infrastructure to unicellular, animal, and plant science (ALLBIO)
Date du début: 1 oct. 2011, Date de fin: 30 sept. 2014,
The main aim of AllBio will be the coordination of the partner's activities that are aimed at the extension of a large number of bioinformatics facilities towards applicability in target life science areas beyond human health. Bioinformatics facilities developed for the human health area will be extensively tested on unicellular (incl. bacterial), plant and (farm) animal genomes, and they will be ...
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11
Participants partenaires
TERMINÉ
Dissecting the transcriptional mechanisms controlling growth during normal development and cancer (GrowthControl)
Date du début: 1 mars 2009, Date de fin: 28 févr. 2014,
The main scientific questions addressed in this proposal relate to the understanding of molecular mechanisms of growth control and cancer through the combined use of high-throughput technologies and computational biology. We aim to create a systems-level understanding of the cell cycle, and its regulation by physiological growth factors and oncogenes through the use high-throughput biology to iden ...
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1
Participant partenaire
TERMINÉ
Understanding Hedgehog signalling in breast cancer and mammary gland stem cells using tissue specific expression of Gli1 the main effector of the Hedgehog pathway (MammaHogLgr)
Date du début: 1 juil. 2009, Date de fin: 30 juin 2011,
Only a subset of tumour cells is capable of giving rise to new tumours. These so called “tumour stem-cells” are functionally similar to adult stem cells and have been identified in tumours of several tissues. Whether transformation of adult stem cells into tumour stem cells is the event leading to the disease is not clear. Alternatively, tumours could arise from the population of committed progeni ...
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