Plus de 40 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Finding noncoding cancer drivers (NONCODRIVERS)
Date du début: 1 déc. 2016, Date de fin: 30 nov. 2021,
Finding the mutations, genes and pathways directly involved in cancer is of paramount importance to understand the mechanisms of tumour development and devise therapeutic strategies to overcome the disease. Due to their role in cancer development and maintenance, the proteins encoded by cancer genes are candidate therapeutic targets. Indeed, in recent years we have witnessed the development of suc ...
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2
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TERMINÉ
European Academy for Biomedical Science (ENABLE)
Date du début: 1 juil. 2016, Date de fin: 31 déc. 2020,
The proposed European Academy for Biomedical Science (ENABLE) consortium will connect aspiring European researchers of tomorrow with prominent scientists of today, in particular to inspire and to give them the necessary tools to follow in their footsteps. ENABLE will organize peer-reviewed symposia celebrating European life science achievements from molecule to man/patient. These symposia will hav ...
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6
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TERMINÉ
Description of information transfer across macromolecules by concerted conformational changes (CONCERT)
Date du début: 1 juil. 2015, Date de fin: 30 juin 2020,
Signal transduction in biology relies on the transfer of information across biomolecules by concerted conformational changes that cannot currently be characterized experimentally at high resolution. In CONCERT we will develop a method based on the use of nuclear magnetic resonance spectroscopy in solution that will provide very detailed descriptions of such changes by using the information about s ...
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2
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TERMINÉ
Dissecting gamma-TuRC composition and activity by Single Molecule Pull-down (GTR)
Date du début: 1 sept. 2017, Date de fin: 31 août 2019,
In this project I will use Single Molecule Pull-down (SiMPull) for studying activity and regulation of human gamma-tubulin ring complexes (gamma-TuRCs). Gamma-TuRCs are the main nucleators of microtubule (MT) polymerization. Additionally, gamma-TuRCs may play a role in modulating MT dynamics. Regulation of gamma-TuRC activity is key to organizing the dynamic MT arrays needed for essential processe ...
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2
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TERMINÉ
ELIXIR-EXCELERATE: Fast-track ELIXIR implementation and drive early user exploitation across the life-sciences. (ELIXIR-EXCELERATE)
Date du début: 1 sept. 2015, Date de fin: 31 août 2019,
The life sciences are undergoing a transformation. Modern experimental tools study the molecules, reactions, and organisation of life in unprecedented detail. The precipitous drop in costs for high-throughput biology has enabled European research laboratories to produce an ever-increasing amount of data. Life scientists are rapidly generating the most complex and heterogeneous datasets that scienc ...
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47
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TERMINÉ
A genome editing-based approach to study the stem cell hierarchy of human colorectal cancers (editCRC)
Date du début: 1 avr. 2014, Date de fin: 31 mars 2019,
A hallmark of cancer is tumor cell heterogeneity, which results from combinations of multiple genetic and epigenetic alterations within an individual tumor. In contrast, we have recently discovered that most human colorectal cancers (CRCs) are composed of mixtures of phenotypically distinct tumor cells organized into a stem cell hierarchy that displays a striking resemblance to the healthy colonic ...
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2
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TERMINÉ
A systems pharmacology approach to the discovery of novel therapeutics in Alzheimer´s disease (SysPharmAD)
Date du début: 1 avr. 2014, Date de fin: 31 mars 2019,
Alzheimer´s disease (AD) is the most common form of dementia, with over 35 million people suffering from it worldwide, and it constitutes a personal and societal tragedy of immense proportions. Fifty years of intense research have revealed many key elements of the biology of this neurodegenerative disorder. However, our understanding of the molecular bases of the disease is still very limited, and ...
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2
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TERMINÉ
Global BioImaging Project - International imaging infrastructure services for the life science community (Global BioImaging)
Date du début: 1 déc. 2015, Date de fin: 30 nov. 2018,
"The EC H2020 funded "Global BioImaging Project" enables Euro-BioImaging, the research infrastructure for access to biological and medical imaging technologies on the ESFRI roadmap, to work together with its international counterparts - the Australian Microscopy and Microanalysis Research Facility (AMMRF), the National Imaging Facility (Australia) and India-BioImaging - on concrete and sustainable ...
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8
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TERMINÉ
Centre of Excellence for Biomolecular Research (BioExcel)
Date du début: 1 nov. 2015, Date de fin: 31 oct. 2018,
Life Science research has become increasingly digital, and this development is accelerating rapidly. Biomolecular modelling techniques such as homology modelling, docking, and molecular simulation have advanced tremendously due to world-leading European research, resulting in extreme demands for better computational performance and throughput as these tools are used in applied research and industr ...
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13
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TERMINÉ
Multi-Scale Complex Genomics (MuG)
Date du début: 1 nov. 2015, Date de fin: 31 oct. 2018,
Genomics is probably the fastest evolving field in current science. A decade ago our main concern was to obtain the sequence (the 1D code) of the genome; but today the big challenges are to determine how genotype information is transferred into phenotype, and how pathological phenotypic changes can be predicted from genome alterations. While investigating these points, we have realized that a part ...
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7
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TERMINÉ
IRB Barcelona International Postdoctoral Programme 2.0 (IRBPostPro2.0)
Date du début: 2 avr. 2013, Date de fin: 1 avr. 2018,
IRB Barcelona is an independent, non-profit research institution engaged in basic and applied biomedical science at the interface between biology, chemistry and medicine, recently nominated a Severo Ochoa Centre of Excellence by the Spanish Ministry of Science and Innovation. One of the main missions of IRB Barcelona is to provide young life scientists with the opportunity to do training and resea ...
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2
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TERMINÉ
Early warning signals of ageing in human stem cells and age-related disorders (SYSTEMAGE)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,
The regenerative power of a living organism is linked to the potential of its stem cells to replace the corresponding damaged tissue. Therefore organisms are as old as their stem cells. Whereas the vulnerability to cancer and chronic inflammation is associated with a decline of the immune system, the latter is in turn a sum product of interactions among hematopoietic stem cells (HSC), endothelial ...
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11
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TERMINÉ
Spatiotemporal regulation of epidermal stem cells by circadian rhythms: impact on homeostasis and aging (STEMCLOCK)
Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,
"Most adult stem cells are compartmentalized in functionally deterministic niches where they self-renew and maintain homeostasis. From there, stem cells are instructed by combinations of signals and spatial tensile forces which they translate into a specific behavior. However how stem cells spatiotemporally coordinate their stem cell potential with niche- and systemic cues is poorly understood. Th ...
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3
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TERMINÉ
Advanced multiscale simulation of DNA (simDNA)
Date du début: 1 juil. 2012, Date de fin: 30 juin 2017,
The availability of new computers and software is making possible the theoretical representation of DNA, increasing then our knowledge on the behavior of one of the most relevant biological macromolecules. Unfortunately, current simulation procedures present two major problems, which handicapped their use: i) classical force-fields present well known biases, which limit their accuracy; ii) current ...
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2
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TERMINÉ
Modelling Cancer Traits in Drosophila (FliesCan)
Date du début: 1 juil. 2012, Date de fin: 30 juin 2017,
Despite significant advance, cancer treatment remains suboptimal. Anatomical and physiological differences between humans and simple model organisms like Drosophila are many and major, and preclude the modelling of key aspects of the disease as it proceeds in vertebrates. However, malignant tumors in vertebrates and flies are made of cells that have derailed from their normal course of development ...
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2
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TERMINÉ
Signal integration and rewiring during tumor development (p38Cancer)
Date du début: 1 juil. 2012, Date de fin: 30 juin 2017,
Cell fate decisions rely on signaling pathways that integrate external signals to coordinate specific intracellular programs. One of these pathways leads to the activation of p38α MAPK, which plays key roles in cell responses to many types of stresses as well as chemotherapeutic agents and oncogenes. Importantly, p38α acts in a cell context-specific and cell type-specific manner to integrate signa ...
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2
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TERMINÉ
New Oral Nanomedicines: Transporting Therapeutic Macromolecules across the Intestinal Barrier (TRANS-INT)
Date du début: 1 mai 2012, Date de fin: 30 avr. 2017,
Despite the increasing number of macromolecules with potential impact in the treatment of devastating systemic diseases, these therapies have failed to deliver on their expectations because they cannot be administered in the fashion which is most cost efficient and has the highest patient compliance: the oral route. The availability of an oral form of administration could lead to a great improveme ...
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20
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TERMINÉ
New breast cancer therapies based on available p38 MAPK inhibitors (p38Cure)
Date du début: 1 oct. 2015, Date de fin: 31 mars 2017,
Breast tumors are classified by several grading systems and divided into four main molecular subtypes: Luminal A, Luminal B, Triple negative/basal-like and HER2+. Since luminal A tumors tend to be ER+, their treatment often includes hormonal therapy. HER2+ tumors can be treated with Trastuzumab, an anti-Her2 receptor antibody. Hormonal therapies or Trastuzumab cannot be used for triple negative tu ...
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2
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TERMINÉ
Testing and validation of bispecific antibody combinations targeting treatment-resistant cancer stem cells using organoid-based screening tools: a new drug discovery paradigm (SUPPRESSTEM)
Date du début: 1 juin 2013, Date de fin: 30 nov. 2016,
Colorectal cancer (CRC) was diagnosed in 1.23 million people worldwide (EU 333,000) in 2008 and 608,000 (EU 148,000) died of the disease. While some new treatments have been advanced in CRC many have failed clinical testing; metastatic CRC is still largely incurable.In CRC, Cancer Stem Cells (CSC) are responsible for tumour progression and resistant to standard chemotherapies. The Wnt signal trans ...
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5
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TERMINÉ
Computational Design of Highly Active Biocatalysts of Interest in the Chemical Industry (CompBiocatDesign)
Date du début: 1 mars 2013, Date de fin: 31 août 2016,
Developing new enzymes for catalyzing non natural reactions is a grand challenge for obtaining more efficient synthetic strategies for chemical industry as well as building complex molecules under enantioselective control with potential applications in medicine. Given the high specificity of natural enzymes for their substrates, new techniques are necessary for redesigning natural enzymes to perfo ...
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2
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TERMINÉ
Study of cis/trans proline isomerization as a novel regulatory mechanism of protein function (ProProteinRegulation)
Date du début: 1 sept. 2012, Date de fin: 31 août 2016,
Cellular processes are regulated through wide and complex signaling networks that require a tight spatial and temporal control over protein function. Recently a growing body of evidence has emerged supporting the role of prolyl cis-trans isomerization as a new intrinsic molecular regulatory mechanism with important consequences for protein function. Proline is the only amino acid in proteins that ...
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2
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TERMINÉ
COLOStage : A new prognosis test for the prediction of metastasis in Colorectal Cancer and Hepatocellular Carcinoma (COLOStage)
Date du début: 1 mars 2015, Date de fin: 31 août 2016,
ColoStage is a new prognostic test, based on a novel gene expression signature, able to predict robustly the risk of disease relapse after therapeutic intervention in colorectal cancer (CRC) and potentially in hepatocellular carcinoma (HCC). We have previously demonstrated that CRC recurrence and metastasis strictly depend on high TGF-beta signaling (Calon et al., 2012). ColoStage is a gene expre ...
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2
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TERMINÉ
Development of a new methodology for the synthesis of mercapto amino acids for protein synthesis by cysteine-free native chemical ligation (CYSTEINE-FREE NCL)
Date du début: 14 avr. 2014, Date de fin: 13 avr. 2016,
Proteins are in the heart of almost every single biological function and therefore are essential tools for drug discovery. Although the use of recombinant DNA techniques has been successfully applied to the synthesis of many proteins, the access to proteins bearing non natural amino acids, naturally obtained through post-translational modifications, remains limited. However, with the invention of ...
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2
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TERMINÉ
Mechanisms of prevention of type 2 diabetes by lifestyle intervention in subjects with pre-diabetes or at high-risk for progression (DEXLIFE)
Date du début: 1 janv. 2012, Date de fin: 31 déc. 2015,
"Type 2 diabetes (T2DM) is preventable by sustained changes in diet and physical exercise. Despite this, modern societies are already approaching 10% population prevalence of diabetes, and another 15% with pre-diabetes. The costs of T2DM are huge, approaching 10% of all health costs. Prevention of diabetes is a priority for national healthcare agencies and for the health insurance industry. Inve ...
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12
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TERMINÉ
IRB Barcelona International Postdoctoral Programme (IRBPostPro)
Date du début: 15 nov. 2010, Date de fin: 14 juil. 2015,
IRB Barcelona is an independent, non-profit research institution engaged in basic and applied biomedical science at the interface between biology, chemistry and medicine. One of the main missions of IRB Barcelona is to provide young life scientists with the opportunity to do training and research in a unique and multidisciplinary scientific environment. The Institute has a young but well-establish ...
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2
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TERMINÉ
Study of the Determinants of Heterochromatin Formation and Maintenance (HETCHROMPROJECT)
Date du début: 1 juin 2011, Date de fin: 31 mai 2015,
Heterochromatin is a conserved organizational structure of the genetic material that is indispensable for cell viability. Heterochromatin is associated with the formation of functionally conserved centromeric and telomeric structures. These structures are both essential for the integrity and proper segregation of the genetic material during mitosis and meiosis. Heterochromatin structure is also im ...
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2
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TERMINÉ
Peptide Dendrimers - A Chemical Platform for Functional Diversity (Peptide Dendrimers)
Date du début: 13 juin 2011, Date de fin: 12 juin 2014,
Peptides have emerged as a therapeutically important class of drugs and offer the advantage of great specificity, potency and low toxicity. Short circulation half-life, poor proteolytic stability and bioavailability have however prevented them from becoming a mainstream source of drug candidates. Dendrimers are versatile, derivatizable, well-defined branched synthetic macromolecules with promising ...
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2
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TERMINÉ
Ligand Engineering for Pauson-Khand Reactions (LE-PKR)
Date du début: 1 sept. 2011, Date de fin: 30 nov. 2013,
"This project is centered on several technological developments around the intermolecular Pauson-Khand reaction, a cobalt catalyzed multicomponent cycloaddition with an unexploited potential to streamline the synthesis of complex organic molecules. The first aim is to find new ligands for the cobalt catalyzed intermolecular Pauson-Khand reaction. A ligand accelerated version of this transformation ...
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2
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TERMINÉ
"Nuclease Immune Mediated Brain and Lupus-like conditions (NIMBL): natural history, pathophysiology, diagnostic and therapeutic modalities with application to other disorders of autoimmunity" (NIMBL)
Date du début: 1 juin 2010, Date de fin: 30 nov. 2013,
"Nuclease Immune Mediated Brain and Lupus-like (NIMBL) conditions, comprising Aicardi-Goutieres Syndrome, Retinal Vasculopathy with Cerebral Leukodystrophy and some cases of Systemic Lupus Erythematosus, are devastating genetic disorders resulting in greatly reduced quality of life, high mortality especially in children, and significant risks of recurrence within affected families. NIMBL condition ...
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10
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TERMINÉ
Membrane Enhanced Tide Synthesis - A New Paradigm Peptide / Oligonucleotide Synthesis Technology (MEMTIDE)
Date du début: 1 déc. 2009, Date de fin: 30 nov. 2013,
"The MemTide Initial Training Network will create a new generation of synthesis technologies for peptide and oligonucleotide (“tide”) manufacture, with focus on the use of emerging membrane technology to effect critical separations. New nanofiltration membranes with improved chemical stability, and closely controlled molecular discrimination properties, will be developed. Novel synthesis strategie ...
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7
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TERMINÉ
Epigenetic control of chromatin structure - Solving an intertwined puzzle with a specialized coarse-grained model (EPICHROMATIN)
Date du début: 15 sept. 2011, Date de fin: 14 sept. 2013,
"This project will develop a highly sophisticated coarse-grained model of chromatin fibers from precise all-atom simulations of dinucleosomes and DNA segments. The purpose of the proposed project is to enhance our understanding of the mechanism by which different patterns of epigenetic modifications (of DNA and histone proteins) interact with each other to control the structure of the chromatin fi ...
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2
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TERMINÉ
Dissecting the roles of the beta-catenin and Tcf genetic programmes during colorectal cancer progression (CRC programme)
Date du début: 1 sept. 2008, Date de fin: 31 août 2013,
Most colorectal cancers (CRCs) are initiated by activating mutations in components of the Wnt signalling pathway. Physiological Wnt signals are required for the specification and maintenance of the stem and progenitor cell compartments of the intestinal crypts. We demonstrated that early colorectal lesions exhibit a constitutive Wnt target gene programme, which is very similar to that of normal in ...
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2
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TERMINÉ
Studies of neurosecretion by remote control of exocytosis and endocytosis with ligt (OPTICALBULLET)
Date du début: 1 sept. 2008, Date de fin: 31 août 2013,
"Optical switches are photoisomerizable compounds that allow to remotely controlling the activity of proteins, cells and entire organisms with light. These tools are revolutionizing research in biology with their high selectivity and spatiotemporal resolution. Here we propose to develop and apply optical switches to investigate the fundamental processes of secretion, exocytosis and endocytosis, in ...
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3
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TERMINÉ
Identification and validation of novel drug targets in Gram-negative bacteria by global search: a trans-system approach (AntiPathoGN)
Date du début: 1 févr. 2009, Date de fin: 31 juil. 2013,
Multi-drug-resistant bacterial infections are increasing at an alarming pace in both developing and developed countries and in both community and nosocomial settings. The few antimicrobial agents that have been launched during the last decade (e.g. linezolid, daptomycin) have a good activity against Gram-positive bacteria. However, multi-drug-resistant bacteria are often found among the Gram-negat ...
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11
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TERMINÉ
Understanding inflammation-associated tumorigenesis for the rational design of novel anti-cancer therapeutic strategies (INFLA-CARE)
Date du début: 1 janv. 2009, Date de fin: 30 juin 2013,
Epidemiological and experimental evidence supports a link between chronic inflammation and cancer and indicates a role for inflammatory cells in the initiation, progression and metastasis of malignancy. The objective of the collaborative integrated project INFLA-CARE is to structure a European collective of scientific and technological excellence in the field of ‘Inflammation & Cancer’ which will ...
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22
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TERMINÉ
Incorporating flexibility into protein-ligand docking (IFLPD)
Date du début: 1 nov. 2009, Date de fin: 31 oct. 2012,
"One of the major goals of current drug discovery methods is the correct treatment of the flexibility of the receptor (i.e., protein) in small ligand docking. Computer-aided drug discovery through ligand docking-based virtual screening is already a key component in the lengthy and costly process of developing new drugs not only for academy but also for the pharmaceutical industries. In this propos ...
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2
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TERMINÉ
Peptide ligands with restricted mobility through a Suzuki reaction: design, synthesis and evaluation (suzuki peptides)
Date du début: 1 oct. 2009, Date de fin: 30 sept. 2012,
The aim of this research proposal is the application of the Suzuki-Miyaura reaction to the synthesis of peptidic libraries with restricted mobility. Specifically, we envision the synthesis of a family of cyclic peptides that will contain a biaryl bond, to further restrain their conformation. This biaryl bond will be obtained through a Suzuki-Miyaura set of reactions between two aromatic amino acid ...
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2
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TERMINÉ
Microtubule organizing centers and microtubule nucleation in mitosis (MTOC function)
Date du début: 21 juil. 2008, Date de fin: 20 juil. 2012,
Centrosomes are multifunctional organelles crucial for a large number of cellular functions including the organization of microtubules. In mitosis centrosomes contribute to assembly, orientation and function of the mitotic spindle, which is important for proper segregation of the chromosomes. Defects in centrosome number and function are strongly associated with the cancer phenotype and centrosome ...
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2
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TERMINÉ
Analysis of the pathological implications of the abnormal accumulation of glycogen in specific cell types (MGS and disease)
Date du début: 1 juil. 2010, Date de fin: 13 juil. 2012,
Glucose is stored in specialized tissues (mainly liver and muscle) in the form of a branched polymer called glycogen. Glycogen Synthase is the only enzyme able to catalyze this polymerization and its two isoforms (LGS and MGS) are mainly expressed in liver and in muscle, respectively. However, MGS is also expressed in all other tissues, regardless of their limited capacity to produce Glycogen. MGS ...
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2
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TERMINÉ
Targeting Protein Synthesis in the Apicoplast and Cytoplasm of Plasmodium (MEPHITIS)
Date du début: 1 janv. 2009, Date de fin: 30 juin 2012,
"The protein synthesis machinery represents one of the most useful targets for the development of new anti-infectives. Several families of broadly used antibiotics (tetracyclines, macrolides, and novel glycopeptides like vancomycin, among others) exert their function by blocking the protein synthesis machinery. Doxicycline, a tetracycline antibiotic, remains a useful tool for the prevention of pal ...
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