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33 projets européens trouvés

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 TERMINÉ 

Breast CAncer STratification: understanding the determinants of risk and prognosis of molecular subtypes (B-CAST)

Date du début: 1 sept. 2015, Date de fin: 31 août 2020,

Breast tumours are heterogeneous, and result from the complex interplay of multiple lifestyle/environmental and genetic risk factors. Through the EU-funded COGS project, we have identified a large number of germline variants that influence the risk of breast cancer. In combination, these variants can identify women at wide ranges of genetic risk, even in the absence of family history of breast can ...
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 13

 TERMINÉ 

Phylogeography and somatic evolution of cancer tumor cells (PHYLOCANCER)

Date du début: 1 oct. 2014, Date de fin: 30 sept. 2019,

"By far, most evolutionary research has focused on the changes that occur in the germline of individuals across generations, within and between species. For different reasons, much less attention has been given to the process of change within the somatic line of a multicellular individual. The formation of cancer tumors due to uncontrolled cell proliferation is one of the most prominent forms of s ...
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 4

 TERMINÉ 

ELIXIR-EXCELERATE: Fast-track ELIXIR implementation and drive early user exploitation across the life-sciences. (ELIXIR-EXCELERATE)

Date du début: 1 sept. 2015, Date de fin: 31 août 2019,

The life sciences are undergoing a transformation. Modern experimental tools study the molecules, reactions, and organisation of life in unprecedented detail. The precipitous drop in costs for high-throughput biology has enabled European research laboratories to produce an ever-increasing amount of data. Life scientists are rapidly generating the most complex and heterogeneous datasets that scienc ...
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 47

 TERMINÉ 

Dynamics of human genome architecture in stable and transient gene expression changes (4D-GENOME)

Date du début: 1 juin 2014, Date de fin: 31 mai 2019,

The classical view of genomes as linear sequences has been replaced by a vision of nuclear organization that is both dynamic and complex, with chromosomes and genes non-randomly positioned in the nucleus. Process compartmentalization and spatial location of genes modulate the transcriptional output of the genomes. However, how the interplay between genome structure and gene regulation is establish ...
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 2

 TERMINÉ 

Multi-Scale Complex Genomics (MuG)

Date du début: 1 nov. 2015, Date de fin: 31 oct. 2018,

Genomics is probably the fastest evolving field in current science. A decade ago our main concern was to obtain the sequence (the 1D code) of the genome; but today the big challenges are to determine how genotype information is transferred into phenotype, and how pathological phenotypic changes can be predicted from genome alterations. While investigating these points, we have realized that a part ...
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 7

 TERMINÉ 

RD-CONNECT: An integrated platform connecting registries, biobanks and clinical bioinformatics for rare disease research (RD-CONNECT)

Date du début: 1 nov. 2012, Date de fin: 31 oct. 2018,

Despite examples of excellent practice, rare disease (RD) research is still mainly fragmented by data and disease types. Individual efforts have little interoperability and almost no systematic connection between detailed clinical and genetic information, biomaterial availability or research/trial datasets. By developing robust mechanisms and standards for linking and exploiting these data, RD-Con ...
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 30

 TERMINÉ 

Spatiotemporal regulation of epidermal stem cells by circadian rhythms: impact on homeostasis and aging (STEMCLOCK)

Date du début: 1 janv. 2013, Date de fin: 31 déc. 2017,

"Most adult stem cells are compartmentalized in functionally deterministic niches where they self-renew and maintain homeostasis. From there, stem cells are instructed by combinations of signals and spatial tensile forces which they translate into a specific behavior. However how stem cells spatiotemporally coordinate their stem cell potential with niche- and systemic cues is poorly understood. Th ...
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 3

 TERMINÉ 

BBMRI - Large Prospective Cohorts (BBMRI-LPC)

Date du début: 1 févr. 2013, Date de fin: 31 janv. 2017,

In recent years, biomedical research has crossed international borders in large, collaborative studies showing the value of multidisciplinarity and scale advantage. This has yielded valuable insights and some led to new and better medicines and treatments for diseases. However, disease-focused studies provide less insight in the real disease onset, the relative disease burden in the population, an ...
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 36

 TERMINÉ 

A BLUEPRINT of Haematopoietic Epigenomes (BLUEPRINT)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2016,

In response to the call for a high impact initiative on the human epigenome, the BLUEPRINT Consortium has been formed with the aim of generating at least 100 reference epigenomes and studying them to advance and exploit knowledge of the underlying biological processes and mechanisms in health and disease. BLUEPRINT will focus on distinct types of haematopoietic cells from healthy individuals and o ...
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 45

 TERMINÉ 

Wnt/beta-Catenin Signalling Pathway Controls Reprogramming: The Basis Of Regeneration In Higher Vertebrates (RERE)

Date du début: 1 janv. 2010, Date de fin: 31 déc. 2015,

Differentiation from zygotes in all cells of the body has been considered a unidirectional route. Recently, however, it has become clear that the inverse path is possible, as the reprogramming of somatic nuclei, i.e. the de-differentiation of somatic cells in pluripotent stem-like cells. To date, reprogramming has been induced in vitro by transferring somatic nuclei into enucleated oocytes, by fus ...
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 3

 TERMINÉ 

Infrastructure for Systems Biology - Europe (ISBE)

Date du début: 1 août 2012, Date de fin: 31 juil. 2015,

The Infrastructure for Systems Biology in Europe (ISBE) programme comprises an infrastructure that is designed to meet the needs of European systems biology, in terms of development, applications and training. In order to address this requirement, we are proposing a distributed, interconnected infrastructure which primarily comprises three types of centres: Data Integration Centres (DICs), and sys ...
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 24

 TERMINÉ 

European Sequencing and Genotyping Infrastructure (ESGI)

Date du début: 1 févr. 2011, Date de fin: 31 juil. 2015,

The objective of this project is the integration of world class high-throughput sequencing and genotyping facilities that will provide sequencing and genotyping technologies and data analysis methodologies to the scientific community.The European Sequencing and Genotyping Infrastructure (ESGI) will enable external users to generate data rapidly and to acquire knowledge efficiently. By providing ac ...
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 11

 TERMINÉ 

CRG International Interdisciplinary Postdoctoral Programme (InterPod)

Date du début: 1 mars 2010, Date de fin: 30 avr. 2015,

The current proposal aims at creating, at the Centre for Genomic Regulation (CRG), an International Interdisciplinary Postdoctoral Programme (InterPod) to train young scientists, in accordance with the objectives of the Marie Curie COFUND action. The goal of this new incoming mobility Programme is to provide highly talented postdocs with the opportunity to increase their trans-national mobility an ...
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 2

 TERMINÉ 

European Consortium for Communicating Stem Cell Research (EuroStemCell)

Date du début: 1 mars 2010, Date de fin: 28 févr. 2015,

The European Consortium for Communicating Stem Cell Research, EUROSTEMCELL, brings together the major current FP6 and FP7 stem cell projects, the European Clinical Research Infrastructure Network, and four internationally recognized European stem cell centres to develop a comprehensive, coordinated platform for collation, dissemination and archiving of information on stem cell biology and regenera ...
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 11

 TERMINÉ 

Quantitative understanding of a living system and its engineering as a cellular organelle (CellDoctor)

Date du début: 1 mars 2009, Date de fin: 28 févr. 2015,

The idea of harnessing living organisms for treating human diseases is not new but, so far, the majority of the living vectors used in human therapy are viruses which have the disadvantage of the limited number of genes and networks that can contain. Bacteria allow the cloning of complex networks and the possibility of making a large plethora of compounds, naturally or through careful redesign. On ...
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 2

 TERMINÉ 

Systems biology of Mycobacterium tuberculosis (SYSTEMTB)

Date du début: 1 avr. 2010, Date de fin: 30 sept. 2014,

Tuberculosis (TB) is a re-emerging global health threat caused by Mycobacterium tuberculosis (Mtb). One third of the world's population is infected with Mtb and new infections occur at a rate of one per second. Despite global research efforts, mechanisms underlying pathogenesis, virulence and persistence of Mtb infection remain poorly understood. Simple reductionist approaches are insufficient to ...
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 14

 TERMINÉ 

Engineering zinc fingers to target cancer hub genes (ZINC-HUBS)

Date du début: 1 oct. 2008, Date de fin: 30 sept. 2014,

"For the last ten years, protein engineering technologies have been developed to make zinc finger peptides to recognise a wide variety of user-defined DNA sequences. This has enabled the construction of synthetic transcription factors that can upregulate or repress target genes at will. More recently, synthetic zinc fingers have been linked to nucleases to direct double stranded breaks at desired ...
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 4

 TERMINÉ 

Communication of European Health Research (COMMHERE)

Date du début: 1 oct. 2011, Date de fin: 30 sept. 2014,

The overall aim of CommHERE is to improve communication on the outcome of EU funded health research projects to the media, the general public and other target groups including the EC in all of Europe.The CommHERE consortium comprises 10 partners, all research institutions active in the health research area. All partners are responsible for the coordination of EU-funded health research projects. Th ...
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 12

 TERMINÉ 

Euro-BioImaging - Research infrastructure for imaging technologies in biological and biomedical sciences (Euro-BioImaging)

Date du début: 1 déc. 2010, Date de fin: 31 mai 2014,

Euro-BioImaging brings together imaging technologies stretching from basic biological imaging with advanced light microscopy, in vivo molecular imaging of single cells to animal models up to the clinical and epidemiological level of medical imaging of humans and populations. Euro-BioImaging, in close consultation with its stakeholders, will address the imaging requirements of both biological and m ...
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 44

 TERMINÉ 

Genetic interaction networks: From C. elegans to human disease (2-HIT)

Date du début: 1 sept. 2008, Date de fin: 30 avr. 2014,

"Most hereditary diseases in humans are genetically complex, resulting from combinations of mutations in multiple genes. However synthetic interactions between genes are very difficult to identify in population studies because of a lack of statistical power and we fundamentally do not understand how mutations interact to produce phenotypes. C. elegans is a unique animal in which genetic interactio ...
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 2

 TERMINÉ 

Elaboration and refinement of sensorineural dendritic architecture (SENSORINEURAL)

Date du début: 1 sept. 2008, Date de fin: 28 févr. 2014,

"Vertebrate sensory perception and integration depend on the formation of ordered connections between sensory neurons and their target cells that occur along several steps: a- establishment of cellular identity, b- neuronal axon growth, arborization and dendritogenesis, c- somatodendritic contact and synaptic refinement. Although there is a wealth of information about the molecular mechanisms cont ...
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 3

 TERMINÉ 

Sharing capacity across Europe in high-throughput sequencing technology to explore genetic variation in health and disease (GEUVADIS)

Date du début: 1 oct. 2010, Date de fin: 31 déc. 2013,

"High-throughput next-generation DNA sequencing technologies allow investigators to sequence entire human genomes at an affordable price and within a short time frame. The correct interpretation, storage, and dissemination of the large amount of produced genomics data generate major challenges. Tackling these challenges requires extensive exchange of data, information and knowledge between medical ...
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 17

 TERMINÉ 

From Sequence to Consequence - Tools for the Exploitation of Livestock Genomes (Quantomics)

Date du début: 1 juin 2009, Date de fin: 30 nov. 2013,

QUANTOMICS will deliver a step-change in the availability of cutting edge technologies and tools for the economic exploitation of livestock genomes. We will provide the tools to identify rapidly the causative DNA variation underpinning sustainability in livestock and for industry to exploit high-density genomic information. Our adaptable quantitative and genomic tools each based on cutting-edge te ...
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 18

 TERMINÉ 

In Vivo Imaging of Beta cell Receptors by Applied Nano Technology (VIBRANT)

Date du début: 1 juil. 2009, Date de fin: 30 juin 2013,

Currently, around 30 million people in the enlarged Europe suffer from diabetes, with a prevalence of 7.5% in member states. In recent years the emergence of type 2 diabetes in children and adolescents is a new and serious health challenge to the youth of Europe, their families and society. By 2025, the number of people with diabetes is expected to rise to around 50 million in Europe, thus increas ...
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 11

 TERMINÉ 

PROteomics SPECification in Time and Space (PROSPECTS)

Date du début: 1 avr. 2008, Date de fin: 31 mars 2013,

"Proteomics is a major new field in biomedical research, which deals with the large-scale identification and characterization of large groups of proteins, or “proteomes”. These can either be the components of a subcellular organelle or compartment, or even the entire protein complement of whole cells and tissues. Proteomics is essential in the functional annotation of the genome and in future atte ...
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 11

 TERMINÉ 

Eukaryotic unicellular organism biology – systems biology of the control of cell growth and proliferation (UNICELLSYS)

Date du début: 1 avr. 2008, Date de fin: 31 mars 2013,

The overall objective of UNICELLSYS is a quantitative understanding of fundamental characteristics of eukaryotic unicellular organism biology: how cell growth and proliferation are controlled and coordinated by extracellular and intrinsic stimuli. Achieving an understanding of the principles with which bio-molecular systems function requires integrating quantitative experimentation with simulation ...
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 20

 TERMINÉ 

MicroRNAs and Cancer: From Bench to Bedside (ONCOMIRS)

Date du début: 1 févr. 2008, Date de fin: 31 janv. 2013,

"Although studies addressing their role in cancer pathogenesis are at an early stage, it is apparent that specific microRNAs (miRs) and molecules involved in their biogenesis contribute to tumorigenesis. The ONCOMIRS consortium proposes a natural succession of four experimental strategies. Fist, we will DISCOVER and unveil novel miRs and components of their biogenesis machinery and investigate lin ...
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 8

 TERMINÉ 

Unraveling the mechanisms of odor coding and sent-tracking in Drosophila larvae (MnemoSmell)

Date du début: 1 sept. 2008, Date de fin: 31 août 2012,

To survive and prosper, any motile organism must extract relevant cues from its external environment and convert them into coherent internal representations. Responses elicited by the flow of internal representations form the basis of adaptive behaviours. The overall goal of this project is to elucidate how olfactory signalling and behavioural decisions emerge from the integration of molecular and ...
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 2

 TERMINÉ 

Targeting the Leishmania kinome for the development of novel anti-parasitic strategies (LEISHDRUG)

Date du début: 1 oct. 2008, Date de fin: 31 mars 2012,

"Visceral leishmaniasis is caused by the protozoan parasites Leishmania donovani and Leishmania infantum and is a potentially fatal disease in endemic areas around the world. During the infectious cycle, Leishmania alternate between the insect promastigote stage and the vertebrate aflagellate amastigote stage that proliferates inside infected host macrophages provoking the pathology of the disease ...
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 13

 TERMINÉ 

Regulation of epidermal stem cells by a molecular clock during tissue homeostasis and cancer (EpistemCLOCK)

Date du début: 1 avr. 2010, Date de fin: 31 mars 2012,

Most adult tissues contain a reservoir of adult stem cells that maintain homeostasis. Loss of stem cell function can lead to severe tissue dysfunction, accelerated aging, and cancer. We study epidermal stem cells (epSCs) as a model of adult stem cell function. In steady state conditions, epSCs express high levels of ¨molecular breaks¨ that make them refractory to activating stimuli, remaining quie ...
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 2

 TERMINÉ 

High throughput molecular diagnostics in individual patients for genetic diseases with heterogeneous clinical presentation (TECHGENE)

Date du début: 1 févr. 2009, Date de fin: 31 janv. 2012,

"Since the sequencing of the human genome has been completed the demand for genetic analysis in the human health care system is drastically increasing, and the extension of molecular genetic diagnostics is urgently needed. However, the majority of genetic diseases is molecularly and clinically highly heterogeneous, and until recently the available techniques lacked the required capacity to analyze ...
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 12

 TERMINÉ 

Establishment and refinement of sensory innervation in the lateral-line system of the zebrafish (Sensory innervation)

Date du début: 1 mai 2009, Date de fin: 30 avr. 2011,

The establishment of sensory-organ innervation is crucial for behaviour, social interactions and survival. Neuronal arborisation is dictated by signals that guide neurites to their appropriate targets in combination with the spatial distribution of the target cells. To date, most emphasis has been placed on the genetic bases of neuronal-type specification and organ formation during embryonic devel ...
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 2

 TERMINÉ 

The evolution of genetic robustness (2B-Robust)

Date du début: 1 mars 2008, Date de fin: 28 févr. 2010,

Most genes are not required for viability. This robustness to mutation is a fundamental property of complex biological systems but the mechanism(s) underlying it and how it evolves is unclear. It has been proposed that robustness can result from genetic redundancy through gene duplication and the distributed nature of biological networks. The robustness of both yeast and C. elegans has been dissec ...
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 2