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29 projets européens trouvés

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 TERMINÉ 

Mechanisms and regulators coordinating replication integrity and DNA damage tolerance. (REPSUMODDT)

Date du début: 1 juil. 2016, Date de fin: 30 juin 2021,

Accurate chromosomal DNA replication is of fundamental importance for cellular function, genome integrity and development. In response to replication perturbations, DNA damage response (DDR) and DNA damage tolerance (DDT) pathways become activated and are crucial for detection and tolerance of lesions, as well as for facilitating replication completion and supporting chromosome structural integrit ...
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 1

 TERMINÉ 

Targeting SYNthetic lethal interactions for new cancer treatments TRAINing network (SYNTRAIN)

Date du début: 1 sept. 2016, Date de fin: 31 août 2020,

Breast and ovarian cancer constitute serious health challenges in the EU. To identify new improved cancer therapeutic approaches, we will pursue a multi-facetted synthetic lethal approach, which takes advantage of the inherent genetic instability of cancer cells. Most mutations acquired by cancer cells do not cause lethality, but the very same mutations may cause cell death when a second gene in a ...
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 10

 TERMINÉ 

Brain barriers training (BtRAIN)

Date du début: 1 sept. 2015, Date de fin: 31 août 2019,

The brain barriers function to protect the central nervous system (CNS) from neurotoxic compounds. By the same traits they unfortunately block delivery of drugs to the CNS thus hindering proper diagnosis and effective treatment of neurological disorders including Alzheimer’s disease and multiple sclerosis. The unusual complexity of the brain barriers has severely hampered progress in the market of ...
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 11

 TERMINÉ 

The role of essential DNA metabolism genes in vertebrate chromosome replication (DNAMEREP)

Date du début: 1 juin 2014, Date de fin: 31 mai 2019,

"Faithful chromosomal DNA replication is essential to maintain genome stability. A number of DNA metabolism genes are involved at different levels in DNA replication. These factors are thought to facilitate the establishment of replication origins, assist the replication of chromatin regions with repetitive DNA, coordinate the repair of DNA molecules resulting from aberrant DNA replication events ...
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 1

 TERMINÉ 

The Development of Medium- and Large-Scale Sustainable Manufacturing Process Platforms for Clinically Compliant Solid Core Nanopharmaceuticals (NANOFACTURING)

Date du début: 1 févr. 2015, Date de fin: 31 janv. 2019,

A number of nanomedicine formulations have enabled, or been shown to hold considerable potential for enabling more effective and less toxic therapeutic interventions. However, progress to date in translating these initiatives to commercial success has been limited. One of the main reasons for this bottleneck is due to the inability of researchers and stakeholders to manufacture batches of the na ...
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 10

 TERMINÉ 

AusBildung wird Forschung - DKFZ-Auszubildende forschen europaweit

Date du début: 1 juil. 2016, Date de fin: 30 juin 2018,

In our 24 months project "AusBildung wird Forschung - DKFZ-Auszubildende forschen europaweit", the German Cancer Research Center will grant 32 apprentices the opportunity to partake in an internship as biological laboratory assistants, animal care takers, office clerks and qualified IT specialists. They will all finish the second year of training during the internship and they successfully complet ...
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 7

 TERMINÉ 

A novel direct role of non coding RNA in DNA damage response activation (DDRNA)

Date du début: 1 juin 2013, Date de fin: 31 mai 2018,

DNA, if damaged, cannot be replaced. If not replaceable, it must be repaired. The so-called “DNA damage response” (DDR) is a coordinate set of evolutionary conserved events that arrest the cell-cycle (DNA damage checkpoint function) in proliferating cells and attempts DNA repair. Until DNA damage has not been repaired in full, cell proliferation is not resumed in normal cells.DNA damage is a physi ...
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 1

 TERMINÉ 

Crosstalk between nuclear envelope and DNA Damage Response: Role of nucleoporin TPR in the maintenance of genomic integrity (ENVERESP)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2018,

Each cell in the human body receives thousands of DNA lesions per day. To counteract threats posed by DNA damage, cells have evolved an integrated signaling network called the DNA-damage response (DDR). This mechanism allows cells to detect DNA lesions, signal their presence and promote their repair. Mutation of DDR genes, which serves as a biological barrier against tumor progression, leads to ca ...
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 1

 TERMINÉ 

ATR-mediated mechanotransduction and connections with the actin cytoskeleton (MECHANOCHECK)

Date du début: 1 avr. 2016, Date de fin: 31 mars 2018,

The ATR protein kinase controls the DNA damage response (DDR), with ATM, Chk1 and Chk2. DDR genes are often mutated in cancer cells and act as an anti-cancer barrier in response to oncogenic stimuli. ATR is essential and protects the integrity of replicating chromosomes, prevents fragile site expression and aberrant condensation events. The Foiani laboratory recently found that ATR associates with ...
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 1

 TERMINÉ 

Novel nanotechnology-enabled system for endovascular in vivo near-infrared fluorescence molecular imaging and endovascular near-infrared targeted photodynamic therapy of atherosclerotic heart disease (CosmoPHOS-nano)

Date du début: 1 mars 2013, Date de fin: 28 févr. 2018,

CosmoPHOS-nano is a multidisciplinary, translational and business-oriented project, aiming to accomplish the following objectives:1) develop the CosmoPHOS system, which is a novel theranostic (diagnostic & therapeutic) nanotechnology-enabled portable combination system enabling endovascular in vivo near-infrared fluorescence molecular imaging, endovascular near-infrared targeted photodynamic thera ...
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 20

 TERMINÉ 

Vascular Endothelial interactionS and SpEciaLization (Vessel)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2016,

The vascular network plays essential roles in animal biology. Local disruption or impaired function of the vascular network is known to cause various pathological conditions, such as ischemic heart disease and stroke. The angiogenic growth of blood vessels is critically required during development, growth and regeneration, but it can also promote the growth of cancer cells and contribute to diabet ...
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 9

 TERMINÉ 

DDRNA-based cancer therapy targeted telomeres (DDRNA)

Date du début: 1 juin 2015, Date de fin: 30 nov. 2016,

The so-called “DNA damage response” (DDR) is a coordinated set of evolutionary-conserved events that, triggered upon DNA damage detection, arrests the cell-cycle and attempts DNA repair. Recently, we have unveiled and reported that DDR activation depends on RNA. We observed that DNA double-strand breaks (DSBs) trigger the local generation of small non-coding RNAs at the site of DNA damage carryi ...
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 1

 TERMINÉ 

The role of Chronic DNA damage in Ageing and Age-related pathology (CodeAge)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

Ageing is an inexorable homeostatic failure of largely unknown aetiology that leads to increased vulnerability to disease limiting the quality of life in the elderly and creating high costs to the society. Until recently, the daunting complexity of the ageing process, the conspicuous lack of tools to study it, and a dearth of experimentally tractable model systems have greatly hindered any hypothe ...
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 9

 TERMINÉ 

Joint training and research network on Chromatin Dynamics and the DNA Damage Response (ADDRESS)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

DNA is tightly wrapped around histones to form chromatin, a highly dynamic structure that can adopt different conformations with contrasting degrees of compaction. Essential processes of DNA metabolism, such as DNA repair, replication or transcription operate in the context of chromatin and higher order chromosomal organization. Understanding how modulation of chromatin structure and repair influe ...
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 10

 TERMINÉ 

Transcriptional regulation of endothelial blood brain barrier differentiation by Wnt signaling (Wnt for brain)

Date du début: 1 août 2011, Date de fin: 31 juil. 2016,

The brain vasculature has evolved to protect the central nervous system from the constantly changing milieu in the blood stream. Endothelial cells of brain capillaries form the so called blood brain barrier (BBB), an active permeability barrier and transport system which allows a selective passage of nutrients from blood to the nervous tissue. The continuous cross talk of endothelial cells, pericy ...
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 1

 TERMINÉ 

THE ENDOCYTIC AND CYTOSKELETAL MATRIX IN THE PLASTICITY OF TUMOR CELL INVASION AND MIGRATION (The MetaEndoMatrix)

Date du début: 1 août 2011, Date de fin: 31 juil. 2016,

"Tumor cells can adopt different modes of cell motility. The ability to switch between diverse modes of migration enables tumors to adapt to micro-environmental conditions and to metastasize. The critical pathways and cellular processes underlying the plasticity of tumor cell motility have only begun to be identified.Endocytosis, originally thought of as a device to internalize nutrients and membr ...
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 1

 TERMINÉ 

AusBildung wird Forschung - DKFZ-Auszubildende forschen europaweit

Date du début: 1 juil. 2014, Date de fin: 30 juin 2016,

In our 24 months project "AusBildung wird Forschung - DKFZ-Auszubildende forschen europaweit", 21 apprentices, 1 animal keeper who completed his training in 2015 and 3 staff members of the training department had the opportunity to partake. Most of the participants are completing an apprenticeship as biological laboratory assistants (17), office clerks (3) and qualified IT specialists (1). They al ...
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 7

 TERMINÉ 

Activation of vasculature associated stem cells and muscle stem cells for the repair and maintenance of muscle tissue (Endostem)

Date du début: 1 janv. 2010, Date de fin: 31 déc. 2014,

We propose to develop new strategies to mobilize skeletal muscle tissue-associated stem cells as a tool for efficient tissue repair. This will be combined with exploring novel approaches that limit tissue damage, and will focus on agents that modify muscle and muscle vasculature progenitor cells. These molecules include nitric oxide associated with non-steroidal anti-inflammatory drugs, HMGB1, Cri ...
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 22

 TERMINÉ 

Regulatory mechanisms coordinating replication integrity and intra-S repair (REPSUBREP)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2014,

"The RecQ family of helicases, including BLM in human and its Saccharomyces cerevisiae homolog Sgs1, have important roles in maintaining genome stability. Sgs1 plays a specific role in response to intra-S DNA damage by resolving the pseudo double HJs resulting from replication-related sister chromatid junctions (SCJs). These catenated DNA structures are thought to represent template switch (TS) in ...
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 1

 TERMINÉ 

A Coordinated and Structured International Post-Doctoral Program to Foster Trans-national Mobility and Independent Career of Scientists in Biomedicine (SIPOD)

Date du début: 16 mars 2009, Date de fin: 15 sept. 2014,

"This program encompasses the coordinated action of three major Biomedicine Research Centers and a Biotech shell in Lombardy, to launch a new Structured International Post-Doctoral program (SIPOD). These research centers operate in conjunction with the Scuola Europea di Medicina Molecolare (SEMM) whose aim is to promote the training and research of young scientists within emerging sectors of biome ...
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 4

 TERMINÉ 

Blood-brain barrier junctions as targets for paracellular drug delivery to the brain (JUSTBRAIN)

Date du début: 1 nov. 2009, Date de fin: 30 avr. 2014,

"To maintain homeostasis of the central nervous system (CNS) the blood-brain barrier (BBB) prevents the free transcellular passage of hydrophilic molecules from the blood into the CNS. Because of this, the BBB is now recognised as the major obstacle to the treatment of most neurological disorders, as it hinders the delivery of many potentially important therapeutic and diagnostic substances to the ...
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 8

 TERMINÉ 

Mechanisms coordinating chromosome replication with transcription (REPTRA)

Date du début: 1 mars 2012, Date de fin: 28 févr. 2014,

"Genome stability during chromosome replication can be challenged by drugs affecting fork progression and intra-S DNA damage. While the mechanisms preserving the integrity of replicating chromosomes in response to replication stress induced by exogenous genotoxic events have been widely studied (Branzei and Foiani 2005; Branzei and Foiani 2007), those controlling fork stability under unperturbed c ...
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 1

 TERMINÉ 

Molecular mechanisms of the regulation of mammary stem cell homeostasis and their subversion in cancer (MAMMASTEM)

Date du début: 1 mars 2009, Date de fin: 28 févr. 2014,

Stem cells (SCs) are thought to be integral to the development and progression of cancer, and their eradication may be essential for the cure of cancer. Yet, direct proof is lacking due to our poor understanding of the molecular differences between normal and cancer SCs. We will investigate normal and cancer mammary stem cells (MSCs) by focusing on the role of the cell fate determinant Numb in two ...
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 1

 TERMINÉ 

Optimization of stem cell therapy for clinical trials of degenerative skin and muscle diseases (OptiStem)

Date du début: 1 janv. 2009, Date de fin: 31 déc. 2013,

This proposal aims to develop and implement efficacy of clinical trials with adult, tissue stem cells for degenerative diseases of epithelia and skeletal muscle. Extraordinary progress in the understanding of several key features of stem cells has been rapidly translated into novel cell therapy protocols that have yielded positive results in pre-clinical models of genetic and acquired diseases and ...
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 20

 TERMINÉ 

European Stroke Research Network (EUSTROKE)

Date du début: 1 mars 2008, Date de fin: 31 août 2013,

The European Stroke Research Network (EUSTROKE) will be a collaborative effort that brings together researchers, government, industry, the non-profit sector and patient group associations. This network will put Europe at the forefront of stroke research through its multi-disciplinary research program, high-quality training for European scientists and clinicians, and national and global partnership ...
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 17

 TERMINÉ 

Targeting of DNA deaminase AID via transcription and the RNA pol II elongation complex (AID Recruitment)

Date du début: 1 mars 2011, Date de fin: 28 févr. 2013,

In B cells, antibody repertoire is created via two DNA instability complexes, one of which uses DNA cytosine deamination and is needed for immunoglobulin (Ig) diversification. Targeting of DNA deamination is poorly understood and mis-targeting can lead to genetic pathologies. Activation induced deaminase (AID) catalyses the hydrolytic deamination of cytosine residues, with the resulting uracil ind ...
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 1

 TERMINÉ 

Angiogenesis-inducing Bioactive and Bioresponsive Scaffolds in Tissue Enginering (AngioScaff)

Date du début: 1 déc. 2008, Date de fin: 30 nov. 2012,

Angiogenesis underlies almost all biological processes of morphogenesis, including those in tissue repair and regeneration. Physiological angiogenesis is controlled by a complex interplay between cells and their environment: the extracellular matrix (ECM) provides signaling via numerous ECM adhesion molecules and growth factors bound to ECM polysaccharide components; and cells locally degrade and ...
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 33

 TERMINÉ 

Genomic instability and genomic alterations in pre-cancerous lesions and/or cancer (GENINCA)

Date du début: 1 janv. 2008, Date de fin: 30 juin 2011,

"GENINCA will address two tumor entities, for which we have good access to pre-malignant lesions and in which genomic instability is a common feature: colorectal and liver cancer. Colorectal cancer amounts to 13.2% of all incident cases of cancer, the second most common form of cancer, surpassed only by lung cancer (13.3%). Liver cancer accounts for about 2% of total cancers, however, the most com ...
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 14

 TERMINÉ 

Genomic Instability in Cancer and Precancer (GENICA)

Date du début: 1 janv. 2008, Date de fin: 31 déc. 2010,

"Genomic instability is a characteristic of practically all human cancers. Recent results generated by members of this Consortium suggest that signs of genomic instability are evident from the very beginning of human cancer development, even in precancerous lesions. In these early lesions, the genomic instability affects primarily specific genomic loci, called common fragile sites. Because common ...
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 11