6 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
A multidisciplinary approach to cell division: From human oocyte to synthetic biology (DivIDe)
Date du début: 1 avr. 2016, Date de fin: 31 mars 2020,
The cell is the universal unit of living matter, and there cannot be propagation of life without cell division. DivIDe aims to investigate the mechanisms and principles of cell division and to reproduce them in vitro with synthetic approaches. Crucial to cell division is the mitotic spindle, a structure whose main duty is the separation of chromosomes. The spindle is made of microtubules (MT), mol ...
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9
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TERMINÉ
Targeted small-molecule Stabilisation of Protein-Protein Interactions (TASPPI)
Date du début: 1 févr. 2016, Date de fin: 31 janv. 2020,
... between academia and industry and to increase their employability in both areas. To this end we have teamed up in a consortium comprising 5 partners from industry (AstraZeneca, GlaxoSmithKline, UCB, Lead Disocvery Center, Taros Chemicals) and 6 partners from academia (Universities of Dundee, Eindhoven, Leeds, Lille, Prague, and Siena). The scientific objective of the multi-sectorial Training Netw ...
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10
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TERMINÉ
Big Data in Chemistry (BIGCHEM)
Date du début: 1 janv. 2016, Date de fin: 31 déc. 2019,
...ientific, but also economic relevance. Currently, the international data market already grows six times faster than the entire IT sector, and growth rates further increase. Achieving and sustaining a leadership positions in the big data arena represent critically important challenges for the EU. The economic developments in the emerging big data field are science-driven. Due to complexity and hete ...
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9
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TERMINÉ
European Lead Factory (EUC²LID)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,
The European Lead Factory concept proposed by the EUC2LID Consortium relates to the discovery of novel small molecule candidates to serve as starting points for subsequent optimization to either drug candidates or high-quality pharmacological tools for the experimental validation of targets. The concept intends to bridge academic and applied research interests. The European Lead Factory will provi ...
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34
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TERMINÉ
Innovative anti-influenza drugs excluding viral escape (ANTIFLU)
Date du début: 1 juin 2011, Date de fin: 31 mai 2016,
...nsortium will pursue the identification and validation of smallmolecule ligands and inhibitory RNA molecules effective against influenza infection.Promising modulators will form the basis to generate lead molecules that will be furtherrefined to yield clinically applicable therapeutics. Initial preclinical studies will aim at providingproof of concept in animal models, safety and toxicology profil ...
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11
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TERMINÉ
Small molecule stabilizers of 14-3-3 Protein-Protein Interactions as novel drugs in cancer and neurodegenerative diseases (14-3-3Stabs)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,
...ative approach to develop small molecules that bind selectively to the interaction surface of specific disease-related protein complexes thereby stabilizing their interaction which might lead to a beneficial therapeutic effect. This approach is complementary to today’s strategy of developing inhibitors that target the active site of single enzymes and opens new possibilities to address “undrugable ...
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