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Plus de 40 projets européens trouvés

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 TERMINÉ 

Systems Medical Diagnostics by In-vivo Ambient Mass Spectrometric Profiling of Tissue Lipidome (MASSLIP)

Date du début: 1 juin 2014, Date de fin: 31 mai 2019,

"The objective of the proposal is the development of ambient mass spectrometric methods for the characterisation of mucosal metabolome and lipidome. While recent advent of ambient MS provided new means for in-situ and imaging analyses and led to the development of real-time, in-vivo MS characterisation of tissues, there are no methods available for minimally invasive testing of mucosal surfaces in ...
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 2

 TERMINÉ 

Platform foR European Preparedness Against (Re-)emerging Epidemics (PREPARE)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,

Far from receding, the threats posed by infections with epidemic potential grow ever greater. Although Europe has amongst the best healthcare systems in the world, and also the world’s supreme researchers in this field, we lack co-ordination and linkage between networks that is required to respond fast to new threats. This consortium of consortia will streamline our response, using primary and sec ...
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 27

 TERMINÉ 

Neuropathic pain: biomarkers and druggable targets within the endogenous analgesia system (NEUROPAIN)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,

Neuropathic pain has a high incidence in Europe and often affects the patient’s emotional balance and quality of life. Recent meta-analyses have shown that conventional analgesic drugs are not sufficiently effective in these patients and are limited by serious side effects. The search for new analgesics is extremely difficult despite identification of several new potential targets and enormous inv ...
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 12

 TERMINÉ 

Metagenomics in Cardiometabolic Diseases (METACARDIS)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2018,

METACARDIS applies a systems medicine multilevel approach to identify biological relationships between gut microbiota, assessed by metagenomics, and host genome expression regulation, which will improve understanding and innovative care of cardiometabolic diseases (CMD) and their comorbidities. CMD comprise metabolic (obesity, diabetes) and heart diseases characterized by a chronic evolution in ag ...
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 18

 TERMINÉ 

Targets and biomarkers for antiepileptogenesis (EPITARGET)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

Epilepsy is a devastating condition affecting over 50 million people worldwide. This multidisciplinary project is focused on the process leading to epilepsy, epileptogenesis, in adults. Our main hypothesis is that there are combinations of various causes, acting in parallel and/or in succession, that lead to epileptogenesis and development of seizures. Our central premise and vision is that a comb ...
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 20

 TERMINÉ 

Hepatic and Cardiac Toxicity Systems modelling (HECATOS)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

HeCaToS aims at developing integrative in silico tools for predicting human liver and heart toxicity. The objective is to develop an integrated modeling framework, by combining advances in computational chemistry and systems toxicology, for modelling toxic perturbations in liver and heart across multiple scales. This framework will include vertical integrations of representations from drug(metabol ...
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 14

 TERMINÉ 

Next Generation Sequencing to Identify Genes Underlying Extreme Psychiatric Illness and Extraordinary Cognition (GACPD)

Date du début: 1 avr. 2014, Date de fin: 25 août 2018,

The goal of this research is to use next generation sequencing (NGS) to identify genes that have pronounced, early-onset effects on specific cognitive and psychiatric processes by sequencing children with exceptional cognitive abilities or exceptionally early onset psychotic illness. Mental disorders present an enormous societal burden, largely because of our inability to effectively treat them. ...
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 2

 TERMINÉ 

Regulation of Chromatin by Combinatorial DNA and Histone Modifications (ROCCOMO)

Date du début: 1 mai 2013, Date de fin: 30 avr. 2018,

"The normal expression of genes is tightly regulated. Modifications on histones or on DNA play a central role in the control of gene expression and errors in their regulation often result in diseases such as cancer. These modifications can recruit proteins that regulate chromatin function. Since chromatin is a large macromolecular assembly, modifications most likely act in a concerted manner. Howe ...
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 2

 TERMINÉ 

Oncogene-induced DNA damage as driver of B cell lymphoma genesis (OncIndLymph)

Date du début: 1 mars 2014, Date de fin: 28 févr. 2018,

Recurrent oncogenic chromosomal rearrangements are a hallmark of lymphoid malignancies and are considered to be the driving force in tumor survival and progression. While oncogenes typically induce uncontrolled proliferation, they also induce metabolic stress and constitutive DNA damage. Hence, at the time of diagnosis tumor genomes are typically highly mutated. Not surprisingly, forced expression ...
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 2

 TERMINÉ 

Human frontal lobe contributions to executive function and executive dysfunction (Human PFC function)

Date du début: 1 déc. 2013, Date de fin: 30 nov. 2017,

Adaptability is a defining characteristic of the human species. Our ability to solve logical problems, to plan ahead, to focus despite distraction and to adapt when circumstances change far exceeds that of even our closest relatives. These abilities are closely associated with the most developed structure in the human brain: the frontal lobes. When the frontal lobes are damaged, the consequence is ...
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 2

 TERMINÉ 

Pathogen COinfection: HIV, Tuberculosis, Malaria and Hepatitis C virus (PathCO)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2017,

Acquired immune deficiency (AIDS), tuberculosis (TB) and malaria are the primary infectious diseases causing death world wide. In addition to these pathogens, 170 million people are infected with hepatitis C virus (HCV), which leads to chronic liver disease. Because of shared routes of transmission, HCV co-infection is recognized as a major cause of morbidity and mortality among HIV-1 infected per ...
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 11

 TERMINÉ 

Stem-cell based therapy for kidney repair (STELLAR)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2017,

Chronic kidney disease (CKD) affects 8% of the European population and ultimately results in renal failure due to progressive fibrosis. CDK carries a high mortality risk and the number of affected people rises, increasing the demand on renal replacement therapies while the number of available donor organs stays stable.The STELLAR consortium proposes to develop an alternative to renal replacement ...
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 15

 TERMINÉ 

Advanced Immunization Technologies (ADITEC)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2017,

Vaccines so far have been developed mostly by following an empiric approach. To prevent and possibly cure unresolved and emerging infectious diseases we need to fully exploit the potential of the human immune system. Progress in science and technology makes it possible to achieve what was previously deemed impossible. The scope of this project is to produce knowledge necessary to develop novel and ...
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 53

 TERMINÉ 

The Human Early-Life Exposome – novel tools for integrating early-life environmental exposures and child health across Europe (HELIX)

Date du début: 1 janv. 2013, Date de fin: 30 juin 2017,

The aim of HELIX is to exploit novel tools and methods (remote sensing/GIS-based spatial methods, omics-based approaches, biomarkers of exposure, exposure devices and models, statistical tools for combined exposures, novel study designs, and burden of disease methodologies), to characterise early-life exposure to a wide range of environmental hazards, and integrate and link these with data on majo ...
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 16

 TERMINÉ 

Community-based scheduled screening and treatment of malaria in pregnancy for improved maternal and infant health: a cluster-randomized trial (COSMIC)

Date du début: 1 sept. 2012, Date de fin: 31 mai 2017,

Pregnant women are very susceptible to malaria infection and Malaria in Pregnancy (MiP) is a major cause of maternal anaemia and low birth weight (LBW) that leads to infant mortality, poor growth and development. In low transmission areas, malaria can become severe, resulting in maternal and foetal death. In sub-Saharan Africa (SSA) MiP is responsible for 8–14% of LBW, 3–8% of infant deaths, highe ...
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 9

 TERMINÉ 

Quantitative T cell Immunology (QuanTI)

Date du début: 1 mai 2013, Date de fin: 30 avr. 2017,

The primary objective of this ITN is to train a new generation of European quantitative immunologists, who will be able to address challenges arising in Systems Immunology. This will be achieved with the proposed Network, Quantitative T cell Immunology (QuanTI), that will train 11 ESRs and 4 ERs, bringing together renowned experimental and theoretical scientists from private and academic instituti ...
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 12

 TERMINÉ 

Vaccination against Shigella and ETEC: novel antigens, novel approaches (STOPENTERICS)

Date du début: 1 nov. 2010, Date de fin: 30 avr. 2017,

To contribute to the development of vaccines against Shigella and ETEC for children of the developing world, STOPENTERICS will provide novel solutions by imposing a two-fold paradigm switch: (i) to break the dogma of serotype-specificity by inducing a cross-protective immunity (ii) to improve the immunogenicity of Shigella glycoconjugates by using synthetic oligosacharides mimicking the lipopolysa ...
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 20

 TERMINÉ 

Enhanced exposure assessment and omic profiling for high priority environmental exposures in Europe (EXPOSOMICS)

Date du début: 1 nov. 2012, Date de fin: 30 avr. 2017,

This project aims to predict individual disease risk related to the environment, by characterizing the external and internal exposome for common exposures (air and drinking water contaminants) during critical periods of life, including in utero. A large amount of health data is now available from longitudinal cohorts in both children and adults, with detailed information on risk factors, confounde ...
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 15

 TERMINÉ 

The impact of DEmographic Changes on Infectious DisEases transmission and control in middle/low income countries (DECIDE)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2017,

Population structure and change and social contact patterns are major determinants of the observed epidemiology of infectious diseases, including the consequences on health. Demographic structure and the components of demographic dynamics are changing over time and substantially differ within countries and most critically between countries. However, some of the overall consequences of demographic ...
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 4

 TERMINÉ 

Deciphering the ubiquitin code of the TNF receptor signalling complex and its functional role in inflammation and immunity (UB-DECODED)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2017,

Tumour necrosis factor (TNF) is a cytokine with important functions in inflammation, immunity and cancer. Signalling processes mediated by ubiquitin are crucial for TNF signalling. The seven lysine (K) residues and the N-terminus of ubiquitin can be used to form ubiquitin chains. Employing a method newly developed in our laboratory we identified the presence of four of these ubiquitin chain linkag ...
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 3

 TERMINÉ 

Biomaterials for Tracheal Replacement in Age-related Cancer via a Humanly Engineered Airway (BIOtrachea)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2017,

Age-related cancers, especially of the trachea, are neoplastic lesions that significantly impact upon the lives of thousands of European patients each year. Unfortunately, most present with inoperable lesions for which median survival is less than 12 months. Based on our previous clinically successful experiences with in vivo completely tissue engineered tracheal replacement in benign tracheal dis ...
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 13

 TERMINÉ 

Co-morbidity in relation to Aids (COBRA)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2017,

Persons with HIV on combination antiretroviral therapy (cART) are at increased risk of the premature development of age-associated non-communicable comorbidities (AANCC), including cardiovascular, chronic kidney, liver and pulmonary disease, diabetes mellitus, osteoporosis, non-AIDS associated malignancies, and neurocognitive impairment. It has therefore been hypothesised that such individuals, de ...
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 12

 TERMINÉ 

BBMRI - Large Prospective Cohorts (BBMRI-LPC)

Date du début: 1 févr. 2013, Date de fin: 31 janv. 2017,

In recent years, biomedical research has crossed international borders in large, collaborative studies showing the value of multidisciplinarity and scale advantage. This has yielded valuable insights and some led to new and better medicines and treatments for diseases. However, disease-focused studies provide less insight in the real disease onset, the relative disease burden in the population, an ...
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 36

 TERMINÉ 

Biomarkers For Enhanced Vaccine Safety (BIOVACSAFE)

Date du début: 1 mars 2012, Date de fin: 31 déc. 2016,

BioVacSafe is a concise consortium of selected academic, public, and SME participants used to co-working in industry-led projects, organised into focused Activity Cores to generate knowledge and tools to benchmark licensed vaccine reactogenicity, and create practical and generalizable guidelines and techniques to enhance immunosafety of novel vaccines from pre-development to post-marketing surveil ...
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 24

 TERMINÉ 

The role of TREM proteins in inflammatory lung disease (ALLOSERGON)

Date du début: 1 févr. 2013, Date de fin: 23 déc. 2016,

• Both asthma and pneumococcal infection independently affect millions of people world-wide causing significant mortality/morbidity and an associated high economic burden. It is indicated that pathogenesis in asthma is due to enhanced bacterial replication and invasiveness in the lung rather than a worsening of asthma itself.• The overall scientific objective is to combine established models of re ...
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 2

 TERMINÉ 

Preparedness, Prediction and Prevention of Emerging Zoonotic Viruses with Pandemic Potential using Multidisciplinary Approaches (PREDEMICS)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2016,

The capacity of zoonotic RNA viruses to emerge as major agents of human disease can appear limitless. Current intervention strategies have demonstrated limited success. Rapid, innovative and effective solutions are needed to reduce the apparently accelerating process of zoonotic disease emergence. We will study the following zoonotic viruses with epidemic potential in Europe: influenza virus, hepa ...
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 20

 TERMINÉ 

The role of neutrophils and their proteases in the pathology of allergic airway disease (NEUPROTALL)

Date du début: 1 oct. 2014, Date de fin: 30 sept. 2016,

"Asthma is an active area of respiratory research due to its impact on morbidity and mortality worldwide. The limited treatment options available to severe asthmatics represent a great challenge. Severe asthma is associated with neutrophilia but the role of neutrophils in this pathology remains poorly defined. A greater understanding of the role of neutrophil proteases will lead to the development ...
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 2

 TERMINÉ 

European Asthma Research and Innovation Partnership (EARIP)

Date du début: 1 sept. 2013, Date de fin: 31 août 2016,

Europe has 30 million people with asthma, whose treatment costs about €20 bn annually. Productivity lost through poor asthma control in Europe is estimated to be €9.8 bn per year. By 2020 approximately 120,000 people in Europe will die from asthma attacks, and 4 million hospitalisations will be needed for the most severely affected.The Objectives of EARIP (European Asthma Research and Innovation P ...
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 14

 TERMINÉ 

Identification of pathways and genetic drivers for childhood epileptic encephalopathies by integrating whole-exome sequencing and gene network approaches (IGENEE)

Date du début: 1 sept. 2014, Date de fin: 31 août 2016,

The objective of the iGENEE project (Integrated Genetic Networks for Epileptic Encephalopathies) is the identification of pathways and genetic drivers for childhood epileptic encephalopathies (EE) by integrating whole-exome sequencing and gene network approaches. It will be supervised by Dr Petretto, Head of the Integrative Genomics and Medicine Group at the MRC Institute of Clinical Sciences, and ...
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 2

 TERMINÉ 

Multi-phenotype Analysis of Rare Variants – devELopment of an analysis method and software with implementation to large-scale data to unravel pleiotropic genetic effects behind cardiometabolic traits (MARVEL)

Date du début: 1 août 2014, Date de fin: 31 juil. 2016,

The obesity rates are rapidly increasing worldwide concomitantly with rising prevalence of chronic diseases, including cardiovascular disease and type 2 diabetes. Individual trait genome-wide association studies of common variants (minor allele frequency, MAF>5%) have highlighted complex genetic relationships between related cardiometabolic phenotypes with an intriguing pattern of associated overl ...
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 2

 TERMINÉ 

Application of new technologies and methods in nutrition research – the example of phenotypic flexibility (NutriTech)

Date du début: 1 janv. 2012, Date de fin: 30 juin 2016,

NutriTech will build on the foundations of traditional human nutrition research using cutting-edge analytical technologies and methods to comprehensively evaluate the diet-health relationship and critically assess their usefulness for the future of nutrition research and human well-being. Technologies include genomics, transcriptomics, proteomics, metabolomics, laser scanning cytometry, NMR based ...
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 25

 TERMINÉ 

Innovative anti-influenza drugs excluding viral escape (ANTIFLU)

Date du début: 1 juin 2011, Date de fin: 31 mai 2016,

ANTIFLU is to develop innovative drugs against influenza virus infections based on a novelconcept that precludes the development of viral resistance and ensures efficacy againstupcoming pandemic influenza strains. Viral replication is known to depend on multiple hostfactors. Whilst traditional anti-influenza treatments usually target viral factors, ANTIFLU willaim at drugs interfering with host-re ...
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 11

 TERMINÉ 

EPIGENomic markers for AIR pollution-induced health effects (EPIGENAIR)

Date du début: 1 mai 2014, Date de fin: 30 avr. 2016,

Exposure to particulate matter (PM) has detrimental effects on the health outcomes. Recently is shown that particulate matter increases the risk for lung cancer at the population level, which is assessed within the framework of the European Study of Cohorts for Air Pollution Effects (ESCAPE). This study dramatically increased the epidemiological weight of this association, however mechanistic evid ...
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 2

 TERMINÉ 

Addictions and Lifestyles In Contemporary Europe – Reframing Addictions Project (ALICE RAP)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2016,

ALICE RAP is a Europe wide project of 43 partner research institutions involving 107 researchers from 25 European countries providing 1000 months of a plurality of scientific endeavour to analyse the place and challenges of addictions and lifestyles to the cohesion, organization and functioning of contemporary European society. Through integrated multidisciplinary research, a wide range of factors ...
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 46

 TERMINÉ 

"Prevention and improved diagnosis of adolescent genital disease in schistosomiasis endemic KwaZulu-Natal, South Africa" (VIBE-FGS-EUSAN)

Date du début: 1 août 2011, Date de fin: 31 mars 2016,

"The VIBE-FGS-EUSAN project is a joint initiative by six partner universities in Europe and one partner university in Africa who have developed collaborative links in the last decade. This network of translational research aims to facilitate a strong collaboration between laboratories at the forefront of basic research and field projects trying to resolve tropical issues on the ground. In the poor ...
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 7

 TERMINÉ 

Microbicide Optimization Through Innovative Formulation for Vaginal and Rectal Delivery (MOTIF)

Date du début: 1 oct. 2012, Date de fin: 31 mars 2016,

"The 40% protection against HIV-1 infection with vaginally-applied tenofovir gel demonstrated in the CAPRISA004 trial, has emphasized development of anti-retroviral (ARV)-based microbicides. Combining ARVs in a single product may provide increased protection. Development of a generally applicable formulation platform for combining ARVs (even if chemically incompatible) and understanding of the pro ...
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 9

 TERMINÉ 

Sarcomere based Signals in Muscle Remodelling (SARCOSI)

Date du début: 1 avr. 2012, Date de fin: 31 mars 2016,

The sarcomere is the structural unit of striated muscle tissues where thick and thin filaments cooperate to achieve muscle contraction. Recently it is becoming increasingly clear that sarcomeres have in addition to muscle contraction also important signaling functions: Stretch and strain sensing signalosomes are assembled by the giant muscle proteins titin and nebulin, that in turn are embedded in ...
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 14

 TERMINÉ 

Post-infectious immune reprogramming and its association with persistence and chronicity of respiratory allergic diseases (PreDicta)

Date du début: 1 oct. 2010, Date de fin: 31 mars 2016,

Chronic inflammatory diseases associated with allergy, including asthma and rhinitis, constitute a major and continuously growing public health concern for Europe. However, the causative factors and mechanisms converting a physiological inflammatory reaction to a chronic response triggering allergic disease remain elusive.Viral infections, particularly those caused by human rhinoviruses (RV) are t ...
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 13

 TERMINÉ 

Epigenetics towards systems biology (EPIGENESYS)

Date du début: 1 oct. 2010, Date de fin: 31 mars 2016,

The ‘EpiGeneSys’ Network of Excellence aims to enable European epigenetics research to enter the arena of systems biology, a new step forward with major implications for human health. Many diseases, not explained solely by gene mutation, have rather been associated with epigenetic disorders. Following the identification of key epigenetic regulators, a move towards a systems biology approach is nee ...
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 28

 TERMINÉ 

Prevention of Liver Fibrosis and Cancer in Africa (PROLIFICA)

Date du début: 1 févr. 2011, Date de fin: 31 janv. 2016,

"Chronic hepatitis B virus (HBV) infection affects 350 million people worldwide and 25-30% of these individuals will die as a result of their infection mainly as a results of hepatocellular carcinoma HCC. Liver cirrhosis, high viral load and dietary exposure to aflatoxin are recognised as risk factors for hepatocellular carcinoma amongst HBV carriers. However, these variables do not account for al ...
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 8