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36 projets européens trouvés

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 TERMINÉ 

The inflammatory gene expression program in macrophages: An integrative approach for the systematic characterization of transcriptional co-regulators (MEDICI)

Date du début: 1 nov. 2016, Date de fin: 31 oct. 2021,

Tissue responses to microbial and endogenous danger signals involve the activation of both resident and monocyte-derived macrophages, as well as the coordinated inducible expression of hundreds of inflammatory genes. Gene transcription is controlled by the information contained in thousands of genomic regulatory elements (enhancers and promoters), which is first read by transcription factors (TFs ...
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 2

 TERMINÉ 

SMart weArable Robotic Teleoperated Surgery (SMARTsurg)

Date du début: 1 janv. 2017, Date de fin: 31 déc. 2019,

Robot-assisted minimally invasive surgery (RAMIS) offers many advantages when compared to traditional MIS, including improved vision, precision and dexterity. While the popularity of RAMIS is steadily increasing, the potential for improving patient outcomes and penetrating into many procedures is not fully realised, largely because of serious limitations in the current instrumentation, control and ...
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 11

 TERMINÉ 

Training Network for the Immunotherapy of Cancer (IMMUTRAIN)

Date du début: 1 déc. 2015, Date de fin: 30 nov. 2019,

In the European Union, cancer is the leading cause of death and the overall cancer incidence is still increasing. As a result of expanding efforts to improve cancer outcome, a main paradigm change is occurring in cancer therapy towards individualized medicine. Antibody-based therapies form an integral and constantly growing part of this approach. Antibody-based therapies will strongly influence th ...
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 9

 TERMINÉ 

Female cancer prediction using cervical omics to individualise screening and prevention (FORECEE)

Date du début: 1 sept. 2015, Date de fin: 31 août 2019,

While prevention of most female specific cancers (ovarian, breast, endometrial) has not progressed substantially in recent years, significant progress has been made with cervical cancer due to accessibility of the cell of origin (cervical smear) and availability of a test for the causal agent (human papilloma virus); together these enable identification of high risk individuals and interventions t ...
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 14

 TERMINÉ 

Modeling Disease through Cell Reprogramming: a Translational Approach to the Pathogenesis of Syndromes Caused by Symmetrical Gene Dosage Imbalances (DISEASEAVATARS)

Date du début: 1 sept. 2014, Date de fin: 31 août 2019,

The fundamental limitation in our ability to dissect human diseases is the scarce availability of human tissues at relevant disease stages, which is particularly salient for neural disorders. Somatic cell reprogramming is overcoming this limitation through the derivation of patient-specific induced pluripotent stem cells (iPSC) that can be differentiated into disease-relevant cell-types. Despite t ...
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 3

 TERMINÉ 

Immune mechanisms that control the homeostasis of the gut and that are deregulated in intestinal pathologies cancer (HOMEOGUT)

Date du début: 1 juil. 2014, Date de fin: 30 juin 2019,

This project stems from an ERC STG grant that I received in 2007 (DENDROworld) in which we analyzed several aspects of the homeostasis of the gut and how defects in controlling this process could result in different pathologies, including inflammatory bowel disease (IBD) and cancer. In the present project, we will continue working on the immune homeostasis of the gut and we will focus on fundament ...
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 3

 TERMINÉ 

Inside mechanisms sustaining cancer stem cells (InMec)

Date du début: 1 juil. 2014, Date de fin: 30 juin 2019,

The “Cancer Stem Cell (CSC) Hypothesis” postulates that the capacity to maintain tumour growth is owned by rare cancer cells, the CSCs, endowed with self-renewal properties. This hypothesis implies that CSCs must be eliminated to achieve cancer cure. Nevertheless, direct proof is still lacking, and recent findings challenge our concepts of CSCs, showing the limits of the CSC-defining assay (transp ...
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 1

 TERMINÉ 

Integrating Epidemiology and Experimental Biology to Improve Risk Assessment of Exposure to Mixtures of Endocrine Disruptive Compounds (EDC-MixRisk)

Date du début: 1 mai 2015, Date de fin: 30 avr. 2019,

A large body of evidence supports associations between exposure to anthropogenic chemicals and endocrine disruptive effects, leading to disorders in humans and wildlife. Based on the scientific documentation it is beyond doubt that endocrine disrupting chemicals (EDCs) are of concern and need to be handled according to the risks they pose, as single chemicals or as mixtures. To develop chemical ri ...
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 14

 TERMINÉ 

Leading Innovative measures to reach gender Balance in Research Activities (LIBRA)

Date du début: 1 oct. 2015, Date de fin: 31 mars 2019,

The main goals of LIBRA are to implement innovative Gender Equality Plans (GEPs) that will empower women researchers to achieve successful careers in science, remove gender barriers and biases at an institutional level, and raise awareness of gender aspects in the experimental design of pre-clinical research projects. To achieve these goals we will: 1) conduct an initial external assessment of eac ...
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 11

 TERMINÉ 

iManageCancer - Empowering patients and strengthening self-management in cancer diseases (iManageCancer)

Date du début: 1 févr. 2015, Date de fin: 31 juil. 2018,

Chronic cancer treatment places new demands on patients and families to manage their own care. The iManageCancer project will support this challenge and provide a cancer disease self-management platform designed according to the specific needs of patient groups and focusing on the wellbeing of the cancer patient with special emphasis on psycho-emotional evaluation and self-motivated goals. The pla ...
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 11

 TERMINÉ 

European Consortium for Communicating Stem Cell Research (EuroStemCell)

Date du début: 1 janv. 2015, Date de fin: 31 mars 2018,

The European Consortium for Communicating Stem Cell Research (EuroStemCell) unites 33 partner institutions, that collectively represent >400 stem cell research groupings across Europe. Our common goal is to provide trusted high quality information on stem cells accessible to citizens and stakeholders across Europe, through support and further development of the multi-lingual European Stem Cell Inf ...
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 32

 TERMINÉ 

Universal Flu Vaccine (UNIVACFLU)

Date du début: 1 nov. 2013, Date de fin: 31 oct. 2017,

Currently licensed influenza vaccines promote an effective antibody response, but only against influenza virus strains that antigenically match the vaccine composition. Little protection is induced by these vaccines against antigenically drifted strains such as those emerging from an avian or swine reservoir. Hence there is a great need to develop broadly cross-reactive flu-vaccines.The aim is to ...
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 8

 TERMINÉ 

A European Platform for Translational Cancer Research (EUROCANPLATFORM)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2016,

Europe has a number of advantages as regards developing translational cancer research, yet there is no clear European strategy to meet the increasing burden posed by cancer. The FP6 Eurocan+Plus project analysed the barriers underlying the increasing fragmentation of cancer research and stressed the need to improve collaboration between basic/preclinical and comprehensive cancer centres (CCCs), in ...
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 29

 TERMINÉ 

Developing a global understanding of the PRC and NuRD complexes in stem cell differentiation, in health and disease (4DCELLFATE)

Date du début: 1 déc. 2011, Date de fin: 30 nov. 2016,

Embryonic stem (ES) cells have the potential to differentiate into any type of cell as well as to renew indefinitely in culture. They hold great potential for the development of personalized medicines. However, the molecular mechanisms underpinning cell fate decisions by individual cells are poorly understood. There is compelling evidence that two large multi-protein machines, the Nucleosome Remod ...
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 13

 TERMINÉ 

A BLUEPRINT of Haematopoietic Epigenomes (BLUEPRINT)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2016,

In response to the call for a high impact initiative on the human epigenome, the BLUEPRINT Consortium has been formed with the aim of generating at least 100 reference epigenomes and studying them to advance and exploit knowledge of the underlying biological processes and mechanisms in health and disease. BLUEPRINT will focus on distinct types of haematopoietic cells from healthy individuals and o ...
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 45

 TERMINÉ 

"Connecting the activities of c-Myc in genome regulation, cellular growth control and oncogenesis" (MYCNEXT)

Date du début: 1 juil. 2011, Date de fin: 30 juin 2016,

"The c-myc proto-oncogene is a general driving force in cancer. The cmyc product (Myc) is a transcription factor that binds thousands of genomic loci. However, the identity of the Myc-target genes that influence tumor development, as well as the mechanisms through which Myc acts on these genes, remain most elusive questions in the field. We will use next-generation DNA sequencing to create a multi ...
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 1

 TERMINÉ 

Systems biology of liver cancer: an integrative genomic-epigenomic approach (MODHEP)

Date du début: 1 janv. 2011, Date de fin: 30 juin 2016,

"Cancer is a complex disease involving multiple genetic and epigenetic events occurring, and influencing each other, over a long period of time. Understanding cancer, and ultimately developing effective targeted therapies, will therefore require that mutations and epigenetic alterations be systematically investigated during the multiple stages of disease development, from identifiable pre-neoplast ...
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 18

 TERMINÉ 

The genomic blueprint of macrophages: dissecting players and mechanisms through an integrative approach (NORM)

Date du début: 1 juin 2011, Date de fin: 31 mai 2016,

"Macrophages are highly specialized cells widely distributed in tissues and active both as immune effectors and as housekeeping phagocytes responsible for maintenance of tissue integrity. Macrophages display a striking heterogeneity that reflects a complex interplay between different micro-environmental signals provided by various tissues (as well as by microbial and endogenous stress signals), an ...
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 1

 TERMINÉ 

Role of human papillomavirus infection and other co-factors in the aetiology of head and neck cancer in India and Europe (HPV-AHEAD)

Date du début: 1 sept. 2011, Date de fin: 31 août 2015,

Human papillomavirus (HPV) is responsible for approximately 25% of head and neck cancer (HNC) worldwide and appears to be associated with a better response to treatment and improved prognosis. Evidence suggests that HPV-induced HNC has steadily increased in the USA and some European countries in the last decades. However, whether this is a worldwide phenomenon and specific risk factors are associa ...
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 11

 TERMINÉ 

From data sharing and integration via VPH models to personalised medicine (p-medicine)

Date du début: 1 févr. 2011, Date de fin: 31 juil. 2015,

Medicine is undergoing a revolution that is transforming the nature of healthcare from reactive to preventive. The changes are catalyzed by a new systems approach to disease which focuses on integrated diagnosis, treatment and prevention of disease in individuals. This will replace our current mode of medicine over the coming years with a personalized predictive treatment . While the goal is clea ...
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 19

 TERMINÉ 

AnThocyanin and polyphenol bioactives for Health Enhancement through Nutritional Advancement (ATHENA)

Date du début: 1 juil. 2010, Date de fin: 30 juin 2015,

Anthocyanins are health promoting dietary polyphenols that protect against cardiovascular disease, caner and obesity in preclinical studies with animals. The ATHENA project will address how good dietary anthocyanins are in protecting against chronic disease, by addressing the following questions: • Benefits and risks: What is the dose response to anthocyanin phytonutrients? Are anthocyanins from d ...
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 14

 TERMINÉ 

Systems Biology of Mitosis (MitoSys)

Date du début: 1 juin 2010, Date de fin: 31 mai 2015,

"MitoSys will generate a comprehensive mathematical understanding of mitotic division in human cells, a process of fundamental importance for human health. To create the critical mass and multidisciplinarity that is needed to achieve this ambitious goal, internationally leading mathematicians, biochemists/biophysicists and biologists working at twelve universities, research institutes, internation ...
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 14

 TERMINÉ 

Molecular bases of kinetochore-microtubule attachment and their implications for cell cycle control (KINCON)

Date du début: 1 mars 2009, Date de fin: 30 sept. 2014,

Equal partition of the genetic material to the daughter cells in mitosis requires the accurate anchorage of the mother cell s chromosomes to spindle microtubules. This process takes place at kinetochores, complex scaffolds containing ~100 different proteins. Conceptually, kinetochores can be viewed as performing four distinct but highly integrated functions: 1) they bind centromeric chromatin at a ...
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 3

 TERMINÉ 

A Coordinated and Structured International Post-Doctoral Program to Foster Trans-national Mobility and Independent Career of Scientists in Biomedicine (SIPOD)

Date du début: 16 mars 2009, Date de fin: 15 sept. 2014,

"This program encompasses the coordinated action of three major Biomedicine Research Centers and a Biotech shell in Lombardy, to launch a new Structured International Post-Doctoral program (SIPOD). These research centers operate in conjunction with the Scuola Europea di Medicina Molecolare (SEMM) whose aim is to promote the training and research of young scientists within emerging sectors of biome ...
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 4

 TERMINÉ 

Euro-BioImaging - Research infrastructure for imaging technologies in biological and biomedical sciences (Euro-BioImaging)

Date du début: 1 déc. 2010, Date de fin: 31 mai 2014,

Euro-BioImaging brings together imaging technologies stretching from basic biological imaging with advanced light microscopy, in vivo molecular imaging of single cells to animal models up to the clinical and epidemiological level of medical imaging of humans and populations. Euro-BioImaging, in close consultation with its stakeholders, will address the imaging requirements of both biological and m ...
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 44

 TERMINÉ 

Mucosal dendritic cells in intestinal homeostasis and bacteria-related diseases (DENDROWORLD)

Date du début: 1 juil. 2008, Date de fin: 30 juin 2013,

The bacterial microflora has always been regarded as beneficial for the host but recent studies have shown that this symbiosis has risks as well as benefits. Although active mechanisms allow tolerating the commensal flora, the physiological stress that is associated with the symbionts’ metabolism can exhaust the intestinal barrier resulting in serious effects on the health of the host. Protracted ...
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 1

 TERMINÉ 

Health-promoting cross-talk between intestinal microbiota and Humans (CROSS-TALK)

Date du début: 1 oct. 2008, Date de fin: 30 sept. 2012,

The multi-partner initial training network entitled “Health-Promoting Cross-talk between Intestinal Microbiota and Humans (CROSS-TALK)” aims at: • Preparing qualified young professionals/researchers and future scientific leaders in the field of an emerging supra-discipline, the human microbiome metagenomics (which calls for new researcher curricula and fosters a dynamic scientific community) throu ...
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 10

 TERMINÉ 

European Consortium for Systematic Stem Cell Biology (EUROSYSTEM)

Date du début: 1 mars 2008, Date de fin: 31 août 2012,

EuroSyStem brings together elite European research teams to create a unique and world-leading programme in fundamental stem cell biology. By interconnecting complementary biological and computational expertise we will drive the generation of new knowledge on the characteristics of normal and abnormal stem cells. We will pave the way for application of systems methodology by measuring and modelling ...
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 25

 TERMINÉ 

Metagenomics of the Human Intestinal Tract (MetaHIT)

Date du début: 1 janv. 2008, Date de fin: 30 juin 2012,

A detailed understanding of human biology will require not only knowledge of the human genome but also of the human metagenome, defined here as the ensemble of the genomes of human-associated microorganisms. Our proposal focuses on the microorganisms of the gut, which are particularly abundant and complex and have an important role for human health and well-being. We shall implement and integrate ...
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 16

 TERMINÉ 

Genomic determinants of inflammation: from physical measurements to system perturbation and mathematical modeling (Model-In)

Date du début: 1 déc. 2008, Date de fin: 31 mai 2012,

Inflammation is a complex biochemical and cellular response essential for the viability of higher organisms because of its requirement in anti-microbial defence and protection from the consequences of tissue injury. However, uncontrolled or sustained inflammation leads to several diseases with a huge social impact, ranging from autoimmune diseases to septic shock and cancer. While the requirement ...
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 11

 TERMINÉ 

Dynamic imaging the mucosal immune system (GutImmunoImaging)

Date du début: 1 juin 2008, Date de fin: 31 mai 2012,

Dendritic cells (DCs) resident just beyond the epithelial cells (ECs) monolayer are able to extend dendrites from the lamina propria across ECs into the intestinal lumen to capture bacteria (1-3). During my post-doctoral studies, I visualized in vivo (1), for the first time, by two-photon (2P) intravital microscopy, the ability of intestinal DCs to project dendrites into the lumen to capture lumen ...
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 1

 TERMINÉ 

Establishing an efficient network for cancer communication in Europe (Eurocancercoms)

Date du début: 1 mai 2009, Date de fin: 30 sept. 2011,

The lack of efficient communication among cancer health professionals, patients and policy makers remains a significant barrier to collaboration in the EU. Information overload and a very fractionated, exhaustive array of resources, networks and knowledge providers are seriously hindering the translation and implementation of research in Europe. With the constant explosion of data we can expect to ...
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 18

 TERMINÉ 

Mucosal protease and their inhibitors in inflammatory bowel disease: From etiopathogenetic insight to innovative therapy (IBDase)

Date du début: 1 mars 2008, Date de fin: 31 mai 2011,

IBDase addresses the etiology and pathogenesis of inflammatory bowel disease (IBD) with a multidisciplinary plan for innovative diagnosis and therapy focused on mucosal proteases and their inhibitors (P/PIs). The incidence of IBD, a multifactorial disease influenced by environmental factors in a background of complex genetic susceptibility, is rising, particularly among European children. Current ...
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 10

 TERMINÉ 

Early and late health risks to normal/healthy tissues from the use of existing and emerging techniques for radiation therapy (ALLEGRO)

Date du début: 1 févr. 2009, Date de fin: 31 mars 2011,

Curative cancer treatment with radiation seeks to optimise the magnitude of the radiation dose to the treatment volume while restricting the dose to normal healthy tissue. With an increasing population of surviving cancer patients treated with radiation therapy, the harmful effects of the radiation to normal tissue are becoming more evident. The ALLEGRO project will address the many aspects of n ...
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 13

 TERMINÉ 

Structural and Functional Characterization of the RZZ Complex (RZZ)

Date du début: 1 avr. 2009, Date de fin: 31 mars 2011,

"This application is concerned with the structural and functional characterization of the RZZ protein complex, a critical constituent of metazoan kinetochores. The RZZ, a 400-kDa trimer, is named after the initials of its components, Rod, Zwilch and Zw10. The RZZ is implicated in the execution of mitosis, the process of equal partitioning of the genetic material. In mitosis, the sister chromatids ...
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 1

 TERMINÉ 

Genomic Instability in Cancer and Precancer (GENICA)

Date du début: 1 janv. 2008, Date de fin: 31 déc. 2010,

"Genomic instability is a characteristic of practically all human cancers. Recent results generated by members of this Consortium suggest that signs of genomic instability are evident from the very beginning of human cancer development, even in precancerous lesions. In these early lesions, the genomic instability affects primarily specific genomic loci, called common fragile sites. Because common ...
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 11