13 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
CHROMATIN-REPAIR-CODE: Hacking the chromatin code for DNA repair (CHROMATINREPAIRCODE)
Date du début: 1 mars 2014, Date de fin: 28 févr. 2019,
"Our cells receive tens of thousands of different DNA lesions per day. Failure to repair these lesions will lead to cell death, mutations and genome instability, which contribute to human diseases such as neurodegenerative disorders and cancer. Efficient recognition and repair of DNA damage, however, is complicated by the fact that genomic DNA is packaged, through histone and non-histone proteins, ...
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1
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TERMINÉ
Human Pluripotent Stem Cells: the new heart patient? (STEMCARDIOVASC)
Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,
"The ability to generate pluripotent stem cells (iPSC) by reprogramming somatic tissues is arguably the greatest breakthrough in biomedical science of the last decade. The most inaccessible cells of the body can now be derived repeatedly from any individual. This could have a huge impact on understanding disease and the development of new therapeutic drugs but it will require a new level of sophis ...
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1
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TERMINÉ
Pluripotent stem cell resources for mesodermal medicine (PLURIMES)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2018,
Harnessing the capacity of pluripotent stem cells (PSCs) to produce functional cell types with precision and at scale will enable new treatment modalities for degenerative diseases. A major target for such therapies is mesodermal tissue, muscle, bone and cartilage. The goal of PluriMes is to create a bioengineering platform for directing PSCs into specific classes of mesodermal/mesenchymal progeni ...
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12
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TERMINÉ
Risk, Stem Cells and Tissue Kinetics – Ionising Radiation (RISK - IR)
Date du début: 1 nov. 2012, Date de fin: 30 avr. 2017,
The magnitude of cancer risk in humans exposed to low radiation doses (
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16
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TERMINÉ
MARie CuRIe AGEing Network (MARRIAGE)
Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,
"One of achievements of developed societies has been the remarkable extension of human lifespan. In the upcoming decades the number of Europeans with advanced age will increase dramatically. It is evident that age-associated diseases will become much more prevalent. This poses challenges for society but also opportunities for commercial enterprises that develop strategies to combat deleterious con ...
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11
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TERMINÉ
Low Dose Research towards Multidisciplinary Integration (DOREMI)
Date du début: 1 janv. 2010, Date de fin: 31 déc. 2015,
The aim of DoReMi is to promote the sustainable integration of low dose risk research in Europe in order to aid the effective resolution of the key policy questions identified by the High Level Expert Group (HLEG) on Low Dose Risk Research (www.hleg.de). DoReMi provides an operational tool for the development of the proposed MELODI platform (Multidisciplinary European Low Dose Risk Re-search Initi ...
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39
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TERMINÉ
Realizing the European Network in Biodosimetry (RENEB)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,
Creating a sustainable network in biological dosimetry that involves a large number of experienced laboratories throughout the EU will significantly improve the accident and emergency response capabilities in case of a large-scale radiological emergency. A well organised cooperated action involving EU laboratories will offer the only chance for a fast and trustworthy dose assessment urgently neede ...
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28
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TERMINÉ
Epidemiological Studies of Exposed Southern Urals Populations (SOLO)
Date du début: 1 mars 2010, Date de fin: 28 févr. 2015,
This project aims to improve estimates of the risks of long-term health effects associated with protracted external and internal radiation exposures, through further studies of exposed populations in the Southern Urals (Russian Federation). Specific objectives of the project are as follows: 1. To develop improved modules for estimating external doses to exposed cohorts in the Southern Urals. It is ...
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13
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TERMINÉ
The DNA damage response and breast cancer (DDRESPONSE)
Date du début: 1 févr. 2011, Date de fin: 31 janv. 2015,
We will exploit the DNA damage response (DDR) to assess and predict individual susceptibility and response focussed on breast cancer and breast cancer therapies. The 1st targeted therapy based on the DDR is inhibition of PARP by olaparib, which induces synthetic lethality in cancer cells with a specific DDR defect. Our members discovered olaparib, which is currently in Phase II trials. Its use in ...
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6
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TERMINÉ
Developmental and Genetic Analysis of DNA Double-Strand Break Repair (DSBrepair)
Date du début: 1 mai 2008, Date de fin: 30 avr. 2014,
The DNA within our cells is constantly being damaged by both environmental and endogenous agents; of the many forms of DNA damage, the DNA double-strand break (DSB) is considered to be most dangerous. Correct processing of DSBs is not only essential for maintaining genomic integrity but is also required in specific biological processes, such as meiotic recombination and V(D)J recombination, in whi ...
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2
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TERMINÉ
Human pluripotent stem cells for modeling and correcting long-QT syndrome (HPSCLQT)
Date du début: 1 mai 2012, Date de fin: 30 avr. 2014,
"The long QT syndrome (LQTS) is an inherited or acquired disorder characterized by delayed ventricular repolarization predisposing affected individuals to fatal cardiac arrhythmias. In ~90% of the familial cases, LQTS is associated with mutation in two potassium voltage-gated channel genes: KCNQ1, causing LQT1, and KCNH2, causing LQT2. Since the first report of human induced pluripotent stem cells ...
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1
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TERMINÉ
Translational Research in Europe – Applied Technologies for Osteoarthritis (TREAT OA)
Date du début: 1 janv. 2008, Date de fin: 30 juin 2013,
TREAT-OA will address the need for better treatment and diagnostics for osteoarthritis (OA) - the most common cause of disability in Europe. Currently there are no drugs that can cure, reverse or halt the disease. Nor are there yet reliable clinical biochemical markers for diagnosis or prognosis which is an impediment to the management of OA, costs of therapeutic trials and the development of dise ...
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11
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TERMINÉ
Comparative stem cell research in mouse and humans (INDUSTEM)
Date du début: 1 janv. 2009, Date de fin: 31 déc. 2012,
The InduStem project is aimed at creating a mutually beneficial training and transfer of knowledge program between a Hungarian SME and a Dutch and a German academic research institution. The scientific and industrial aim is to generate novel information on the generation and maintenance of induced pluripotent stem (iPS) cells in mouse and human and on their differentiation towards cardiac cells. T ...
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