15 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Combatting Bacterial Resistance in Europe - Molecules against Gram Negative Infections (COMBACTE-MAGNET)
Date du début: 1 janv. 2015, Date de fin: 31 déc. 2021,
Antimicrobial resistance (AMR) is a major global public health threat, and most troublesome is the rapid emergence and dissemination of multidrug resistant (MDR) Enterobacteriaceae, Acinetobacter species and Pseudomonas aeruginosa. There is an unmet medical need to prevent P. aeruginosa infection in critically ill patients and to develop new antibiotics for infections caused by Gram-negative bacte ...
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44
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TERMINÉ
Combatting Bacterial Resistance in Europe - Carbapenem Resistance (COMBACTE-CARE)
Date du début: 1 mars 2015, Date de fin: 28 févr. 2020,
Multi-drug resistant Gram-negative bacteria (MDR-GNB): the ultimate challenge!Antibiotic resistance is a global public health concern recently elevated to the top three threats identified by the WHO, and subject of numerous national and international government activities. Although focused strategies have beneficially influenced infection rates due to methicillin resistant Staphylococcus aureus (M ...
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23
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TERMINÉ
The making and breaking of ubiquitin chains in cholesterol metabolism (UNICOM)
Date du début: 1 mai 2014, Date de fin: 30 avr. 2019,
"Elevated levels of circulating LDL-cholesterol are a major determinant contributing to atherogenesis and coronary artery disease. Therefore, many studies address the central transcriptional pathways that regulate cholesterol metabolism. However, transcriptional regulation does not allow cells to quickly adapt to the cholesterol fluxes that they encounter. For this, rapid and reversible post-trans ...
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1
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TERMINÉ
The roles of innate lymphoid cells and rhinovirus in asthma exacerbations (AsthmaVir)
Date du début: 1 mars 2014, Date de fin: 28 févr. 2019,
Asthma exacerbations represent a high unmet medical need in particular in young children. Human Rhinoviruses (HRV) are the main triggers of these exacerbations. Till now Th2 cells were considered the main initiating effector cell type in asthma in general and asthma exacerbations in particular. However, exaggerated Th2 cell activities alone do not explain all aspects of asthma and exacerbations. B ...
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1
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TERMINÉ
Platform foR European Preparedness Against (Re-)emerging Epidemics (PREPARE)
Date du début: 1 févr. 2014, Date de fin: 31 janv. 2019,
Far from receding, the threats posed by infections with epidemic potential grow ever greater. Although Europe has amongst the best healthcare systems in the world, and also the world’s supreme researchers in this field, we lack co-ordination and linkage between networks that is required to respond fast to new threats. This consortium of consortia will streamline our response, using primary and sec ...
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27
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TERMINÉ
Anti-tick Vaccines to Prevent Tick-borne Diseases in Europe (ANTIDotE)
Date du début: 1 déc. 2013, Date de fin: 30 nov. 2018,
Background Ixodes ricinus transmits bacterial, protozoal and viral pathogens that cause Lyme borreliosis, babesiosis and tick-borne encephalitis respectively and exceedingly affect Central and Eastern Europe (CEE). During feeding, ticks introduce salivary proteins in the skin that interfere with host defense mechanisms. However, in animals repeated tick infestations as well as vaccination against ...
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8
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TERMINÉ
Targets and biomarkers for antiepileptogenesis (EPITARGET)
Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,
Epilepsy is a devastating condition affecting over 50 million people worldwide. This multidisciplinary project is focused on the process leading to epilepsy, epileptogenesis, in adults. Our main hypothesis is that there are combinations of various causes, acting in parallel and/or in succession, that lead to epileptogenesis and development of seizures. Our central premise and vision is that a comb ...
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20
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TERMINÉ
Long-term, prospective study evaluating clinical and molecular biomarkers of epileptogenesis in a genetic model of epilepsy – tuberous sclerosis complex (EPISTOP)
Date du début: 1 nov. 2013, Date de fin: 31 oct. 2018,
Despite a great progress in the management of epilepsy, still one third of patients is refractory to available medications. The incidence of epilepsy is highest in infancy and 50% of children experience epilepsy-related comorbidities, such as developmental delay and autism. The development of epilepsy (epileptogenesis), extensively studied in animals, is barely studied in humans, as patients usual ...
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16
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TERMINÉ
Unraveling and targeting mitochondrial biogenesis in CD8+ T cells to improve memory formation and vaccine efficacy (MITOCHONDRIA)
Date du début: 1 juin 2014, Date de fin: 28 févr. 2018,
Immunological memory is the basis of vaccination. This has been the subject of intense study, but the underlying cellular mechanisms regulating the generation and persistence of long-lived memory T cells (TM) remain largely undefined. Recently, it was shown that CD8+ T cell responses following bacterial infection could be manipulated by modulating cellular metabolism. Since then immunometabolism h ...
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1
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TERMINÉ
Nanomedicine for target-specific imaging and treatment of atherosclerosis: development and initial clinical feasibility (NanoAthero)
Date du début: 1 févr. 2013, Date de fin: 31 janv. 2018,
NanoAthero aims to have demonstration of initial clinical feasibility of nanosystems for targeted imaging and treatment of advanced atherosclerotic disease in humans. The nanosystems are assemblies of following components: nanocarrier, targeting, imaging agent/drug. They have proven safety records, and strong preliminary in vitro and in vivo proofs of efficacy are available. Partners have patented ...
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17
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TERMINÉ
Community-based scheduled screening and treatment of malaria in pregnancy for improved maternal and infant health: a cluster-randomized trial (COSMIC)
Date du début: 1 sept. 2012, Date de fin: 31 mai 2017,
Pregnant women are very susceptible to malaria infection and Malaria in Pregnancy (MiP) is a major cause of maternal anaemia and low birth weight (LBW) that leads to infant mortality, poor growth and development. In low transmission areas, malaria can become severe, resulting in maternal and foetal death. In sub-Saharan Africa (SSA) MiP is responsible for 8–14% of LBW, 3–8% of infant deaths, highe ...
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9
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TERMINÉ
Memory control; Molecular mechanisms underlying the scope of immunological memory (MEMORY CONTROL)
Date du début: 1 mars 2014, Date de fin: 28 févr. 2017,
T cell mediated immunity protects us against pathogens and cancer. The naïve T cell pool consists of millions of clones, each one unique based on its T cell receptor (TCR). Upon infection, only a few of these clones are recruited to generate antigen-specific memory. Selection of memory clones is a trade-off between specificity and diversity; too much specificity restricts antigen-recognition, whic ...
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1
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TERMINÉ
Stabilizing the exposure of neutralization epitopes on HIV-1 envelope glycoprotein trimer vaccines (SHEV)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2016,
"The impact of HIV/AIDS on world healthcare is tremendous, particularly in the Third World. To curtail the HIV epidemic a cheap and effective vaccine is urgently needed, but despite massive research efforts no vaccine is available yet. Although most vaccines work by inducing neutralizing antibodies, HIV has evolved many ways to limit the induction and binding of neutralizing antibodies. The challe ...
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1
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TERMINÉ
Translation of the direct-on-blood PCR-NALFIA system into an innovative near point-of-care diagnostic for malaria (DIAGMAL)
Date du début: 1 sept. 2013, Date de fin: 31 août 2016,
Accurate diagnosis of malaria is essential to timely install proper treatment. Current diagnostic methods for malaria have limitations, such as detection limit and problems with antigen persistence after successful treatment (rapid diagnostic tests) or may require technical expertise and equipment (microscopy). Treatment on the basis of clinical symptoms only (fever = malaria) must be abandoned.Mo ...
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5
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TERMINÉ
Tackling socioeconomic inequalities in smoking: learning from natural experiments by time trend analyses and cross-national comparisons (SILNE)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2014,
For any strategy aimed to reduce socioeconomic inequities in health in Europe it is vital to tackle the large and widening inequalities in smoking. However, there is only limited evidence on effectiveness of tobacco control policies in terms of reducing inequalities. Especially lacking are evaluations of the effects of policies that have actually been implemented in different European countries. I ...
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