24 projets européens trouvés
Recherche sur 125080 projets européens
TERMINÉ
Breast CAncer STratification: understanding the determinants of risk and prognosis of molecular subtypes (B-CAST)
Date du début: 1 sept. 2015, Date de fin: 31 août 2020,
Breast tumours are heterogeneous, and result from the complex interplay of multiple lifestyle/environmental and genetic risk factors. Through the EU-funded COGS project, we have identified a large number of germline variants that influence the risk of breast cancer. In combination, these variants can identify women at wide ranges of genetic risk, even in the absence of family history of breast can ...
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13
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TERMINÉ
Phylogeography and somatic evolution of cancer tumor cells (PHYLOCANCER)
Date du début: 1 oct. 2014, Date de fin: 30 sept. 2019,
"By far, most evolutionary research has focused on the changes that occur in the germline of individuals across generations, within and between species. For different reasons, much less attention has been given to the process of change within the somatic line of a multicellular individual. The formation of cancer tumors due to uncontrolled cell proliferation is one of the most prominent forms of s ...
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4
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TERMINÉ
Dynamics of human genome architecture in stable and transient gene expression changes (4D-GENOME)
Date du début: 1 juin 2014, Date de fin: 31 mai 2019,
The classical view of genomes as linear sequences has been replaced by a vision of nuclear organization that is both dynamic and complex, with chromosomes and genes non-randomly positioned in the nucleus. Process compartmentalization and spatial location of genes modulate the transcriptional output of the genomes. However, how the interplay between genome structure and gene regulation is establish ...
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2
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TERMINÉ
RD-CONNECT: An integrated platform connecting registries, biobanks and clinical bioinformatics for rare disease research (RD-CONNECT)
Date du début: 1 nov. 2012, Date de fin: 31 oct. 2018,
Despite examples of excellent practice, rare disease (RD) research is still mainly fragmented by data and disease types. Individual efforts have little interoperability and almost no systematic connection between detailed clinical and genetic information, biomaterial availability or research/trial datasets. By developing robust mechanisms and standards for linking and exploiting these data, RD-Con ...
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30
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TERMINÉ
Health and Environment-wide Associations based on Large population Surveys (HEALS)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2018,
Assessing individual exposure to environmental stressors and predicting health outcomes implies that both environmental exposures and epi/genetic variations are reliably measured simultaneously. HEALS (Health and Environment-wide Associations based on Large population Surveys) brings together in an innovative approach a comprehensive array of novel technologies, data analysis and modeling tools th ...
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37
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TERMINÉ
MULTISCALE APPROACH TO THE IDENTIFICATION OF MOLECULAR BIOMARKERS IN ACUTE HEART FAILURE INDUCED BY SHOCK (Shockomics)
Date du début: 1 oct. 2013, Date de fin: 30 sept. 2017,
The management of cardiovascular stability in shock patients is of paramount importance in critical care. New, cutting edge knowledge is necessary to overcome the shortcomings of available therapies, in order to cope with the challenges that anesthesiologists, intensive care specialists and emergency physicians face when dealing with shock patients.Current therapies are targeted to reduce symptoms ...
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11
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TERMINÉ
BBMRI - Large Prospective Cohorts (BBMRI-LPC)
Date du début: 1 févr. 2013, Date de fin: 31 janv. 2017,
In recent years, biomedical research has crossed international borders in large, collaborative studies showing the value of multidisciplinarity and scale advantage. This has yielded valuable insights and some led to new and better medicines and treatments for diseases. However, disease-focused studies provide less insight in the real disease onset, the relative disease burden in the population, an ...
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36
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TERMINÉ
A BLUEPRINT of Haematopoietic Epigenomes (BLUEPRINT)
Date du début: 1 oct. 2011, Date de fin: 30 sept. 2016,
In response to the call for a high impact initiative on the human epigenome, the BLUEPRINT Consortium has been formed with the aim of generating at least 100 reference epigenomes and studying them to advance and exploit knowledge of the underlying biological processes and mechanisms in health and disease. BLUEPRINT will focus on distinct types of haematopoietic cells from healthy individuals and o ...
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45
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TERMINÉ
Airway Disease PRedicting Outcomes through Patient Specific Computational Modelling (AirPROM)
Date du début: 1 mars 2011, Date de fin: 30 juin 2016,
The airways diseases asthma and chronic obstructive pulmonary disease affect over 400 million people world-wide and cause considerable morbidity and mortality. Airways disease costs the European Union in excess of €56 billion per annum. Current therapies are inadequate and we do not have sufficient tools to predict disease progression or response to current or future therapies. Our consortium, Air ...
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40
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TERMINÉ
European Sequencing and Genotyping Infrastructure (ESGI)
Date du début: 1 févr. 2011, Date de fin: 31 juil. 2015,
The objective of this project is the integration of world class high-throughput sequencing and genotyping facilities that will provide sequencing and genotyping technologies and data analysis methodologies to the scientific community.The European Sequencing and Genotyping Infrastructure (ESGI) will enable external users to generate data rapidly and to acquire knowledge efficiently. By providing ac ...
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11
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TERMINÉ
European Infrastructure of Open Screening Platforms for Chemical Biology (EU-OPENSCREEN)
Date du début: 1 nov. 2010, Date de fin: 30 avr. 2015,
The EU-OPENSCREEN Preparatory Phase forms the basis for the construction and operation of a pan-European infrastructure of open screening platforms for Chemical Biology. EU-OPENSCREEN will bring together leading laboratories from 14 European countries covering all aspects of Chemical Biology from high-throughput screening with a dedicated compound library to assay development, chemical synthesis f ...
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24
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TERMINÉ
Monitoring public opinion on Nanotechnology in Europe (NANOPINION)
Date du début: 1 mai 2012, Date de fin: 31 oct. 2014,
NANOPINION will provide a multi-tasking and enlivening online science-technology-social media-based platform for learning, information, outreach, dialogue and monitoring for young people, general public and consumer opinion on NT, realising the need for enhanced communication and dialogue between science and society for successful technology development and societal acceptance. A central dialogue ...
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20
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TERMINÉ
Sharing capacity across Europe in high-throughput sequencing technology to explore genetic variation in health and disease (GEUVADIS)
Date du début: 1 oct. 2010, Date de fin: 31 déc. 2013,
"High-throughput next-generation DNA sequencing technologies allow investigators to sequence entire human genomes at an affordable price and within a short time frame. The correct interpretation, storage, and dissemination of the large amount of produced genomics data generate major challenges. Tackling these challenges requires extensive exchange of data, information and knowledge between medical ...
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17
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TERMINÉ
Membrane Enhanced Tide Synthesis - A New Paradigm Peptide / Oligonucleotide Synthesis Technology (MEMTIDE)
Date du début: 1 déc. 2009, Date de fin: 30 nov. 2013,
"The MemTide Initial Training Network will create a new generation of synthesis technologies for peptide and oligonucleotide (“tide”) manufacture, with focus on the use of emerging membrane technology to effect critical separations. New nanofiltration membranes with improved chemical stability, and closely controlled molecular discrimination properties, will be developed. Novel synthesis strategie ...
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7
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TERMINÉ
Finding biomarkers of anti-microbial drug resistance via a systems biology analysis of fungal pathogen interactions with the human immune system (SYBARIS)
Date du début: 1 nov. 2009, Date de fin: 30 avr. 2013,
We propose a systems biology study of the specificity of response of the cell-mediated immune system to fungal microorganisms in order to investigate the genetic basis of susceptibility to fungal disease and elucidate molecular mechanisms of drug resistance in fungal pathogens. An integrative approach, combining high-throughput and traditional wet-lab work with computational and bioinformatics met ...
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9
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TERMINÉ
REvolutionary Approaches and Devices for Nucleic Acid Analysis (READNA)
Date du début: 1 juin 2008, Date de fin: 30 nov. 2012,
"The REvolutionary Approaches and Devices for Nucleic Acid analysis – READNA – consortium is composed of researchers from 10 academic institutions, 5 SMEs and 3 large companies. The goals of the READNA consortium are to revolutionize nucleic acid analysis methods, by 1) improving elements necessary to use the currently emerging generation of nucleic acid sequencers in a meaningful and accessible w ...
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20
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TERMINÉ
A European gateway to the science and research of health, through online and offline innovative activities aimed at citizens, patients, pupils and teachers (Xplore Health)
Date du début: 1 janv. 2010, Date de fin: 31 août 2012,
Xplore Health is a joint initiative to build and promote an online and offline interactive environment – with multimedia tools and attending activities – that will nurture active engagement of society with state-of-the-art science and research around health and its wider ethical, legal and social aspects (ELSA) by facilitating an effective dissemination of attractive, accessible and rigorous resou ...
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5
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TERMINÉ
Targeting Protein Synthesis in the Apicoplast and Cytoplasm of Plasmodium (MEPHITIS)
Date du début: 1 janv. 2009, Date de fin: 30 juin 2012,
"The protein synthesis machinery represents one of the most useful targets for the development of new anti-infectives. Several families of broadly used antibiotics (tetracyclines, macrolides, and novel glycopeptides like vancomycin, among others) exert their function by blocking the protein synthesis machinery. Doxicycline, a tetracycline antibiotic, remains a useful tool for the prevention of pal ...
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9
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TERMINÉ
IT Future of Medicine (ITFoM)
Date du début: 1 mai 2011, Date de fin: 30 avr. 2012,
Data-rich, individualised medicine poses unprecedented challenges for IT, in hardware, storage and communication. We propose a data-driven, individualised medicine of the future, based on molecular/physiological/anatomical data from individual patients. We shall make general models of human pathways, tissues, diseases and ultimately of the human as a whole. Individualised versions of the models, ...
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25
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TERMINÉ
Markers for emphysema versus airway disease in COPD (EvA)
Date du début: 1 oct. 2008, Date de fin: 31 mars 2012,
COPD is characterized by emphysema (destruction of the lung alveoli) and airway disease (inflammation and thickening of the bronchial wall) both of which lead to airway obstruction. These two features co-exist in most patients but some patients present with only emphysema (E) or only airway disease (A). The aim of the project is to identify markers specific to E and A of COPD. Our hypothesis is th ...
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15
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TERMINÉ
Coopération transnationale pour l'innovation technologique dans le développement de molécules pour le traitement de l'obésité et du diabète (DIOMED)
Date du début: 31 mars 2009, Date de fin: 30 mars 2012,
DIOMED pretende contribuir a hacer frente a las barreras que limitan el desarrollo del sector biomédico en la zona SUDOE. El proyecto impulsará la transferencia de conocimiento e innovaciones de la universidad a la empresa lo que ayudará a acortar el tiempo para lograr la convergencia con el resto de Europa en cuanto a impacto económico y creación de empleo en sectores sector de ciencias de la vid ...
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6
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TERMINÉ
Communicating NANOtechnology to European YOUth (NANOYOU)
Date du début: 1 avr. 2009, Date de fin: 30 juin 2011,
NANOYOU will design and undertake a communication and outreach program in nanotechnology (NT) aimed at European youth. The project will reach 11-18 year olds through school programs to take place in at least 20 EU Member States and Associated States. Additional programs aimed at young adults aged 19-25 will be offered in science centres. The school programs are planned to involve at least 400 scho ...
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9
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TERMINÉ
European network of regional projects for school partnerships on climate change research (CARBOSCHOOLS+)
Date du début: 1 janv. 2008, Date de fin: 31 déc. 2010,
CarboSchools+ proposes to link carbon science laboratories with secondary schools to develop partnerships where young Europeans learn and conduct experiments about climate research and reduction of greenhouse gas emissions. In partnership projects, scientists and teachers co-operate over several months to give young people a practical experience of research through real-time experiments, site visi ...
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11
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TERMINÉ
Best Practices for IPR and Technology Transfer in Nanotechnology Developments (Nano2Market)
Date du début: 1 juil. 2009, Date de fin: 31 août 2010,
The lack of models for technology transfer at nanotechnology developments is of increasing concern for the sector. This CSA will fulfil this gap providing guidelines for technology transfer and rules for IPR and license agreements in nanotechnology developments. To achieve these objectives, a consortium is formed by: 1) Key European research centres in different areas of nano and converging techno ...
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