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Plus de 40 projets européens trouvés

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 TERMINÉ 

Model-based preclinical development of anti-tuberculosis drug combinations (PREDICT-TB)

Date du début: 1 mai 2012, Date de fin: 30 oct. 2017,

Drug development in TB requires new integrated methods to transition the novel combination regimens needed to shorten first-line therapy and combat multi-drug resistance. Although new agents are emerging, the path to registration of such regimens remains uncertain while capacity for pivotal trials is limited. Selection and optimization of drug combinations for development depends on preclinical sy ...
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 23

 TERMINÉ 

Advanced Immunization Technologies (ADITEC)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2017,

Vaccines so far have been developed mostly by following an empiric approach. To prevent and possibly cure unresolved and emerging infectious diseases we need to fully exploit the potential of the human immune system. Progress in science and technology makes it possible to achieve what was previously deemed impossible. The scope of this project is to produce knowledge necessary to develop novel and ...
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 53

 TERMINÉ 

More Medicines for Tuberculosis (MM4TB)

Date du début: 1 févr. 2011, Date de fin: 31 juil. 2016,

The More Medicines for Tuberculosis (MM4TB) consortium evolved from the highly successful FP6 project, New Medicines for TB (NM4TB), that delivered a candidate drug for clinical development two years ahead of schedule. Building on these firm foundations and exploiting its proprietary pharmacophores, MM4TB will continue to develop new drugs for TB treatment. An integrated approach will be impleme ...
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 27

 TERMINÉ 

Systems biology of liver cancer: an integrative genomic-epigenomic approach (MODHEP)

Date du début: 1 janv. 2011, Date de fin: 30 juin 2016,

"Cancer is a complex disease involving multiple genetic and epigenetic events occurring, and influencing each other, over a long period of time. Understanding cancer, and ultimately developing effective targeted therapies, will therefore require that mutations and epigenetic alterations be systematically investigated during the multiple stages of disease development, from identifiable pre-neoplast ...
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 18

 TERMINÉ 

Dietary Fibers supporting Gut and Immune Function - From polysaccharide compound to health claim (FIBEBIOTICS)

Date du début: 1 janv. 2012, Date de fin: 30 juin 2016,

The project goal is to support the development of functional food ingredients and products that are beneficial for the human gut & immune system and therefore of crucial importance for quality of life. The project will study the effects of specific non-digestible polysaccharides which have shown health potential in this field. The health effects of NPS will be focused around enhancing immune defen ...
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 17

 TERMINÉ 

Innovative anti-influenza drugs excluding viral escape (ANTIFLU)

Date du début: 1 juin 2011, Date de fin: 31 mai 2016,

ANTIFLU is to develop innovative drugs against influenza virus infections based on a novelconcept that precludes the development of viral resistance and ensures efficacy againstupcoming pandemic influenza strains. Viral replication is known to depend on multiple hostfactors. Whilst traditional anti-influenza treatments usually target viral factors, ANTIFLU willaim at drugs interfering with host-re ...
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 11

 TERMINÉ 

Innovative tools and strategies for surveillance and control of dengue (DengueTools)

Date du début: 1 sept. 2011, Date de fin: 30 avr. 2016,

Current surveillance systems and control efforts are clearly insufficient to combat dengue in endemic countries and to prevent spread to previously uninfected areas (including Europe). We will focus on the following aspects of the call: better diagnosis, surveillance, prevention as well as prediction and/or prevention of the spread of Dengue fever to previously uninfected regions (including Europe ...
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 14

 TERMINÉ 

Evolution and Transfer of Antibiotic Resistance (EVOTAR)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2015,

Antibiotics are essential therapeutics in the treatment of bacterial infections. However, the indiscriminate use of antibiotics has led to the emergence of antibiotic resistant bacteria that pose a major threat to human health as options for treating infections by these bacteria have become limited. The evolution, emergence and spread ofantibiotic resistance genes are still only poorly understood ...
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 19

 TERMINÉ 

Biology and control of vector-borne infections in Europe (EDENext)

Date du début: 1 janv. 2011, Date de fin: 30 juin 2015,

To address the call for proposals 'Biology and control of vector-borne infections in Europe' launched by the European Commission, we want to investigate the biological, ecological and epidemiological components of vector-borne diseases (VBD) introduction, emergence and spread, and to propose innovative tools for controlling them, building on the basis of acquired knowledge. We have selected the ma ...
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 54

 TERMINÉ 

Towards the establishment of a permanent European Virtual Institute dedicated to Malaria Research (EVIMalaR) (EVIMalaR)

Date du début: 1 oct. 2009, Date de fin: 31 mars 2015,

This is a proposal from 55 partners from 36 institutes to form a NoE that will seek to integrate European malaria research that is directed towards a better understanding of the basic biology of the parasite, its vector and of the biology of the interactions between the parasite and both its mammalian host and vectors. All the member institutes and researchers have demonstrated both their excellen ...
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 40

 TERMINÉ 

Small-molecule Inhibitor Leads Versus emerging and neglected RNA viruses (SILVER)

Date du début: 1 oct. 2010, Date de fin: 31 mars 2015,

RNA virus infections kill millions of humans annually, largely due to the lack of suitable vaccines and drugs to control them. This problem is addressed in this FP7 call and in response a consortium of Europe’s and Asia’s leading molecular virologists, structural biologists, medicinal chemists and bioinformaticians has been brought together to generate a state-of-the-art drug discovery and design ...
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 25

 TERMINÉ 

Reinforcing IPT capacities in Genomic Medicine, Non Communicable Diseases Investigation and international cooperation (GM_NCD_IN_CO)

Date du début: 1 déc. 2011, Date de fin: 30 nov. 2014,

The aim of the proposal is reinforcing IPT capacities (i) in genomic medicine, withapplications in Non Communicable Diseases (NCD) investigation, and (ii) in International Cooperation activities. This project will facilitate joint research and innovation related activities between European and Tunisian researchers in the field of NCD.To achieve these aims the following actions are proposed: Settin ...
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 3

 TERMINÉ 

Integration of Chikungunya research (ICRES)

Date du début: 1 déc. 2010, Date de fin: 30 nov. 2014,

Since 2005 Chikungunya fever has affected millions of people producing a high fever and a debilitating arthralgia which can persist for months and progress to chronic arthritis. Chikungunya virus has been associated with periodic outbreaks of human disease and is spread by mosquitoes. The current epidemic rose to prominence in 2005/6 following infection of >250,000 people on La Réunion. The virus ...
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 15

 TERMINÉ 

Protecting the food chain from prions: shaping European priorities through basic and applied research (PRIORITY)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2014,

"Bovine Spongiform Encephalopathy (BSE) started, 20 years ago, a devastating health and food crisis throughout Europe. Classical BSE is now under control as a result of the meat and bone meal ban. However, tonsil analyses suggest that there may be an alarmingly high number of asymptomatic PrPSc positive cases. Transmission through blood transfusion is another important concern, as are recent “atyp ...
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 21

 TERMINÉ 

Molecular Targets Open for Regulation by the gut flora – New Avenues for improved Diet to Optimize European health (TORNADO)

Date du début: 1 sept. 2009, Date de fin: 31 août 2014,

"Europe is facing major diet related health problems. Attitudes to eating habits have to be changed and the benefits of alternative treatment regimes substantiated. This can only be achieved by providing guidelines regulating health claims based on scientific data. Thus, there is a unique opportunity to use gut flora in potential treatment regimes and as a preventive target for major diet related ...
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 24

 TERMINÉ 

"Fungi in the setting of inflammation, allergy and autoimmune diseases:Translating basic science into clinical practices" (ALLFUN)

Date du début: 1 déc. 2010, Date de fin: 31 mai 2014,

"The ALLFUN proposal aims at defining the cellular and molecular mechanisms by which ubiquitous airborne or commensal fungi contribute to immune homeostasis and its dysregulation leading to allergy and inflammatory diseases. Breakthroughs in understanding how mucosal homeostasis is established, maintained or disrupted in the presence of fungi should be sources of new therapeutic targets and drugs ...
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 14

 TERMINÉ 

"Spontaneous clearance in Patients acutely infected with HCV - Immune profiling, Novel biomarkers and X-omics approaches" (SPHINX)

Date du début: 1 nov. 2010, Date de fin: 30 avr. 2014,

"The proposed project aims to identify novel biomarkers and provide new insight into the mechanisms of spontaneous clearance of hepatitis C virus (HCV) during the early stages of acute infection. Indeed hepatitis C is a major public health problem with high incidence in regions such as Egypt and other Mediterranean Partner Countries (MPCs). Our current application follows from an FP5 project entit ...
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 10

 TERMINÉ 

Discovery and preclinical development of new generation tuberculosis vaccines (NEWTBVAC)

Date du début: 1 janv. 2010, Date de fin: 28 févr. 2014,

"With 14.4 million prevalent cases and 1.7 million deaths tuberculosis (TB) remains one of the most serious infectious diseases to date. An estimated 2 billion people are believed to be infected with Mycobacterium tuberculosis and at risk of developing disease. Multi- and extensively drug resistant strains are increasingly appearing in many parts of the world, including Europe. While with current ...
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 39

 TERMINÉ 

Vector-borne Risks for Europe: Risk assessment and control of West Nile and Chikungunya virus (VECTORIE) (VECTORIE)

Date du début: 1 nov. 2010, Date de fin: 31 janv. 2014,

VECTORIE provides for a multidisciplinary approach combining the expertise of (basic) virology, entomology and advanced vaccinology to monitor the spread of and diagnose, prevent and treat infections caused by West Nile virus (WNV) and Chikungunya virus (CHIKV). VECTORIE therefore addresses Europe’s need to prepare for these vector-borne diseases along three strands:Vector biology: WNV and CHIKV a ...
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 9

 TERMINÉ 

Optimization of stem cell therapy for clinical trials of degenerative skin and muscle diseases (OptiStem)

Date du début: 1 janv. 2009, Date de fin: 31 déc. 2013,

This proposal aims to develop and implement efficacy of clinical trials with adult, tissue stem cells for degenerative diseases of epithelia and skeletal muscle. Extraordinary progress in the understanding of several key features of stem cells has been rapidly translated into novel cell therapy protocols that have yielded positive results in pre-clinical models of genetic and acquired diseases and ...
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 20

 TERMINÉ 

Folding and assembly of the outer membrane component PulD of the type II secretion pathway of Klebsiella oxytoca (FAPUL)

Date du début: 2 nov. 2011, Date de fin: 1 nov. 2013,

"Type II secretion in Gram-negative bacteria is the general exit route for proteins that function outside the cell. During secretion, preproteins are first translocated across the inner membrane, after which the dedicated type II secretion system transports the protein across the outer membrane. In Klebsiella oxytoca the outer membrane pore is formed upon dodecamerisation of PulD, a founder member ...
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 1

 TERMINÉ 

Role and natural host targets of Shigella IpaH during infection (IpaH functions)

Date du début: 1 avr. 2011, Date de fin: 30 sept. 2013,

Numerous pathogens grow inside host cells. During the intracellular stage of infection, pathogen proteins establish intricate interactions with host proteins to hijack their cellular machinery. The bacterium Shigella flexneri thrives in the cytoplasm of human intestinal epithelial cells. To do so this bacterium must inject proteins that are dubbed effectors before and after cell invasion. IpaH are ...
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 1

 TERMINÉ 

The role of peptidoglycan in bacterial cell physiology: from bacterial shape to host-microbe interactions (PGNfromSHAPEtoVIR)

Date du début: 1 août 2008, Date de fin: 31 juil. 2013,

Peptidoglycan (PGN) is a major essential and unique component of the cell wall of both of Gram-negative and Gram-positive bacteria. Because of the central role of PGN metabolism in bacterial cell structure and shape, in antibiotic resistance and in host-microbe interactions, any process affecting one of these aspects has direct consequence on the other two. Hence, the study of PGN metabolism is of ...
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 1

 TERMINÉ 

Identification and development of vaccine candidates for Buruli Ulcer Disease (BuruliVac)

Date du début: 1 mars 2010, Date de fin: 31 mai 2013,

Buruli ulcer disease (BUD), caused by Mycobacterium ulcerans, is a neglected bacterial infection of the poor in remote rural areas, mostly affecting children. BUD, the third most common mycobacterial disease in immunocompetent humans after tuberculosis and leprosy, is most endemic in West Africa, but cases have been reported from more than 30 countries. BUD is a mutilating disease leading to sever ...
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 16

 TERMINÉ 

Predicting antibiotic resistance (PAR)

Date du début: 1 avr. 2010, Date de fin: 31 mars 2013,

"The aim of this proposal is to describe and predict the dynamics of antibiotic resistance development at the level of the drug target, the microbe and the host. That is, we want to generate the knowledge required to be able to connect resistance mechanism --> bacterial physiology and fitness --> bacterial survival within a host --> bacterial spread between hosts. To achieve this goal we will deve ...
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 12

 TERMINÉ 

Building a cooperative strategy between Europe and Mediterranean Countries for upgrading tuberculosis research and control (EUMEDNETvsTB)

Date du début: 1 mars 2010, Date de fin: 28 févr. 2013,

Tuberculosis (TB) accounts amongst the most deadly infectious diseases worldwide. Despite the availability of a vaccine and effective drugs, Mycobacterium tuberculosis, the etiologic agent of TB, still defies the humanity. An alarming increase in drug resistance and emergence of outbreaks has made it urgent the need for increased surveillance and control. With its structured global geographical di ...
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 7

 TERMINÉ 

Carbohydrate Multivalent Systems as tools to study Pathogen interaction with DC-SIGN (CARMUSYS)

Date du début: 1 janv. 2009, Date de fin: 31 déc. 2012,

"The importance of glycosciences in the development of biology and medicine and the central role played by chemistry in this process have recently been pointed out by ESF. However, it appears that exposure of young scientists in their training phase to the chemical biology of carbohydrates is still lacking. This multidisciplinary project intends to approach the design and synthesis of carbohydrate ...
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 13

 TERMINÉ 

NOTCH SIGNALING IN DEVELOPMENT AND PATHOLOGY (NotchIT)

Date du début: 1 janv. 2009, Date de fin: 31 déc. 2012,

Eight partners from six different EU countries will converge in NotchIT, a multi-site ITN aimed to increase the knowledge of cellular and molecular mechanisms by which Notch signaling regulates the development and pathology of different tissues. Notch signaling plays a key role in cell-fate determination and differentiation of various cell types and aberrant Notch signaling is associated with path ...
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 11

 TERMINÉ 

A system view on the differential activities of human type I interferons (IFNaction)

Date du début: 1 janv. 2009, Date de fin: 31 déc. 2012,

Type I interferons (IFNs) form a restricted network of highly related immune cytokines that elicit differential biological responses through a single cell surface receptor comprised of the subunits IFNAR1 and IFNAR2. We have shown that differential signal activation correlates with differential interaction and conformational dynamics of the receptor induced by binding of different member of the IF ...
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 5

 TERMINÉ 

Development of cardiomyocyte replacement strategy for the clinic (CARDIOCELL)

Date du début: 1 mai 2009, Date de fin: 31 oct. 2012,

"Heart failure as a result of myocardial infarction or ischemic heart disease is a major health problem in Europe. Currently the only long term solution is heart transplantation but one in three patients die while awaiting a match. Transplantation of an alternative cell source is extremely attractive but has so far met with very little success. Thus, skeletal muscle myoblasts led to recurrent arrh ...
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 7

 TERMINÉ 

Pathogenomics and Systems Biology of Fungal Infections – An Integrative Approach (FINSysB)

Date du début: 1 oct. 2008, Date de fin: 30 sept. 2012,

The vision of the FINSysB Network is to generate bright, ambitious and well-trained young researchers capable of contributing significantly to the knowledge-base and economy of the European Union. We will achieve this goal by providing a strong, multidisciplinary training for early stage and experienced researchers in the pathobiology, genomics, molecular biology, bioinformatics and systems biolo ...
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 13

 TERMINÉ 

Intervention strategies against malaria (InterMalTraining)

Date du début: 1 oct. 2008, Date de fin: 30 sept. 2012,

Malaria exacts a devastating social and economic cost across the globe. Europe is at the forefront of the battle against this disease. It contains many of the leading malaria research groups, most of which are members of at least one of two consortia; BioMalPar, a Network of Excellence focused on basic research into the biology and pathology of malaria; and AntiMal, an integrated project aiming ...
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 13

 TERMINÉ 

European Consortium for Microbial Resource Centres (EMbaRC)

Date du début: 1 févr. 2009, Date de fin: 30 sept. 2012,

EMbaRC will establish a self-sustainable community of European Microbial Resource Centres representing a large bio-diversity and offering a wide-range of not only bio-resources but also expert services. These services will enable the development of new partnerships with public institutes in the field of biodiversity and will facilitate revenue-generating partnerships with the economic sector (larg ...
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 10

 TERMINÉ 

Supporting EU Access to Canadian Research and Innovation Programmes (Access2Canada)

Date du début: 1 sept. 2009, Date de fin: 31 août 2012,

The Access2Canada project is based on the need to solve the lack of awareness among EU researchers about the opportunities and obstacles for European researchers to access Canadian research and innovation programmes. The objective of this project is therefore to strengthen and increase EU-Canada S&T and innovation cooperation by supporting the access to these programmes for EU researchers. In orde ...
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 6

 TERMINÉ 

European Consortium for Systematic Stem Cell Biology (EUROSYSTEM)

Date du début: 1 mars 2008, Date de fin: 31 août 2012,

EuroSyStem brings together elite European research teams to create a unique and world-leading programme in fundamental stem cell biology. By interconnecting complementary biological and computational expertise we will drive the generation of new knowledge on the characteristics of normal and abnormal stem cells. We will pave the way for application of systems methodology by measuring and modelling ...
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 25

 TERMINÉ 

Neurotransmitter Cys-loop receptors: structure, function and disease (NeuroCypres)

Date du début: 1 févr. 2008, Date de fin: 31 juil. 2012,

Cys-loop receptors (CLRs) form a superfamily of structurally related neurotransmitter-gated ion channels, comprising nicotinic acetylcholine, glycine, GABA-A/C and serotonin (5HT3) receptors, crucial to function of the peripheral and central nervous system. CLRs cover a wide spectrum of functions, ranging from muscle contraction to cognitive functions. CLR (mal)function is linked to various disord ...
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 24

 TERMINÉ 

Signalling in life cycle stages of malaria parasites (MALSIG)

Date du début: 1 févr. 2009, Date de fin: 31 juil. 2012,

Malaria is a major public health problem in the developing world and is endemic in many regions of India. The development of novel strategies for malaria control requires a better understanding of the biology of malaria parasites. Our project aims at bringing a significant contribution to this field, through dissecting the signalling pathways that regulate essential processes in the life cycle o ...
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 18

 TERMINÉ 

Human Brain Project (HBP)

Date du début: 1 mai 2011, Date de fin: 30 avr. 2012,

The human brain can be seen as an immensely powerful, energy efficient, self-learning, self-repairing computer. If we could understand and mimic the way the brain works, we could revolutionize information technology, medicine and society. But to do so we have to bring together everything we know and everything we can learn about the inner workings of the brain's molecules, cells and circuits. The ...
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 13

 TERMINÉ 

Initiative on Optimizing Malaria Vaccine Lab Assays Evaluation (OPTIMALVAC)

Date du début: 1 avr. 2009, Date de fin: 31 mars 2012,

"A broad-range of candidate malaria vaccines derived from diverse novel technologies have resulted from the multiple approaches being taken by different groups in developing malaria vaccines. The majority of the candidates are recombinant proteins based on complex native antigens found on the surface of the parasite. Vaccine potential of these parasite surface antigens is often supported by epidem ...
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 14

 TERMINÉ 

Targeting the Leishmania kinome for the development of novel anti-parasitic strategies (LEISHDRUG)

Date du début: 1 oct. 2008, Date de fin: 31 mars 2012,

"Visceral leishmaniasis is caused by the protozoan parasites Leishmania donovani and Leishmania infantum and is a potentially fatal disease in endemic areas around the world. During the infectious cycle, Leishmania alternate between the insect promastigote stage and the vertebrate aflagellate amastigote stage that proliferates inside infected host macrophages provoking the pathology of the disease ...
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 13