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14 projets européens trouvés

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 TERMINÉ 

Applied Public-Private Research enabling OsteoArthritis Clinical Headway (APPROACH)

Date du début: 1 juin 2015, Date de fin: 30 nov. 2020,

The problem: finding the right patient for the right treatmentDespite a large and growing disease burden in osteoarthritis (OA), many pharmaceutical companies have de-emphasized or even abandoned OA drug development due to perceived hurdles. Crucial in this is the lack of appropriate outcome measures that can robustly identify patient benefit from a specific therapy. The lack of specific and sensi ...
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 25

 TERMINÉ 

Novel Diagnostics and Biomarkers for Early Identification of Chronic Inflammatory Joint Diseases (D-BOARD)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2017,

"Chronic inflammatory diseases of joints are major causes of disability in the ageing population. Osteoarthritis (OA) is one of the most common types of arthritis and a major cause of pain and disability in older individuals. OA is expected to place a heavy burden on European healthcare systems, as European citizens grow older. Cartilage damage in OA is detected radiographically by decreases in jo ...
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 15

 TERMINÉ 

Open Project for the European Radiation Research Area (OPERRA)

Date du début: 1 juin 2013, Date de fin: 31 mai 2017,

"Within the OPERRA project, it is proposed that the MELODI Association, as a well-advanced network, takes the lead in establishing the necessary structures able to manage the long-term European research programmes in radiation protection, also taking advantage of the valuable experience gathered through the DoReMi network of excellence. Whilst in fields adjacent to low-dose risk research (radioeco ...
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 71

 TERMINÉ 

"Eukaryotic genomic origins, parasites, and the essential nature of mitochondria" (EUKORIGINMIT)

Date du début: 1 mars 2011, Date de fin: 28 févr. 2017,

"Understanding the origin and evolution of eukaryotes, their genomes and organelles, are among the most important and exciting challenges facing biology. However, determining ancient gene origins tests methods and data to their limits, and it is unrealistic to expect progress to be easy. A comparative cross-disciplinary approach involving sophisticated phylogenetics allied with mathematical unde ...
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 1

 TERMINÉ 

Defining the functions of novel integral membrane regulator, CMTM family in B cell development and acute lymphoblastic leukemia (Leukemia signalling)

Date du début: 1 juin 2014, Date de fin: 30 nov. 2016,

Despite the vast improvements in survival, acute lymphoblastic leukaemia (ALL) remains one of the major causes of death in children. The current combination chemotherapy causes acute and long-term toxicity. Hence, there is a compelling need to understand the development of ALL and identify key players that could be used in targeted therapy. The B cell receptor (BCR) and its precursor, pre-BCR, con ...
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 1

 TERMINÉ 

Observational Prolonged Trial In Myotonic dystrophy type 1 to Improve QoL-Standards, a Target Identification Collaboration (OPTIMISTIC)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2016,

OPTIMISTIC is a proposal for a European collaborative project of doctors, scientists, relevant stakeholders (TREAT-NMD, patient organizations) and SMEs with the aim to improve clinical practice for patients suffering from a rare, inherited, and neglected disease, myotonic dystrophy type 1 (DM1). It is one of the most variable human diseases with complex, multi-systemic and progressively worsening ...
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 9

 TERMINÉ 

Modulation of mitochondrial complex I as a strategy to increase lifespan and prevent age-related diseases (ComplexI&Aging)

Date du début: 1 févr. 2011, Date de fin: 30 sept. 2016,

Nowadays, ageing is one of the main problems in Western society. The increase in the percentage of elderly people serves to strain the Social Security to the point of bankruptcy. The only way to alleviate the suffering caused by age-related degenerative disease is to fully understand the underlying forces which drive ageing and design strategies to delay it. Mitochondria are considered as central ...
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 2

 TERMINÉ 

MARie CuRIe AGEing Network (MARRIAGE)

Date du début: 1 oct. 2012, Date de fin: 30 sept. 2016,

"One of achievements of developed societies has been the remarkable extension of human lifespan. In the upcoming decades the number of Europeans with advanced age will increase dramatically. It is evident that age-associated diseases will become much more prevalent. This poses challenges for society but also opportunities for commercial enterprises that develop strategies to combat deleterious con ...
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 11

 TERMINÉ 

Development of high throughput in vivo oncogenomic screening strategies in acute leukaemia (ONCOGENOMICS)

Date du début: 1 mai 2010, Date de fin: 30 avr. 2016,

Within a highly successful research environment, we will develop a state-of the-art high throughput functional in vivo oncogenicity assay, using mouse bone marrow transplant models of leukaemia to conclusively identify the important genetic changes involved in the development and progression of cancer. This study will focus on B-lineage acute lymphoblastic leukaemia (ALL), for which there is a wea ...
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 1

 TERMINÉ 

Social Innovations Promoting Active and Healthy Ageing (INNOVAGE)

Date du début: 1 déc. 2012, Date de fin: 30 nov. 2015,

"INNOVAGE is an ambitious project is dedicated to developing and testing, as well as surveying and cataloguing, social innovations that will have a solid impact on improving the quality of life and well-being of older people. In particular the project aims to make a major contribution to the EU goal of extending healthy life years. It has four clear and achievable objectives that are intended to ...
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 9

 TERMINÉ 

ATMP GMP Open Access Research Alliance - AGORA (AGORA)

Date du début: 1 sept. 2013, Date de fin: 31 oct. 2015,

We propose an academic & industrial partnership to facilitate safe and effective delivery of new advanced therapy medicines within the framework of the relevant EU regulations which our previous FP7 funded project have identified as creating unanticipated barriers to development of this field. Over 80% of advanced therapy medicines (ATMPs) trials in the EU are academic investigator led and sponsor ...
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 8

 TERMINÉ 

Introducing diagnostic applications of ‘3Gb-testing’ in human genetics (3GB-TEST)

Date du début: 1 sept. 2013, Date de fin: 31 août 2015,

The landscape of genetic testing is rapidly changing. Soon, whole genome sequence analysis (3Gb-testing) will be an effective and financially viable alternative to targeted gene analysis. New technologies that allow efficient sequencing of a whole human genome in a diagnostic setting will have an enormous impact on diagnostic centres replacing many existing molecular and cytogenetic tests.Patients ...
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 11

 TERMINÉ 

Identification and characterization of factors involved in chromosome organization and septum positioning in bacteria (COSP)

Date du début: 1 févr. 2013, Date de fin: 31 janv. 2015,

"The cell cycle is one of the most pivotal and fundamental processes in biology and encompasses a set of inter-related events, most prominently, chromosome replication, chromosome segregation and cell division. Each of these steps is highly complex, and bacterial cells offer the opportunity to study cell cycle processes in a simplified, relatively tractable context. Investigation of the bacterial ...
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 1

 TERMINÉ 

NCDs and their social determinants in Mediterranean partner countries: building sustainable research capacity for effective policy intervention (RESCAP-MED)

Date du début: 1 janv. 2012, Date de fin: 31 déc. 2014,

The main purpose of RESCAP-MED is to enhance the non-communicable diseases (NCDs) research landscape in southern and eastern Mediterranean countries by (a) strengthening capacity in a set of disciplines most relevant to improving public health and reducing health inequalities, and (b) enhancing networking, cooperation, and collaboration between researchers in the Mediterranean region. The main co ...
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 12