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 TERMINÉ 

Secondary prEvention of CardiovascUlaR disease in the Elderly trial (SECURE)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2020,

While Cardiovascular diseases (CVD) are the main cause of death worldwide, they are responsible for half of all deaths in Europe. The overall ageing of the European population and improving survival of patients with coronary heart disease has created a large population of older adults eligible for secondary prevention. Despite the established efficacy of cardiovascular medications, suboptimal adhe ...
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 13

 TERMINÉ 

Matrix glycans as multifunctional pathogenesis factors and therapeutic targets in cancer (GLYCANC)

Date du début: 1 juil. 2015, Date de fin: 30 juin 2019,

Cancer is a leading cause of mortality within the aging European population. Therapeutic targeting is hampered by the complexity of the disease, which includes not only molecular changes within the tumor cell itself, but also within its microenvironment. Tumor angiogenesis, tumor-stroma interactions, interactions with immune cells, with the extracellular matrix and cancer stem cell niches allow fo ...
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 10

 TERMINÉ 

Added Value for Oral Care (ADVOCATE)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2019,

ADVOCATE brings together top principal investigators from prestigious universities, the public sector, and the private sector to address the most common diseases affecting humanity, as measured by the recent Global Burden of Disease Study. ADVOCATE strives to optimise delivery of oral health and wellbeing to the population in EU Member States. This requires a change in oral health care delivery to ...
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 13

 TERMINÉ 

Diagnostic Imaging Strategies for Patients with Stable Chest Pain and Intermediate Risk of Coronary Artery Disease: Comparative Effectiveness Research of Existing Technologies (DISCHARGE)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

Coronary artery disease (CAD) is the leading cause of death in high-income countries. Invasive coronary angiography (ICA) is the reference standard for the diagnosis of CAD and allows immediate therapy. However, only 40% of patients undergoing ICA actually have obstructive CAD and ICA has relatively rare but considerable risks. Coronary computed tomography (CT) is the most accurate diagnostic test ...
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 38

 TERMINÉ 

Dobutamine for NEOnatal CIRCulatory failure defined by novel biomarkers (NEO-CIRC)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2018,

Dobutamine and adrenaline are widely used as second line therapy for systemic hypotension in infants. Dopamine is currently the most widely used first line drug. In neonates, sustained hypotension may, and impaired organ perfusion will, cause brain injury and poor neurodevelopmental outcomes. All three catecholamines are currently used off-label and have different modes of action which may result ...
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 20

 TERMINÉ 

Collaborative REsearch on ACute Traumatic brain Injury in intensiVe care medicine in Europe (CREACTIVE)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

"Traumatic brain injury (TBI) is among the leading causes of death and disability and the main cause of death among the under-45s. Most patients with moderate to severe TBI are admitted to intensive care units (ICUs)The “PROSAFE” ICU network was recently established in 6 European countries through EU funding (PHEA 2007331), and has continued to collect high-quality data beyond the grant duration. ...
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 11

 TERMINÉ 

Novel nanotechnology-enabled system for endovascular in vivo near-infrared fluorescence molecular imaging and endovascular near-infrared targeted photodynamic therapy of atherosclerotic heart disease (CosmoPHOS-nano)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2018,

CosmoPHOS-nano is a multidisciplinary, translational and business-oriented project, aiming to accomplish the following objectives:1) develop the CosmoPHOS system, which is a novel theranostic (diagnostic & therapeutic) nanotechnology-enabled portable combination system enabling endovascular in vivo near-infrared fluorescence molecular imaging, endovascular near-infrared targeted photodynamic thera ...
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 20

 TERMINÉ 

Nanomedicine for target-specific imaging and treatment of atherosclerosis: development and initial clinical feasibility (NanoAthero)

Date du début: 1 févr. 2013, Date de fin: 31 janv. 2018,

NanoAthero aims to have demonstration of initial clinical feasibility of nanosystems for targeted imaging and treatment of advanced atherosclerotic disease in humans. The nanosystems are assemblies of following components: nanocarrier, targeting, imaging agent/drug. They have proven safety records, and strong preliminary in vitro and in vivo proofs of efficacy are available. Partners have patented ...
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 17

 TERMINÉ 

Mobile Therapeutic Attention for Patients with Treatment Resistant Schizophrenia (m-RESIST)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2017,

In European Union approximately 5 million people suffer from psychotic disorders. Between 30-50% can be considered resistant to treatment, and 10-20% ultra-resistant. These patients present persistent positive symptomatology, require extensive periods of hospital care, and have a greater risk of excess mortality and multi-morbidity. In addition, a high proportion of the total cost for treating sch ...
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 15

 TERMINÉ 

Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in EUrope (EU-CERT-ICD)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

An estimated 500.000 sudden cardiac deaths (SCD) occur each year in the European Union. Patients at risk for SCD may benefit from prophylactic treatment with an implantable cardioverter-defibrillator (ICD). ICD implantations have dramatically increased in recent years leading to multi-billion Euros of costs with significant regional disparities across Europe. Information on risks, benefits and cos ...
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 27

 TERMINÉ 

Intelligent Catheters in Advanced Systems for Interventions (INCITE)

Date du début: 1 mars 2014, Date de fin: 1 mars 2017,

INCITE aims to develop intelligent catheter technologies and systems that will accelerate the paradigm shift from costly, burdensome surgical treatments to cost-effective and patient-friendly minimally invasive interventions. It will also enable the creation of new advanced treatments for currently complex surgical procedures. This will allow for more individuals to be treated thereby contributing ...
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 24

 TERMINÉ 

Imaging of Neuroinflammation in Neurodegenerative Diseases (INMiND)

Date du début: 1 mars 2012, Date de fin: 28 févr. 2017,

The goal of this proposal (INMiND) is to carry out collaborative research on molecular mechanisms that link neuroinflammation with neurodegeneration in order to identify novel biological targets for activated microglia, which may serve for both diagnostic and therapeutic purposes, and to translate this knowledge into the clinic. The general objectives of INMiND are:(i) to identify novel mechanisms ...
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 32

 TERMINÉ 

PanCare Childhood and Adolescent Cancer Survivor Care and Follow-up Studies (PanCareSurFup)

Date du début: 1 févr. 2011, Date de fin: 31 janv. 2017,

Over the last 40 years, treatment for childhood and adolescent cancer has improved greatly; 5- year survival after childhood cancer is now 80% in developed countries. Approximately 1 individual in 750 of young adults is now a childhood cancer survivor. Epidemiologic data on the number of European childhood cancer long-term survivors are not available, but estimates suggest a number between 300,000 ...
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 18

 TERMINÉ 

Expressive Agents for Symbiotic Education and Learning (EASEL)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2016,

EASEL will explore and develop a theoretical understanding of human-robot symbiotic interaction (HRSI) where symbiosis is defined as the capacity of the robot and the person to mutually influence each other, and alter each other's behaviour over different time-scales (for instance, within encounters and across encounters). Symbiosis requires that the robot can read, and be responsive to, the behav ...
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 5

 TERMINÉ 

Interdisciplinary training network for Tourette Syndrome; structuring European Training capacities for neurodevelopmental disorders (TS-EUROTRAIN)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

There is a striking lack in structured and standardized training infrastructure for neurodevelopmental disorders across Europe. Such training will be fundamental to promoting standards of care across Europe and will ultimately lead to strategies for the promotion of childhood mental health in Europe. The focus of this Initial Training Network (ITN) is Gilles de la Tourette Syndrome (TS), an inheri ...
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 12

 TERMINÉ 

The CLIO consortium: Optimization of Cerenkov Luminescence Imaging for Image-Guided Cancer Surgery (CLI)

Date du début: 1 janv. 2014, Date de fin: 31 août 2016,

Cancer is the second largest cause of death and morbidity in Europe, with more than 3 million new cases diagnosed each year. The most effective treatment strategy for most forms of cancer is early detection followed by surgery. However, cancers frequently recur following surgery. For example, nearly 1 in 4 breast cancer patients will see their tumour recur after surgery. The consequences of cancer ...
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 8

 TERMINÉ 

Assessing the effect of early social environment on epigenetic modification (SEEM)

Date du début: 1 sept. 2011, Date de fin: 30 août 2016,

"Genetic and environmental factors shape resiliency and vulnerability to psychiatric disorders, as in other complex inheritance diseases. Recent studies show that environmental factors can exert their effects through epigenetic modifications, such as DNA methylation, affecting expression level of crucial genes. Pre- and postnatal environment (e.g. maternal diet, stress, early care) in critical per ...
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 2

 TERMINÉ 

Airway Disease PRedicting Outcomes through Patient Specific Computational Modelling (AirPROM)

Date du début: 1 mars 2011, Date de fin: 30 juin 2016,

The airways diseases asthma and chronic obstructive pulmonary disease affect over 400 million people world-wide and cause considerable morbidity and mortality. Airways disease costs the European Union in excess of €56 billion per annum. Current therapies are inadequate and we do not have sufficient tools to predict disease progression or response to current or future therapies. Our consortium, Air ...
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 40

 TERMINÉ 

Creating the Hungarian Centre of Excellence for Molecular Medicine (HU-MOLMEDEX)

Date du début: 1 juin 2015, Date de fin: 31 mai 2016,

Existing European disparity in research and innovation performance is a barrier to competitiveness and growth. To overcome this disparity, the leading institute in molecular life sciences and three research universities of Hungary have joined forces forming a new Centre of Excellence for Molecular Medicine (HCEMM). These institutions have the necessary basic research and clinical portfolio to init ...
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 7

 TERMINÉ 

DYNAMIC INTERACTIVE NANOSYSTEMS (DYNANO)

Date du début: 1 nov. 2011, Date de fin: 29 févr. 2016,

"The key and direct objective of DYNANO is to provide training with a deep knowledge and expertise on Dynamic Interactive Nanosystems for biomedical and biotechnological applications on the basis of the existing scientific and technological areas: dynamic chemistry / glycosciences / biology / nanosciences. DYNANO will expose researchers in training to the process of design, generation, optimizatio ...
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 13

 TERMINÉ 

Treat Infections in NeoNates 2 - Evaluation of an infective agent (azithromycin) for the treatment of infections in preterm and term neonates (TINN2)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2015,

"The aim of TINN2 is to evaluate azithromycin, included in the EMEA priority list of the therapeutic areas that need specific drug evaluation in preterm and term neonates. Azithromycin is a macrolid antibiotic with anti-inflammatory properties active against Ureaplasma. It might be effective in reducing the severity of bronhopulmonary disease in which Ureaplasma infection and inflammation play a r ...
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 17

 TERMINÉ 

Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U-BIOPRED)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2015,

RationaleThe inability of pre-clinical studies to predict clinical efficacy is a major bottleneck in drug development. In severe asthma this bottleneck results from: a lack of useful and validated biomarkers, underperforming pre-clinical models, inadequate and incomplete sub-phenotyping, and insufficient disease understanding.HypothesisThe use of biomarker profiles comprised of various types of hi ...
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 42

 TERMINÉ 

A Roadmap for Mental Health Research in Europe (ROAMER)

Date du début: 1 oct. 2011, Date de fin: 31 mars 2015,

"On the regional level, Europe has one of the highest levels of resources for mental health care. Despite this, the high burden and impact of mental disorders in Europe is expected to rise. “ROAdmap for Mental health Research” (ROAMER) is designed to develop a comprehensive, consensus-based roadmap to promote and integrate mental health and well-beingresearch in Europe. Research advances and innov ...
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 15

 TERMINÉ 

Contribution of beta-arrestin-dependent receptor signaling to the physiological regulation of the endocannabinoid system (CB1R arrestin)

Date du début: 1 mai 2011, Date de fin: 28 févr. 2015,

The endocannabinoid system is composed of endocannabinoids, such as anandamide and 2-arachidonoylglycerol (2-AG), their metabolizing enzymes and cannabinoid receptors. To date, two cannabinoid receptors have been identified by molecular cloning, the CB1 and CB2 receptors. The endocannabinoid system has been implicated in a number of physiological functions, and pharmacological manipulation of this ...
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 2

 TERMINÉ 

Systems biology towards novel chronic kidney disease diagnosis and treatment (SysKID)

Date du début: 1 janv. 2010, Date de fin: 31 déc. 2014,

Chronic kidney disease (CKD) affects up to 10% of the population. Besides eventual progression towards end stage renal disease CKD impacts the patient’s quality of life by causing serious comorbidities including cardiovascular complications and bone metabolism disorders. On the everyday clinical level early stage diagnosis and tailored treatment of CKD are still inadequate. In addition, CKD seems ...
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 30

 TERMINÉ 

Predicting individual response and resistance to VEGFR/mTOR pathway therapeutic intervention using biomarkers discovered through tumour functional genomics (PREDICT)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2014,

"The strategic development of accurate biomarkers to predict response to therapy in cancer medicine will enhance clinical outcome and reduce the health economic impact of drug resistant disease. The PREDICT consortium will identify and validate predictive biomarkers for two drugs which have direct anti-tumour cell and anti-angiogenic activity and for which no established predictive biomarkers of t ...
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 16

 TERMINÉ 

Pharmaceutical Medicine Training Programme (PHARMATRAIN)

Date du début: 1 mai 2009, Date de fin: 30 avr. 2014,

"The proposed Pharmaceutical Medicine Training Programme provides a comprehensive solution for the complex needs of integrated drug development for all professionals involved, incl. physicians, pharmaceutical scientists,biologists, biometricians, health economists, and safety and regulatory scientists from universities, regulatory agencies, large, middle-sized and small pharmaceutical enterprises, ...
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 52

 TERMINÉ 

EuroHOPE – European Health Care Outcomes, Performance and Efficiency (EuroHOPE)

Date du début: 1 janv. 2010, Date de fin: 30 avr. 2014,

By using available databases as well as by collecting additional data on health-related quality of life measures (enabling Quality Adjusted Life Years as an outcome measure) and patient satisfaction (including expectations) the EuroHOPE project will evaluate, through a microeconomic disease-based approach, the performance of European health care systems in terms of outcomes, quality, use of resour ...
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 12

 TERMINÉ 

Molecular dissection of inflammatory pathways (MOLINFLAM)

Date du début: 1 oct. 2008, Date de fin: 31 mars 2014,

Inflammatory diseases are highly prevalent, often chronic diseases that cause diminished quality of life and are connected with major causes of death in Western societies. Despite their societal impact, their pathomechanism is incompletely understood, hindering development of novel therapeutic strategies. In particular, little is known about the intracellular signal transduction processes involved ...
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 2

 TERMINÉ 

Researchers of tomorrow live among us – A Hungarian Night for Researchers 2013 (REACH tomorrow)

Date du début: 1 juin 2013, Date de fin: 31 déc. 2013,

In Hungary the partnership of 18 institutions (one organisation managing and coordinating EU and educational and training grants, 14 top universities, two research institutes, one Observatory and numerous additional HEIs, science museums, research institutes and research groups joining the consortium as indirect partners) will organise RN 2013 with the aim of enhancing the public recognition of re ...
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 19

 TERMINÉ 

EUropean Cross Border Care Collaborations Short Title: CrossEurope (EUCBCC)

Date du début: 1 mai 2010, Date de fin: 31 oct. 2013,

"EUCBCC aims to facilitate a process whereby Europe's citizens can make informed choices about whether to seek health care in another Member State and, if they so choose, to ensure that the admin and clinical processes are straightforward and ensure continuity of care. It takes as its starting point the recent draft Directive on Patients' Rights, augmented by the existing body of research on cross ...
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 15

 TERMINÉ 

European Project on Mendelian Forms of Parkinson’s Disease (MEFOPA)

Date du début: 1 avr. 2010, Date de fin: 30 sept. 2013,

"The Collaborative Project on Mendelian Forms of Parkinson’s Disease (MEFOPA) will bring together the major groups in Europe with a track-record in basic and clinical research on rare Mendelian forms of Parkinson’s disease (PD) in order to identify and validate relevant disease-related molecular pathways, drug-targets and biomarkers for disease susceptibility and progression.. Over the last years ...
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 27

 TERMINÉ 

Optimizing suicide prevention programs and their implementation in Europe (OSPI-Europe)

Date du début: 1 oct. 2008, Date de fin: 31 mars 2013,

Suicide is a serious public health problem in the EU calling for effective interventions. The aim of this project is to provide EU member states with an evidence based prevention concept, concrete materials and instruments for running and evaluating these interventions and recommendations for the proper implementation of the intervention. These aims will be achieved by the following objectives: &g ...
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 15

 TERMINÉ 

Chip Architectures by Joint Associated Labs for European Diagnostics (CAJAL4EU)

Date du début: 1 mars 2010, Date de fin: 1 févr. 2013,

The main objective of the ENIAC JU project CAJAL4EU is to develop miniaturised biosensor technology platforms enabling diagnostic test manufacturers to build multi-parameter in-vitro test applications rapidly in a robust, user-friendly and cost-effective way. They will involve nanoelectronic-based transducers with chemical sensing capabilities providing the interface with the clinical samples. In ...
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 28

 TERMINÉ 

A Hungarian Night for Researchers 2011- Hungary-EU Research Careers (HEURECA 2012)

Date du début: 1 juin 2012, Date de fin: 31 déc. 2012,

"The protagonists of the 2012 RN will be researchers and the focus of the event will be on their public recognition. We will make a special effort to provide opportunities for both the public and the researchers to learn and think outside the box and present the truth that are behind stereotypes.Researchers will be at the center of all the individual programmes and of the awareness raising activit ...
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 19

 TERMINÉ 

MyUI: Mainstreaming Accessibility through Synergistic User Modelling and Adaptability (MyUI)

Date du début: 1 févr. 2010, Date de fin: 31 oct. 2012,

MyUI will foster the mainstreaming of accessible and highly individualized ICT products – a major issue for e-Inclusion. The project addresses important barriers which include developers' lack of awareness and expertise, time and cost requirements of incorporating accessibility and missing validated approaches and infrastructures.The project's approach goes beyond the notion of Universal Design by ...
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 11

 TERMINÉ 

HEALTH PROfessional Mobility in THe European Union Study (HEALTH PROMeTHEUS)

Date du début: 1 janv. 2009, Date de fin: 30 juin 2012,

Health professionals have always moved to, from and within Europe for work and other reasons. However, concerns about the scale of movement and its impacts on health systems are increasing. New disease patterns, new technology and increasingly global markets have multiplied pressures on health systems. Policy makers and managers need to respond but do not know enough about what is happening. EHMA ...
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 12

 TERMINÉ 

A Hungarian Night for Researchers 2011- Hungary-EU Research Careers (HEURECA)

Date du début: 1 juin 2011, Date de fin: 31 déc. 2011,

"We will focus on enhancing researchers’ public recognition. Researchers, presented as persons that everyday people can relate to, can draw attention to science; and can make science seen as a casual but interesting adventure. Better understanding science can also lead to improving researchers’ recognition. Thus, the main message of the event will emphasize the human, accessible yet important figu ...
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 18

 TERMINÉ 

Biobanking and Biomolecular Resources Research Infrastructure (BBMRI)

Date du début: 1 févr. 2008, Date de fin: 31 janv. 2011,

The Preparatory Phase for a pan-European Biobanking and Biomolecular Resources Research Infrastructure (BBMRI) will focus on technical, legal, governance, and financial issues to • prepare to construct BBMRI, building on existing biobanks, resources and technologies, specifically complemented with innovative components and properly embedded into European scientific, ethical, legal and societal fra ...
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 55

 TERMINÉ 

A Hungarian Night for Researchers - Hungary-EU Research Careers (HEURECA)

Date du début: 1 juin 2010, Date de fin: 31 déc. 2010,

"The 2010 HEURECA Researchers' night will build upon the experience the consortium gained in organizing the event in the previous years. It will actually consist of a further expanded version of the previous events.Partnership will be enlarged by 3 new cooperating bodies joining the 18 experienced partners, and possibly by several non profit organisations and companies having already expressed the ...
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 18