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 TERMINÉ 

Fostering responsive mental health systems in the Syrian refugee crisis (STRENGTHS)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2021,

STRENGTHS aims to provide effective community-based health care implementation strategies to scale-up the delivery and uptake of effective mental health interventions in different country contexts. The current refugee crisis across Europe and the Middle East effects both individual refugees’ psychological well-being, as they face extreme stressors in their flight from their home country, but also ...
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 15

 TERMINÉ 

Towards evidence-based tailored implementation strategies for eHealth (ImpleMentAll)

Date du début: 1 janv. 2017, Date de fin: 31 mars 2021,

ImpleMentAll will develop, apply, and evaluate tailored implementation strategies in the context of on-going eHealth implementation initiatives in the EU and beyond. Common mental health disorders account for an alarming proportion of the global burden of disease. Being regarded as an evidence-based psychotherapeutic eHealth intervention, Internet-based Cognitive Behavioural Therapy (iCBT), has th ...
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 19

 TERMINÉ 

Personalised Risk assessment in febrile illness to Optimise Real-life Management across the European Union (PERFORM)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

The management of febrile patients is one of the most common and important problems facing healthcare providers. Distinction between bacterial infections and trivial viral infection on clinical grounds is unreliable, and as a result innumerable patients worldwide undergo hospitalization, invasive investigation and are treated with antibiotics for presumed bacterial infection when, in fact, they ar ...
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 19

 TERMINÉ 

Understanding asthma phenotypes: going beyond the atopic/non-atopic paradigm (AsthmaPhenotypes)

Date du début: 1 janv. 2016, Date de fin: 31 déc. 2020,

Fifteen years ago it was widely believed that asthma was an allergic/atopic disease caused by allergen exposure in infancy; this produced atopic sensitization and continued exposure resulted in eosinophilic airways inflammation, bronchial hyper-responsiveness and reversible airflow obstruction. It is now clear that this model is at best incomplete. Less than one-half of asthma cases involve allerg ...
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 6

 TERMINÉ 

EU-TOPIA: TOWARDS IMPROVED SCREENING FOR BREAST, CERVICAL AND COLORECTAL CANCER IN ALL OF EUROPE (EU-TOPIA)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

Breast, colorectal and cervical cancer cause 250,000 deaths each year, representing 20% of EU-cancer mortality. Although important progress has been made in both detection and treatment, there is persisting inequity in progress to reduce its burden. Screening programmes vary substantially between countries and in most long-term effectiveness of screening has not yet been assessed. The objective of ...
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 7

 TERMINÉ 

Translational regulation in the persistence and drug susceptibility of Mycobacterium tuberculosis (MtbTransReg)

Date du début: 1 juin 2015, Date de fin: 31 mai 2020,

Mycobacterium tuberculosis causes human tuberculosis but can also persist for decades as an asymptomatic latent infection. The mechanisms underlying persistence are poorly understood, and the emergence of drug-resistant tuberculosis makes the development of effective new treatments an urgent challenge. Understanding the ability of M. tuberculosis to switch between replicating and non-replicating s ...
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 1

 TERMINÉ 

Secondary prEvention of CardiovascUlaR disease in the Elderly trial (SECURE)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2020,

While Cardiovascular diseases (CVD) are the main cause of death worldwide, they are responsible for half of all deaths in Europe. The overall ageing of the European population and improving survival of patients with coronary heart disease has created a large population of older adults eligible for secondary prevention. Despite the established efficacy of cardiovascular medications, suboptimal adhe ...
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 13

 TERMINÉ 

Female cancer prediction using cervical omics to individualise screening and prevention (FORECEE)

Date du début: 1 sept. 2015, Date de fin: 31 août 2019,

While prevention of most female specific cancers (ovarian, breast, endometrial) has not progressed substantially in recent years, significant progress has been made with cervical cancer due to accessibility of the cell of origin (cervical smear) and availability of a test for the causal agent (human papilloma virus); together these enable identification of high risk individuals and interventions t ...
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 14

 TERMINÉ 

Heart OMics in AGEing (HOMAGE)

Date du début: 1 févr. 2013, Date de fin: 31 janv. 2019,

As more people survive into old age, the prevalence of heart failure (HF), one of the most common and debilitating diseases in older people, will rise still further. Delaying or preventing HF will have great benefit to those at personal risk, their families, society and the economy. HOMAGE aims to provide a biomarker (BM) approach that will a) help identify i. patients at high risk of developing ...
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 22

 TERMINÉ 

"Cardiovascular Health effects of Air pollution in Andhra Pradesh, India" (CHAI)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,

"While there is convincing evidence that exposure to particulate air pollution causes cardiovascular mortality and morbidity, nearly all of this evidence is based on populations in high-income countries where concentrations are relatively low. There is large uncertainty regarding the relationship between combustion particles and cardiovascular risk for concentrations higher than outdoor concentrat ...
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 3

 TERMINÉ 

TBVAC2020; Advancing novel and promising TB vaccine candidates from discovery to preclinical and early clinical development (TBVAC2020)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,

The TBVAC2020 proposal builds on the highly successful and long-standing collaborations in subsequent EC-FP5-, FP6- and FP7-funded TB vaccine and biomarker projects, but also brings in a large number of new key partners from excellent laboratories from Europe, USA, Asia, Africa and Australia, many of which are global leaders in the TB field. This was initiated by launching an open call for Express ...
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 49

 TERMINÉ 

Control of leishmaniasis, from bench to bedside and community (EUROLEISH-NET)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2018,

Leishmaniasis control is the topic for EUROLEISH-NET, a Marie Sklodowska-Curie – Innovative Training Network. Leishmaniasis is a neglected infectious disease and a major public health and veterinary problem that afflicts both developing countries and Europe. The current technological and epidemiological advances underpin the necessity to develop training programmes aiming at developing new tools a ...
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 9

 TERMINÉ 

Impacts and risks from higher-end scenarios: Strategies for innovative solutions (IMPRESSIONS)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

IMPRESSIONS will provide empirically-grounded, transformative science that quantifies and explains the consequences of high-end climate scenarios for both decision-makers and society. IMPRESSIONS will develop and apply a novel participatory methodology that explicitly deals with uncertainties and strong non-linear changes focussing on high-end climate change, but also including intermediate warmin ...
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 25

 TERMINÉ 

Accelerated Development of Vaccine benefit-risk Collaboration in Europe (ADVANCE)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,

Aim: The ADVANCE vision is focused on Timely and Best Evidence on Vaccine Effects. Our mission is to establish a best practice framework to rapidly provide robust data on vaccine benefits and risks to support accelerated decision-making.Approach: To achieve this vision through a public-private partnership, ADVANCE partners 1. establish common grounds and rules for collaboration between public and ...
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 30

 TERMINÉ 

Investigation of the Type VI secretion system-associated toxins of Burkholderia thailandensis (BURK-6)

Date du début: 1 sept. 2015, Date de fin: 31 août 2018,

Secretion systems are evolved machineries enabling bacteria to deliver toxins and virulence factors, called effectors, into target cells to enable the onset of infectious diseases. Uncovering these effectors is essential for the understanding of bacterial pathogenesis and the establishment of appropriate therapeutic strategies to tackle infectious diseases. The recently identified Type Six Secreti ...
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 1

 TERMINÉ 

"Family life courses, intergenerational exchanges and later life health" (FAMHEALTH)

Date du début: 1 juil. 2013, Date de fin: 30 juin 2018,

"The overall aim of this research programme is to uncover how family life courses influence health and well-being in later adulthood, whether family related strengths or disadvantages relevant to health offset or compound socio-economic sources of disadvantage, and the extent to which these associations are influenced by societal factors. An important element will be to consider the role of interg ...
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 4

 TERMINÉ 

European Research Infrastructures for Poverty Related Diseases (EURIPRED)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,

HIV/AIDS, Tuberculosis (TB) and Malaria alone account for more than six million deaths worldwide every year. Despite substantial efforts made in recent years, Poverty Related Diseases are still spreading. New therapeutic interventions are therefore urgently required to combat Poverty Related Diseases. The existence of a well-developed HIV/TB/Malaria infrastructure presents a prime opportunity to a ...
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 18

 TERMINÉ 

The role of the gut in experimental visceral leishmaniasis and Chagas disease (GutTryp)

Date du début: 1 oct. 2014, Date de fin: 30 sept. 2017,

Leishmania donovani and Trypanosoma cruzi cause the neglected infectious diseases visceral leishmaniasis (VL) and Chagas disease (CD) respectively. The host normally controls the initial wave of infection but rarely, if ever, fully clears the infection. Chronic, low-level infection then often progresses to serious clinical syndromes. Infection of a limited set of favoured tissues is a parasite st ...
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 1

 TERMINÉ 

Parasite population genomics and functional studies towards development of a blood stage malaria vaccine (GENINVADE)

Date du début: 1 juil. 2012, Date de fin: 30 juin 2017,

"An effective malaria vaccine is needed, particularly against P. falciparum as this species causes more human mortality than all other eukaryotic pathogens combined. An understanding of natural selection operating on parasites in local endemic populations can enable understanding of core molecular mechanisms of global relevance. The objectives are to- Advance understanding of alternative pathways ...
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 5

 TERMINÉ 

Pandemic Risk and Emergency Management (PANDEM)

Date du début: 1 sept. 2015, Date de fin: 28 févr. 2017,

The European Union (EU) faces a growing health security threat posed by pandemics due to the convergence of risk factors driving disease emergence, amplification and dissemination of pathogens with pandemic potential. Protecting the health and security of citizens in the EU in the face of these pandemic threats requires a coherent response by all stakeholders driven by effective pandemic risk mana ...
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 7

 TERMINÉ 

Getting Research Into Policy in Public Health : transforming the evidence-to-policy response through utilisation of political insights (GRIP-HEALTH)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2016,

There has been increasing frustration in the field of public health with the lack of uptake of research evidence, and continued difficulties in getting evidence of effective health interventions into policy and practice. Calls have often been made to ‘bridge the gap’ between researchers and policy makers, yet little work has been done to analyse the political factors influencing research-to-polic ...
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 2

 TERMINÉ 

African Vector Control: New Tools (AvecNet)

Date du début: 1 févr. 2011, Date de fin: 31 déc. 2016,

The AvecNet consortium will develop practical solutions to the current limitations of vector control strategies in Africa using a combination of translationally-aware, state of the art science and end user analysis to ensure successful development and uptake of the new and improved approaches to malaria control and elimination. Our carefully balanced, multidisciplinary team of European and Africa ...
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 17

 TERMINÉ 

Care Package for Treatment and Control of Visceral Leishmaniasis in East Africa (AfriCoLeish)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,

Visceral leishmaniasis (VL) is fatal if left untreated; East Africa is one of the key endemic areas in the world. Untreated patients are part of the retransmission cycle and VL-HIV co-infection is an additional emerging problem.Existing VL monotherapies are difficult to administer, toxic, costly and long with emerging resistance. Sodium stibogluconate and paromomycin (SSG&PM) has been developed as ...
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 6

 TERMINÉ 

Incorporating real-life clinical data into drug development (GETREAL)

Date du début: 1 oct. 2013, Date de fin: 31 déc. 2016,

When a new medicine reaches the market, it is accompanied by an extensive data package that provides information about the safety and efficacy of the medicine in a clinical trial setting. However, assessing the expected future value of the medicines when used in “real world” clinical practice requires additional information next to traditional (pre-authorisation) clinical trials. Regulatory, HTA ...
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 32

 TERMINÉ 

European-COMPARative Effectiveness research on online Depression (E-COMPARED)

Date du début: 1 janv. 2014, Date de fin: 31 déc. 2016,

In 2010, 30 million Europeans were affected by depression and their number is still growing. Half of Europeans in need of mental care for depression do not have access to care services, do not always receive evidence-based treatments, are confronted with long waiting lists or high care expenditures. Internet-based treatment has the potential to addresses the drawbacks of standard care and keep dep ...
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 16

 TERMINÉ 

Emergency evaluation of convalescent blood and plasma for Ebola Viral Disease (EVD) in affected West African countries. (Ebola_Tx)

Date du début: 1 nov. 2014, Date de fin: 31 oct. 2016,

The objective of this proposal is to urgently determine the efficacy, safety and feasibility of convalescent whole blood (CWB) and convalescent plasma (CP) therapy, as a treatment for patients with Ebola Viral Disease (EVD) to reduce the case fatality rate in the present EVD epidemic in West Africa. The trial will take place in three consecutive phases; i) initial phase to initiate harmonized stan ...
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 8

 TERMINÉ 

Genetic studies of pre-eclampsia in Central Asian and European populations (INTERPREGGEN)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2016,

Pre-eclampsia, one of the most dangerous cardiometabolic complications of pregnancy, claims the lives of 50,000 mothers and almost one million babies annually. Pre-eclampsia and other hypertensive disorders of pregnancy remain the second most common cause of maternal death. The incidence of pre-eclampsia in Central Asian countries is over twice as high as in western Europe. Inter-population differ ...
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 13

 TERMINÉ 

ASSURED Point-of-Care Device for Syphilis and HIV in Pregnant Women and New Born (PREVENTIT)

Date du début: 1 sept. 2012, Date de fin: 31 juil. 2016,

The incidence of mother to child transmission of syphilis and HIV is still increasing and these infections are major cause of early death and severe morbidity of the young infant. Most case of congenital syphilis and HIV infection occur in hard to reach populations. The availability of an affordable and patient and user friendly point-of-care test that allows same day testing and treatment would s ...
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 6

 TERMINÉ 

Syndromic approach to Neglected Infectious Diseases (NID) at primary health care level: an international collaboration on integrated diagnostic-treatment platforms (NIDIAG)

Date du début: 1 nov. 2010, Date de fin: 30 avr. 2016,

Neglected Infectious Diseases (NID) such as trypanosomiasis, leishmaniasis, schistosomiasis and soil-transmitted helminthiasis receive less than 5% of the global investment for tropical diseases research. Clinical praxis in disease-endemic countries (DEC) is rarely evidence based and does not make use of the latest innovations in diagnostic technology. NID–related research on diagnostics is partic ...
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 13

 TERMINÉ 

Innovative tools and strategies for surveillance and control of dengue (DengueTools)

Date du début: 1 sept. 2011, Date de fin: 30 avr. 2016,

Current surveillance systems and control efforts are clearly insufficient to combat dengue in endemic countries and to prevent spread to previously uninfected areas (including Europe). We will focus on the following aspects of the call: better diagnosis, surveillance, prevention as well as prediction and/or prevention of the spread of Dengue fever to previously uninfected regions (including Europe ...
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 14

 TERMINÉ 

Addictions and Lifestyles In Contemporary Europe – Reframing Addictions Project (ALICE RAP)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2016,

ALICE RAP is a Europe wide project of 43 partner research institutions involving 107 researchers from 25 European countries providing 1000 months of a plurality of scientific endeavour to analyse the place and challenges of addictions and lifestyles to the cohesion, organization and functioning of contemporary European society. Through integrated multidisciplinary research, a wide range of factors ...
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 46

 TERMINÉ 

Universal coverage in Tanzania and South Africa: Monitoring and evaluating progress (UNITAS)

Date du début: 1 janv. 2011, Date de fin: 31 mars 2016,

"The goal of universal health coverage is receiving growing attention. How best to improve risk pooling and to ensure that the most socially disadvantaged receive priority in having their health care costs met, are questions yet to be answered, particularly within the African context where very few countries have achieved universal health systems. South Africa is introducing National Health Insura ...
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 7

 TERMINÉ 

Formulating new Goals for global health, and proposing new Governance for global health that will allow the achievement of these goals (GO4HEALTH)

Date du début: 1 sept. 2012, Date de fin: 29 févr. 2016,

The MDGs succeeded in generating consensus on and mobilising resources towards agreed goals. They were less successful at clarifying responsibilities for achieving them. The MDG target on sharing global health innovation is particularly ambiguous about the allocation of responsibilities.The members of the consortium behind this proposal assume that the new goals for global health will need to be b ...
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 14

 TERMINÉ 

Sustainable prevention of obesity through integrated strategies (SPOTLIGHT)

Date du début: 1 mars 2012, Date de fin: 29 févr. 2016,

BACKGROUNDThe prevalence of overweight and obesity in Europe is high and contribute to mortality and the burden of many chronic diseases, especially within groups of lower social-economic status. Obesity is largely determined by modifiable lifestyle dependent risk factors such as reduced physical activity, sedentary behaviour and an unhealthy diet. There is growing evidence that influences on indi ...
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 16

 TERMINÉ 

Genomic and lifestyle predictors of foetal outcome relevant to diabetes and obesity and their relevance to prevention strategies in South Asian peoples (GIFTS)

Date du début: 1 févr. 2012, Date de fin: 31 janv. 2016,

Despite a strong genetic component to diabetes and obesity, the rapidly rising prevalence of these disorders is due to adaptation to a changing environment. The epicentre of the ‘diabetes epidemic’ is in South Asia and this is reflected in the migrant populations in Europe. Current prevention strategies are focused on adult life and target over-nutrition in high-risk adults. However, for many popu ...
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 16

 TERMINÉ 

Advancing and strengthening the methodological tools and practices relating to the application and implementation of Health Technology Assessment (HTA) (ADVANCE_HTA)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2015,

"The use of HTA has increased recently in Europe and more widely (e.g. Americas) to enable evidence-based coverage decisions and improve efficiency in resource allocation.HTA has often resulted in different coverage decisions across settings despite the same evidence being used for this purpose. This may reflect in part societal preferences about value, priorities or risk perceptions, suggesting a ...
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 13

 TERMINÉ 

Novel Statistical Methodology for Diagnostic/Prognostic and Therapeutic Studies and Systematic Reviews (MEDIASRES)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

"Novel statistical methodology promises to greatly facilitate development of approaches for personalised medicine. While state-of-the-art statistical techniques have already advanced clinical trials and diagnostic/prognostic studies as the major source of evidence in clinical medicine, increasing availability of molecular techniques holds an even greater promise. However, for leveraging such infor ...
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 10

 TERMINÉ 

Type 2 diabetes and obesity among sub-Saharan African native and migrant populations: dissection of environment and endogenous predisposition (RODAM)

Date du début: 1 janv. 2012, Date de fin: 30 sept. 2015,

"Migration from Sub-Saharan Africa (SSA) to Europe is increasing. The limited evidence suggests that the risk of type 2 diabetes (T2D) and obesity among SSA migrants is higher than among their SSA peers living in Africa and European host populations. The reasons for these observations are only poorly understood, but may involve migration-related changes in lifestyle, genetic predisposition as well ...
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 9

 TERMINÉ 

Building Sustainable Research capacity for Health and its Social Determinants in Low- and Middle-Income Countries (SDH-Net)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2015,

...g networks of best in its kind public health institutions from Mexico, Colombia, Brazil and South Africa, Tanzania, and Kenya. The team is complemented by three distinguished European institutions: London School of Hygiene and Tropical Medicine; COHRED, and University of Geneva. SDH-Net is coordinated by GIZ with long term experience in health research and capacity building in LMIC, and IESE Busin ...
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 11

 TERMINÉ 

Family Matters: Intergenerational Influences on Fertility (FAMMAT)

Date du début: 1 mars 2011, Date de fin: 31 août 2015,

Why do people have children? Why do they have the number of children they do? These questions are of fundamental importance, but we do not yet have satisfactory answers. I propose to bring an interdisciplinary perspective, involving demography, evolutionary biology, anthropology and psychology, to bear on this topic. The aim is to test the hypothesis that intergenerational influences are important ...
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 2