6 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Systematic investigation of epistasis in molecular evolution (EinME)
Date du début: 1 janv. 2014, Date de fin: 31 déc. 2018,
Why does a mutation have a deleterious effect when it occurs in one species but shows no apparent consequences on the phenotype when it occurs in another species? What are some of possible explanations on the molecular basis of this phenomenon? Are the computational predictions of the extent of this phenomenon in nature accurate? The present project aims to take a swing at answering, at least part ...
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1
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TERMINÉ
Uncovering and understanding RNA through Massively Parallel Sequencing (RNA-MAPS)
Date du début: 1 avr. 2012, Date de fin: 31 déc. 2017,
The overarching goal of the proposal presented here is the use of massively parallel sequencing for the identification of novel genetic and epigenetic factors playing role in RNA processing. Specifically, we plan to focus on the role of long non-coding RNAs and histone modifications in splicing regulation during cell differentiation. Towards that end, we plan to monitor RNA and chromatin changes a ...
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1
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TERMINÉ
The Role of Non-coding RNA in Protein Networks and Neurodegenerative Diseases (RIBOMYLOME)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,
"A major portion of the eukaryotic genome is occupied by DNA sequences whose transcripts do not code for proteins. This part of the genome is transcribed in a developmentally regulated manner and in response to external stimuli to produce large numbers of long non-coding RNAs (lncRNAs). From the beginning of transcription through splicing and translation, RNA molecules are associated with numerous ...
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1
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TERMINÉ
The germline mutational landscape of chronic lymphocytic leukemia (CLLrisk)
Date du début: 1 mars 2014, Date de fin: 20 juin 2016,
Chronic lymphocytic leukemia (CLL) is a cancer of B-lymphocytes, which expands in the bone marrow, lymph nodes, spleen and blood. While many genes have been implicated in CLL development through sequencing the genome of tumor cells, they do not completely explain the pathogenesis of the disease, nor define the early events that lead the B-cells to proliferate and become cancerous, accumulating the ...
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1
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TERMINÉ
European Sequencing and Genotyping Infrastructure (ESGI)
Date du début: 1 févr. 2011, Date de fin: 31 juil. 2015,
The objective of this project is the integration of world class high-throughput sequencing and genotyping facilities that will provide sequencing and genotyping technologies and data analysis methodologies to the scientific community.The European Sequencing and Genotyping Infrastructure (ESGI) will enable external users to generate data rapidly and to acquire knowledge efficiently. By providing ac ...
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11
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TERMINÉ
Small RNA toxicity and DNA damage response in Huntington´s disease (RNAneuroTOX)
Date du début: 1 avr. 2013, Date de fin: 21 juil. 2015,
Huntington´s disease (HD) is an incurable and fatal neurodegenerative disease, manifested by a progressive loss of neurons, causing neuronal motor dysfunction, cognitive decline and death. The disease is caused by a CAG repeat expansion in the Huntingtin (HTT) gene. The CAG expansion induces a neurotoxic effect, mainly thought to be caused by the expanded protein. However, also expanded RNA transc ...
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