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25 projets européens trouvés

Recherche sur 125080 projets européens

 TERMINÉ 

Cancer treatment and monitoring through identification of circulating tumour cells and tumour related nucleic acids in blood (CANCER-ID)

Date du début: 1 janv. 2015, Date de fin: 31 déc. 2019,

Blood-based biomarkers such as Circulating Tumor Cells (CTCs), circulating free tumor DNA (cfDNA) and microRNAs (miRNAs) have the potential to improve the development of personalized medicines for cancer patients. This is of particular importance when biopsies of the primary tumor or metastases are not accessible (e.g. at early disease stages or in minimal residual disease) or possible and the ass ...
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 34

 TERMINÉ 

Unravelling the genetic influences of reproductive behaviour and gene-environment interaction (SOCIOGENOME)

Date du début: 1 juil. 2014, Date de fin: 30 juin 2019,

"This project will be the first to engage in a comprehensive study of the role of genes and gene-environment (GxE) interaction on reproductive behaviour. Until now, social science research has focussed on socio-environmental explanations, largely neglecting the role of genes. Due to unprecedented advances in molecular genetics over the last two decades, for the first time in history we are able to ...
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 2

 TERMINÉ 

Multidisciplinary Approaches to Translational Research In Conduct Syndromes (MATRICS)

Date du début: 1 mars 2014, Date de fin: 28 févr. 2019,

Conduct Disorder (CD) is the key paediatric disorder characterized by severe aggression. It is heterogeneous, and our understanding of the neurobiology to subtype aggression is limited. MATRICS is a multidisciplinary consortium of academic partners and SMEs that focuses on the subtyping of aggression both within CD and of the broader cross-disorder trait of aggression. MATRICS will test the hypoth ...
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 21

 TERMINÉ 

RD-CONNECT: An integrated platform connecting registries, biobanks and clinical bioinformatics for rare disease research (RD-CONNECT)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2018,

Despite examples of excellent practice, rare disease (RD) research is still mainly fragmented by data and disease types. Individual efforts have little interoperability and almost no systematic connection between detailed clinical and genetic information, biomaterial availability or research/trial datasets. By developing robust mechanisms and standards for linking and exploiting these data, RD-Con ...
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 30

 TERMINÉ 

Aggression subtyping for improved insight and treatment innovation in psychiatric disorders (AGGRESSOTYPE)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,

Aggression is a basic physiological trait with important roles throughout evolution, both in defence and predation. When expressed in humans in the wrong context, aggression leads to maladjustment, social impairment and crime. Despite this, knowledge about aggression aetiology is limited and current treatment strategies are insufficient. Contingent to a subdivision into impulsive and instrumental ...
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 27

 TERMINÉ 

Translating disease to cardiovascular health (TransCard)

Date du début: 1 sept. 2013, Date de fin: 31 août 2018,

Cardiovascular disease (CVD) is the leading cause of death in Europe and the world. Drugs that lower cholesterol in blood are the most efficient drugs used to date but we are currently still facing a 50-70% residual risk of suffering from CVD. This clearly illustrates an urgent need for the identification, characterization and validation of novel therapeutically relevant targets. Over the last dec ...
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 8

 TERMINÉ 

Consortium on Organ Preservation in Europe (COPE)

Date du début: 1 janv. 2013, Date de fin: 30 juin 2018,

The discrepancy between organ supply and demand remains the biggest challenge facing the transplant community today. In order to increase the amount of available donor organs, transplant specialists are increasingly turning to sub-optimal donor organs. Organs from such donors, usually have normal or near normal function before death, but retrieval, storage and transplantation cause progressive inj ...
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 16

 TERMINÉ 

Personalized diagnosis and treatment of hyperinsulinemic hypoglycaemia caused by beta-cell pathology (BETACURE)

Date du début: 1 avr. 2014, Date de fin: 31 mars 2018,

Background:Hyperinsulinaemic hypoglycaemia (HH) is a potentially lethal disease caused by over functioning beta cells derived from the pancreatic islets of Langerhans. Lethal HH and brain damage is a problem especially in infants with congenital HH. Current therapeutic approaches are associated with severe side effects/morbidity (diabetes, exocrine pancreas insufficiency etc.) considered acceptabl ...
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 17

 TERMINÉ 

"Apathy in schizophrenia: time for a DRASTIC (Dual Routes to Apathy in Schizophrenia: Treatment, Imaging, Cognition) study" (DRASTIC)

Date du début: 1 avr. 2013, Date de fin: 31 mars 2018,

"Apathy is a prominent and severely debilitating aspect of several psychiatric disorders, most notably schizophrenia. Little is known regarding the neuroscientific basis of apathy, however. Clinically, it has been suggested that two forms of apathy can be distinguished: cognitive apathy (CA) which concerns reduced initiative to start daily activities and social-emotional apathy (SEA) which concern ...
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 1

 TERMINÉ 

Universal Influenza Vaccines Secured (UNISEC)

Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,

UNISEC brings together a European consortium of 3 University partners, 5 National Health Institutes and 3 SMEs, all with leading expertise in influenza vaccine research and development, to work on promising recently developed concepts for a universal influenza vaccine. The consortium is exceptionally strong, interdisciplinary and intersectional in nature, and encompasses a unique combination of sc ...
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 15

 TERMINÉ 

Recognising Adverse Drug Reactions (WEB-RADR)

Date du début: 1 sept. 2014, Date de fin: 31 août 2017,

WEB-RADR is a consortium of leading experts in pharmacovigilance from regulatory agencies, research, academia and patient support groups. Together with EFPIA partners our aims will be to set policy & guidance and deliver robust information technology tools to address the potential for the reporting of adverse drug reactions (ADRs) through mobile applications and the recognition of drug safety sign ...
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 20

 TERMINÉ 

BBMRI - Large Prospective Cohorts (BBMRI-LPC)

Date du début: 1 févr. 2013, Date de fin: 31 janv. 2017,

In recent years, biomedical research has crossed international borders in large, collaborative studies showing the value of multidisciplinarity and scale advantage. This has yielded valuable insights and some led to new and better medicines and treatments for diseases. However, disease-focused studies provide less insight in the real disease onset, the relative disease burden in the population, an ...
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 36

 TERMINÉ 

Incorporating real-life clinical data into drug development (GETREAL)

Date du début: 1 oct. 2013, Date de fin: 31 déc. 2016,

When a new medicine reaches the market, it is accompanied by an extensive data package that provides information about the safety and efficacy of the medicine in a clinical trial setting. However, assessing the expected future value of the medicines when used in “real world” clinical practice requires additional information next to traditional (pre-authorisation) clinical trials. Regulatory, HTA ...
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 32

 TERMINÉ 

Immune responses in neurodegenerative diseases: Protection or progression? (Saving dying neurons)

Date du début: 1 sept. 2012, Date de fin: 31 août 2016,

Many neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are progressive and incurable. Much attention has been paid to understand the insults likely to kill neurons, such as reactive oxygen species and protein aggregation. In addition, it is clear that immune and inflammatory responses are involved in these diseases, but in general it is unclear whether they are protective ...
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 2

 TERMINÉ 

Thematic Network Innovation for age-friendly environments in the European Union (AFE-INNOVNET)

Date du début: 1 févr. 2014, Date de fin: 31 janv. 2016,

The overarching goal of AFE-INNOVNET is to set up a large EU wide community of local and regional authorities (LRAs) and other relevant stakeholders who want to work together to find smart and innovative evidence based solutions to support active and healthy ageing and develop age-friendly environments (AFE).Many innovative solutions supporting active and healthy ageing have been developed as pilo ...
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 29

 TERMINÉ 

Building data bridges between biological and medical infrastructures in Europe (BIOMEDBRIDGES)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

The ESFRI infrastructures in Biological and BioMedical Sciences face substantial challenges in accessing and sharing data and resources. The BioMedBridges consortium brings together the six established ESFRI infrastructures with common goals to define, implement and deliver data interoperability across the biological and biomedical domains.The first objective is to ensure that interoperable stand ...
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 26

 TERMINÉ 

Multidisciplinary evaluation of the cancer risk from neutrons relative to photons using stem cells and the induction of second malignant neoplasms following paediatric radiation therapy (ANDANTE)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,

The ANDANTE project will investigate the relative risk of neutrons compared to photons for tumorigenesis, as a function of dose and energy. The approach will be multidisciplinary, including physics measurements and modelling, molecular biology, radiobiology, and epidemiology. The relative risk of neutrons will be studied using human and animal stem cells irradiated with either photons or neutron ...
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 9

 TERMINÉ 

Treat Iron-Related Childhood-Onset Neurodegeneration (TIRCON)

Date du début: 1 nov. 2011, Date de fin: 31 oct. 2015,

Neurodegeneration with brain iron accumulation (NBIA) is a heterogeneous group of rare hereditary neurodegenerative disorders characterized by high levels of brain iron. The most common form is pantothenate kinase-associated neurodegeneration (PKAN). Classic PKAN and most other NBIA cases are characterised by early childhood onset and rapid progression. Currently, there is no proven therapy to hal ...
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 14

 TERMINÉ 

Joint European and South African Research Network in Anxiety Disorders (EUSARNAD)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2015,

The overall aim of our proposal is to build on the strengths of an existing European network for research into causes and maintaining factors in anxiety disorders and to extend these by establishing firmer research collaboration with the University of Cape Town in South Africa.Through establishing this research exchange, we aim to share knowledge and expertise among participating centres, and ensu ...
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 13

 TERMINÉ 

Mental representations of and adaptation to the speech signal transmitted via cochlear implants: How the impoverished signal finds its way to the mental lexicon (MARCI)

Date du début: 1 juin 2013, Date de fin: 31 mai 2015,

Cochlear implants (CIs) allow many people to re-gain their speech perception. After implantation listeners need to adapt to a very different sensory experience and the CI transmits only parts and patterns of the information that is present in the acoustically rich natural signal. There are individual differences in the success of this adaptation. This study aims at examining causes of individual v ...
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 1

 TERMINÉ 

Ion ChaNnel SENSors (ICANSENSE)

Date du début: 1 avr. 2014, Date de fin: 31 mars 2015,

Super-sensitive detection mechanisms offer numerous opportunities for fundamental science in fields such as biophysics and chemistry and are a highly needed advancement for applied fields such as medicine, environmental pollution monitoring and defence. Developing sensors that are even capable of detecting single molecules has therefore become an important field of research. At this moment there i ...
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 2

 TERMINÉ 

FAll Repository for the design of Smart and sElf-adaptive Environments prolonging INdependent livinG (FARSEEING)

Date du début: 1 janv. 2012, Date de fin: 31 mars 2015,

Description FARSEEING wants to provide an information basis for research and therapy development for fall prediction, prevention and support, by building the world’s largest fall repository. This database will facilitate the collection, analysis and processing of behavioural and physiological data related to falls, daily activity and physiol ...
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 12

 TERMINÉ 

EUROCANCER STEMCELL TRAINING NETWORK (EuroCSCTraining)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2014,

The recent identification of tumor initiating (TIC) or cancer stem cells (CSC) has opened a new area of research for scientists interested in cancer. Understanding the biology of cancer stem cells has already unraveled pathways and potential targets. However, accumulating data has underscored the complexity of the CSC research area and prompts hence the need for well-structured networks to provid ...
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 11

 TERMINÉ 

Development of OPN-305 as an orphan drug for the treatment of Delayed Graft Function post solid organ transplantation (MABSOT)

Date du début: 1 déc. 2010, Date de fin: 30 sept. 2014,

Delayed graft function (DGF) is defined as the need for dialysis within seven days of renal transplantation (DGF promotes allograft rejection, requires prolonged dialysis and hospitalisation, and increases the likelihood of graft failure and ultimately the duration of renal graft survival-expectancy. The incidence of DGF occurs in 21-44% of cases following cadaveric renal graft. Several rare dise ...
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 10

 TERMINÉ 

Genotype-To-Phenotype Databases: A Holistic Solution (GEN2PHEN)

Date du début: 1 janv. 2008, Date de fin: 30 juin 2013,

"The GEN2PHEN project aims to unify human and model organism genetic variation databases towards increasingly holistic views into Genotype-To-Phenotype (G2P) data, and to link this system into other biomedical knowledge sources via genome browser functionality. The project will establish the technological building-blocks needed for the evolution of today’s diverse G2P databases into a future seaml ...
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 23