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28 projets européens trouvés

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 TERMINÉ 

RD-CONNECT: An integrated platform connecting registries, biobanks and clinical bioinformatics for rare disease research (RD-CONNECT)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2018,

Despite examples of excellent practice, rare disease (RD) research is still mainly fragmented by data and disease types. Individual efforts have little interoperability and almost no systematic connection between detailed clinical and genetic information, biomaterial availability or research/trial datasets. By developing robust mechanisms and standards for linking and exploiting these data, RD-Con ...
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 30

 TERMINÉ 

Hepatic and Cardiac Toxicity Systems modelling (HECATOS)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

HeCaToS aims at developing integrative in silico tools for predicting human liver and heart toxicity. The objective is to develop an integrated modeling framework, by combining advances in computational chemistry and systems toxicology, for modelling toxic perturbations in liver and heart across multiple scales. This framework will include vertical integrations of representations from drug(metabol ...
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 14

 TERMINÉ 

European Autism Interventions - A Multicentre Study for Developing New Medications (EU-AIMS)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2017,

Despite dramatic advances in molecular and imaging technologies, there are currently no effective pharmacological treatments for the core symptoms of autism spectrum disorder (ASD). Major obstructions to this include a lack of aetiologically-driven or pathophysiologically-accurate animal models; an absence of tests that indicate efficacy; and reliance of clinical trials on DSM/ICD10 categories wh ...
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 29

 TERMINÉ 

SYSTEMS BIOLOGY OF PATHWAYS INVOLVING BRAIN AGEING (AGEDBRAINSYSBIO)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,

In spite of valuable approaches applied to get a broad understanding of genetic, epidemiologic and molecular and system-level biological principles of human aging, cognitive decline remains as one of the greatest health challenges of the old age, with nearly 50% of adults over 85 afflicted of Alzheimer’s disease. Furthermore, drug development has not performed as expected in clinical trials, at le ...
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 15

 TERMINÉ 

A BLUEPRINT of Haematopoietic Epigenomes (BLUEPRINT)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2016,

In response to the call for a high impact initiative on the human epigenome, the BLUEPRINT Consortium has been formed with the aim of generating at least 100 reference epigenomes and studying them to advance and exploit knowledge of the underlying biological processes and mechanisms in health and disease. BLUEPRINT will focus on distinct types of haematopoietic cells from healthy individuals and o ...
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 45

 TERMINÉ 

Drug Disease Model Resources (DDMORE)

Date du début: 1 mars 2011, Date de fin: 31 août 2016,

Model based-drug development (MBDD) is accepted as a vital approach in understanding patient risk/benefit and attrition. At the core of MBDD lies Modelling and Simulation (M&S), a technology providing the basis for informed, quantitative decision-making.M&S facilitates the continuous integration of available information related to a drug or disease into constantly-evolving mathematical models capa ...
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 28

 TERMINÉ 

Epigenetics towards systems biology (EPIGENESYS)

Date du début: 1 oct. 2010, Date de fin: 31 mars 2016,

The ‘EpiGeneSys’ Network of Excellence aims to enable European epigenetics research to enter the arena of systems biology, a new step forward with major implications for human health. Many diseases, not explained solely by gene mutation, have rather been associated with epigenetic disorders. Following the identification of key epigenetic regulators, a move towards a systems biology approach is nee ...
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 28

 TERMINÉ 

Electronic Health Record systems for Clinical Research (EHR4CR)

Date du début: 1 mars 2011, Date de fin: 29 févr. 2016,

Current medical needs, the growth of targeted therapies and personalized medicines, and escalating R&D costs result in formidable cost pressures on healthcare systems and the pharmaceutical industry. Clinical research is also growing in complexity, labour intensity and cost. There is a growing realization that the development and integration of Electronic Health Record systems (EHRs) for medical ...
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 37

 TERMINÉ 

SEcreted Membrane vesicles: role in the therapeutic plasticity of neural StEM cells (SEM_SEM)

Date du début: 1 déc. 2010, Date de fin: 30 nov. 2015,

Compelling evidence exists that somatic stem cell-based therapies protect the central nervous system from chronic inflammation-driven degeneration, such as that occurring in experimental autoimmune encephalomyelitis and stroke. It was first assumed that stem cells directly replace lost/damaged cells, but it has now become clear that they are able to protect the damaged nervous system through mecha ...
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 2

 TERMINÉ 

Infrastructure for Systems Biology - Europe (ISBE)

Date du début: 1 août 2012, Date de fin: 31 juil. 2015,

The Infrastructure for Systems Biology in Europe (ISBE) programme comprises an infrastructure that is designed to meet the needs of European systems biology, in terms of development, applications and training. In order to address this requirement, we are proposing a distributed, interconnected infrastructure which primarily comprises three types of centres: Data Integration Centres (DICs), and sys ...
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 24

 TERMINÉ 

European Sequencing and Genotyping Infrastructure (ESGI)

Date du début: 1 févr. 2011, Date de fin: 31 juil. 2015,

The objective of this project is the integration of world class high-throughput sequencing and genotyping facilities that will provide sequencing and genotyping technologies and data analysis methodologies to the scientific community.The European Sequencing and Genotyping Infrastructure (ESGI) will enable external users to generate data rapidly and to acquire knowledge efficiently. By providing ac ...
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 11

 TERMINÉ 

European Infrastructure of Open Screening Platforms for Chemical Biology (EU-OPENSCREEN)

Date du début: 1 nov. 2010, Date de fin: 30 avr. 2015,

The EU-OPENSCREEN Preparatory Phase forms the basis for the construction and operation of a pan-European infrastructure of open screening platforms for Chemical Biology. EU-OPENSCREEN will bring together leading laboratories from 14 European countries covering all aspects of Chemical Biology from high-throughput screening with a dedicated compound library to assay development, chemical synthesis f ...
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 24

 TERMINÉ 

European large-scale functional genomics in the rat for translational research (EURATRANS)

Date du début: 1 avr. 2010, Date de fin: 31 mars 2015,

Genetic studies in model organisms and humans, including human genome-wide association studies, have pinpointed genomic regions that contribute susceptibility to common disease. However, to date, these data have provided limited insights into the genes, molecular pathways and mechanisms underlying disease pathophysiology.The EU FP6 Euratools consortium has been a remarkable success that establishe ...
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 19

 TERMINÉ 

From Data to Models: New Bioinformatics Methods and Tools for Data-Driven Predictive Dynamic Modelling in Biotechnological Applications (BIOPREDYN)

Date du début: 1 oct. 2011, Date de fin: 31 mars 2015,

Currently, biologists are collecting enormous amounts of ‘omics’ data in a vast number of different databases. Predictive, data-driven computational models are needed to understand the complex, multi-scale biological networks underlying these high-throughput datasets. Such models are non-linear and contain many parameters, which are difficult (or impossible) to measure directly. Instead, parameter ...
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 12

 TERMINÉ 

European Grid Initiative: Integrated Sustainable Pan-European Infrastructure for Researchers in Europe (EGI-InSPIRE)

Date du début: 1 mai 2010, Date de fin: 31 déc. 2014,

Scientific research is no longer conducted within national boundaries and is becoming increasing dependent on the large-scale analysis of data, generated from instruments or computer simulations housed in trans-national facilities, by using e Infrastructure (distributed computing and storage resources linked by high-performance networks).The 48 month EGI-InSPIRE project will continue the transitio ...
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 143

 TERMINÉ 

Breast Cancer Somatic Genetics Study (BASIS)

Date du début: 1 juil. 2010, Date de fin: 31 déc. 2014,

"All cancers arise due to somatically acquired mutations in their genomes which alter the function of key cancer genes. Understanding these critical mutational events underlying cancer development is paramount for advancing prevention, early detection, monitoring and treatment of the disease. Breast cancer is the most common class of cancer diagnosed in women worldwide with more than one million c ...
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 16

 TERMINÉ 

A novel drug discovery method based on systems biology: combination therapy and biomarkers for Multiple Sclerosis (CombiMS)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2014,

The therapeutic challenge of complex diseases requires the use of combination therapies to target the distinct mechanisms and pathways involved. Such complex diseases will benefit from the design of computational models adopting a systems perspective to integrate the knowledge generated by ‘omics technologies and clinical data. Multiple Sclerosis is a prototypic debilitating complex disease in whi ...
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 8

 TERMINÉ 

Synaptic Systems: dissecting brain function in health and disease (SYNSYS)

Date du début: 1 juil. 2010, Date de fin: 31 déc. 2014,

Major disorders of the Central Nervous System (CNS) affect one in three people in the developed world, often seriously disable the affected individual, and together account for the single largest burden on the healthcare systems of the EU. Most of these disorders act at the neuronal synapse, a cellular organelle comprising in the order of 2000 proteins. Pleiotropy, cross-talk between proteins and ...
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 19

 TERMINÉ 

2nd-Generation Open Access Infrastructure for Research in Europe (OpenAIREplus)

Date du début: 1 déc. 2011, Date de fin: 31 déc. 2014,

OpenAIREplus will build a 2nd-Generation Open Access Infrastructure by significantly expanding in several directions the outcomes of the OpenAIRE project, which implements the EC Open Access (OA) pilot. Capitalizing on the OpenAIRE infrastructure, built for managing FP7 and ERC funded articles, and the associated supporting mechanism of the European Helpdesk System, OpenAIREplus will "develop an o ...
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 42

 TERMINÉ 

Coordinating the cooperation of the ESFRI project Infrafrontier with the International Phenotyping Consortium (IMPC) (INFRACOMP)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2014,

InfraCoMP will establish efficient coordination mechanisms between the ESFRI project Infrafrontier and the International Mouse Phenotyping Consortium. Infrafrontier is a pan-European initative to build a sustainable research infrastructure for systemic phenotyping, archiving and distribution of mouse models of human diseases. The IMPC is a global project to carry out systemic phenotyping of mouse ...
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 9

 TERMINÉ 

Cancer Genomics of the Kidney (CAGEKID)

Date du début: 1 mars 2010, Date de fin: 31 août 2014,

The International Cancer Genome Consortium (ICGC) has the goal of obtaining a comprehensive description of genomic, transcriptomic and epigenomic changes in 50 different tumour types and/or subtypes, with the aim of elucidating the genomic changes present in the many forms of cancers that contribute to the burden of disease throughout the world. We present a proposal for a European contribution to ...
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 15

 TERMINÉ 

International Data Exchange and Data Representation Standards for Proteomics (ProteomeXchange)

Date du début: 1 janv. 2011, Date de fin: 30 juin 2014,

Over the last few years the field of proteomics has evolved into a prolific data producer. As a result, various databases that collect and redistribute the acquired data have been established. While data format standards for quantitative proteomics have now been defined and implemented with significant contribution from the recently completed EU ProDaC grant, standards for quantitative proteomics ...
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 13

 TERMINÉ 

Next generation methods to preserve farm animal biodiversity by optimizing present and future breeding options (NextGen)

Date du début: 1 avr. 2010, Date de fin: 31 mars 2014,

NEXTGEN proposes the bold step of using whole genome data to develop and optimise conservation genetic management of livestock diversity for the foreseeable future. The rationale for choosing whole genome data is to ‘future-proof’ DNA-based analysis in livestock conservation against upcoming changes in technology and analysis. Thus, in the context of whole genome data availability, our global obje ...
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 11

 TERMINÉ 

Sharing capacity across Europe in high-throughput sequencing technology to explore genetic variation in health and disease (GEUVADIS)

Date du début: 1 oct. 2010, Date de fin: 31 déc. 2013,

"High-throughput next-generation DNA sequencing technologies allow investigators to sequence entire human genomes at an affordable price and within a short time frame. The correct interpretation, storage, and dissemination of the large amount of produced genomics data generate major challenges. Tackling these challenges requires extensive exchange of data, information and knowledge between medical ...
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 17

 TERMINÉ 

The Microme Project: A Knowledge-Based Bioinformatics Framework for Microbial Pathway Genomics (Microme)

Date du début: 1 déc. 2009, Date de fin: 30 nov. 2013,

The exponential increase in microbial genome and metagenome sequencing throughput has widened the gap between sequence and functional understanding. A clear picture of metabolic processes across the spectrum of bacterial species is essential to enable the exploitation of microbial genomics for the purposes of environmental biotechnology. The Microme project endeavors to extend the scope of microbi ...
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 16

 TERMINÉ 

Indexing for Life (i4Life)

Date du début: 1 nov. 2010, Date de fin: 31 oct. 2013,

Partners to this proposal include the six major global programmes exploring the full extent of species diversity, a core dimension in human knowledge of global biodiversity.They are: GBIF and distribution modelling, the EBI/INDSC, and Barcode of Life initiatives and molecular diversity, IUCN Red Lists and the species conservation movement, and the Species 2000 Catalogue of Life taxonomic framework ...
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 18

 TERMINÉ 

Proteomics Standards International Molecular Exchange - Systematic Capture of Published Molecular Interaction Data (PSIMEx)

Date du début: 1 mars 2009, Date de fin: 31 août 2013,

The aim of the PSIMEx proposal is to systematically make published molecular interaction data computationally accessible. We plan to further develop the existing standard for molecular interactions developed by the HUPO Proteomics Standards Initiative, and to promote its implementation in the entire chain from experiment planning via data formatting and analysis to data representation in journal p ...
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 15

 TERMINÉ 

IT Future of Medicine (ITFoM)

Date du début: 1 mai 2011, Date de fin: 30 avr. 2012,

Data-rich, individualised medicine poses unprecedented challenges for IT, in hardware, storage and communication. We propose a data-driven, individualised medicine of the future, based on molecular/physiological/anatomical data from individual patients. We shall make general models of human pathways, tissues, diseases and ultimately of the human as a whole. Individualised versions of the models, ...
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 25