22 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Mechanisms of transcription in HIV latency; novel strategies to activate (Trxn-PURGE)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,
The persistence of a transcriptionally competent but latent HIV infected memory CD4+T cell reservoir, despite the effectiveness of Highly Active Antiretroviral therapy (HAART) against active virus, presents the main impediment to HIV eradication. A novel concept in HIV eradication is to activate latent virus to subsequently eliminate with HAART. Much effort has gone into identification of protein ...
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1
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TERMINÉ
Excision Repair and chromatin interaction dynamics (ERC-ID)
Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,
"DNA damage is a fact of life. Lesions hamper genome function, induce mutations causing cancer and trigger senescence or cell death contributing to aging. Therefore cells are equipped with a sophisticated defence machinery: DNA Damage Response (DDR) including different repair pathways. Nucleotide excision repair (NER) is versatile repair process, eliminating helix-distorting lesions, e.g. bulky ad ...
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1
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TERMINÉ
Cracking the Cerebellar Code (CCC)
Date du début: 1 avr. 2012, Date de fin: 31 mars 2017,
"Spike trains transfer information to and from neurons. Most studies so far assume that the average firing rate or “rate coding” is the predominant way of information coding. However, spikes occur at millisecond precision, and their actual timing or “temporal coding” can in principle strongly increase the information content of spike trains. The two coding mechanisms are not mutually exclusive. Ne ...
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1
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TERMINÉ
EUROPEAN FORENSIC GENETICS Network of Excellence (EUROFORGEN-NOE)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2016,
The EUROFORGEN-NoE proposal aims to develop a network of excellence for the creation of a European Virtual Centre of Forensic Genetic Research. Forensic genetics is a highly innovative field of applied science with a strong impact on the security of citizens. However, the genetic methods to identify offenders as well as the creation of national DNA databases have caused concerns to the possible vi ...
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19
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TERMINÉ
THALAssaemia MOdular Stratification System for personalized therapy of beta-thalassemia (THALAMOSS)
Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,
THALAMOSS is aimed at development of universal sets of markers and techniques for stratification of β-thalassaemia patients into treatment subgroups for (a) onset and frequency of blood transfusions, (b) choice of iron chelation, (c) induction of fetal hemoglobin, (d) prospective efficacy of gene-therapy. At present, no framework exists to guide therapeutic decisions and personalised treatment of ...
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14
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TERMINÉ
MARie CuRIe AGEing Network (MARRIAGE)
Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,
...rcial enterprises. Multiple complementary training schemes have been implemented in the Network. These include specific research projects (including multiple academic and industrial secondments), a variety of dedicated courses organized by the academic partners of the Network, and finally, training organized by the industrial partners of the Network. Trainees will become experts in the multidiscip ...
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11
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TERMINÉ
Joint training and research network on Chromatin Dynamics and the DNA Damage Response (ADDRESS)
Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,
DNA is tightly wrapped around histones to form chromatin, a highly dynamic structure that can adopt different conformations with contrasting degrees of compaction. Essential processes of DNA metabolism, such as DNA repair, replication or transcription operate in the context of chromatin and higher order chromosomal organization. Understanding how modulation of chromatin structure and repair influe ...
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10
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TERMINÉ
Molecular mechanisms controlling X chromosome inactivation (Activation of XCI)
Date du début: 1 avr. 2011, Date de fin: 31 mars 2016,
In mammals, gene dosage of X-chromosomal genes is equalized between sexes by random inactivation of either one of the two X chromosomes in female cells. In the initial phase of X chromosome inactivation (XCI), a counting and initiation process determines the number of X chromosomes per nucleus, and elects the future inactive X chromosome (Xi). Xist is an X-encoded gene that plays a crucial role in ...
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1
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TERMINÉ
Reproductive Biology Early Research Training (REPRO-TRAIN)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,
The “Reproductive Biology Early Research Training” network (REPRO-TRAIN) aims to provide all the elements required to train the nextgeneration of researchers with the latest skills to solve the current societal problems in male reproductive biology (Andrology). Thedecline in sperm counts and concomitant increase in testicular cancer demands research in this field as an urgent priority.Spermatogene ...
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8
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TERMINÉ
Low Dose Research towards Multidisciplinary Integration (DOREMI)
Date du début: 1 janv. 2010, Date de fin: 31 déc. 2015,
The aim of DoReMi is to promote the sustainable integration of low dose risk research in Europe in order to aid the effective resolution of the key policy questions identified by the High Level Expert Group (HLEG) on Low Dose Risk Research (www.hleg.de). DoReMi provides an operational tool for the development of the proposed MELODI platform (Multidisciplinary European Low Dose Risk Re-search Initi ...
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39
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TERMINÉ
Cognitive and Cerebrovascular Effects Induced by Low Dose Ionising Radiation (CEREBRAD)
Date du début: 1 oct. 2011, Date de fin: 31 mars 2015,
The major elements of scientific uncertainty in the context of radiation protection policy and of risk assessment for cerebrovascular diseases, set the following key topics (1) the direct assessment of health effects through epidemiological studies of groups exposed to low doses, (2) doses-response and biological effects from different types of radiation and (3) the biological processes in cells a ...
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12
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TERMINÉ
on-Demand System Reliability (DeSyRe)
Date du début: 1 oct. 2011, Date de fin: 31 janv. 2015,
DeSyRe will perform research on the design of future reliable Systems-on-Chip (SoCs). These are systems that guarantee continuous and correct operation in the existence of different types of faults. It is a well known fact that various systems are extremely sensitive to faults. Typical examples are medical (i.e. implantable cardiac pacemakers) or automotive systems (i.e. vehicle stability control) ...
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8
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TERMINÉ
Training Urology Scientists to develop Treatments (TRUST)
Date du début: 1 janv. 2010, Date de fin: 31 déc. 2014,
...t a profound integration of multiple scientific disciplines. The TRUST ITN proposes an interdisciplinary research training network of 8 European university institutes and 3 enterprises, with a wide variety of complementary expertise in UI and OABS. The network covers all required disciplines from anatomy, urology, neuroscience, pathology, pharmacology, biomedical engineering, clinical science, bio ...
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11
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TERMINÉ
DNA damage and the connection with cancer, premature aging and longevity (DAMAGE)
Date du début: 1 janv. 2010, Date de fin: 31 déc. 2014,
We study DNA damage and genome stability and its impact on human health using nucleotide excision repair (NER) as paradigm. Patients with NER defects present a perplexing clinical heterogeneity ranging from extreme cancer predisposition to dramatic neurodevelopmental deficits. To elucidate the underlying mechanism we adopted an integral strategy from gene to patient and contributed to resolving th ...
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1
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TERMINÉ
The Molecular Mechanisms of Stem Cell Self Renewal (MMSR)
Date du début: 1 août 2010, Date de fin: 31 juil. 2014,
"Over the past few years, a view has emerged that pluripotency in mouse embryonic stem cells (ESCs) is cell-autonomous and does not depend on external signals. This was based on work that showed that a combination of a small molecule ERK inhibitor with a GSK3 kinase inhibitor was sufficient to maintain self-renewal, in absence of any growth factors. I have now discovered that autocrine or paracrin ...
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1
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TERMINÉ
Recombinational DNA repair analyzed by simultaneous scanning force and single molecule fluorescence microscopy: role of RAD54 in presynaptic and postsynaptic events (DNArepair at 3Detail)
Date du début: 1 avr. 2011, Date de fin: 31 mars 2014,
The goal of the research is to understand the mechanistic of human genetic recombination at the single molecular level.Homologous recombination, the exchange of sequences between homologous DNA molecules, is essential for accurate genome duplication, DNA damage repair and chromosome segregation. Single molecule analysis provides information on intermediate states, functional and structural variabi ...
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1
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TERMINÉ
LED Cued Learning Technology (LCLT)
Date du début: 1 mars 2013, Date de fin: 28 févr. 2014,
"During the first period of our ERC funded study, we have developed a new technology for the field of behavioural neuroscience. This so called LED Cued Learning Technology enables us to run behaviorally cued dynamic profiles on a Ladder setup. We are confident that this technology has substantial potential and we would like to investigate to what extent it may be exploited by industry. We want to ...
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1
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TERMINÉ
Synergistic effect of DNA damage and oxidative stress in aging (DNA-damage redox age)
Date du début: 1 févr. 2010, Date de fin: 31 janv. 2014,
Population aging will become one of the most dramatic challenges in public health faced by the western world in the near future. Aging affects the organism systemically even though its consequences on the brain are of particular importance because of the progressive decline of cognitive functions. Aging impacts not only individuals; it will exert profound effects on the entire society because it c ...
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1
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TERMINÉ
Unraveling the role of Nucleotide Excision Repair factors and the dynamic of chromatin structure in the repair of oxidative DNA damages in vivo (OXIDNA-REPAIR-CHROMA)
Date du début: 1 août 2010, Date de fin: 31 juil. 2012,
"Oxidation of DNA bases by reactive oxygen species (ROS) leads to mutations that have been linked with cancer and neurodegenerations. The occurrence of these major diseases increases upon organism aging. The life expectancy in western society and particularly EU has considerably increased in the XXth century. Thus mortality caused by cancer and neurodegenerations has become massive. Therefore figh ...
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1
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TERMINÉ
Function and dynamics of Lmo4-containing complexes during erythropoiesis (LmoFunDyn)
Date du début: 1 avr. 2008, Date de fin: 31 mars 2010,
Anemias and erythroid malignancies caused by impaired formation of erythrocytes (red blood cells) are common disorders. These diseases have a severe impact on the quality of life of the patients. It is essential to unravel the molecular mechanisms underlying erythropoiesis (the development of red blood cells) to be able to fully understand the etiology of these diseases and to devise novel treatme ...
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1
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TERMINÉ
Dynamic single-molecule approach to DNA homologous recombination (DYNASING)
Date du début: 1 avr. 2008, Date de fin: 31 mars 2010,
"The goal of the research is to understand the mechanisms and biological function of complex genome transactions such as homologous recombination. Homologous recombination, the exchange of sequences between homologous DNA molecules, is essential for accurate genome duplication, DNA damage repair and chromosome segregation. Single molecule analysis provides information on intermediate states, funct ...
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1
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TERMINÉ
TCF4 transcriptional program in crypt stem cells and resulting differentiated cells (gut gene regulation)
Date du début: 1 mars 2008, Date de fin: 28 févr. 2010,
The Wnt pathway is a key regulatory pathway in development and carcinogenesis. Many of the components of the pathway connecting Wnt to the transcription factor TCF4 have been identified. However, our knowledge of the regulation of TCF4 promoter and enhancer elements in response to the Wnt signal, resulting in development from a stem cell to a differentiated cell, is limited. Largely due to technic ...
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