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 TERMINÉ 

Multiple manifestations of genetic and non-genetic factors in Multiple Sclerosis disentangled with a multi-omics approach to accelerate personalised medicine (MultipleMS)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

The complex interactions between genetic and non-genetic factors produce heterogeneities in patients as reflected in the diversity of pathophysiology, clinical manifestations, response to therapies, disease development and progression. Yet, the full potential of personalized medicine entails biomarker-guided delivery of efficient therapies in stratified patient populations.MultipleMS will therefor ...
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 25

 TERMINÉ 

Post-transcriptional Regulation of Germinal Center B Cell Responses in Immunity and Disease (GCB-PRID)

Date du début: 1 sept. 2016, Date de fin: 31 août 2021,

Antibodies secreted by B cells of the adaptive immune system establish an essential barrier against bacteria and viruses and their presence is the hallmark of protective vaccinations. B cells are licensed for their tasks during germinal center (GC) reactions and differentiation into antibody-secreting plasma cells. Unfortunately, B cell-derived autoantibodies and proinflammatory cytokines can caus ...
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 2

 TERMINÉ 

Dissecting the role of the ubiquitin proteasome system in the pathogenesis and therapy of B-cell malignancies (BCM-UPS)

Date du début: 1 sept. 2016, Date de fin: 31 août 2021,

B-cell malignancies are characterized by high levels of genomic instability, which critically contribute to their pathogenesis and evolution. Recently, the fundamental role of the ubiquitin proteasome system (UPS) in maintaining genome integrity has been appreciated. Two major new therapeutic modalities in B-cell malignancies, proteasome inhibitors and imunomodulatory drugs (IMiDs), target the UPS ...
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 2

 TERMINÉ 

Individualised medicine in chronic inflammatory skin diseases (IMCIS)

Date du début: 1 juil. 2016, Date de fin: 30 juin 2021,

More than 100 million EU citizens suffer from chronic inflammatory skin diseases such as psoriasis and atopic eczema (AE). The diseases imply a devastating life quality similar to that of cancer, and cause direct socio-economic costs in the magnitude of 100 billion Euro each year in the EU. Despite all efforts, psoriasis and AE remain undertreated and the concept of individualised (also called pre ...
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 2

 TERMINÉ 

TRANSATLANTIC TRADE AND INVESTMENT PARTNERSHIP-INTERNATIONAL TRAINING NETWORK (TTIP-ITN)

Date du début: 1 avr. 2017, Date de fin: 31 mars 2021,

The EU currently is negotiating a controversial Transatlantic Trade and Investment Partnership (TTIP) agreement with the USA, the main features of which will be the abolition of tariffs, the reduction of non-tariff barriers to trade between the EU and the USA and the introduction of a dispute settlement mechanism. The objective of the proposed TTIP Innovative Training Network (TTIP-ITN) is to fost ...
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 11

 TERMINÉ 

Magnetic resonance imaging platform for probing fat microstructure (ProFatMRI)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2021,

Metabolic syndrome and osteoporosis are the two metabolic diseases with the highest and most rapidly growing prevalence, transforming them into a major global health and socioeconomic concern. Metabolic syndrome can be diagnosed with established biomarkers, but the selection of optimal prevention strategies for each individual patient is still problematic. Osteoporosis can be treated, but its curr ...
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 2

 TERMINÉ 

Next-generation in vivo models for improved pancreatic cancer therapies (PanCaT)

Date du début: 1 févr. 2016, Date de fin: 31 janv. 2021,

Maintenance and drug resistance of pancreatic ductal adenocarcioma (PDAC) depends on cancer cell intrinsic mechanisms and a stroma that supports tumor growth. Mouse models of human PDAC have provided important insights into the evolution of this highly lethal tumor, but there are no models that allow secondary genetic manipulation of autochthonous tumors, the tumor microenvironment or the metastat ...
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 2

 TERMINÉ 

Small vessel diseases in a mechanistic perspective: Targets for InterventionAffected pathways and mechanistic exploitation for prevention of stroke and dementia (SVDs-at-target)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Stroke and dementia rank among the most pressing health issues in Europe. Cerebral small vessel diseases (SVDs) have emerged as a central link between these two major co-morbidities. SVDs account for more than 30% of strokes and at least 40% of dementia cases. They encounter multiple distinct diseases that can be separated based on their underlying genetic defects, risk factors, and clinical prese ...
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 14

 TERMINÉ 

Light induced spatially EXact and genetically encoded labeling of immune cells for monitoring of lOng Distance and Ultra-compartment Shuttling during autoimmunity and chronic inflammation (EXODUS)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

The incidence of autoimmune diseases including multiple sclerosis is dramatically increasing. While there is a genetically defined “bedrock” susceptibility to develop T cell mediated autoimmunity, environmental cues likely determine the threshold for disease development. Yet, little is known on how environmental cues sensed at body/environment interfaces are translated into immunopathology in dist ...
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 2

 TERMINÉ 

Individualized treatment planning in chronic back pain patients by advanced imaging and multi-parametric biomechanical models (iBack)

Date du début: 1 juin 2015, Date de fin: 31 mai 2020,

Chronic back pain is a major burden and source of disability worldwide. It is primarily attributed to biomechanical factors. In elderly patients, osteoporosis complicates the biomechanical scenario. Surgery is often required to treat instability-related pain and to restore the balance of the spine. However, when and how to perform surgery remains a highly subjective decision based on the surgeon’s ...
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 3

 TERMINÉ 

Autologous Stem Cell Seeded Tissue Engineered Trachea (TETRA)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,

CLINICAL PROBLEM AND UNMET NEEDThere are 11,827 patients with severe structural airway disease in Europe. Even with the current standard of care, when hospitalised this group of patients has a 22% risk of dying. Patients are currently subjected to repeated surgical interventions (stent insertion) which have a high failure rate. Other therapeutic strategies under development include synthetic trac ...
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 14

 TERMINÉ 

Platform for Open Development of Systems of Artificial Intelligence (Bonseyes)

Date du début: 1 déc. 2016, Date de fin: 30 nov. 2019,

The Bonseyes project aims to develop a platform consisting of a Data Marketplace, Deep Learning Toolbox, and Developer Reference Platforms for organizations wanting to adopt Artificial Intelligence in low power IoT devices (“edge computing”), embedded computing systems, or data center servers (“cloud computing”). It will bring about orders of magnitude improvements in efficiency, performance, reli ...
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 15

 TERMINÉ 

Integrative Analysis of Gene Functions in Cellular and Animal Models of Pancreatic Cancer (CAM-PAC)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

Cancers are genetic disease arising from the accumulation of multiple molecular alterations in affected cells. Large-scale genomic, transcriptomic and proteomic analyses have established comprehensive catalogues of molecules which are altered in their structure and/or abundance in malignant tumors as compared to healthy tissues. Far less developed are concepts and methods to integrate data from di ...
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 18

 TERMINÉ 

Schizophrenia Psychological Interventions Network Meta-Analysis of randomized evidence (SPIN-MA)

Date du début: 1 oct. 2016, Date de fin: 30 sept. 2018,

...isions according to an evidence based medicine approach. This addresses several EU programs’ aims. I will be hosted at the Department of Psychiatry and Psychotherapy of Klinikum rechts der Isar der Technischen Universität München, under the supervision of Professor Stefan Leucht, who has outstanding expertise both in the field of schizophrenia treatment and in the methodology of NMA. A partner or ...
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 2

 TERMINÉ 

implementAtion anD OPeration of the gateway for healTh into BBMRI-ERIC (ADOPT BBMRI-ERIC)

Date du début: 1 oct. 2015, Date de fin: 30 sept. 2018,

"BBMRI-ERIC: the Biobanking and BioMolecular resources Research Infrastructure - European Research Infrastructure Consortium, aims to establish, operate and develop a Pan-European distributed research infrastructure in order to facilitate the access to biological resources as well as facilities and to support high quality biomolecular and biomedical research. The ADOPT BBMRI-ERIC proposal aims at ...
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 22

 TERMINÉ 

Statistical multi-Omics UNDerstanding of Patient Samples (SOUND)

Date du début: 1 sept. 2015, Date de fin: 31 août 2018,

Bioinformatic analysis is the biggest bottleneck in many genomic medicine projects. Our objective is to enable researchers to dramatically increase statistically informed use of personal multi-omic data in medicine. Soon, multiple types of omic technologies will be applied to 100,000s of patient-derived samples, with the three-stage goal of better understanding disease biology, discovery of new in ...
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 11

 TERMINÉ 

Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in EUrope (EU-CERT-ICD)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

An estimated 500.000 sudden cardiac deaths (SCD) occur each year in the European Union. Patients at risk for SCD may benefit from prophylactic treatment with an implantable cardioverter-defibrillator (ICD). ICD implantations have dramatically increased in recent years leading to multi-billion Euros of costs with significant regional disparities across Europe. Information on risks, benefits and cos ...
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 27

 TERMINÉ 

Optimizing Exercise Training in Prevention and Treatment of Diastolic Heart Failure (OptimEx)

Date du début: 1 oct. 2013, Date de fin: 31 mars 2017,

More than 14 million Europeans suffer from heart failure (HF), of which more than 50 % have HF with preserved left ventricular (LV) ejection fraction (EF) (HFPEF, “diastolic heart failure”). HFPEF is the only cardiovascular disease with increasing prevalence and incidence, affecting 10-20% of the elderly and contributing substantially to hospitalizations of elderly HF patients. Currently, no medic ...
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 9

 TERMINÉ 

Anti-Biopharmaceutical Immunization:Prediction and analysis of clinical relevance to minimize the risk (ABIRISK)

Date du début: 1 mars 2012, Date de fin: 28 févr. 2017,

The ABIRISK project provides an integrated approach to the study of immunization against biopharmaceuticals, bringing together a unique panel of experts from different disciplines. ABIRISK will involve many of the European leaders in rheumatology, gastroenterology, hemophilia and multiple sclerosis, caring for ~30,000 patients treated with biopharmaceuticals, with ~10,000 additional patients recru ...
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 39

 TERMINÉ 

Improving HSCT By Validation Of Biomarkers & Development Of Novel Cellular Therapies (CELLEUROPE)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

Novel transplant regimens are currently being developed to improve beneficial GvL effects and reduce GvHD and infections via several new forms of cellular therapies. This newly emerging supra-disciplinary field of cellular therapy and regenerative medicine is also being used to improve outcomes in autoimmune disease (such as Rheumatoid Arthritis) and cancers. The goal of this research programme is ...
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 13

 TERMINÉ 

Treat Iron-Related Childhood-Onset Neurodegeneration (TIRCON)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,

Neurodegeneration with brain iron accumulation (NBIA) is a heterogeneous group of rare hereditary neurodegenerative disorders characterized by high levels of brain iron. The most common form is pantothenate kinase-associated neurodegeneration (PKAN). Classic PKAN and most other NBIA cases are characterised by early childhood onset and rapid progression. Currently, there is no proven therapy to hal ...
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 14

 TERMINÉ 

Future Internet Social and Technological Alignment Research (FI-STAR)

Date du début: 1 avr. 2013, Date de fin: 30 sept. 2015,

FI-STAR will establish early trials in the Health Care domain building on Future Internet (FI) technology leveraging on the outcomes of FI-PPP Phase 1. It will become self-sufficient after the end of the project and will continue on a sustainable business model by several partners. In order to meet the requirements of a global Health industry FI-STAR will use a fundamentally different, "reverse" c ...
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 44

 TERMINÉ 

Novel multimodal endoscopic probes for simultaneous PET/ultrasound imaging for image-guided interventions (ENDOTOFPET-US)

Date du début: 1 janv. 2011, Date de fin: 30 juin 2015,

In the frame of this project it is proposed to define and build a bi-modal PET-US (Positron Emission Tomography and Ultrasound) endoscopic probe combining in a miniaturized system a fully digital, 200ps time resolution Time of Flight PET detector head (TOF-PET) coupled to a commercial ultrasound (US) assisted biopsy endoscope and to launch the first steps of clinical validation.The project address ...
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 16

 TERMINÉ 

Ultrafine Particles – an evidence based contribution to the development of regional and European environmental and health policy (UFIREG)

Date du début: 30 juin 2011, Date de fin: 30 déc. 2014,

Air quality is a topic of concern for all citizens. It directly influences life-quality and span. In order to meet the challenges resulting from increased air pollution, regional authorities have to adapt to innovative interdisciplinary approaches. A little attention has however been paid so far to the measurement of ultrafine particles and to providing knowledge-based contributions to regional po ...
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 7

 TERMINÉ 

Targeting the tumour microenvironment to improve pancreatic cancer prognosis (EPC-TM-Net)

Date du début: 1 févr. 2011, Date de fin: 31 juil. 2014,

Pancreatic cancer is one of the most lethal human cancers with a five-year survival rate of less than 5%. Late presentation and a high level of resistance to chemotherapeutic drugs are among the major reasons for this dismal prognosis. The presence of the highest degree of desmoplasia among all solid tumours and the fact that chronic inflammatory pancreatic disease is associated with an increased ...
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 17

 TERMINÉ 

Embryonic Stem cell-based Novel Alternative Testing Strategies (ESNATS)

Date du début: 1 avr. 2008, Date de fin: 30 sept. 2013,

"ESNATS aims at developing a novel toxicity test platform based on embryonic stem cells (ESC), especially human ESC (hESC), to accelerate drug development, reduce R&D costs and propose a powerful alternative to animal tests (3 Rs). ESNATS will address current drug-testing shortcomings: - testing takes place late in the development cycle - animal test systems bear the risk of non-prediction due to ...
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 34

 TERMINÉ 

Zukunftsfähige Landbewirtschaftung (Standortkonzepte zukunftsfähige Landwirtschaft)

Date du début: 28 févr. 2007, Date de fin: 30 mars 2013,

Das landwirtschaftliche Bauen im Projektgebiet ist gekennzeichnet durch einen steten Struktur-wandel. Kleinere Betriebe werden stillgelegt, was zur Folge hat, dass die frei werdenden Produkti-onsflächen von wachsenden Betrieben übernommen werden. Mit dieser Vergrößerung geht in der Regel auch eine Vergrößerung der baulichen Anlagen einher. Diese stehen häufig im Konflikt mit dem herkömmlichen Bild ...
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 11

 TERMINÉ 

Transnational Forestry Management Strategies in Response to Regional Climate Change Impacts (ForeStClim)

Date du début: 31 déc. 2007, Date de fin: 27 févr. 2013,

Climate Change reflects itself on the regional level by a changing regional climate and impacts on the environmental. societal and economic worlds. Hand in hand with this will be an inevitable shift in forest site conditions in the next decades with serious implications for sustainable forest management. Hence the project will show regionalized climate change impacts on forest site characterist ...
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 21

 TERMINÉ 

CAMbrella – A pan-European research network for Complementary and Alternative Medicine (CAM) (CAMbrella)

Date du début: 1 janv. 2010, Date de fin: 31 déc. 2012,

The goal of this collaboration is to develop a roadmap for future European research in CAM that is appropriate for the health care needs of EU citizens, and acceptable to the EU parliament as well as their national research funders and healthcare providers. We will enable meaningful reliable comparative research and communication within Europe and create a sustainable structure and policy. CAMbrel ...
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 17

 TERMINÉ 

Evaluation of Integrated Cardiac Imaging for the Detection and Characterization of Ischemic Heart Disease (EVINCI-study)

Date du début: 1 janv. 2009, Date de fin: 30 juin 2012,

The main purpose of the EVINCI-study is to test the impact of combined “anatomo-functional” non invasive cardiac imaging for detection and characterization of Ischemic Heart Disease (IHD). The EVINCI-study is a prospective clinical European multicenter trial performed in a cohort of 700 patients with suspected IHD. Patients with intermediate pre-test probability will undergo clinical and biohumora ...
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 22

 TERMINÉ 

Schutzwaldplattformen/-foren in Tirol und Bayern

Date du début: 31 déc. 2008, Date de fin: 30 déc. 2011,

Während in Österreich bereits Erfahrungen mit der Arbeit von Schutzwaldplattformen bestehen, die innerhalb des Projekts zur Optimierung des Konzepts genutzt werden, wird in Bayern auf der Basis des österreichischen Konzepts eine Strategie zur Etablierung von Schutzwaldforen entwickelt. Auf dieser Basis erstellt ein externer Dienstleister in enger Absprache mit den Projektpartnern ein Schulungskonz ...
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 3

 TERMINÉ 

The mechanisms of cardiovascular risks after low radiation doses (CARDIORISK)

Date du début: 1 févr. 2008, Date de fin: 30 juin 2011,

"Recent epidemiologic evidence suggests that moderate and low radiation doses to the heart may result in a moderate, but significant increase in cardiovascular mortality. So far, the pathogenesis of radiation induced heart disease has not been studied in detail. Pathohistologic studies suggest that microvascular damage plays a crucial role in the development of radiation induced cardiovascular dis ...
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 14

 TERMINÉ 

Waldinformationssystem Nordalpen

Date du début: 30 juin 2008, Date de fin: 29 juin 2011,

• Beurteilung der Wälder hinsichtlich ihres Standortes sowie des potenziellen Zustandes durch ein neues Waldtypisierungsverfahren. • Erstellung einer Waldtypenkarte für das Wuchsgebiet Nördliche Randalpen durch die Kombination verschiedener Geoparameter (digitale geologische Karte, digitale Geländemodelle, Klimamodelle). Die Modellierung der Waldstandortseinheiten wird durch Geländeaufnahmen (Veg ...
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 6

 TERMINÉ 

Netzwerk Verbraucherschutz Bayern/Tschechien ConNet

Date du début: 31 août 2008, Date de fin: 30 déc. 2010,

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 2

 TERMINÉ 

Grundlagen für die Prognose von Borkenkäferübervermehrungen

Date du début: 31 août 2008, Date de fin: 30 août 2010,

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 2

 TERMINÉ 

LArge scale adjustment of new technology for fast, precise and cost-efficient hydraulic 2d-modelling of flood (hazard) areas by combining laser scanning with remote sensing data (FLOODSCAN)

Date du début: 1 juil. 2006, Date de fin: 31 déc. 2009,

Background Climate changes are expected to fuel an increase in the magnitude and frequency of flood incidents for many parts of the EU. Floods regularly cause heavy environmental and economic damages and recent EU flood incidents demonstrate deficiencies in forecasting flood hazards and threat locations. International action programmes emphasise greater ...
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 3

 TERMINÉ 

CARBON balance drafting and new resources management tools according to Kyoto PROtocol (CARBON-PRO) (CARBON-PRO)

Date du début: 31 mars 2006, Date de fin: 30 déc. 2007,

Areas used by agriculture and forestry are important for storing atmospheric CO2, which is a by-product of employing conventional sources of energy. It is also one of the greenhouse gases mainly responsible for global climate change. An adequate management of agriculture and forestry resources might help to reduce the impact of CO2 emissions. In the Kyoto Protocol some strategies have already been ...
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 9

 TERMINÉ 

ALPINE AWARENESS - Transalpine Awareness Raising for Sustainable Mobility (ALPINE AWARENESS)

Date du début: 30 sept. 2003, Date de fin: 29 juin 2007,

The „Alpine Awarenes“ project partners follow a common main strategy of contributing to sustainability in transport in the Alpine Region, thus promoting a new, sustainable way of life in the Alps.Alpine Awareness deals with the provision and dissemination of information about sustainable development in the transport and mobility sector, which are important instruments for the creation resp. streng ...
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 13

 TERMINÉ 

MOVET

MOVET explores a practical approach to a system ECVET. The modules for students end with an especially designed assessment of learning outcomes. Training providers, companies, competent bodies and other protagonists of vocational education validate the acquired learning outcomes as relevant for the training profile and award credit points. A memorandum of understanding of all involved partners ser ...
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 15

 TERMINÉ 

Heritage (EU-India)

Date du début: 15 juil. 2012,

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 18