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38 projets européens trouvés

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 TERMINÉ 

A Unified Approach to Evaluating Cellular Immunotherapy in Solid Organ Transplantation (THE ONE STUDY)

Date du début: 1 nov. 2010, Date de fin: 31 oct. 2017,

Preventing immunological rejection of transplanted organs without the need for long-term use of pharmacological immunosuppression is a primary objective in transplantation medicine. Reducing the need for immunosuppression would dramatically improve the outcome for transplant recipients and reduce health costs for society. The means to achieve this goal has not been realised with pharmacological or ...
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 16

 TERMINÉ 

Imaging liver immunopathology by intravital microscopy (IVM): a new approach to study the pathogenesis of hepatitis B virus (HBV) infection (Liver IVM and HBV)

Date du début: 1 sept. 2010, Date de fin: 31 mars 2016,

Overall objective and Specific Aims. The overall objective of this proposal is to elucidate the pathogenesis ofHBV infection with the ultimate hope that this knowledge will lead to the development of new therapeuticstrategies to terminate persistent infection and its attendant costs and complications. Our approach is to dissectpoorly understood cellular and molecular pathways responsible for both ...
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 2

 TERMINÉ 

Towards Safe and Effective Hematopoietic Stem Cell Gene Therapy: Targeting Integration to Genomic Safe Harbors and Exploiting Endogenous microRNA to Regulate Transgene Expression (TARGETINGGENETHERAPY)

Date du début: 1 mai 2010, Date de fin: 31 janv. 2016,

Hematopoietic stem cell gene therapy has a tremendous potential to treat human disease. Yet, in conjunction with the first successful results in the clinic, severe adverse events linked to the gene transfer protocol were reported. Recently, we provided proof-of-principle of two new powerful strategies to improve the efficacy and safety of gene transfer: 1) regulating transgene expression by exploi ...
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 3

 TERMINÉ 

Beta Cell Therapy in Diabetes (BETACELLTHERAPY)

Date du début: 1 janv. 2010, Date de fin: 30 juin 2015,

Type 1 diabetes is a serious chronic disease with major health risks and heavy burden on patients and society. It is caused by massive immune-mediated loss of insulin-producing beta cells in the pancreas that can so far not be locally corrected. A cellular allotransplant in the liver can install a new beta cell mass but the size is insufficient and the procedure faces limitations of donor shortage ...
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 18

 TERMINÉ 

Combined Highly Active Anti-retroviral Microbicides (CHAARM)

Date du début: 1 janv. 2010, Date de fin: 30 juin 2015,

This proposal is for a large scale collaborative project in which we propose both to develop novel microbicides directed against new intracellular targets and to investigate novel combinations of highly active anti-retroviral drugs which may be particularly effective as microbicides. Combinations may enhance efficacy but equally importantly will increase the genetic barrier to the development of r ...
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 34

 TERMINÉ 

Effect of PTPN22 on Treg to Teff equilibrium in human and murine autoimmune diabetes (PTPN22 in T1D)

Date du début: 1 avr. 2011, Date de fin: 31 mars 2015,

"Type 1 diabetes (T1D) is a chronic inflammatory disease, where predisposing genetic factors along with environmental influences result in loss of immunological tolerance and destruction of insulin-producing beta cells. Genetic studies have identified three main T1D susceptibility loci, the human leukocyte antigens (HLA), insulin and most recently PTPN22, which encodes for Lyp/Pep, a lymphoid tyro ...
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 2

 TERMINÉ 

EUROCANCER STEMCELL TRAINING NETWORK (EuroCSCTraining)

Date du début: 1 janv. 2011, Date de fin: 31 déc. 2014,

The recent identification of tumor initiating (TIC) or cancer stem cells (CSC) has opened a new area of research for scientists interested in cancer. Understanding the biology of cancer stem cells has already unraveled pathways and potential targets. However, accumulating data has underscored the complexity of the CSC research area and prompts hence the need for well-structured networks to provid ...
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 11

 TERMINÉ 

Intelligent Surgical Robotics (I-SUR)

Date du début: 1 mars 2011, Date de fin: 31 déc. 2014,

Description I-SUR will develop advanced technologies for automation in minimally invasive and open surgery. Currently, automation is not used in the operating room for a number of technical and legal reasons, but it may provide a solution to improve performance and efficiency without increasing operating costs. I-SUR aims at breaking new gro ...
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 9

 TERMINÉ 

Activation of vasculature associated stem cells and muscle stem cells for the repair and maintenance of muscle tissue (Endostem)

Date du début: 1 janv. 2010, Date de fin: 31 déc. 2014,

We propose to develop new strategies to mobilize skeletal muscle tissue-associated stem cells as a tool for efficient tissue repair. This will be combined with exploring novel approaches that limit tissue damage, and will focus on agents that modify muscle and muscle vasculature progenitor cells. These molecules include nitric oxide associated with non-steroidal anti-inflammatory drugs, HMGB1, Cri ...
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 22

 TERMINÉ 

Tie2-expressing monocytes: Role in tumor angiogenesis and therapeutic targeting (Tie2+Monocytes)

Date du début: 1 nov. 2009, Date de fin: 31 oct. 2014,

Recent data indicated that tumor-infiltrating myeloid cells promote tumor angiogenesis. We contributed to this concept by showing that Tie2-expressing monocytes (TEMs) have a requisite role in this process. Indeed, the specific elimination of TEMs inhibits tumor angiogenesis and growth in several models. Yet, little is known of the biological bases of TEMs activity in tumors. Building upon my prev ...
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 2

 TERMINÉ 

Adaptive Strategies for Sustainable Long-Term Social Interaction (ALIZ-E)

Date du début: 1 mars 2010, Date de fin: 31 août 2014,

Description From theory to practice: Methods for an adaptive and prolonged child-robot interaction The goal of ALIZ-E is to develop novel methods for developing and testing interactive, mobile robots which will be able to socially interact with human users over extended periods of time, i.e. a pos ...
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 12

 TERMINÉ 

Aberrant gene expression and muscular dystrophy: role of non-coding RNAs and alternative splicing in the pathogenesis and potential therapies (NCRNAS-SPLICING-FSHD)

Date du début: 1 sept. 2008, Date de fin: 31 août 2014,

Our goal is to characterize the molecular pathogenesis of facioscapulohumeral muscular dystrophy (FSHD) in order to develop possible therapeutic approaches. FSHD is the third most important myopathy. Currently, no therapeutic treatment is available for FSHD. Unlike the majority of genetic diseases, FSHD is not caused by mutation in a protein-coding gene. Instead, FSHD is the result of a complex ep ...
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 2

 TERMINÉ 

Targeting the tumour microenvironment to improve pancreatic cancer prognosis (EPC-TM-Net)

Date du début: 1 févr. 2011, Date de fin: 31 juil. 2014,

Pancreatic cancer is one of the most lethal human cancers with a five-year survival rate of less than 5%. Late presentation and a high level of resistance to chemotherapeutic drugs are among the major reasons for this dismal prognosis. The presence of the highest degree of desmoplasia among all solid tumours and the fact that chronic inflammatory pancreatic disease is associated with an increased ...
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 17

 TERMINÉ 

Immunomodulatory Effects of Exercise in Type 1 Diabetes (IMMEEDIA)

Date du début: 1 juil. 2010, Date de fin: 30 juin 2014,

"Diabetes is a major metabolic disease with huge costs for healthcare system throughout the EU and worldwide. Type 1 Diabetes (T1DM) is a chronic condition in which pancreas produces little or no insulin, believed to result from a disorder of immunoregulation. For decades it has been known that regular aerobic exercise improves insulin sensitivity in diabetic patients, reducing insulin requirement ...
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 5

 TERMINÉ 

Role of secretases in myelination (Secretases & Myelin)

Date du début: 1 mai 2010, Date de fin: 30 avr. 2014,

The development of glial cells, oligodendrocytes (OL) in CNS and Schwann cells (SC) in PNS, critically depends on axonal contact. Gliogenesis and the phenotype of myelinating glia are regulated by axons. Glial cells promote neuronal survival, regulate the organization of myelinated axons and promote axonal differentiation and myelin sheath production.We recently showed that type III NRG1, a member ...
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 2

 TERMINÉ 

Quantifying transcription factor search mechanism by three-dimensional single molecule tracking (SMT of TFs)

Date du début: 16 avr. 2012, Date de fin: 15 avr. 2014,

Transcription factors (TFs) are capable to identify their target sites on DNA in a extremely efficient fashion. The observation that a simple 3D diffusion search cannot account for such efficient targeting has led to different mechanisms to be proposed in the last decades, including compact exploration induced by facilitated diffusion (i.e. combination of 1D sliding and 3D diffusion) or by fracta ...
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 2

 TERMINÉ 

Novel strategies for the cell therapy of muscular dystrophies (Stem cells for DMD)

Date du début: 1 mars 2009, Date de fin: 28 févr. 2014,

This project aims to develop an effective cell therapy for Duchenne Muscular Dystrophy (DMD). To reach this goal we plan to transfer a human artificial chromosome containing the whole dystrophin locus into dystrophic mesoangioblasts. As the transfer is inefficient and requires selection, it is impossible to use primary cells that would undergo senescence during selection. Therefore we need to rev ...
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 3

 TERMINÉ 

Optimization of stem cell therapy for clinical trials of degenerative skin and muscle diseases (OptiStem)

Date du début: 1 janv. 2009, Date de fin: 31 déc. 2013,

This proposal aims to develop and implement efficacy of clinical trials with adult, tissue stem cells for degenerative diseases of epithelia and skeletal muscle. Extraordinary progress in the understanding of several key features of stem cells has been rapidly translated into novel cell therapy protocols that have yielded positive results in pre-clinical models of genetic and acquired diseases and ...
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 20

 TERMINÉ 

Advanced Teaching and TRaining for Adoptive Cell Therapy (ATTRACT)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2013,

Considerable resources are devoted to fighting cancer throughout Europe, yet these efforts are not producing the results that health practitioners and citizens might expect. This is partly due to the fragmentation and duplication of research efforts within Member states and the lack of co-ordination at European level. However it can also be attributed to the need to retain and most importantly dev ...
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 16

 TERMINÉ 

Novel therapeutic antibodies for multiple myeloma (MMSC)

Date du début: 1 oct. 2009, Date de fin: 30 sept. 2013,

"Multiple Myeloma (MM) is an incurable plasma cell neoplasm with a median survival of 3 years. A critical step towards the development of more effective therapies is the identification of dominantly acting oncogenes. We have implemented an integrated oncogenomic approach that utilizes high-resolution gene-specific array-CGH and comprehensive expression profiling to identify the spectrum of geneti ...
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 2

 TERMINÉ 

Leukemic Stem Cells in Chronic Lymphocytic Leukemia (LSC CLL)

Date du début: 1 oct. 2010, Date de fin: 30 sept. 2013,

"B cell Chronic Lymphocytic Leukemia (CLL) is the most common leukemia in western countries. Although substantial therapeutic improvements have been obtained, the disease is incurable and causes 4000 deaths/year in the sole USA.We plan to in vivo evaluate CLL B cells division by measuring Deuterium (2H) incorporation into newly synthesized DNA. 2H given to patients in the form of deuterated water ...
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 1

 TERMINÉ 

Linking research organisations in the fields of Tissue Engineering and Regenerative Medicine through European cooperation between regional research clusters (TERM)

Date du début: 1 oct. 2010, Date de fin: 30 sept. 2013,

"The development of innovative 'Advanced Therapies' offers new approaches to tackle major diseases such as cancer, diabetes, Alzheimer or Parkinson. The progress made in the fields of 'Tissue Engineering' and 'Regenerative Medicine' (TERM) promises to deliver long awaited new solutions. They are recognized as potential sources for medical progress and significant economic growth where Europe shoul ...
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 16

 TERMINÉ 

Therapeutic challenge in Leukodystrophies: Translational and ethical research towards clinical trials (LEUKOTREAT)

Date du début: 1 mars 2010, Date de fin: 31 août 2013,

Leukodystrophies (LDs) are inherited rare neurodegenerative diseases of the white matter and its main component, the myelin, that are affecting predominantly children. Severity of the disease is related to the axonal dysfunction due to myelin deficiency or destruction. Despite the achievement of remarkable advances made in the past decade, there is no current curative therapy. The development of t ...
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 25

 TERMINÉ 

"Early diagnosis, treatment and prevention of mood disorders targetting the activated inflammatory response system" (MOODINFLAME)

Date du début: 1 nov. 2008, Date de fin: 30 avr. 2013,

"Partners come from 10 European countries to achieve two main objectives: A) The further exploration of 3 animal models (the OBX rat, GS rat and NOD mouse) characterized by an activated immune response system (IRS), an abnormal tryptophan catabolism and a depressive-like behaviour to study the pathogenesis of inflammation-related mood disorders and the efficacy/working mechanism of anti-inflammat ...
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 21

 TERMINÉ 

Patient Safety in Robotic Surgery (SAFROS)

Date du début: 1 avr. 2010, Date de fin: 31 mars 2013,

This proposal addresses the development of technologies for patient safety in robotic surgery. We define patient safety metrics for surgical procedures and then develop methods that abide by safety requirements, formulated in terms of our metrics. We aim at demonstrating that a properly controlled robotic surgery carried out in accordance to our safety criteria can improve the level of patient saf ...
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 12

 TERMINÉ 

Role of angiogenesis in leukemia (leukemia and VEGF)

Date du début: 1 janv. 2009, Date de fin: 31 déc. 2012,

Our interest is to understand the role of VEGF expression and angiogenesis in leukemogenesis. Recently, emerging data is suggesting that in addition to promoting the growth and metastatic spread of solid tumors, angiogenesis may play an important role also in the pathophysiology of hematological malignancies. Clinical studies indicate that leukemia patients express high levels of pro-angiogenic fa ...
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 2

 TERMINÉ 

Angiogenesis-inducing Bioactive and Bioresponsive Scaffolds in Tissue Enginering (AngioScaff)

Date du début: 1 déc. 2008, Date de fin: 30 nov. 2012,

Angiogenesis underlies almost all biological processes of morphogenesis, including those in tissue repair and regeneration. Physiological angiogenesis is controlled by a complex interplay between cells and their environment: the extracellular matrix (ECM) provides signaling via numerous ECM adhesion molecules and growth factors bound to ECM polysaccharide components; and cells locally degrade and ...
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 33

 TERMINÉ 

European Consortium for Systematic Stem Cell Biology (EUROSYSTEM)

Date du début: 1 mars 2008, Date de fin: 31 août 2012,

EuroSyStem brings together elite European research teams to create a unique and world-leading programme in fundamental stem cell biology. By interconnecting complementary biological and computational expertise we will drive the generation of new knowledge on the characteristics of normal and abnormal stem cells. We will pave the way for application of systems methodology by measuring and modelling ...
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 25

 TERMINÉ 

Next Generation HIV-1 Immunogens inducing broadly reactive Neutralising antibodies (NGIN)

Date du début: 1 févr. 2008, Date de fin: 31 juil. 2012,

"The elicitation of broadly neutralising antibodies (Nab) remains the primary and most challenging goal in HIV-1 vaccine development. Although a few anti-HIV-1 monoclonal antibodies with broadly neutralising capability have been isolated from infected individuals, none of the immunization strategies thus far explored has proven effective in inducing similar antibodies. Objective of this applicatio ...
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 18

 TERMINÉ 

European Network for the Study of Orphan Nephropathies (EUNEFRON)

Date du début: 1 mai 2008, Date de fin: 30 avr. 2012,

"In this proposal, we have mobilized a critical mass of expertise to investigate, on a Europe-wide scale, the natural history and pathophysiology of rare inherited diseases affecting important structures of the kidney. The project will use and develop multiple models (in vitro and in vivo) with the aim to develop preventive, diagnostic and therapeutic interventions that should alleviate the burden ...
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 10

 TERMINÉ 

Neuron-Glia Interactions in Nerve Development and Disease (NGIDD)

Date du début: 1 avr. 2008, Date de fin: 31 mars 2012,

"The characteristic appearance of white matter in the nervous system results from a remarkable cellular structure called myelin. This membraneous sheath is wrapped around axons by dedicated glial cells, thereby allowing the rapid propagation of impulses along the axons. The importance of the myelin sheath is underscored by the many neurological diseases that are caused by loss or destabilization o ...
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 8

 TERMINÉ 

Roles of Homeoproteins in Lymphoid Organ Development (HinLOD)

Date du début: 3 sept. 2007, Date de fin: 2 sept. 2011,

Lymphoid organ development results from a complex interplay of genetically controlled molecular and cellular networks. While most of the molecular mechanisms underlying lymphoid organogenesis remain unknown, recent findings demonstrate that homeodomain transcription factors are essential to these processes. One such homeoprotein is Pbx1 that binds DNA with a subset of Hox proteins, including the H ...
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 1

 TERMINÉ 

"DIAbetes type 1 PRediction, Early Pathogenesis and Prevention" (DIAPREPP)

Date du début: 1 avr. 2008, Date de fin: 31 août 2011,

"The earliest currently identifiable process in the pathogenesis of type 1 diabetes (T1D) is the development of autoimmunity to islet beta cells in the form of autoantibodies. Hindering attempts to prevent autoimmune T1D, the aetiology and pathogenesis of the islet auto-immunization, including whether it is preceded by metabolic abnormalities and cell-mediated autoimmunity, is still poorly underst ...
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 12

 TERMINÉ 

Point-Of-Care MONitoring and DIagnostics for Autoimmune Diseases (POCEMON)

Date du début: 1 janv. 2008, Date de fin: 31 août 2011,

The POCEMON project aims to the hardware and software development of a multi-purpose autoimmune diseases diagnostic platform by combining Lab-on-Chip (LOC) technologies, genomic microarrays of HLA (human leukocyte antigens) typing, microelectronics, mobile devices, intelligent algorithms and wireless communications. The multi-purpose platform will be provided as a portable integrated platform with ...
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 20

 TERMINÉ 

A new platform for fast molecular detection of MDR and XDR resistant strains of M. tuberculosis and of drug resistant malaria (TM-REST)

Date du début: 1 janv. 2008, Date de fin: 30 juin 2011,

"Recent developments in molecular tools combined with updated epidemiological data provide novel challenges to the development of modern molecular diagnostics. The increasing threat of infections due to Mycobacterium tuberculosis, including multidrug-resistant (MDR) and extensively drug-resistant (XDR) infections poses important questions that call for development of integrated tools for rapid dia ...
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 9

 TERMINÉ 

Managing Assurance, Security and Trust for sERvices (MASTER)

Date du début: 1 févr. 2008, Date de fin: 31 janv. 2011,

The business of the future will be characterized by highly dynamic service-oriented architectures where outsourcing and distributed management constitute the norm rather than the exception with an increasing complexity in security and trust requirements from regulations and business standards. Best-effort security will no longer be accepted and business entities will have to provide certified ass ...
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 15

 TERMINÉ 

Prevention of Diseases (Preve)

Date du début: 1 déc. 2009, Date de fin: 30 nov. 2010,

PREVE is a Support Action identifying ICT research directions for disease prevention. The proposal focuses on primary prevention, because the market for PHS based services in secondary prevention is already emerging. Also, the focus will be on the ways and means by which an individual can be a producer of health with the support of health professionals (when needed). The work will be guided by a t ...
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 4

 TERMINÉ 

Assessment of cognitive dysfunction in Multiple Sclerosis using the simultaneous acquisition of event-related potentials and functional magnetic resonance imaging during executive tasks (MS, fMRI, ERP)

Date du début: 1 juil. 2008, Date de fin: 30 juin 2010,

Multiple Sclerosis (MS) is one the most important neurological diseases by virtue of its frequency, chronicity and tendency to attack young adults. Cognitive impairment may affect approximately all patients with MS, and has been reported to negatively impact employment, social functioning, quality of life, and the ability to perform instrumental activities of daily living, with a high social cost. ...
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 1